Antofagasta Region Vacations

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Top destinations in Antofagasta Region

A desert landscape with a dirt road leading through rocky terrain and mountains.
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San Pedro de Atacama

San Pedro de Atacama
A desert landscape with sparse vegetation and distant snow-capped mountains.
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María Elena

María Elena

Antofagasta Region Hotel Deals

Diego de Almagro San Pedro de Atacama

Diego de Almagro San Pedro de Atacama

3 out of 5
Toconao 460 San Pedro de Atacama Antofagasta
Fully refundableReserve now, pay when you stay
The price is AED 459 per night from Nov 18 to Nov 19
AED 459
AED 459 total
18 Nov - 19 Nov
8.2/10 Very Good! (414 reviews)
"excellent location, well maintained property. Rooms basic but good. Well stocked breakfasts. Recommend."

Reviewed on 5 November 2026

Diego de Almagro San Pedro de Atacama
Geotel Calama

Geotel Calama

3.5 out of 5
Cobija 2273 Calama Antofagasta
Fully refundableReserve now, pay when you stay
The price is AED 270 per night from Dec 11 to Dec 12
AED 270
AED 270 total
11 Dec - 12 Dec
8.8/10 Excellent! (244 reviews)
"Chambre très confortable, petit déjeuner complet et stationnement sécurisé. Tout etait parfait"

Reviewed on 8 November 2026

Geotel Calama
Hotel La Casa de Don Tomas

Hotel La Casa de Don Tomas

3 out of 5
Calle Tocopilla Sitio 18 San Pedro de Atacama
9.2/10 Wonderful! (468 reviews)
"We spent 5 nights at El Refugio La Casa de Don Tomas and thoroughly enjoyed our stay. The entire property was exceptionally clean, with great facilities, a beautiful garden area, and a fantastic terrace that was perfect for viewing the night sky. The staff were remarkably friendly and welcoming, ..."

Reviewed on 9 November 2026

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Hotel La Casa de Don Tomas
See all 304 properties in Antofagasta Region
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Antofagasta Region attractions

Valley of the Moon

9.2/10 (244 reviews)
Explore the great outdoors at Valley of the Moon, a lovely green space in San Pedro de Atacama. You can seek out the local tours in this quaint area.
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