The Best Hotels Closest to Buffalo Museum of Science in Buffalo for 2026

A large mammoth skeleton in a museum with classical architecture.

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Our top choices for Buffalo Museum of Science hotels

A spacious room with a wooden floor, a fireplace, a dining table, and several chairs.

A historic building with a prominent tower and a traditional brick facade.

A traditional living room with a green sofa, a wooden coffee table with books, a blue armchair, and various potted plants.

A room with a textured ceiling, a chandelier, and walls painted in a two-tone color scheme.

1. Buffalo Harmony House

Allentown, 3.2 km from Buffalo Museum of Science

John

A spacious dining area with a long table, multiple chairs, a chandelier, and a fireplace.

A living room with a fireplace, two leather armchairs, a coffee table, and a chandelier.

A bedroom with a four-poster bed, a yellow sofa, a white coffee table, and a desk with a chair.

A spacious room with a large wooden table, several chairs, a sofa, and two chandeliers.

2. The Edward Hotel

Elmwood Village, 2.4 km from Buffalo Museum of Science

Grace

A two-story building with a white exterior, a red door, and large windows.

A living room with a fireplace, leather sofa, and a television mounted on the wall.

A living room with a fireplace, a chandelier, leather sofas, and a glass coffee table.

A spacious living area with a granite island, wooden chairs, a fireplace, and a television.

3. Buffalo Guesthouse

Allentown, 2.4 km from Buffalo Museum of Science

Jan

A spacious lobby with a large sofa, a coffee table, and potted plants. There is a decorative wall with a painting and a large window providing natural light.

A compact kitchen with wooden cabinets, a black refrigerator, a microwave, and a coffee maker.

A hotel dining area with multiple tables and chairs, a reception desk, and framed pictures on the walls.

A multi-story hotel with a modern facade, large windows, and a covered entrance area.

4. Wyndham Garden Buffalo Downtown

Downtown Buffalo, 1.9 km from Buffalo Museum of Science

Julian

A modern hotel lobby with a bar area, seating, and a large TV screen.

A modern restaurant with a long counter, bar stools, and a refrigerated display.

A modern indoor swimming pool with clear blue water, surrounded by lounge chairs and a glass-enclosed area.

A modern hotel lobby with seating areas, a flat-screen TV, and a bookshelf.

5. Residence Inn by Marriott Buffalo Downtown

Allentown, 2.6 km from Buffalo Museum of Science

Karen

A hotel room with a bed, desk, chair, TV, and a bathroom with a sink and mirror.

A modern gym with cardio machines, a mirrored wall, and a blue accent wall.

A modern hotel lobby with a round coffee table, two grey armchairs, a TV, and a reception desk.

A modern kitchen with a central island, bar stools, and various appliances.

6. Best Western on the Avenue

Allentown, 2.8 km from Buffalo Museum of Science

John

A dining area with a wooden table and chairs, a fireplace, and large windows with a view of greenery outside.

A modern kitchen with a large window, stainless steel appliances, and wooden cabinetry.

A grand staircase with a decorative railing and a Christmas tree adorned with ornaments and ribbons.

A casino interior with slot machines, a large illuminated pillar, and comfortable seating areas.

7. Summer Street Guest House

Bryant, 3 km from Buffalo Museum of Science

Anthony

A hotel room with a bed, a TV, a desk, a chair, and a sofa.

A gym with exercise equipment, a mirror, and a television.

A coffee station with two coffee makers, a coffee dispenser, and various coffee cups and containers.

A modern hotel room with a wooden dresser, a flat-screen TV, a kitchenette, a blue sofa, and a small table.

8. Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

Buffalo Theater District, 3.1 km from Buffalo Museum of Science

Charles

A lobby with a staircase, seating area, and a view of the outdoors.

A hotel with a classic brick facade, a glass entrance, and flags.

A bathroom with a toilet, sink, and shower curtain.

A reception area with a marble wall, a reception desk with glass panels, a clock, and a television mounted on the wall.

9. Lenox Hotel and Suites

Allentown, 2.6 km from Buffalo Museum of Science

Thomas

A rooftop terrace with wicker furniture, a bar area, and a view of the cityscape.

A modern living room with a large window, a flat-screen TV, a sofa, a coffee table, and a patterned rug.

A modern hotel with a glass facade, multiple floors, and a prominent 'Aloft' sign.

A modern cafe with round tables and chairs, a bar area, and a neon sign.

10. Aloft by Marriott Buffalo Downtown

Buffalo Theater District, 3 km from Buffalo Museum of Science

Anthony T

A dining area with a wooden table set for four, surrounded by chairs. There is a kitchen area with cabinets and appliances in the background.

A kitchen with wooden cabinets, a dishwasher, and a dining area with a table and chairs.

A bedroom with a bed, bedside lamps, a nightstand, a window with curtains, and wall art.

A kitchen with wooden cabinets, stainless steel appliances, and a red toaster.

11. 4 Mi to Dtwn: Family Home in Buffalo

Masten Park, 1.4 km from Buffalo Museum of Science

A buffet setup with various food items and utensils.

A hotel room with a large bed, a desk with a chair, a bathroom with a bathtub, and a mirror.

A building with a large illuminated sign reading "Russells STEAKS - CHOPS - AND MORE".

A hotel room with a sofa, a bed, a desk, and a chair. There are lamps on the desk and bedside tables.

12. Salvatores Grand Hotel

13.1 km from Buffalo Museum of Science

Margaret

A hotel with a prominent entrance, a clock tower, and the name "REIKART HOUSE" displayed above the entrance.

An outdoor patio area with tables and chairs, string lights, and greenery.

A spacious living area with a fireplace, a large sofa, and a dining area with a table and chairs.

13. Reikart House, Buffalo, a Tribute Portfolio Hotel

8.3 km from Buffalo Museum of Science

Brandon

A modern lounge area with sofas, round tables, and a stone accent wall.

A lobby with teal armchairs, a round table, a flat-screen TV, and a stone wall with a fireplace.

14. The Mosey Buffalo Williamsville, Tapestry Collection by Hilton

9 km from Buffalo Museum of Science

Randy

A modern hotel room with a bed, a desk with a chair, a flat-screen TV, a microwave, and a large mirror.

15. Hampton Inn Buffalo - Amherst, NY

10.6 km from Buffalo Museum of Science

Warren

A spacious lobby with high ceilings, a grand staircase, and a gift shop.

A bar area with leather barstools, a bar counter, and a television screen.

A bar area with red upholstered bar stools, a bar counter, and a chandelier.

A hotel room with two beds, a desk, a chair, a coffee machine, and a large window with curtains.

16. The Delavan Hotel & Spa

12.4 km from Buffalo Museum of Science

Peter

A patio area with outdoor seating, a barbecue grill, and a stone wall.

A modern lounge area with seating, tables, and hanging chairs.

A modern hotel lobby with a central seating area, a reception desk, and a colorful mural.

17. Tru by Hilton Williamsville Buffalo Airport

13 km from Buffalo Museum of Science

Lachelle

A large indoor swimming pool with clear blue water, surrounded by lounge chairs and a sauna area.

A modern lounge area with blue upholstered chairs, a wooden rocking chair, a round table, and a patterned rug.

A hotel lobby with a seating area featuring sofas, ottomans, and tables. A reception desk and a bar are visible in the background.

A modern hotel room with a large bed, a desk, a TV, and a view of the outdoors.

18. Hampton Inn Buffalo-Williamsville

9.6 km from Buffalo Museum of Science

Robert

A modern hotel room with a large window, a sofa, a coffee table, and a TV.

A spacious bedroom with a large bed, a comfortable armchair, and a view of a body of water through floor-to-ceiling windows.

A modern hotel lobby with a reception desk, seating area, and a large window offering a view of the city.

A modern kitchen with a central island, bar stools, and built-in appliances.

19. Buffalo Marriott at LECOM HARBORCENTER

Downtown Buffalo, 4.4 km from Buffalo Museum of Science

Vincent

A modern kitchen with a central island, wooden cabinets, and a bar area with stools.

A modern hotel lobby with a curved seating area, a flat-screen TV, and a dining area.

An outdoor patio with a round table, chairs, a cushioned seating area, and a barbecue grill.

A hotel room with a bed, a TV, a desk, a lamp, and a mirror.

20. Springhill Suites Buffalo Airport

13 km from Buffalo Museum of Science

Matthias

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Compare popular hotels close to Buffalo Museum of Science

Property	Property class	Guest rating
Buffalo Harmony House	10.0 Exceptional 56 reviews	View
The Edward Hotel	9.6 Exceptional 268 reviews	View
Buffalo Guesthouse	9.4 Exceptional 218 reviews	View
Wyndham Garden Buffalo Downtown	9.0 Wonderful 1,898 reviews	View
Residence Inn by Marriott Buffalo Downtown	9.2 Wonderful 387 reviews	View

Top Buffalo Museum of Science Hotel Reviews

Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

8/10 Good

"Hotel was very clean and quiet"

Buffalo Guesthouse

10/10 Excellent

"Staff was extremely helpful when my arrival was delayed - I could not check in until 11pm. Property was clean, comfortable, and conveniently located. Will plan to stay at Buffalo Guesthouse for future trips. Go Bills."

The Richardson Hotel

10/10 Excellent

"This is very unique stay in Buffalo. It is located within walking distance two The Burchfield Penny Art Center and the Buffalo AKG. The historic context of this building was fascinating, and the room was very comfortable. A great stay!"

Lenox Hotel and Suites

10/10 Excellent

"Enjoyed our stay"

Elmwood Village home

8/10 Good

"Classic Buffalo turn of the century home. Very clean inside. Second bathroom down the stairs outside of the apartment. Three comfy beds but one not as great. Place doesn't look impressive on the outside but quite nice on the inside.Host was very responsive to some minor issues that arose."

Stunning Elmwood Village Lower

10/10 Excellent

"Tv system would not let us see bills game"

Home away from home!

10/10 Excellent

"We will definitely be back to stay. Sandi’s place was perfect, a true home away from home! She is a wonderful host and we enjoyed our stay. The location is on a quiet street, so peaceful."

Spacious Historical Home by Parks, Shops, 4bd 2ba Save Weekly & monthly.

10/10 Excellent

"Great place to stay during our trip to Buffalo. House was clean and comfortable. Area was walkable to many of our activities."

Delightful dwelling

10/10 Excellent

"Property was very clean, functional and provided everything we needed. The location was good - short drives to most attractions. We would stay again."

Other attractions near Buffalo Museum of Science

Buffalo Central Terminal

You can find out about the history of Buffalo when you stop by Buffalo Central Terminal. Experience the entertainment choices and great live music in this vibrant area.

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Johnnie B. Wiley Sport Pavilion

Catch an event at Johnnie B. Wiley Sport Pavilion during your trip to Buffalo. Experience the area's entertainment choices and great live music.

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Paul Robeson Theater

Enjoy a show at Paul Robeson Theater, a theater with a story to tell in Buffalo. Experience the area's entertainment choices and great live music.

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African American Cultural Center

Enjoy a stop at African American Cultural Center, an entertaining place to visit in Buffalo. Experience the area's acclaimed theater scene and great live music.

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Broadway Market

You can enjoy retail therapy at Broadway Market during your stay in Buffalo. Experience the area's acclaimed theater scene and great live music.

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Koessler Athletic Center

Catch an event at Koessler Athletic Center during your trip to Buffalo.

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Montante Cultural Center

Enjoy an outing to Montante Cultural Center during your stay in Buffalo.

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Hellenic Orthodox Church of the Annunciation

After visiting Hellenic Orthodox Church of the Annunciation, make a plan to see the other sights and activities in Buffalo.

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Frequently asked questions

What's the area like around Buffalo Museum of Science?

Buffalo Museum of Science is located in a historic area of Buffalo known for its great live music scene. If you're looking for a convenient place to stay, check out the 14 hotels and other accommodations you'll find within a mile.

What's the best hotel to stay near Buffalo Museum of Science?

Wyndham Garden Buffalo Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers free breakfast and a 24-hour fitness center. It's located 1.2 mi (1.9 km) from Buffalo Museum of Science. Other good choices within 5 miles include Hyatt Regency Buffalo / Hotel and Conference Center and Buffalo Guesthouse.

How many hotels will I be able to find close to Buffalo Museum of Science?

Expedia has 14 hotels and other accommodations within a mile from Buffalo Museum of Science.

If I need to cancel the hotel reservation for my stay near Buffalo Museum of Science, will I receive a refund?

Yes, most hotel room reservations are refundable if you cancel prior to the accommodation's cancellation deadline, which is often 24 or 48 hours before your scheduled arrival. If you booked a non-refundable reservation, you might be able to still cancel and receive a refund within 24 hours of your booking. Plug in your dates, click on "Search", then filter by "fully refundable" to review the top deals on offer near Buffalo Museum of Science.

Where can I learn more about changing or cancelling my trip in the area near Buffalo Museum of Science?

For more information about picking new dates or cancelling your stay near Buffalo Museum of Science, go to https://www.expedia.com/service/.

What can I see and do near Buffalo Museum of Science?

Study the collections at Buffalo AKG Art Museum, Buffalo History Museum, or Buffalo and Erie County Naval and Military Park. Some landmarks that you won't want to miss include Buffalo Central Terminal, Statler Tower, and Richardson Olmsted Complex. You can watch performances at Kleinhans Music Hall, Town Ballroom, and Road Less Traveled Productions if you're interested in local theater.

Find hotels near Buffalo Museum of Science, Buffalo from AED 439

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Treat yourself

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Our top choices for Buffalo Museum of Science hotels

1. Buffalo Harmony House

2. The Edward Hotel

3. Buffalo Guesthouse

4. Wyndham Garden Buffalo Downtown

5. Residence Inn by Marriott Buffalo Downtown

6. Best Western on the Avenue

7. Summer Street Guest House

8. Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

9. Lenox Hotel and Suites

10. Aloft by Marriott Buffalo Downtown

11. 4 Mi to Dtwn: Family Home in Buffalo

12. Salvatores Grand Hotel

13. Reikart House, Buffalo, a Tribute Portfolio Hotel

14. The Mosey Buffalo Williamsville, Tapestry Collection by Hilton

15. Hampton Inn Buffalo - Amherst, NY

16. The Delavan Hotel & Spa

17. Tru by Hilton Williamsville Buffalo Airport

18. Hampton Inn Buffalo-Williamsville

19. Buffalo Marriott at LECOM HARBORCENTER

20. Springhill Suites Buffalo Airport

Compare popular hotels close to Buffalo Museum of Science

Top Buffalo Museum of Science Hotel Reviews

Holiday Inn Express & Suites Buffalo Downtown - Medical CTR by IHG

Buffalo Guesthouse

The Richardson Hotel

Lenox Hotel and Suites

Elmwood Village home

Stunning Elmwood Village Lower

Home away from home!

Spacious Historical Home by Parks, Shops, 4bd 2ba Save Weekly & monthly.

Delightful dwelling

Other attractions near Buffalo Museum of Science

Buffalo Central Terminal

Johnnie B. Wiley Sport Pavilion

Paul Robeson Theater

African American Cultural Center

Broadway Market

Koessler Athletic Center

Montante Cultural Center

Hellenic Orthodox Church of the Annunciation

Frequently asked questions