A steel bridge with a sunset in the background.

Cairo Vacations

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Discover the most popular places to visit in Cairo

Fort Defiance State Park

7.4/10 (15 reviews)

Where the mighty Mississippi and Ohio rivers converge, Fort Defiance Park offers a rare view of this natural phenomenon. Explore the historic grounds where Lewis and Clark once trained the Corps of Discovery in 1803.

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Cairo Hotel Deals

A hotel lobby with a reception desk, seating area, and a large window.

Quality Inn Cairo I-57

4.3 km from Cairo

"Carpet was unswept. Toilet didn’t work properly. Towels were stained. Breakfast was cereal and waffles and not much of it."

AED 286 total

includes taxes & fees

4 Dec - 5 Dec

A hotel room with a large bed, two bedside lamps, a framed picture of a bridge, and a wooden nightstand with a phone.

Super 8 by Wyndham Charleston/Sikeston East MO

16.2 km from Cairo

"Friendly helpful check in, room was comfortable. we were travelling with our dog and it has a large area to walk him around. excellent Mexican restaurant next door we would definitely stay again"

AED 241 total

includes taxes & fees

1 Dec - 2 Dec