The Best Hotels Closest to Duke Regional Hospital in Raleigh for 2026

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Our top choices for Duke Regional Hospital hotels

A breakfast area with a chalkboard menu, a sign indicating breakfast starts here, and a variety of food items like waffles, oatmeal, and fruits.

A hotel room with a bed, a desk with a chair, a flat-screen TV, a microwave, and a mirror.

A narrow hallway with shelves stocked with snacks and beverages, leading to a room with a desk and chair.

A large indoor swimming pool with clear blue water, surrounded by beige tiled flooring and walls, with large windows allowing natural light.

1. Hampton Inn & Suites Durham/North I-85

2.2 km from Duke Regional Hospital

Darrel

AED 450

AED 510 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with two beds, a flat-screen TV, a wooden headboard, and a carpeted floor.

A breakfast buffet with a bakery section, a coffee station, and a sign indicating the availability of breakfast.

A Holiday Inn Express hotel with a modern design, featuring a prominent sign, multiple windows, and a well-lit entrance.

A gym with various exercise machines, a large mirror, and a television on the wall.

2. Holiday Inn Express Durham by IHG

2.4 km from Duke Regional Hospital

Kimberly R

AED 389

AED 442 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with a television on a wooden cabinet, a desk with a chair, and a lamp.

A hotel room with a bed, bedside tables, a nightstand, a mirror, and a bathroom with a sink and mirror.

A spacious hallway with wooden flooring, white walls, and multiple windows with blinds. There are two white chairs and a small table with a basket.

A Red Roof Cafe with a stone wall, a coffee machine, and two white chairs.

3. Red Roof Inn Durham - Duke Univ Medical Center

2.3 km from Duke Regional Hospital

Luis

AED 230

AED 268 total

includes taxes & fees

1 Nov - 2 Nov

A stone fire pit surrounded by striped chairs and tables in an outdoor lounge area with a view of a building in the background.

A modern hotel lobby with a reception desk, seating area, and a cityscape mural on the wall.

A modern dining area with a long table, multiple chairs, and a sofa with red ottomans.

An indoor swimming pool with clear blue water, surrounded by lounge chairs and a tiled floor.

4. Hampton Inn & Suites Durham University Medical Center

5 km from Duke Regional Hospital

Nicole

AED 496

AED 563 total

includes taxes & fees

18 Oct - 19 Oct

A bar area with wooden bar stools, pendant lighting, and a counter with a glass display. There are tables and chairs in the background, and the room has a wooden floor.

A covered porch with steps leading to a door, a brick wall, and a street lamp.

A colonial-style building with a covered porch, multiple windows, and outdoor seating.

A hotel room with two beds, a sofa, a TV, and a bathroom visible through a door.

5. The Colonial Inn, an Ascend Collection Hotel

18.6 km from Duke Regional Hospital

Elizabeth

AED 399

AED 452 total

includes taxes & fees

25 Oct - 26 Oct

A multi-story hotel with a prominent "HOME 2" sign, a brick facade, and a well-lit entrance.

6. Home2 Suites by Hilton Durham University Medical Center

5 km from Duke Regional Hospital

katey

AED 512

AED 581 total

includes taxes & fees

18 Oct - 19 Oct

An outdoor patio area with round tables and chairs, large umbrellas, and a glass door entrance.

A hotel room with two beds, a desk, a chair, a sofa, and a TV.

A modern living room with a fireplace, two sofas, a coffee table, and a TV mounted on the wall.

A modern restaurant with round tables and yellow chairs, a bar area, and a 'Hello Fall' sign.

7. Fairfield by Marriott Inn & Suites Durham

18.2 km from Duke Regional Hospital

Chip

AED 436

AED 495 total

includes taxes & fees

25 Oct - 26 Oct

A modern lobby with a central seating area, a TV screen, and a patterned wall.

An indoor swimming pool with clear water, surrounded by lounge chairs and potted plants.

A reception area with a counter, a welcome sign, a digital screen, and a hallway leading to a dining area.

A modern kitchen with a built-in refrigerator, a gray sofa, and a gray armchair.

8. Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

18.2 km from Duke Regional Hospital

Maurice

AED 434

AED 491 total

includes taxes & fees

18 Oct - 19 Oct

A brick pathway flanked by neatly trimmed hedges leading to a building with a red facade and a grey roof.

A modern living room with two sofas facing a glass coffee table, a large window with curtains, and a brick wall.

An outdoor dining area with tables set for four, surrounded by a brick pathway and lush greenery.

A spacious lobby with a long corridor, comfortable seating areas, and large windows providing natural light.

9. Rizzo Center, a Destination by Hyatt Hotel

17 km from Duke Regional Hospital

Andrea

AED 654

AED 742 total

includes taxes & fees

1 Nov - 2 Nov

A hotel entrance with a stone facade, large wooden doors, and a view into the interior.

An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.

A dining area with a chandelier, tables, chairs, and a Christmas tree.

A person performing a yoga pose outdoors with trees and a golf course in the background.

10. Washington Duke Inn & Golf Club

6.6 km from Duke Regional Hospital

Antonio

AED 882

AED 1,001 total

includes taxes & fees

25 Oct - 26 Oct

A spacious lobby with high ceilings, a central fountain, and seating areas.

A modern bedroom with a large bed, a fireplace, a walk-in closet, and a bathroom with a round mirror and vanity.

A bar area with multiple liquor cabinets and hanging pendant lights.

A spacious lobby with a curved seating area, large windows, and a modern chandelier.

11. Embassy Suites by Hilton Raleigh Durham Airport Brier Creek

18.2 km from Duke Regional Hospital

Darren C.

AED 584

AED 662 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with a sofa, a small table, a desk, a chair, a TV, and a window with curtains.

A reception area with two wooden reception desks, a potted plant, and a computer on the wall.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

12. Courtyard Raleigh-Durham Airport/Brier Creek

16.6 km from Duke Regional Hospital

Sharon

AED 508

AED 575 total

includes taxes & fees

18 Oct - 19 Oct

A swimming pool with lounge chairs and a wooden fence.

A spacious lobby with a reception desk, seating area, and artwork on the walls.

A multi-story hotel with a modern design, featuring a prominent entrance with a glass canopy and an American flag.

A hotel room with a bed, a sofa, a desk with a chair, a television, and a painting on the wall.

13. Hyatt Place Durham Southpoint

16.1 km from Duke Regional Hospital

Jessica

AED 496

AED 563 total

includes taxes & fees

21 Oct - 22 Oct

An outdoor seating area with wicker furniture and a stone fire pit.

An indoor swimming pool with clear water, a lifeguard chair, and a sign indicating no diving.

A conference room with a long table, chairs, and a modern chandelier.

A modern hotel lobby with seating areas, large windows, and a dining section.

14. Residence Inn Raleigh-Durham Airport/Brier Creek

16.6 km from Duke Regional Hospital

Janet

AED 512

AED 580 total

includes taxes & fees

18 Oct - 19 Oct

An indoor swimming pool with clear water, a no diving sign, and a seating area with chairs and tables.

A modern hotel lobby with a long dining table, multiple chairs, a sofa, and a bar area.

A modern hotel lobby with a sectional sofa, armchairs, and a coffee table.

A modern kitchen with built-in shelves, a glass backsplash, and a variety of kitchenware.

15. Hyatt House Raleigh / RDU / Brier Creek

17.8 km from Duke Regional Hospital

Alton

AED 404

AED 458 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor seating area with sofas, chairs, and a fire pit, adjacent to a modern building with large windows.

A modern bar area with a long counter, multiple bar stools, and a large screen displaying a sports event.

A modern kitchen with a central island, bar stools, wooden cabinets, and pendant lighting.

A modern reception area with a marble counter, a wooden bench, and a unique chandelier.

16. JB Duke Hotel

6.2 km from Duke Regional Hospital

samantha

AED 731

AED 830 total

includes taxes & fees

13 Oct - 14 Oct

An outdoor patio with a table set for a meal, surrounded by chairs and a red umbrella.

A tented outdoor dining area with round tables set for a meal, each with white chairs and yellow tablecloths.

A compact hotel room with a kitchenette, including a microwave, coffee maker, and dishwasher.

A bathroom with a granite countertop, a mirror, and a potted plant.

17. DoubleTree Suites by Hilton Raleigh - Durham

14.2 km from Duke Regional Hospital

Stephen

AED 362

AED 411 total

includes taxes & fees

8 Nov - 9 Nov

A lobby with a green sofa, yellow chairs, a coffee table with drinks, and a window with plants.

A bar area with a granite countertop, wooden chairs, and a large television screen.

An indoor swimming pool with clear glass walls, a tiled floor, and a seating area with chairs and a table.

A business center with wooden paneling, multiple workstations, and framed artwork on the walls.

18. Hilton Garden Inn Durham/University Medical Center

9th Street District, 4 km from Duke Regional Hospital

Michael

AED 500

AED 567 total

includes taxes & fees

2 Nov - 3 Nov

A spacious, elegantly decorated interior with a central round table, high ceilings, and classic architectural columns.

A large, historic building with a central courtyard, columns, and a brick facade.

A banquet hall with round tables, chandeliers, and floral centerpieces.

A spacious living room with a sofa, armchairs, a coffee table, and a chandelier.

19. The Carolina Inn, a Destination by Hyatt Hotel

19.9 km from Duke Regional Hospital

Stephanie Pauline

AED 1,319

AED 1,497 total

includes taxes & fees

1 Nov - 2 Nov

A modern hotel with a prominent entrance, multiple floors, and a balcony on the second floor.

An outdoor patio with a fire feature, seating, and a building with large windows.

A modern hotel lobby with a reception desk, a beverage refrigerator, and a well-stocked snack bar.

A modern dining area with wooden tables and chairs, large windows, and geometric pendant lighting.

20. SpringHill Suites by Marriott Durham City View

5.4 km from Duke Regional Hospital

Taurean

AED 471

AED 535 total

includes taxes & fees

25 Oct - 26 Oct

View all properties

Compare popular hotels close to Duke Regional Hospital

Property	Property class	Guest rating
Hampton Inn & Suites Durham/North I-85	9.0 Wonderful 1,005 reviews	View
Holiday Inn Express Durham by IHG	8.8 Excellent 1,003 reviews	View
Red Roof Inn Durham - Duke Univ Medical Center	6.8 1,000 reviews	View
Hampton Inn & Suites Durham University Medical Center	9.6 Exceptional 572 reviews	View
The Colonial Inn, an Ascend Collection Hotel	9.6 Exceptional 321 reviews	View

Top Duke Regional Hospital Hotel Reviews

Comfort Inn & Suites Durham near Duke University

10/10 Excellent

"Arrived a little early and was accommodated by getting my room 30 minutes early. The room was very clean and comfy. The bed was firm but comfortable and the water pressure in the shower wasn’t great but was good enough. We never made it down for breakfast so I can’t comment on it. Also lots of good eating choices within a few minutes drive. I would recommend this property if you are wanting a good hotel for an affordable price."

The Lodge at Duke Medical Center

8/10 Good

"Very convenient to the medical center and university. The staff was very helpful. Good value. Very safe."

Millennium Hotel Durham

10/10 Excellent

"Very nice stay!"

Unscripted Durham, Part of JDV by Hyatt

8/10 Good

"The place was awesome! I'm not going into details....I came home with some bed bug bites......🤔"

Hilton Durham near Duke University

10/10 Excellent

"We did not use the amenities, but the hotel was very clean. The bed was very comfortable, and the body wash in the room smelled AMAZING!"

21c Museum Hotel Durham

10/10 Excellent

"Stellar customer service!! Look elsewhere for food."

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

10/10 Excellent

"The house was absolutely immaculate and Kristin could not have nicer or more helpful. The location was just 25 minutes from RDU, 12 minutes from downtown Durham and about a half an hour from Chapel Hill. Comfortable living room for my small group, large screen TV with all the streaming channels and a very cool coffee grinder/maker for regular or espresso coffee. Highly recommend. John L"

Everything within 1 mile

10/10 Excellent

"Perfect size and great location! The host has thought of everything and included so many extra thoughtful touches! So close to everything, quiet, clean, and stocked!"

Cottage with Yard, Mins to Duke

10/10 Excellent

"This was a cheerful home with comfortable beds and many thoughtful extras. We enjoyed our time here."

Frequently asked questions

What's the area like around Duke Regional Hospital?

Duke Regional Hospital is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, check out the 10 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Duke Regional Hospital?

Courtyard Durham Near Duke University/Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and free parking. It's located 2.2 mi (3.5 km) from Duke Regional Hospital. Other good choices within a few miles include Holiday Inn Express Durham by IHG and Red Roof Inn Durham - Duke Univ Medical Center.

How many hotels can I expect to find near Duke Regional Hospital?

Expedia has 10 hotels and other accommodations within a mile from Duke Regional Hospital.

If I need to cancel the hotel reservation for my stay near Duke Regional Hospital, will I receive a refund?

Yes! Most hotel room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Add dates, click "Search", then you can filter by "fully refundable" to get the best deals near Duke Regional Hospital.

Where can I learn more about changing or cancelling my trip in the area near Duke Regional Hospital?

To find more details about changing or cancelling your stay near Duke Regional Hospital, click here.

What can I see and do near Duke Regional Hospital?

You might want to spend some time browsing the exhibits at Museum of Life and Science, Nasher Museum of Art at Duke University, or Bennett Place. While you're exploring, swing by American Tobacco Campus, Cameron Indoor Stadium, and Wallace Wade Stadium to learn a bit about the area. You can enjoy live performances at Carolina Theatre and Common Ground Theatre.

Find hotels near Duke Regional Hospital, Raleigh from AED 268

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Treat yourself

Be picky

Check prices for these dates

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Our top choices for Duke Regional Hospital hotels

1. Hampton Inn & Suites Durham/North I-85

2. Holiday Inn Express Durham by IHG

3. Red Roof Inn Durham - Duke Univ Medical Center

4. Hampton Inn & Suites Durham University Medical Center

5. The Colonial Inn, an Ascend Collection Hotel

6. Home2 Suites by Hilton Durham University Medical Center

7. Fairfield by Marriott Inn & Suites Durham

8. Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

9. Rizzo Center, a Destination by Hyatt Hotel

10. Washington Duke Inn & Golf Club

11. Embassy Suites by Hilton Raleigh Durham Airport Brier Creek

12. Courtyard Raleigh-Durham Airport/Brier Creek

13. Hyatt Place Durham Southpoint

14. Residence Inn Raleigh-Durham Airport/Brier Creek

15. Hyatt House Raleigh / RDU / Brier Creek

16. JB Duke Hotel

17. DoubleTree Suites by Hilton Raleigh - Durham

18. Hilton Garden Inn Durham/University Medical Center

19. The Carolina Inn, a Destination by Hyatt Hotel

20. SpringHill Suites by Marriott Durham City View

Compare popular hotels close to Duke Regional Hospital

Top Duke Regional Hospital Hotel Reviews

Comfort Inn & Suites Durham near Duke University

The Lodge at Duke Medical Center

Millennium Hotel Durham

Unscripted Durham, Part of JDV by Hyatt

Hilton Durham near Duke University

21c Museum Hotel Durham

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

Everything within 1 mile

Cottage with Yard, Mins to Duke

Frequently asked questions