The Best Hotels Closest to Duke Regional Hospital in Raleigh for 2026

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Our top choices for Duke Regional Hospital hotels

A breakfast area with a chalkboard menu, a sign indicating breakfast starts here, and a variety of food items like waffles, oatmeal, and fruits.

A narrow hallway with shelves stocked with snacks and beverages, leading to a room with a desk and chair.

A Hampton Inn hotel with a modern facade, multiple floors, and a parking lot.

A large indoor swimming pool with clear blue water, surrounded by beige tiled flooring and walls, with large windows allowing natural light.

1. Hampton Inn & Suites Durham/North I-85

2.2 km from Duke Regional Hospital

Darrel

AED 434

AED 492 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with two beds, a flat-screen TV, a wooden headboard, and a carpeted floor.

A gym with various exercise machines, a large mirror, and a television on the wall.

A coffee station with two coffee machines, a coffee press, and various coffee-related items on a counter.

A breakfast buffet with a bakery section, a coffee station, and a sign indicating the availability of breakfast.

2. Holiday Inn Express Durham by IHG

2.4 km from Duke Regional Hospital

Kimberly R

AED 426

AED 484 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a television on a wooden cabinet, a desk with a chair, and a lamp.

A Red Roof Inn with a modern architectural design, featuring a prominent red sign and a well-maintained lawn.

A spacious hallway with wooden flooring, white walls, and multiple windows with blinds. There are two white chairs and a small table with a basket.

A hotel room with a bed, bedside tables, a nightstand, a mirror, and a bathroom with a sink and mirror.

3. Red Roof Inn Durham - Duke Univ Medical Center

2.3 km from Duke Regional Hospital

Luis

AED 230

AED 268 total

includes taxes & fees

11 Oct - 12 Oct

A modern living room with a fireplace, comfortable seating, and a large window with curtains.

A hotel lobby with a reception desk, a modern abstract sculpture, and a patterned floor.

A courtyard with a pathway leading to a building with large windows and a yellow facade.

A hotel reception area with a counter, coffee station, and a large window with curtains.

4. La Quinta Inn & Suites by Wyndham Univ Area Chapel Hill

North Garrett Road, 10.4 km from Duke Regional Hospital

Yolanda

AED 308

AED 350 total

includes taxes & fees

11 Oct - 12 Oct

An outdoor patio with a stone fire pit surrounded by wicker furniture and a large window overlooking the building.

A modern bar area with a curved counter, bar stools, a coffee machine, and a refrigerated display of beverages.

A modern hotel lobby with a central bar area, seating arrangements, and large windows offering views of the outdoors.

A modern living room with a fireplace, comfortable seating, and a large window offering a view of the outdoors.

5. Courtyard Durham Near Duke University/Downtown

Croasdaile Farm Master, 3.5 km from Duke Regional Hospital

Billy

AED 303

AED 343 total

includes taxes & fees

18 Oct - 19 Oct

A modern hotel reception area with two wooden reception desks, a large digital display wall, and a seating area with chairs.

A hotel room with two beds, a desk, and a chair.

A modern restaurant with bar seating, a Starbucks sign, and a bar area with a counter and shelves.

6. Hilton Durham near Duke University

5.4 km from Duke Regional Hospital

tigist

AED 419

AED 475 total

includes taxes & fees

18 Oct - 19 Oct

An outdoor seating area with a circular fire pit surrounded by wicker chairs and a table.

An indoor swimming pool with a 3 FT depth marker, a wheelchair-accessible chair, a potted plant, and a view of the outside through large windows.

A modern hotel lobby with a mix of seating areas, a bar, and a large wall-mounted TV.

A reception area with a large screen displaying a sea view, a bench, and a sign indicating the location as Marriott Bonvoy.

7. SpringHill Suites by Marriott Durham Chapel Hill

12.6 km from Duke Regional Hospital

Logan

AED 470

AED 533 total

includes taxes & fees

12 Oct - 13 Oct

A stone fire pit surrounded by striped chairs and tables in an outdoor lounge area with a view of a building in the background.

A Hampton Inn & Suites hotel with a modern facade, multiple windows, and a parking lot.

A modern hotel lobby with a reception desk, seating area, and a cityscape mural on the wall.

An indoor swimming pool with clear blue water, surrounded by lounge chairs and a tiled floor.

8. Hampton Inn & Suites Durham University Medical Center

5 km from Duke Regional Hospital

Nicole

AED 458

AED 520 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a bed, a desk, a chair, a small table, a coffee machine, and a trash bin.

A swimming pool with lounge chairs and umbrellas, surrounded by a building with a clear sky.

A Comfort Inn & Suites hotel with a modern design, featuring a prominent entrance and a landscaped front yard.

A restaurant with a large ice dispenser, wooden paneling, and red cushioned booths.

9. Comfort Inn & Suites Durham near Duke University

Croasdaile Farm Master, 3.3 km from Duke Regional Hospital

BRIAN

AED 309

AED 351 total

includes taxes & fees

18 Oct - 19 Oct

A swimming pool with lounge chairs and a wooden fence.

A spacious lobby with a reception desk, seating area, and artwork on the walls.

A hotel room with a bed, a sofa, a desk with a chair, a television, and a painting on the wall.

A multi-story hotel with a modern design, featuring a prominent entrance with a glass canopy and an American flag.

10. Hyatt Place Durham Southpoint

16.1 km from Duke Regional Hospital

Stephen

AED 496

AED 563 total

includes taxes & fees

21 Oct - 22 Oct

An outdoor seating area with wicker chairs and a large umbrella, a fire feature, and a view of the interior through glass walls.

A modern kitchen with a microwave, coffee maker, and dishwasher. There is a round table with two green chairs in front.

A kitchen with a microwave, coffee maker, and a dishwasher.

A large indoor swimming pool with a skylight ceiling, clear glass walls, and a tiled floor.

11. DoubleTree Suites by Hilton Raleigh - Durham

14.2 km from Duke Regional Hospital

Stephen

AED 361

AED 410 total

includes taxes & fees

5 Nov - 6 Nov

A spacious lobby with a reception desk, seating area, and a balcony.

A hotel room with a bed, a desk with a TV, a chair, and a lamp.

A hotel room with a desk, a television, a chair, a sofa, and a window with curtains.

A Wingate hotel with a beige facade, stone entrance, and an American flag.

12. Wingate by Wyndham Raleigh Durham Airport RTP

18.2 km from Duke Regional Hospital

Supratik

AED 340

AED 386 total

includes taxes & fees

13 Oct - 14 Oct

A lobby with a green sofa, yellow chairs, a coffee table with drinks, and a window with plants.

An indoor swimming pool with clear glass walls, a tiled floor, and a seating area with chairs and a table.

A business center with wooden paneling, multiple workstations, and framed artwork on the walls.

A bar area with a granite countertop, wooden chairs, and a large television screen.

13. Hilton Garden Inn Durham/University Medical Center

9th Street District, 4 km from Duke Regional Hospital

Hal

AED 506

AED 574 total

includes taxes & fees

2 Nov - 3 Nov

A spacious lobby with wooden ceiling beams, a central bar area, multiple seating options including sofas and chairs, and framed pictures on the walls.

A spacious indoor area with high ceilings, modern lighting fixtures, and a mix of seating arrangements including sofas and chairs.

A Hampton Inn Suites hotel with a stone facade, large entrance doors, and a welcoming sign.

A hotel room with two beds, a headboard, bedside lamps, a television, and a window with curtains.

14. Hampton Inn & Suites Chapel Hill/Durham, Area

16 km from Duke Regional Hospital

Laura

AED 419

AED 476 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor seating area with wicker furniture and a stone fire pit.

A hotel lobby with a sofa, chairs, a table, and a large window offering a view of the building.

A conference room with a long table, chairs, and a modern chandelier.

An indoor swimming pool with clear water, a lifeguard chair, and a sign indicating no diving.

15. Residence Inn Raleigh-Durham Airport/Brier Creek

16.6 km from Duke Regional Hospital

Janet

AED 512

AED 580 total

includes taxes & fees

11 Oct - 12 Oct

An outdoor cafe with tables and chairs, umbrellas, and a bicycle parked nearby.

A modern building with a curved facade and a flat roof.

A group of people performing yoga on mats in an outdoor setting with a wooden deck and a city view in the background.

A spacious lobby with a curved ceiling, large windows, and a variety of seating arrangements including sofas, tables, and chairs.

16. The Durham Hotel

Downtown Durham, 4.5 km from Duke Regional Hospital

Connie

AED 683

AED 775 total

includes taxes & fees

18 Oct - 19 Oct

A long, narrow hallway with dark walls and wooden flooring.

A modern reception area with a reception desk, a seating area with chairs and a table, and a bookshelf with books.

A compact kitchenette with a refrigerator, microwave, and a flat-screen TV on a dark cabinet.

17. University Inn Durham next to Duke University Medical Center

4.5 km from Duke Regional Hospital

Wayne

AED 443

AED 503 total

includes taxes & fees

11 Oct - 12 Oct

A hotel room with two beds, a nightstand with a lamp, and a window with a view of trees.

A shelf stocked with various snack items, including boxed cereals and candy.

A Holiday Inn Express & Suites hotel with a parking lot and a large building in the background.

A conference room with a long table, chairs, a whiteboard, and framed artwork on the walls.

18. Holiday Inn Express & Suites Raleigh Airport - Brier Creek by IHG

16.9 km from Duke Regional Hospital

Sharon

AED 397

AED 467 total

includes taxes & fees

4 Nov - 5 Nov

An outdoor patio area with round tables and chairs, large umbrellas, and a glass door entrance.

A hotel room with two beds, a desk, a chair, a sofa, and a TV.

A multi-story hotel with a brick facade, large windows, and a well-lit entrance.

A modern living room with a fireplace, two sofas, a coffee table, and a TV mounted on the wall.

19. Fairfield by Marriott Inn & Suites Durham

18.2 km from Duke Regional Hospital

Yolanda

AED 422

AED 479 total

includes taxes & fees

29 Oct - 30 Oct

An indoor swimming pool with clear water, a no diving sign, and a seating area with chairs and tables.

A modern hotel lobby with a sectional sofa, armchairs, and a coffee table.

A modern hotel lobby with a long dining table, multiple chairs, a sofa, and a bar area.

A modern kitchen with built-in shelves, a glass backsplash, and a variety of kitchenware.

20. Hyatt House Raleigh / RDU / Brier Creek

17.8 km from Duke Regional Hospital

Alton

AED 404

AED 458 total

includes taxes & fees

1 Nov - 2 Nov

View all properties

Compare popular hotels close to Duke Regional Hospital

Property	Property class	Guest rating
Hampton Inn & Suites Durham/North I-85	9.0 Wonderful 1,003 reviews	View
Holiday Inn Express Durham by IHG	8.8 Excellent 1,005 reviews	View
Red Roof Inn Durham - Duke Univ Medical Center	6.8 1,001 reviews	View
La Quinta Inn & Suites by Wyndham Univ Area Chapel Hill	8.6 Excellent 1,991 reviews	View
Courtyard Durham Near Duke University/Downtown	8.2 Very good 1,005 reviews	View

Top Duke Regional Hospital Hotel Reviews

Courtyard Durham Near Duke University/Downtown

10/10 Excellent

"Great room, close to downtown. Wonderfully professional staff. Would stay there again."

Hilton Durham near Duke University

10/10 Excellent

"Would definitely recommend to another. Close to Duke University and the downtown area. Very clean and great customer service."

Comfort Inn & Suites Durham near Duke University

10/10 Excellent

"This was a very good value for money stay. The hotel was clean, staff were friendly and helpful, the bed was very comfortable and the room was spacious. Breakfast was included and was a standard breakfast buffet. We would happily stay here again if visiting Durham."

Millennium Hotel Durham

10/10 Excellent

"Front desk couldn’t find my reservation. I called expedia and after more than an hour they emailed the hotel a new payment code. Gladly, Fernando, hotel front desk representative, was able to quickly make a new reservation and get me and my wife a room. Thanks Fernando (Millenium Hotel) for the great customer service."

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

10/10 Excellent

"The house was absolutely immaculate and Kristin could not have nicer or more helpful. The location was just 25 minutes from RDU, 12 minutes from downtown Durham and about a half an hour from Chapel Hill. Comfortable living room for my small group, large screen TV with all the streaming channels and a very cool coffee grinder/maker for regular or espresso coffee. Highly recommend. John L"

The Lodge at Duke Medical Center

10/10 Excellent

"My stay was great!"

Drexall Haven - Stylish + Peaceful Stay

8/10 Good

"The house is newly renovated so everything looks really nice. The only issue I have is a lack of dressers for our clothes. Otherwise the experience was great. Quiet neighborhood out of the way but accessible."

Everything within 1 mile

10/10 Excellent

"Perfect size and great location! The host has thought of everything and included so many extra thoughtful touches! So close to everything, quiet, clean, and stocked!"

Cottage with Yard, Mins to Duke

10/10 Excellent

"This was a cheerful home with comfortable beds and many thoughtful extras. We enjoyed our time here."

Frequently asked questions

What's the area like around Duke Regional Hospital?

Duke Regional Hospital is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, check out the 10 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Duke Regional Hospital?

Courtyard Durham Near Duke University/Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and free parking. It's located 2.2 mi (3.5 km) from Duke Regional Hospital. Other good choices within a few miles include Holiday Inn Express Durham by IHG and Red Roof Inn Durham - Duke Univ Medical Center.

How many hotels can I expect to find near Duke Regional Hospital?

Expedia has 10 hotels and other accommodations within a mile from Duke Regional Hospital.

If I need to cancel the hotel reservation for my stay near Duke Regional Hospital, will I receive a refund?

Yes! Most hotel room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Add dates, click "Search", then you can filter by "fully refundable" to get the best deals near Duke Regional Hospital.

Where can I learn more about changing or cancelling my trip in the area near Duke Regional Hospital?

To find more details about changing or cancelling your stay near Duke Regional Hospital, click here.

What can I see and do near Duke Regional Hospital?

You might want to spend some time browsing the exhibits at Museum of Life and Science, Nasher Museum of Art at Duke University, or Bennett Place. While you're exploring, swing by American Tobacco Campus, Cameron Indoor Stadium, and Wallace Wade Stadium to learn a bit about the area. You can enjoy live performances at Carolina Theatre and Common Ground Theatre.

Find hotels near Duke Regional Hospital, Raleigh from AED 268

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Treat yourself

Be picky

Check prices for these dates

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Our top choices for Duke Regional Hospital hotels

1. Hampton Inn & Suites Durham/North I-85

2. Holiday Inn Express Durham by IHG

3. Red Roof Inn Durham - Duke Univ Medical Center

4. La Quinta Inn & Suites by Wyndham Univ Area Chapel Hill

5. Courtyard Durham Near Duke University/Downtown

6. Hilton Durham near Duke University

7. SpringHill Suites by Marriott Durham Chapel Hill

8. Hampton Inn & Suites Durham University Medical Center

9. Comfort Inn & Suites Durham near Duke University

10. Hyatt Place Durham Southpoint

11. DoubleTree Suites by Hilton Raleigh - Durham

12. Wingate by Wyndham Raleigh Durham Airport RTP

13. Hilton Garden Inn Durham/University Medical Center

14. Hampton Inn & Suites Chapel Hill/Durham, Area

15. Residence Inn Raleigh-Durham Airport/Brier Creek

16. The Durham Hotel

17. University Inn Durham next to Duke University Medical Center

18. Holiday Inn Express & Suites Raleigh Airport - Brier Creek by IHG

19. Fairfield by Marriott Inn & Suites Durham

20. Hyatt House Raleigh / RDU / Brier Creek

Compare popular hotels close to Duke Regional Hospital

Top Duke Regional Hospital Hotel Reviews

Courtyard Durham Near Duke University/Downtown

Hilton Durham near Duke University

Comfort Inn & Suites Durham near Duke University

Millennium Hotel Durham

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

The Lodge at Duke Medical Center

Drexall Haven - Stylish + Peaceful Stay

Everything within 1 mile

Cottage with Yard, Mins to Duke

Frequently asked questions