The Best Hotels Closest to Duke Regional Hospital in Raleigh for 2026

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Our top choices for Duke Regional Hospital hotels

A breakfast area with a chalkboard menu, a sign indicating breakfast starts here, and a variety of food items like waffles, oatmeal, and fruits.

A large indoor swimming pool with clear blue water, surrounded by beige tiled flooring and walls, with large windows allowing natural light.

A narrow hallway with shelves stocked with snacks and beverages, leading to a room with a desk and chair.

A Hampton Inn hotel with a modern facade, multiple floors, and a parking lot.

1. Hampton Inn & Suites Durham/North I-85

2.2 km from Duke Regional Hospital

Darrel

AED 450

AED 510 total

includes taxes & fees

18 Oct - 19 Oct

A hotel room with two beds, a flat-screen TV, a wooden headboard, and a carpeted floor.

A breakfast buffet with a bakery section, a coffee station, and a sign indicating the availability of breakfast.

A Holiday Inn Express hotel with a modern design, featuring a prominent sign, multiple windows, and a well-lit entrance.

A gym with various exercise machines, a large mirror, and a television on the wall.

2. Holiday Inn Express Durham by IHG

2.4 km from Duke Regional Hospital

Kimberly R

AED 389

AED 442 total

includes taxes & fees

8 Nov - 9 Nov

A hotel room with a television on a wooden cabinet, a desk with a chair, and a lamp.

A hotel room with a bed, bedside tables, a nightstand, a mirror, and a bathroom with a sink and mirror.

A Red Roof Cafe with a stone wall, a coffee machine, and two white chairs.

A spacious hallway with wooden flooring, white walls, and multiple windows with blinds. There are two white chairs and a small table with a basket.

3. Red Roof Inn Durham - Duke Univ Medical Center

2.3 km from Duke Regional Hospital

Luis

AED 230

AED 268 total

includes taxes & fees

1 Nov - 2 Nov

4. Super 8 by Wyndham Durham/University Area NC

2.4 km from Duke Regional Hospital

Jacqueline

AED 285

AED 322 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor seating area with a circular fire pit surrounded by wicker chairs and a table.

A multi-story hotel with a flat facade, large windows, and a clear sky.

A modern hotel lobby with a mix of seating areas, a bar, and a large wall-mounted TV.

A reception area with a large screen displaying a sea view, a bench, and a sign indicating the location as Marriott Bonvoy.

5. SpringHill Suites by Marriott Durham Chapel Hill

12.6 km from Duke Regional Hospital

Logan

AED 434

AED 493 total

includes taxes & fees

18 Oct - 19 Oct

A bar area with wooden bar stools, pendant lighting, and a counter with a glass display. There are tables and chairs in the background, and the room has a wooden floor.

A hotel room with two beds, a sofa, a TV, and a bathroom visible through a door.

A covered porch with steps leading to a door, a brick wall, and a street lamp.

A colonial-style building with a covered porch, multiple windows, and outdoor seating.

6. The Colonial Inn, an Ascend Collection Hotel

18.6 km from Duke Regional Hospital

Elizabeth

AED 399

AED 452 total

includes taxes & fees

25 Oct - 26 Oct

A modern lobby with a central seating area, a TV screen, and a patterned wall.

A modern kitchen with a built-in refrigerator, a gray sofa, and a gray armchair.

A modern hotel room with a bed, bedside table, TV, and a small desk area.

A reception area with a counter, a welcome sign, a digital screen, and a hallway leading to a dining area.

7. Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

18.2 km from Duke Regional Hospital

Maurice

AED 434

AED 491 total

includes taxes & fees

18 Oct - 19 Oct

An outdoor patio area with round tables and chairs, large umbrellas, and a glass door entrance.

A multi-story hotel with a brick facade, large windows, and a well-lit entrance.

A hotel room with two beds, a desk, a chair, a sofa, and a TV.

A modern restaurant with round tables and yellow chairs, a bar area, and a 'Hello Fall' sign.

8. Fairfield by Marriott Inn & Suites Durham

18.2 km from Duke Regional Hospital

Chip

AED 436

AED 495 total

includes taxes & fees

25 Oct - 26 Oct

An indoor swimming pool with clear water, a no diving sign, and a seating area with chairs and tables.

A modern hotel lobby with a long dining table, multiple chairs, a sofa, and a bar area.

A modern hotel lobby with a reception desk, several chairs, a large monitor, and pendant lighting.

A modern kitchen with built-in shelves, a glass backsplash, and a variety of kitchenware.

9. Hyatt House Raleigh / RDU / Brier Creek

17.8 km from Duke Regional Hospital

Alton

AED 404

AED 458 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a bed, a desk, a chair, a small table, a coffee machine, and a trash bin.

A restaurant with a large ice dispenser, wooden paneling, and red cushioned booths.

A Comfort Inn & Suites hotel with a modern design, featuring a prominent entrance and a landscaped front yard.

A reception area with a wooden reception desk, blue seating, a flat-screen TV, and a stone accent wall.

10. Comfort Inn & Suites Durham near Duke University

Croasdaile Farm Master, 3.3 km from Duke Regional Hospital

BRIAN

AED 309

AED 351 total

includes taxes & fees

25 Oct - 26 Oct

A modern living room with a fireplace, comfortable seating, and a large window with curtains.

A swimming pool with lounge chairs and a view of a building with large windows.

A hotel reception area with a counter, coffee station, and a large window with curtains.

A hotel lobby with a reception desk, a modern abstract sculpture, and a patterned floor.

11. La Quinta Inn & Suites by Wyndham Univ Area Chapel Hill

North Garrett Road, 10.4 km from Duke Regional Hospital

Yolanda

AED 317

AED 360 total

includes taxes & fees

18 Oct - 19 Oct

A spacious lobby with high ceilings, a central fountain, and seating areas.

A modern bedroom with a large bed, a fireplace, a walk-in closet, and a bathroom with a round mirror and vanity.

A spacious lobby with a curved seating area, large windows, and a modern chandelier.

A bar area with multiple liquor cabinets and hanging pendant lights.

12. Embassy Suites by Hilton Raleigh Durham Airport Brier Creek

18.2 km from Duke Regional Hospital

Darren C.

AED 584

AED 662 total

includes taxes & fees

18 Oct - 19 Oct

A stone fire pit surrounded by striped chairs and tables in an outdoor lounge area with a view of a building in the background.

A Hampton Inn & Suites hotel with a modern facade, multiple windows, and a parking lot.

A modern hotel lobby with a reception desk, seating area, and a cityscape mural on the wall.

An indoor swimming pool with clear blue water, surrounded by lounge chairs and a tiled floor.

13. Hampton Inn & Suites Durham University Medical Center

5 km from Duke Regional Hospital

Nicole

AED 496

AED 563 total

includes taxes & fees

18 Oct - 19 Oct

A reception area with two wooden reception desks, a potted plant, and a computer on the wall.

An indoor swimming pool with clear water, a lifeguard chair, and a sign indicating no diving.

A hotel room with two beds, a desk, a chair, a TV, and a bathroom.

14. Courtyard Raleigh-Durham Airport/Brier Creek

16.6 km from Duke Regional Hospital

Sharon

AED 508

AED 575 total

includes taxes & fees

18 Oct - 19 Oct

An outdoor seating area with sofas, chairs, and a fire pit, adjacent to a modern building with large windows.

A modern bar area with a long counter, multiple bar stools, and a large screen displaying a sports event.

A modern reception area with a marble counter, a wooden bench, and a unique chandelier.

A modern living room with a fireplace, seating area, and a pool table.

15. JB Duke Hotel

6.2 km from Duke Regional Hospital

samantha

AED 731

AED 830 total

includes taxes & fees

14 Oct - 15 Oct

A modern hotel with a prominent entrance, multiple floors, and a balcony on the second floor.

A modern dining area with wooden tables and chairs, large windows, and geometric pendant lighting.

An outdoor patio with a fire feature, seating, and a building with large windows.

A modern hotel lobby with a reception desk, a beverage refrigerator, and a well-stocked snack bar.

16. SpringHill Suites by Marriott Durham City View

5.4 km from Duke Regional Hospital

Taurean

AED 471

AED 535 total

includes taxes & fees

25 Oct - 26 Oct

A lobby with a green sofa, yellow chairs, a coffee table with drinks, and a window with plants.

A business center with wooden paneling, multiple workstations, and framed artwork on the walls.

A Hilton Garden Inn hotel with a modern design, featuring a large entrance and a parking area with a delivery van.

A bar area with a granite countertop, wooden chairs, and a large television screen.

17. Hilton Garden Inn Durham/University Medical Center

9th Street District, 4 km from Duke Regional Hospital

Michael

AED 500

AED 567 total

includes taxes & fees

2 Nov - 3 Nov

A hotel entrance with a stone facade, large wooden doors, and a view into the interior.

A hotel with a stone lion statue, a covered entrance, and a landscaped garden.

A person performing a yoga pose outdoors with trees and a golf course in the background.

A dining area with a chandelier, tables, chairs, and a Christmas tree.

18. Washington Duke Inn & Golf Club

6.6 km from Duke Regional Hospital

Antonio

AED 882

AED 1,001 total

includes taxes & fees

13 Oct - 14 Oct

A modern hotel reception area with two wooden reception desks, a large digital display wall, and a seating area with chairs.

A hotel room with two beds, a desk, and a chair.

A modern restaurant with bar seating, a Starbucks sign, and a bar area with a counter and shelves.

A modern lobby with a fireplace, seating area, and wooden wall accents.

19. Hilton Durham near Duke University

5.4 km from Duke Regional Hospital

tigist

AED 419

AED 475 total

includes taxes & fees

18 Oct - 19 Oct

An outdoor seating area with wicker furniture and a stone fire pit.

A modern hotel lobby with seating areas, large windows, and a dining section.

A conference room with a long table, chairs, and a modern chandelier.

20. Residence Inn Raleigh-Durham Airport/Brier Creek

16.6 km from Duke Regional Hospital

Janet

AED 512

AED 580 total

includes taxes & fees

18 Oct - 19 Oct

View all properties

Compare popular hotels close to Duke Regional Hospital

Property	Property class	Guest rating
Hampton Inn & Suites Durham/North I-85	9.0 Wonderful 1,004 reviews	View
Holiday Inn Express Durham by IHG	8.8 Excellent 1,003 reviews	View
Red Roof Inn Durham - Duke Univ Medical Center	6.8 1,000 reviews	View
Super 8 by Wyndham Durham/University Area NC	5.0 344 reviews	View
SpringHill Suites by Marriott Durham Chapel Hill	9.2 Wonderful 1,001 reviews	View

Top Duke Regional Hospital Hotel Reviews

Unscripted Durham, Part of JDV by Hyatt

8/10 Good

"The place was awesome! I'm not going into details....I came home with some bed bug bites......🤔"

Comfort Inn & Suites Durham near Duke University

8/10 Good

"Clean, good price/cost ratio"

Hilton Durham near Duke University

10/10 Excellent

"We did not use the amenities, but the hotel was very clean. The bed was very comfortable, and the body wash in the room smelled AMAZING!"

The Lodge at Duke Medical Center

10/10 Excellent

"Good stay. Clean room but could use extra parking"

21c Museum Hotel Durham

10/10 Excellent

"Stellar customer service!! Look elsewhere for food."

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

10/10 Excellent

"The house was absolutely immaculate and Kristin could not have nicer or more helpful. The location was just 25 minutes from RDU, 12 minutes from downtown Durham and about a half an hour from Chapel Hill. Comfortable living room for my small group, large screen TV with all the streaming channels and a very cool coffee grinder/maker for regular or espresso coffee. Highly recommend. John L"

Drexall Haven - Stylish + Peaceful Stay

8/10 Good

"The house is newly renovated so everything looks really nice. The only issue I have is a lack of dressers for our clothes. Otherwise the experience was great. Quiet neighborhood out of the way but accessible."

Everything within 1 mile

10/10 Excellent

"Perfect size and great location! The host has thought of everything and included so many extra thoughtful touches! So close to everything, quiet, clean, and stocked!"

Cottage with Yard, Mins to Duke

10/10 Excellent

"This was a cheerful home with comfortable beds and many thoughtful extras. We enjoyed our time here."

Frequently asked questions

What's the area like around Duke Regional Hospital?

Duke Regional Hospital is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, check out the 10 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Duke Regional Hospital?

Courtyard Durham Near Duke University/Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and free parking. It's located 2.2 mi (3.5 km) from Duke Regional Hospital. Other good choices within a few miles include Holiday Inn Express Durham by IHG and Red Roof Inn Durham - Duke Univ Medical Center.

How many hotels can I expect to find near Duke Regional Hospital?

Expedia has 10 hotels and other accommodations within a mile from Duke Regional Hospital.

If I need to cancel the hotel reservation for my stay near Duke Regional Hospital, will I receive a refund?

Yes! Most hotel room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Add dates, click "Search", then you can filter by "fully refundable" to get the best deals near Duke Regional Hospital.

Where can I learn more about changing or cancelling my trip in the area near Duke Regional Hospital?

To find more details about changing or cancelling your stay near Duke Regional Hospital, click here.

What can I see and do near Duke Regional Hospital?

You might want to spend some time browsing the exhibits at Museum of Life and Science, Nasher Museum of Art at Duke University, or Bennett Place. While you're exploring, swing by American Tobacco Campus, Cameron Indoor Stadium, and Wallace Wade Stadium to learn a bit about the area. You can enjoy live performances at Carolina Theatre and Common Ground Theatre.

Find hotels near Duke Regional Hospital, Raleigh from AED 268

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Treat yourself

Be picky

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Our top choices for Duke Regional Hospital hotels

1. Hampton Inn & Suites Durham/North I-85

2. Holiday Inn Express Durham by IHG

3. Red Roof Inn Durham - Duke Univ Medical Center

4. Super 8 by Wyndham Durham/University Area NC

5. SpringHill Suites by Marriott Durham Chapel Hill

6. The Colonial Inn, an Ascend Collection Hotel

7. Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

8. Fairfield by Marriott Inn & Suites Durham

9. Hyatt House Raleigh / RDU / Brier Creek

10. Comfort Inn & Suites Durham near Duke University

11. La Quinta Inn & Suites by Wyndham Univ Area Chapel Hill

12. Embassy Suites by Hilton Raleigh Durham Airport Brier Creek

13. Hampton Inn & Suites Durham University Medical Center

14. Courtyard Raleigh-Durham Airport/Brier Creek

15. JB Duke Hotel

16. SpringHill Suites by Marriott Durham City View

17. Hilton Garden Inn Durham/University Medical Center

18. Washington Duke Inn & Golf Club

19. Hilton Durham near Duke University

20. Residence Inn Raleigh-Durham Airport/Brier Creek

Compare popular hotels close to Duke Regional Hospital

Top Duke Regional Hospital Hotel Reviews

Unscripted Durham, Part of JDV by Hyatt

Comfort Inn & Suites Durham near Duke University

Hilton Durham near Duke University

The Lodge at Duke Medical Center

21c Museum Hotel Durham

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

Drexall Haven - Stylish + Peaceful Stay

Everything within 1 mile

Cottage with Yard, Mins to Duke

Frequently asked questions