The Best Hotels Closest to Duke Regional Hospital in Raleigh for 2026

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Our top choices for Duke Regional Hospital hotels

A breakfast area with a chalkboard menu, a sign indicating breakfast starts here, and a variety of food items like waffles, oatmeal, and fruits.

A Hampton Inn hotel with a modern facade, multiple floors, and a parking lot.

A narrow hallway with shelves stocked with snacks and beverages, leading to a room with a desk and chair.

A hotel room with a bed, a desk with a chair, a flat-screen TV, a microwave, and a mirror.

1. Hampton Inn & Suites Durham/North I-85

2.2 km from Duke Regional Hospital

Cindy

AED 434

AED 492 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with two beds, a flat-screen TV, a wooden headboard, and a carpeted floor.

A breakfast buffet with a bakery section, a coffee station, and a sign indicating the availability of breakfast.

A gym with various exercise machines, a large mirror, and a television on the wall.

A coffee station with two coffee machines, a coffee press, and various coffee-related items on a counter.

2. Holiday Inn Express Durham by IHG

2.4 km from Duke Regional Hospital

Kimberly R

AED 404

AED 459 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a television on a wooden cabinet, a desk with a chair, and a lamp.

A spacious hallway with wooden flooring, white walls, and multiple windows with blinds. There are two white chairs and a small table with a basket.

A Red Roof Inn with a modern architectural design, featuring a prominent red sign and a well-maintained lawn.

A Red Roof Cafe with a stone wall, a coffee machine, and two white chairs.

3. Red Roof Inn Durham - Duke Univ Medical Center

2.3 km from Duke Regional Hospital

Luis

AED 230

AED 268 total

includes taxes & fees

11 Oct - 12 Oct

A stone fire pit surrounded by striped chairs and tables in an outdoor lounge area with a view of a building in the background.

A Hampton Inn & Suites hotel with a modern facade, multiple windows, and a parking lot.

A modern dining area with a long table, multiple chairs, and a sofa with red ottomans.

An indoor swimming pool with clear blue water, surrounded by lounge chairs and a tiled floor.

4. Hampton Inn & Suites Durham University Medical Center

5 km from Duke Regional Hospital

Nicole

AED 458

AED 520 total

includes taxes & fees

1 Nov - 2 Nov

A bar area with wooden bar stools, pendant lighting, and a counter with a glass display. There are tables and chairs in the background, and the room has a wooden floor.

A hotel room with two beds, a sofa, a TV, and a bathroom visible through a door.

A colonial-style building with a covered porch, multiple windows, and outdoor seating.

A bar area with wooden shelves, a chalkboard menu, and various bottles.

5. The Colonial Inn, an Ascend Collection Hotel

18.6 km from Duke Regional Hospital

Rose

AED 399

AED 452 total

includes taxes & fees

11 Oct - 12 Oct

A modern lobby with a central seating area, a TV screen, and a patterned wall.

A modern hotel room with a bed, bedside table, TV, and a small desk area.

A reception area with a counter, a welcome sign, a digital screen, and a hallway leading to a dining area.

An indoor swimming pool with clear water, surrounded by lounge chairs and potted plants.

6. Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

18.2 km from Duke Regional Hospital

Maurice

AED 434

AED 491 total

includes taxes & fees

11 Oct - 12 Oct

An indoor swimming pool with clear water, a no diving sign, and a seating area with chairs and tables.

A modern hotel lobby with a reception desk, several chairs, a large monitor, and pendant lighting.

A modern kitchen with built-in shelves, a glass backsplash, and a variety of kitchenware.

A modern hotel lobby with a long dining table, multiple chairs, a sofa, and a bar area.

7. Hyatt House Raleigh / RDU / Brier Creek

17.8 km from Duke Regional Hospital

Ahmed

AED 404

AED 458 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor patio area with round tables and chairs, large umbrellas, and a glass door entrance.

A multi-story hotel with a brick facade, large windows, and a well-lit entrance.

A hotel room with two beds, a desk, a chair, a sofa, and a TV.

A modern restaurant with round tables and yellow chairs, a bar area, and a 'Hello Fall' sign.

8. Fairfield by Marriott Inn & Suites Durham

18.2 km from Duke Regional Hospital

Yolanda

AED 436

AED 495 total

includes taxes & fees

23 Oct - 24 Oct

A spacious lobby with high ceilings, a central fountain, and seating areas.

A bar area with multiple liquor cabinets and hanging pendant lights.

A modern bedroom with a large bed, a fireplace, a walk-in closet, and a bathroom with a round mirror and vanity.

An outdoor patio area with wicker furniture, stone pillars, and string lights.

9. Embassy Suites by Hilton Raleigh Durham Airport Brier Creek

18.2 km from Duke Regional Hospital

Darren C.

AED 584

AED 662 total

includes taxes & fees

18 Oct - 19 Oct

A modern bathroom with a granite countertop sink, a large mirror, and a toilet.

A kitchen with a microwave, coffee maker, and a dishwasher.

A hotel room with a large bed, a bedside table with a lamp, a TV mounted on the wall, and a window with curtains.

A large indoor swimming pool with a skylight ceiling, clear glass walls, and a tiled floor.

10. DoubleTree Suites by Hilton Raleigh - Durham

14.2 km from Duke Regional Hospital

Stephen

AED 383

AED 434 total

includes taxes & fees

18 Oct - 19 Oct

A bar area with multiple shelves of bottles, glasses, and a bar counter.

A modern restaurant with long communal tables, hanging pendant lights, and geometric patterned walls.

An outdoor dining area with tables and chairs, large windows, and a view of greenery.

11. The Westin Raleigh-Durham Airport

18.2 km from Duke Regional Hospital

Dina

AED 790

AED 894 total

includes taxes & fees

11 Oct - 12 Oct

An outdoor seating area with wicker furniture and a stone fire pit.

A modern hotel lobby with seating areas, large windows, and a dining section.

A hotel lobby with a sofa, chairs, a table, and a large window offering a view of the building.

An indoor swimming pool with clear water, a lifeguard chair, and a sign indicating no diving.

12. Residence Inn Raleigh-Durham Airport/Brier Creek

16.6 km from Duke Regional Hospital

Janet

AED 512

AED 580 total

includes taxes & fees

11 Oct - 12 Oct

An outdoor seating area with sofas, chairs, and a fire pit, adjacent to a modern building with large windows.

A modern bar area with a long counter, multiple bar stools, and a large screen displaying a sports event.

A modern living room with a fireplace, seating area, and a pool table.

A modern reception area with a marble counter, a wooden bench, and a unique chandelier.

13. JB Duke Hotel

6.2 km from Duke Regional Hospital

samantha

AED 771

AED 876 total

includes taxes & fees

18 Oct - 19 Oct

A hotel entrance with a stone facade, large wooden doors, and a view into the interior.

A dining area with a chandelier, tables, chairs, and a Christmas tree.

A hotel with a stone lion statue, a covered entrance, and a landscaped garden.

A person performing a yoga pose outdoors with trees and a golf course in the background.

14. Washington Duke Inn & Golf Club

6.6 km from Duke Regional Hospital

Antonio

AED 973

AED 1,105 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor seating area with a circular fire pit surrounded by wicker chairs and a table.

A multi-story hotel with a flat facade, large windows, and a clear sky.

A modern hotel lobby with a mix of seating areas, a bar, and a large wall-mounted TV.

A reception area with a large screen displaying a sea view, a bench, and a sign indicating the location as Marriott Bonvoy.

15. SpringHill Suites by Marriott Durham Chapel Hill

12.6 km from Duke Regional Hospital

Logan

AED 470

AED 533 total

includes taxes & fees

11 Oct - 12 Oct

A lobby with a green sofa, yellow chairs, a coffee table with drinks, and a window with plants.

An indoor swimming pool with clear glass walls, a tiled floor, and a seating area with chairs and a table.

A Hilton Garden Inn hotel with a modern design, featuring a large entrance and a parking area with a delivery van.

A bar area with a granite countertop, wooden chairs, and a large television screen.

16. Hilton Garden Inn Durham/University Medical Center

9th Street District, 4 km from Duke Regional Hospital

Hal

AED 506

AED 574 total

includes taxes & fees

2 Nov - 3 Nov

A brick pathway flanked by neatly trimmed hedges leading to a building with a red facade and a grey roof.

A spacious lobby with a long corridor, comfortable seating areas, and large windows providing natural light.

A modern living room with two sofas facing a glass coffee table, a large window with curtains, and a brick wall.

An outdoor dining area with tables set for four, surrounded by a brick pathway and lush greenery.

17. Rizzo Center, a Destination by Hyatt Hotel

17 km from Duke Regional Hospital

Dale

AED 716

AED 813 total

includes taxes & fees

11 Oct - 12 Oct

A hotel room with a sofa, a small table, a desk, a chair, a TV, and a window with curtains.

A reception area with two wooden reception desks, a potted plant, and a computer on the wall.

18. Courtyard Raleigh-Durham Airport/Brier Creek

16.6 km from Duke Regional Hospital

eidy

AED 492

AED 557 total

includes taxes & fees

18 Oct - 19 Oct

A swimming pool with lounge chairs and a wooden fence.

A spacious lobby with a reception desk, seating area, and artwork on the walls.

A modern bar area with a refrigerated display, wooden bar counter, and seating.

A multi-story hotel with a modern design, featuring a prominent entrance with a glass canopy and an American flag.

19. Hyatt Place Durham Southpoint

16.1 km from Duke Regional Hospital

Leslie

AED 496

AED 563 total

includes taxes & fees

11 Oct - 12 Oct

A lobby with a bar area, seating, and a wine display.

A bar area with seating, a bar counter, and a menu board.

A covered outdoor dining area with tables set for a meal, surrounded by chairs, and overlooking a garden with blooming trees.

A spacious lounge with leather sofas, a long dining table, and a waterfall mural.

20. DoubleTree Raleigh Durham Airport at Research Triangle Park

17.7 km from Duke Regional Hospital

Xueqin

AED 419

AED 475 total

includes taxes & fees

11 Oct - 12 Oct

View all properties

Compare popular hotels close to Duke Regional Hospital

Property	Property class	Guest rating
Hampton Inn & Suites Durham/North I-85	9.0 Wonderful 1,001 reviews	View
Holiday Inn Express Durham by IHG	8.8 Excellent 1,003 reviews	View
Red Roof Inn Durham - Duke Univ Medical Center	6.8 1,002 reviews	View
Hampton Inn & Suites Durham University Medical Center	9.6 Exceptional 566 reviews	View
The Colonial Inn, an Ascend Collection Hotel	9.6 Exceptional 320 reviews	View

Top Duke Regional Hospital Hotel Reviews

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

10/10 Excellent

"The house was absolutely immaculate and Kristin could not have nicer or more helpful. The location was just 25 minutes from RDU, 12 minutes from downtown Durham and about a half an hour from Chapel Hill. Comfortable living room for my small group, large screen TV with all the streaming channels and a very cool coffee grinder/maker for regular or espresso coffee. Highly recommend. John L"

Holiday Inn Express Durham by IHG

8/10 Good

"Close to the highway so you can hear the trucks and motorcycles."

Comfort Inn & Suites Durham near Duke University

8/10 Good

"Unsure"

Unscripted Durham, Part of JDV by Hyatt

10/10 Excellent

"Convenient"

University Inn Durham next to Duke University Medical Center

10/10 Excellent

"Very clean and large room. Convenient to Duke campus."

Millennium Hotel Durham

10/10 Excellent

"Good"

The Durham Hotel

10/10 Excellent

"One of the best hotels I have ever been to.. period world wide. Nice rooms, modern era decor, great in house restaurant with superb breakfast at reasonable price and coffee bar. Best cortado I ever had. All staff were friendly and super supportive. Parking in lots street or garage within easy walking distance. Many restaurants and bars in the area. Reasonably safe area but there are panhandlers on occasion. Room had adequate closet space, excellent bathroom and shower. Quiet at night. Super comfy bed. I’m a coffee nerd and they offer fresh ground gourmet options brought to your door each morning if you choose the night before. No hotel I’ve ever stayed at offered this. I liked it so much I returned on a return visit to the city. No pool but workout facility. Highly recommended if you travel in the area.,"

The Lodge at Duke Medical Center

10/10 Excellent

"My stay was great!"

Drexall Haven - Stylish + Peaceful Stay

8/10 Good

"The house is newly renovated so everything looks really nice. The only issue I have is a lack of dressers for our clothes. Otherwise the experience was great. Quiet neighborhood out of the way but accessible."

Frequently asked questions

What's the area like around Duke Regional Hospital?

Duke Regional Hospital is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, check out the 10 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Duke Regional Hospital?

Courtyard Durham Near Duke University/Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and free parking. It's located 2.2 mi (3.5 km) from Duke Regional Hospital. Other good choices within a few miles include Holiday Inn Express Durham by IHG and Red Roof Inn Durham - Duke Univ Medical Center.

How many hotels can I expect to find near Duke Regional Hospital?

Expedia has 10 hotels and other accommodations within a mile from Duke Regional Hospital.

If I need to cancel the hotel reservation for my stay near Duke Regional Hospital, will I receive a refund?

Yes! Most hotel room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Add dates, click "Search", then you can filter by "fully refundable" to get the best deals near Duke Regional Hospital.

Where can I learn more about changing or cancelling my trip in the area near Duke Regional Hospital?

To find more details about changing or cancelling your stay near Duke Regional Hospital, click here.

What can I see and do near Duke Regional Hospital?

You might want to spend some time browsing the exhibits at Museum of Life and Science, Nasher Museum of Art at Duke University, or Bennett Place. While you're exploring, swing by American Tobacco Campus, Cameron Indoor Stadium, and Wallace Wade Stadium to learn a bit about the area. You can enjoy live performances at Carolina Theatre and Common Ground Theatre.

Find hotels near Duke Regional Hospital, Raleigh from AED 268

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Treat yourself

Be picky

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Our top choices for Duke Regional Hospital hotels

1. Hampton Inn & Suites Durham/North I-85

2. Holiday Inn Express Durham by IHG

3. Red Roof Inn Durham - Duke Univ Medical Center

4. Hampton Inn & Suites Durham University Medical Center

5. The Colonial Inn, an Ascend Collection Hotel

6. Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

7. Hyatt House Raleigh / RDU / Brier Creek

8. Fairfield by Marriott Inn & Suites Durham

9. Embassy Suites by Hilton Raleigh Durham Airport Brier Creek

10. DoubleTree Suites by Hilton Raleigh - Durham

11. The Westin Raleigh-Durham Airport

12. Residence Inn Raleigh-Durham Airport/Brier Creek

13. JB Duke Hotel

14. Washington Duke Inn & Golf Club

15. SpringHill Suites by Marriott Durham Chapel Hill

16. Hilton Garden Inn Durham/University Medical Center

17. Rizzo Center, a Destination by Hyatt Hotel

18. Courtyard Raleigh-Durham Airport/Brier Creek

19. Hyatt Place Durham Southpoint

20. DoubleTree Raleigh Durham Airport at Research Triangle Park

Compare popular hotels close to Duke Regional Hospital

Top Duke Regional Hospital Hotel Reviews

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

Holiday Inn Express Durham by IHG

Comfort Inn & Suites Durham near Duke University

Unscripted Durham, Part of JDV by Hyatt

University Inn Durham next to Duke University Medical Center

Millennium Hotel Durham

The Durham Hotel

The Lodge at Duke Medical Center

Drexall Haven - Stylish + Peaceful Stay

Frequently asked questions