The Best Hotels Closest to Duke Regional Hospital in Raleigh for 2026

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Our top choices for Duke Regional Hospital hotels

A breakfast area with a chalkboard menu, a sign indicating breakfast starts here, and a variety of food items like waffles, oatmeal, and fruits.

A hotel room with a bed, a desk with a chair, a flat-screen TV, a microwave, and a mirror.

A Hampton Inn hotel with a modern facade, multiple floors, and a parking lot.

A narrow hallway with shelves stocked with snacks and beverages, leading to a room with a desk and chair.

1. Hampton Inn & Suites Durham/North I-85

2.2 km from Duke Regional Hospital

Cindy

AED 437

AED 496 total

includes taxes & fees

4 Oct - 5 Oct

A hotel room with two beds, a flat-screen TV, a wooden headboard, and a carpeted floor.

A gym with various exercise machines, a large mirror, and a television on the wall.

A Holiday Inn Express hotel with a modern design, featuring a prominent sign, multiple windows, and a well-lit entrance.

A breakfast buffet with a bakery section, a coffee station, and a sign indicating the availability of breakfast.

2. Holiday Inn Express Durham by IHG

2.4 km from Duke Regional Hospital

Kimberly R

AED 404

AED 459 total

includes taxes & fees

4 Oct - 5 Oct

A reception desk with a 'Free Wi-Fi All Rooms' sign, a cash register, and a credit card reader.

A vending machine area with Pepsi and other beverage options, including a selection of juices and sodas.

A spacious hallway with wooden flooring, white walls, and multiple windows with blinds. There are two white chairs and a small table with a basket.

3. Red Roof Inn Durham - Duke Univ Medical Center

2.3 km from Duke Regional Hospital

Luis

AED 230

AED 268 total

includes taxes & fees

11 Oct - 12 Oct

A stone fire pit surrounded by striped chairs and tables in an outdoor lounge area with a view of a building in the background.

An indoor swimming pool with clear blue water, surrounded by lounge chairs and a tiled floor.

A Hampton Inn & Suites hotel with a modern facade, multiple windows, and a parking lot.

A modern dining area with a long table, multiple chairs, and a sofa with red ottomans.

4. Hampton Inn & Suites Durham University Medical Center

5 km from Duke Regional Hospital

Donna

AED 479

AED 544 total

includes taxes & fees

4 Oct - 5 Oct

A bar area with wooden bar stools, pendant lighting, and a counter with a glass display. There are tables and chairs in the background, and the room has a wooden floor.

A colonial-style building with a covered porch, multiple windows, and outdoor seating.

A hotel room with two beds, a sofa, a TV, and a bathroom visible through a door.

A covered porch with steps leading to a door, a brick wall, and a street lamp.

5. The Colonial Inn, an Ascend Collection Hotel

18.6 km from Duke Regional Hospital

Veronica

AED 399

AED 452 total

includes taxes & fees

11 Oct - 12 Oct

A brick pathway flanked by neatly trimmed hedges leading to a building with a red facade and a grey roof.

A modern living room with two sofas facing a glass coffee table, a large window with curtains, and a brick wall.

A spacious lobby with a long corridor, comfortable seating areas, and large windows providing natural light.

A restaurant with brick walls, wooden tables, and blue chairs.

6. Rizzo Center, a Destination by Hyatt Hotel

17 km from Duke Regional Hospital

Dale

AED 716

AED 813 total

includes taxes & fees

11 Oct - 12 Oct

An outdoor patio area with round tables and chairs, large umbrellas, and a glass door entrance.

A multi-story hotel with a brick facade, large windows, and a well-lit entrance.

A modern restaurant with round tables and yellow chairs, a bar area, and a 'Hello Fall' sign.

A modern living room with a fireplace, two sofas, a coffee table, and a TV mounted on the wall.

7. Fairfield by Marriott Inn & Suites Durham

18.2 km from Duke Regional Hospital

Yolanda

AED 410

AED 465 total

includes taxes & fees

22 Oct - 23 Oct

A modern lobby with a central seating area, a TV screen, and a patterned wall.

An indoor swimming pool with clear water, surrounded by lounge chairs and potted plants.

A modern hotel room with a bed, bedside table, TV, and a small desk area.

A reception area with a counter, a welcome sign, a digital screen, and a hallway leading to a dining area.

8. Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

18.2 km from Duke Regional Hospital

Frank

AED 434

AED 491 total

includes taxes & fees

4 Oct - 5 Oct

An outdoor seating area with sofas, chairs, and a fire pit, adjacent to a modern building with large windows.

A modern bar area with a long counter, multiple bar stools, and a large screen displaying a sports event.

A modern living room with a fireplace, seating area, and a pool table.

A modern kitchen with a central island, bar stools, wooden cabinets, and pendant lighting.

9. JB Duke Hotel

6.2 km from Duke Regional Hospital

samantha

AED 731

AED 830 total

includes taxes & fees

19 Oct - 20 Oct

A modern restaurant with long communal tables, hanging pendant lights, and geometric patterned walls.

A modern living room with a pool table, a sofa, and a dining area.

A bar area with multiple shelves of bottles, glasses, and a bar counter.

10. The Westin Raleigh-Durham Airport

18.2 km from Duke Regional Hospital

Dina

AED 790

AED 894 total

includes taxes & fees

4 Oct - 5 Oct

A swimming pool with lounge chairs and a wooden fence.

A modern bar area with a refrigerated display, wooden bar counter, and seating.

A hotel room with a bed, a sofa, a desk with a chair, a television, and a painting on the wall.

A multi-story hotel with a modern design, featuring a prominent entrance with a glass canopy and an American flag.

11. Hyatt Place Durham Southpoint

16.1 km from Duke Regional Hospital

Andres

AED 496

AED 563 total

includes taxes & fees

11 Oct - 12 Oct

A hotel entrance with a stone facade, large wooden doors, and a view into the interior.

An indoor swimming pool with clear blue water, surrounded by lounge chairs and potted plants.

A dining area with a chandelier, tables, chairs, and a Christmas tree.

A person performing a yoga pose outdoors with trees and a golf course in the background.

12. Washington Duke Inn & Golf Club

6.6 km from Duke Regional Hospital

Lowell

AED 918

AED 1,042 total

includes taxes & fees

30 Sep - 1 Oct

An indoor swimming pool with clear water, a no diving sign, and a seating area with chairs and tables.

A modern hotel lobby with a reception desk, several chairs, a large monitor, and pendant lighting.

A modern hotel lobby with a long dining table, multiple chairs, a sofa, and a bar area.

A modern kitchen with built-in shelves, a glass backsplash, and a variety of kitchenware.

13. Hyatt House Raleigh / RDU / Brier Creek

17.8 km from Duke Regional Hospital

Zashia

AED 433

AED 491 total

includes taxes & fees

4 Oct - 5 Oct

A lobby with a green sofa, yellow chairs, a coffee table with drinks, and a window with plants.

A bar area with a granite countertop, wooden chairs, and a large television screen.

A business center with wooden paneling, multiple workstations, and framed artwork on the walls.

A Hilton Garden Inn hotel with a modern design, featuring a large entrance and a parking area with a delivery van.

14. Hilton Garden Inn Durham/University Medical Center

9th Street District, 4 km from Duke Regional Hospital

Hal

AED 539

AED 612 total

includes taxes & fees

11 Oct - 12 Oct

A modern hotel with a prominent entrance, multiple floors, and a balcony on the second floor.

A modern hotel lobby with a reception desk, a beverage refrigerator, and a well-stocked snack bar.

A modern dining area with wooden tables and chairs, large windows, and geometric pendant lighting.

An outdoor patio with a fire feature, seating, and a building with large windows.

15. SpringHill Suites by Marriott Durham City View

5.4 km from Duke Regional Hospital

Taurean

AED 496

AED 563 total

includes taxes & fees

25 Oct - 26 Oct

A spacious, elegantly decorated interior with a central round table, high ceilings, and classic architectural columns.

A large, historic building with a central courtyard, columns, and a brick facade.

A well-lit living room with a sofa, armchairs, a coffee table, and a fireplace.

A banquet hall with round tables, chandeliers, and floral centerpieces.

16. The Carolina Inn, a Destination by Hyatt Hotel

19.9 km from Duke Regional Hospital

Tony

AED 1,319

AED 1,497 total

includes taxes & fees

12 Oct - 13 Oct

A spacious lobby with high ceilings, a central fountain, and seating areas.

An outdoor patio area with wicker furniture, stone pillars, and string lights.

A modern bedroom with a large bed, a fireplace, a walk-in closet, and a bathroom with a round mirror and vanity.

A spacious lobby with a curved seating area, large windows, and a modern chandelier.

17. Embassy Suites by Hilton Raleigh Durham Airport Brier Creek

18.2 km from Duke Regional Hospital

Darren C.

AED 584

AED 662 total

includes taxes & fees

25 Oct - 26 Oct

An outdoor seating area with wicker furniture and a stone fire pit.

A conference room with a long table, chairs, and a modern chandelier.

A hotel lobby with a sofa, chairs, a table, and a large window offering a view of the building.

A modern hotel lobby with seating areas, large windows, and a dining section.

18. Residence Inn Raleigh-Durham Airport/Brier Creek

16.6 km from Duke Regional Hospital

Janet

AED 512

AED 580 total

includes taxes & fees

4 Oct - 5 Oct

An outdoor seating area with wicker chairs and a large umbrella, a fire feature, and a view of the interior through glass walls.

A hotel room with a large bed, a bedside table with a lamp, a TV mounted on the wall, and a window with curtains.

A modern kitchen with a microwave, coffee maker, and dishwasher. There is a round table with two green chairs in front.

A kitchen with a microwave, coffee maker, and a dishwasher.

19. DoubleTree Suites by Hilton Raleigh - Durham

14.2 km from Duke Regional Hospital

Stephen

AED 437

AED 496 total

includes taxes & fees

4 Oct - 5 Oct

An outdoor patio with wicker furniture, a stone fire pit, and a brick building in the background.

A multi-story brick building with a modern entrance and a parking lot.

A spacious lobby with a reception desk, seating area, and a beverage kiosk.

A gym with treadmills, elliptical machines, a bench press, and a blue balance board.

20. Residence Inn Durham McPherson/Duke University Medical Cntr

Trinity Park, 4.1 km from Duke Regional Hospital

Patricia

AED 611

AED 693 total

includes taxes & fees

1 Oct - 2 Oct

View all properties

Compare popular hotels close to Duke Regional Hospital

Property	Property class	Guest rating
Hampton Inn & Suites Durham/North I-85	9.0 Wonderful 1,006 reviews	View
Holiday Inn Express Durham by IHG	8.8 Excellent 1,004 reviews	View
Red Roof Inn Durham - Duke Univ Medical Center	6.8 1,001 reviews	View
Hampton Inn & Suites Durham University Medical Center	9.6 Exceptional 563 reviews	View
The Colonial Inn, an Ascend Collection Hotel	9.6 Exceptional 318 reviews	View

Top Duke Regional Hospital Hotel Reviews

Comfort Inn & Suites Durham near Duke University

10/10 Excellent

"Clean room got coffees in my room and husband had breakfast in te morning before his hospital appointment"

Unscripted Durham, Part of JDV by Hyatt

10/10 Excellent

"I will stay here again—it’s so centrally located, walking distance to tons of shops, restaurants, cafes, and small businesses. Everyone was so friendly and it was easy to come and go. My room was very clean. I travel a lot, and was delighted to find soft beds and towels. Really fun spot."

The Lodge at Duke Medical Center

10/10 Excellent

"My stay was great!"

Holiday Inn Express Durham by IHG

10/10 Excellent

"clean"

Courtyard Durham Near Duke University/Downtown

8/10 Good

"Great Location and staff was helpful"

Drexall Haven - Stylish + Peaceful Stay

8/10 Good

"The house is newly renovated so everything looks really nice. The only issue I have is a lack of dressers for our clothes. Otherwise the experience was great. Quiet neighborhood out of the way but accessible."

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

10/10 Excellent

"Kristin was a wonderful host and we loved our stay! The house was so thoughtfully curated and comfortable. We would definitely stay here again if we visit Durham in the future!"

Everything within 1 mile

10/10 Excellent

"Perfect size and great location! The host has thought of everything and included so many extra thoughtful touches! So close to everything, quiet, clean, and stocked!"

Cottage with Yard, Mins to Duke

10/10 Excellent

"This was a cheerful home with comfortable beds and many thoughtful extras. We enjoyed our time here."

Frequently asked questions

What's the area like around Duke Regional Hospital?

Duke Regional Hospital is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, check out the 9 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Duke Regional Hospital?

Courtyard Durham Near Duke University/Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and free parking. It's located 2.2 mi (3.5 km) from Duke Regional Hospital. Other good choices within a few miles include Red Roof Inn Durham - Duke Univ Medical Center and Holiday Inn Express Durham by IHG.

How many hotels can I expect to find near Duke Regional Hospital?

Expedia has 9 hotels and other accommodations within a mile from Duke Regional Hospital.

If I need to cancel the hotel reservation for my stay near Duke Regional Hospital, will I receive a refund?

Yes! Most hotel room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Add dates, click "Search", then you can filter by "fully refundable" to get the best deals near Duke Regional Hospital.

Where can I learn more about changing or cancelling my trip in the area near Duke Regional Hospital?

To find more details about changing or cancelling your stay near Duke Regional Hospital, click here.

What can I see and do near Duke Regional Hospital?

You might want to spend some time browsing the exhibits at Museum of Life and Science, Nasher Museum of Art at Duke University, or Bennett Place. While you're exploring, swing by American Tobacco Campus, Cameron Indoor Stadium, and Wallace Wade Stadium to learn a bit about the area. You can enjoy live performances at Carolina Theatre and Common Ground Theatre.

Find hotels near Duke Regional Hospital, Raleigh from AED 268

Change your mind

Treat yourself

Be picky

Check prices for these dates

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Star rating

Guest rating

Our top choices for Duke Regional Hospital hotels

1. Hampton Inn & Suites Durham/North I-85

2. Holiday Inn Express Durham by IHG

3. Red Roof Inn Durham - Duke Univ Medical Center

4. Hampton Inn & Suites Durham University Medical Center

5. The Colonial Inn, an Ascend Collection Hotel

6. Rizzo Center, a Destination by Hyatt Hotel

7. Fairfield by Marriott Inn & Suites Durham

8. Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

9. JB Duke Hotel

10. The Westin Raleigh-Durham Airport

11. Hyatt Place Durham Southpoint

12. Washington Duke Inn & Golf Club

13. Hyatt House Raleigh / RDU / Brier Creek

14. Hilton Garden Inn Durham/University Medical Center

15. SpringHill Suites by Marriott Durham City View

16. The Carolina Inn, a Destination by Hyatt Hotel

17. Embassy Suites by Hilton Raleigh Durham Airport Brier Creek

18. Residence Inn Raleigh-Durham Airport/Brier Creek

19. DoubleTree Suites by Hilton Raleigh - Durham

20. Residence Inn Durham McPherson/Duke University Medical Cntr

Compare popular hotels close to Duke Regional Hospital

Top Duke Regional Hospital Hotel Reviews

Comfort Inn & Suites Durham near Duke University

Unscripted Durham, Part of JDV by Hyatt

The Lodge at Duke Medical Center

Holiday Inn Express Durham by IHG

Courtyard Durham Near Duke University/Downtown

Drexall Haven - Stylish + Peaceful Stay

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

Everything within 1 mile

Cottage with Yard, Mins to Duke

Frequently asked questions