The Best Hotels Closest to Duke Regional Hospital in Raleigh for 2026

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Our top choices for Duke Regional Hospital hotels

A breakfast area with a chalkboard menu, a sign indicating breakfast starts here, and a variety of food items like waffles, oatmeal, and fruits.

A large indoor swimming pool with clear blue water, surrounded by beige tiled flooring and walls, with large windows allowing natural light.

A Hampton Inn hotel with a modern facade, multiple floors, and a parking lot.

A hotel room with a bed, a desk with a chair, a flat-screen TV, a microwave, and a mirror.

1. Hampton Inn & Suites Durham/North I-85

2.2 km from Duke Regional Hospital

Shwetha

AED 450

AED 510 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with two beds, a flat-screen TV, a wooden headboard, and a carpeted floor.

A swimming pool with a metal railing, surrounded by a building with multiple windows and a sign indicating no lifeguard on duty.

A Holiday Inn Express hotel with a modern design, featuring a prominent sign, multiple windows, and a well-lit entrance.

A hotel lobby with a seating area, a reception desk, and artwork on the walls.

2. Holiday Inn Express Durham by IHG

2.4 km from Duke Regional Hospital

Kimberly R

AED 378

AED 429 total

includes taxes & fees

15 Nov - 16 Nov

A hotel room with a television on a wooden cabinet, a desk with a chair, and a lamp.

A Red Roof Cafe with a stone wall, a coffee machine, and two white chairs.

A hotel room with a bed, bedside tables, a nightstand, a mirror, and a bathroom with a sink and mirror.

A spacious hallway with wooden flooring, white walls, and multiple windows with blinds. There are two white chairs and a small table with a basket.

3. Red Roof Inn Durham - Duke Univ Medical Center

2.3 km from Duke Regional Hospital

Luis

AED 230

AED 268 total

includes taxes & fees

1 Nov - 2 Nov

A modern living room with a fireplace, comfortable seating, and a large window with curtains.

A courtyard with a pathway leading to a building with large windows and a yellow facade.

A hotel reception area with a counter, coffee station, and a large window with curtains.

A swimming pool with lounge chairs and a view of a building with large windows.

4. La Quinta Inn & Suites by Wyndham Univ Area Chapel Hill

North Garrett Road, 10.4 km from Duke Regional Hospital

Yolanda

AED 311

AED 353 total

includes taxes & fees

1 Nov - 2 Nov

A hotel room with a bed, a desk, a chair, a small table, a coffee machine, and a trash bin.

A restaurant with a large ice dispenser, wooden paneling, and red cushioned booths.

A Comfort Inn & Suites hotel with a modern design, featuring a prominent entrance and a landscaped front yard.

A reception area with a wooden reception desk, blue seating, a flat-screen TV, and a stone accent wall.

5. Comfort Inn & Suites Durham near Duke University

Croasdaile Farm Master, 3.3 km from Duke Regional Hospital

BRIAN

AED 321

AED 364 total

includes taxes & fees

25 Oct - 26 Oct

A modern hotel reception area with two wooden reception desks, a large digital display wall, and a seating area with chairs.

A hotel room with two beds, a desk, and a chair.

A modern restaurant with bar seating, a Starbucks sign, and a bar area with a counter and shelves.

6. Hilton Durham near Duke University

5.4 km from Duke Regional Hospital

tigist

AED 419

AED 475 total

includes taxes & fees

25 Oct - 26 Oct

A modern lobby with a central seating area, a TV screen, and a patterned wall.

A reception area with a counter, a welcome sign, a digital screen, and a hallway leading to a dining area.

A modern kitchen with a built-in refrigerator, a gray sofa, and a gray armchair.

An indoor swimming pool with clear water, surrounded by lounge chairs and potted plants.

7. Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

18.2 km from Duke Regional Hospital

Maurice

AED 434

AED 491 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with two beds, a nightstand with a lamp, and a window with a view of trees.

An outdoor seating area with tables and chairs, a paved walkway, and a fence.

A gym with treadmills, elliptical machines, and exercise bikes.

A shelf stocked with various snack items, including boxed cereals and candy.

8. Holiday Inn Express & Suites Raleigh Airport - Brier Creek by IHG

16.9 km from Duke Regional Hospital

Sharon

AED 404

AED 475 total

includes taxes & fees

15 Nov - 16 Nov

An indoor swimming pool with clear water, a no diving sign, and a seating area with chairs and tables.

A modern hotel lobby with a long dining table, multiple chairs, a sofa, and a bar area.

A modern hotel lobby with a reception desk, several chairs, a large monitor, and pendant lighting.

A modern hotel lobby with a sectional sofa, armchairs, and a coffee table.

9. Hyatt House Raleigh / RDU / Brier Creek

17.8 km from Duke Regional Hospital

Alton

AED 404

AED 458 total

includes taxes & fees

1 Nov - 2 Nov

An outdoor patio with a table set for a meal, surrounded by chairs and a red umbrella.

A hotel room with a large bed, two bedside tables, and two wall-mounted lamps.

A modern hotel room with a kitchenette, a dining area, a living room with a sofa and a coffee table, and a large window with curtains.

A tented outdoor dining area with round tables set for a meal, each with white chairs and yellow tablecloths.

10. DoubleTree Suites by Hilton Raleigh - Durham

14.2 km from Duke Regional Hospital

Stephen

AED 378

AED 429 total

includes taxes & fees

5 Nov - 6 Nov

An outdoor patio with a stone fire pit surrounded by wicker furniture and a large window overlooking the building.

A modern living room with a fireplace, comfortable seating, and a large window offering a view of the outdoors.

A swimming pool with lounge chairs and a building with balconies in the background.

A modern hotel lobby with a central bar area, seating arrangements, and large windows offering views of the outdoors.

11. Courtyard Durham Near Duke University/Downtown

Croasdaile Farm Master, 3.5 km from Duke Regional Hospital

Billy

AED 340

AED 386 total

includes taxes & fees

25 Oct - 26 Oct

A lobby with a green sofa, yellow chairs, a coffee table with drinks, and a window with plants.

A bar area with a granite countertop, wooden chairs, and a large television screen.

A Hilton Garden Inn hotel with a modern design, featuring a large entrance and a parking area with a delivery van.

An indoor swimming pool with clear glass walls, a tiled floor, and a seating area with chairs and a table.

12. Hilton Garden Inn Durham/University Medical Center

9th Street District, 4 km from Duke Regional Hospital

Michael

AED 481

AED 546 total

includes taxes & fees

9 Nov - 10 Nov

A hotel room with a sofa, a small table, a desk, a chair, a TV, and a window with curtains.

A reception area with two wooden reception desks, a potted plant, and a computer on the wall.

An indoor swimming pool with clear water, a lifeguard chair, and a sign indicating no diving.

13. Courtyard Raleigh-Durham Airport/Brier Creek

16.6 km from Duke Regional Hospital

Sharon

AED 491

AED 556 total

includes taxes & fees

18 Oct - 19 Oct

A stone fire pit surrounded by striped chairs and tables in an outdoor lounge area with a view of a building in the background.

A modern dining area with a long table, multiple chairs, and a sofa with red ottomans.

A Hampton Inn & Suites hotel with a modern facade, multiple windows, and a parking lot.

An indoor swimming pool with clear blue water, surrounded by lounge chairs and a tiled floor.

14. Hampton Inn & Suites Durham University Medical Center

5 km from Duke Regional Hospital

Nicole

AED 465

AED 528 total

includes taxes & fees

25 Oct - 26 Oct

A hotel room with two beds, a desk, a TV, and a lamp.

A gym with exercise equipment, a TV, and a rack of dumbbells.

A compact hotel room with a kitchenette, a sofa, a lamp, and a mirror.

A reception desk with a sign reading "Comfort Inn" and a clock above it.

15. Comfort Inn University Durham - Chapel Hill

12.8 km from Duke Regional Hospital

Charity

AED 311

AED 353 total

includes taxes & fees

8 Nov - 9 Nov

A spacious lobby with high ceilings, a central fountain, and seating areas.

A bar area with multiple liquor cabinets and hanging pendant lights.

A spacious lobby with a curved seating area, large windows, and a modern chandelier.

An outdoor patio area with wicker furniture, stone pillars, and string lights.

16. Embassy Suites by Hilton Raleigh Durham Airport Brier Creek

18.2 km from Duke Regional Hospital

Darren C.

AED 584

AED 662 total

includes taxes & fees

25 Oct - 26 Oct

A spacious lobby with a reception desk, seating area, and a balcony.

A Wingate hotel with a beige facade, stone entrance, and an American flag.

A hotel room with a bed, a desk with a TV, a chair, and a lamp.

A hotel dining area with tables, chairs, a decorative water feature, and a large window providing natural light.

17. Wingate by Wyndham Raleigh Durham Airport RTP

18.2 km from Duke Regional Hospital

Supratik

AED 340

AED 386 total

includes taxes & fees

25 Oct - 26 Oct

A long, narrow hallway with dark walls and wooden flooring.

A compact kitchenette with a refrigerator, microwave, and a flat-screen TV on a dark cabinet.

A hotel room with a large bed, two bedside lamps, a chair, a desk, a heater, and a window with curtains.

A modern reception area with a reception desk, a seating area with chairs and a table, and a bookshelf with books.

18. University Inn Durham next to Duke University Medical Center

4.5 km from Duke Regional Hospital

Nicole

AED 380

AED 431 total

includes taxes & fees

25 Oct - 26 Oct

A modern lobby with a sectional sofa, a round coffee table, and a fireplace.

An indoor swimming pool with clear water, surrounded by seating areas and potted plants.

A conference room with a large table and chairs, a plant, and abstract wall art.

A fitness center with treadmills, exercise bikes, and a weight bench.

19. Fairfield Inn & Suites Raleigh Durham Airport/ Brier Creek

17.9 km from Duke Regional Hospital

Michael

AED 443

AED 502 total

includes taxes & fees

25 Oct - 26 Oct

A hotel with a prominent tower, a covered entrance, and a well-maintained garden.

A spacious lobby with a central seating area, a reception desk, and a skylight.

A swimming pool with a lifeguard stand and a metal railing, surrounded by a building with multiple windows and balconies.

A hotel room with two beds, a desk, a chair, a television, a window, and a bathroom with a sink and mirror.

20. La Quinta Inn & Suites by Wyndham Raleigh/Durham Southpoint

14.4 km from Duke Regional Hospital

CHELSEA

AED 268

AED 304 total

includes taxes & fees

15 Nov - 16 Nov

View all properties

Compare popular hotels close to Duke Regional Hospital

Property	Property class	Guest rating
Hampton Inn & Suites Durham/North I-85	9.0 Wonderful 1,000 reviews	View
Holiday Inn Express Durham by IHG	8.8 Excellent 1,000 reviews	View
Red Roof Inn Durham - Duke Univ Medical Center	6.8 1,000 reviews	View
La Quinta Inn & Suites by Wyndham Univ Area Chapel Hill	8.6 Excellent 1,968 reviews	View
Comfort Inn & Suites Durham near Duke University	8.6 Excellent 1,173 reviews	View

Top Duke Regional Hospital Hotel Reviews

Comfort Inn & Suites Durham near Duke University

10/10 Excellent

"Breakfast was great!!!"

Courtyard Durham Near Duke University/Downtown

10/10 Excellent

"Everyone was nice; the room was super clean!"

Hilton Durham near Duke University

10/10 Excellent

"Good location and has all ameneties for a comfortable stay"

Everything within 1 mile

10/10 Excellent

"This home is thoughtfully laid out and much more spacious than it looks in photos. Our kids enjoyed the snacks each night, and their grandma loved that the home is all one level with smooth floors and bright lighting. Location was perfect for attending events in Durham, Wake Forest and Raleigh. There's also a running path across the street."

The Lodge at Duke Medical Center

8/10 Good

"Very convenient to the medical center and university. The staff was very helpful. Good value. Very safe."

Unscripted Durham, Part of JDV by Hyatt

8/10 Good

"The place was awesome! I'm not going into details....I came home with some bed bug bites......🤔"

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

10/10 Excellent

"The house was absolutely immaculate and Kristin could not have nicer or more helpful. The location was just 25 minutes from RDU, 12 minutes from downtown Durham and about a half an hour from Chapel Hill. Comfortable living room for my small group, large screen TV with all the streaming channels and a very cool coffee grinder/maker for regular or espresso coffee. Highly recommend. John L"

Cottage with Yard, Mins to Duke

10/10 Excellent

"This was a cheerful home with comfortable beds and many thoughtful extras. We enjoyed our time here."

Durham Retreat: 10 mins from Duke & Downtown, 20 mins from RTP & RDU I Sleeps 8

10/10 Excellent

"!"

Frequently asked questions

What's the area like around Duke Regional Hospital?

Duke Regional Hospital is located in an area of Durham known for its stunning cathedral. If you're looking for a convenient place to stay, check out the 10 hotels and other accommodations you'll find within a mile.

Where is the best place to stay close to Duke Regional Hospital?

Courtyard Durham Near Duke University/Downtown is one of the top choices for your stay based on our traveler data, and this hotel offers a restaurant and free parking. It's located 2.2 mi (3.5 km) from Duke Regional Hospital. Other good choices within a few miles include Holiday Inn Express Durham by IHG and Red Roof Inn Durham - Duke Univ Medical Center.

How many hotels can I expect to find near Duke Regional Hospital?

Expedia has 10 hotels and other accommodations within a mile from Duke Regional Hospital.

If I need to cancel the hotel reservation for my stay near Duke Regional Hospital, will I receive a refund?

Yes! Most hotel room reservations are fully refundable provided that you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of your scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Add dates, click "Search", then you can filter by "fully refundable" to get the best deals near Duke Regional Hospital.

Where can I learn more about changing or cancelling my trip in the area near Duke Regional Hospital?

To find more details about changing or cancelling your stay near Duke Regional Hospital, click here.

What can I see and do near Duke Regional Hospital?

You might want to spend some time browsing the exhibits at Museum of Life and Science, Nasher Museum of Art at Duke University, or Bennett Place. While you're exploring, swing by American Tobacco Campus, Cameron Indoor Stadium, and Wallace Wade Stadium to learn a bit about the area. You can enjoy live performances at Carolina Theatre and Common Ground Theatre.

Find hotels near Duke Regional Hospital, Raleigh from AED 268

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Treat yourself

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Our top choices for Duke Regional Hospital hotels

1. Hampton Inn & Suites Durham/North I-85

2. Holiday Inn Express Durham by IHG

3. Red Roof Inn Durham - Duke Univ Medical Center

4. La Quinta Inn & Suites by Wyndham Univ Area Chapel Hill

5. Comfort Inn & Suites Durham near Duke University

6. Hilton Durham near Duke University

7. Hampton Inn & Suites Raleigh-Durham Airport-Brier Creek

8. Holiday Inn Express & Suites Raleigh Airport - Brier Creek by IHG

9. Hyatt House Raleigh / RDU / Brier Creek

10. DoubleTree Suites by Hilton Raleigh - Durham

11. Courtyard Durham Near Duke University/Downtown

12. Hilton Garden Inn Durham/University Medical Center

13. Courtyard Raleigh-Durham Airport/Brier Creek

14. Hampton Inn & Suites Durham University Medical Center

15. Comfort Inn University Durham - Chapel Hill

16. Embassy Suites by Hilton Raleigh Durham Airport Brier Creek

17. Wingate by Wyndham Raleigh Durham Airport RTP

18. University Inn Durham next to Duke University Medical Center

19. Fairfield Inn & Suites Raleigh Durham Airport/ Brier Creek

20. La Quinta Inn & Suites by Wyndham Raleigh/Durham Southpoint

Compare popular hotels close to Duke Regional Hospital

Top Duke Regional Hospital Hotel Reviews

Comfort Inn & Suites Durham near Duke University

Courtyard Durham Near Duke University/Downtown

Hilton Durham near Duke University

Everything within 1 mile

The Lodge at Duke Medical Center

Unscripted Durham, Part of JDV by Hyatt

Curated & Caffeinated! Gem near Duke & Downtown • Espresso bar, Eco+, Fire Pit

Cottage with Yard, Mins to Duke

Durham Retreat: 10 mins from Duke & Downtown, 20 mins from RTP & RDU I Sleeps 8

Frequently asked questions