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Check prices for these dates

This weekend
23 Oct - 25 Oct
Next weekend
30 Oct - 1 Nov

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Our top choices for Main Street Fort Pierce hotels

A hotel lobby with a large reception desk, multiple seating areas, and a patterned carpet.

1. Fairfield Inn & Suites by Marriott Fort Pierce

Fairfield Inn & Suites by Marriott Fort Pierce
3.0 star property
7.7 km from Main Street Fort Pierce
8.8 out of 10, Excellent, (1,003 reviews)
"Plenty of parking and cozy room."
United States
Katherine
The price is AED 340
AED 381 total
includes taxes & fees
25 Oct - 26 Oct
Fairfield Inn & Suites by Marriott Fort Pierce
A pool area with lounge chairs and a hot tub, surrounded by palm trees and a view of the ocean.

2. Hutchinson Island Hotel

Hutchinson Island Hotel
2.5 star property
3.1 km from Main Street Fort Pierce
8.2 out of 10, Very good, (1,382 reviews)
"Clean room nice staff and awesome view!! Will be staying there again soon!"
United States
Lana
The price is AED 385
AED 502 total
includes taxes & fees
18 Nov - 19 Nov
Hutchinson Island Hotel
A modern reception area with a long corridor, a reception desk, and a seating area with tables and chairs.

3. Holiday Inn Express Hotel & Suites Fort Pierce West by IHG

Holiday Inn Express Hotel & Suites Fort Pierce West by IHG
2.5 star property
8.3 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (905 reviews)
"I would definitely stay at this hotel again"
United States
Rodney
The price is AED 386
AED 432 total
includes taxes & fees
25 Oct - 26 Oct
Holiday Inn Express Hotel & Suites Fort Pierce West by IHG
Exterior

4. Hampton Inn & Suites Ft. Pierce

Hampton Inn & Suites Ft. Pierce
2.5 star property
7.9 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1,001 reviews)
"My weekend stay was a 10/10.I will definitely book my next stay here"
United States
Angela
The price is AED 340
AED 381 total
includes taxes & fees
8 Nov - 9 Nov
Hampton Inn & Suites Ft. Pierce
An outdoor seating area with fire feature, stone walls, and a view into the building.

5. Home2 Suites by Hilton Ft. Pierce I-95

Home2 Suites by Hilton Ft. Pierce I-95
3.0 star property
7.8 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (276 reviews)
"Nice little breakfast...very clean and easy check in and check out..."
United States
JERRY
The price is AED 453
AED 507 total
includes taxes & fees
12 Nov - 13 Nov
Home2 Suites by Hilton Ft. Pierce I-95
A spacious living area with a grey sofa, a blue sofa, and a wooden accent wall with a flat-screen TV.

6. La Quinta Inn & Suites by Wyndham Ft. Pierce

La Quinta Inn & Suites by Wyndham Ft. Pierce
3.0 star property
7.9 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,007 reviews)
"We have booked rooms at this hotel multiple nights in the last few months for our employees that are working on a project in the area. The staff have been great!"
United States
Tyler
The price is AED 306
AED 342 total
includes taxes & fees
25 Oct - 26 Oct
La Quinta Inn & Suites by Wyndham Ft. Pierce
A restaurant interior with a bar area, wooden flooring, and multiple seating arrangements.

7. Days Inn & Suites by Wyndham Fort Pierce Midtown

Days Inn & Suites by Wyndham Fort Pierce Midtown
2.0 star property
4.5 km from Main Street Fort Pierce
8.8 out of 10, Excellent, (9 reviews)
"Good value"
United States
Cynthia
The price is AED 240
AED 269 total
includes taxes & fees
25 Oct - 26 Oct
Days Inn & Suites by Wyndham Fort Pierce Midtown
A hotel entrance with a welcome sign, a black mat, and two potted plants.

8. At Home Inn

At Home Inn
2.5 star property
8.2 km from Main Street Fort Pierce
8.0 out of 10, Very good, (1,341 reviews)
"Older building but very clean and friendly staff. Nice free breakfast. Right off the turnpike about a block easy to find. Great for the price!!"
United States
Gregory
The price is AED 203
AED 227 total
includes taxes & fees
19 Nov - 20 Nov
At Home Inn
A hotel room with a bed, a sofa, and a small table. There are framed pictures on the wall.

9. Comfort Suites Fort Pierce I-95

Comfort Suites Fort Pierce I-95
2.5 star property
7.7 km from Main Street Fort Pierce
7.8 out of 10, Good, (972 reviews)
"Clean rooms, friendly staff"
United States
Marina
The price is AED 304
AED 340 total
includes taxes & fees
15 Nov - 16 Nov
Comfort Suites Fort Pierce I-95
A hotel room with two beds, a television, a ceiling fan, and a view of the beach.

10. The Royal Inn Beach Hotel Hutchinson Island

The Royal Inn Beach Hotel Hutchinson Island
2.5 star property
3.8 km from Main Street Fort Pierce
7.2 out of 10, Good, (1,005 reviews)
"My go-to hotel when I need a place to get away!"
United States
Taylor
The price is AED 347
AED 448 total
includes taxes & fees
21 Oct - 22 Oct
The Royal Inn Beach Hotel Hutchinson Island
A hotel lobby with a reception desk, a chandelier, a clock, and a sofa.

11. Sleep Inn Fort Pierce I-95

Sleep Inn Fort Pierce I-95
2.5 star property
7.9 km from Main Street Fort Pierce
7.6 out of 10, Good, (921 reviews)
"Staff was very friendly and rooms were clean"
United States
Charity
The price is AED 276
AED 309 total
includes taxes & fees
1 Nov - 2 Nov
Sleep Inn Fort Pierce I-95
A modern hotel room with a reception desk, two computer monitors, a printer, and a seating area with chairs and a sofa.

12. Staybridge Suites Vero Beach by IHG

Staybridge Suites Vero Beach by IHG
3.0 star property
24.1 km from Main Street Fort Pierce
9.6 out of 10, Exceptional, (722 reviews)
"Perfect stay"
United States
Michelle
The price is AED 455
AED 510 total
includes taxes & fees
25 Oct - 26 Oct
Staybridge Suites Vero Beach by IHG
A clear blue swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a gazebo.

13. Best Western Port St. Lucie

Best Western Port St. Lucie
2.5 star property
14 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,007 reviews)
"Good place for a short stay"
United States
BRIAN
The price is AED 331
AED 370 total
includes taxes & fees
8 Nov - 9 Nov
Best Western Port St. Lucie
A self-service snack and beverage area with refrigerated drinks and a variety of snacks.

14. Hampton Inn & Suites Port St. Lucie, West

Hampton Inn & Suites Port St. Lucie, West
2.5 star property
17.4 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (1,004 reviews)
"Very Helpful and Friendly staff, our room was super clean, and breakfast was great!"
United States
Ahim
The price is AED 356
AED 399 total
includes taxes & fees
8 Nov - 9 Nov
Hampton Inn & Suites Port St. Lucie, West
A Holiday Inn Express & Suites hotel with a modern design, featuring a prominent entrance, well-maintained landscaping, and a clear view of the sky.

15. Holiday Inn Express & Suites Port St. Lucie West by IHG

Holiday Inn Express & Suites Port St. Lucie West by IHG
2.5 star property
17.1 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,005 reviews)
"Great stay"
United States
AEON
The price is AED 404
AED 453 total
includes taxes & fees
25 Oct - 26 Oct
Holiday Inn Express & Suites Port St. Lucie West by IHG
A modern living room with a fireplace, a dining area with bar stools, and a large TV mounted on the wall.

16. Hampton Inn & Suites Vero Beach Downtown

Hampton Inn & Suites Vero Beach Downtown
2.5 star property
22.1 km from Main Street Fort Pierce
9.2 out of 10, Wonderful, (1,000 reviews)
"Easy access and secure parking"
United States
Cameron
The price is AED 479
AED 536 total
includes taxes & fees
1 Nov - 2 Nov
Hampton Inn & Suites Vero Beach Downtown
A hotel lobby with a reception desk, seating area, and a hallway leading to other rooms.

17. Days Inn & Suites by Wyndham Fort Pierce I-95

Days Inn & Suites by Wyndham Fort Pierce I-95
2.5 star property
7.8 km from Main Street Fort Pierce
7.4 out of 10, Good, (1,002 reviews)
"The staff was excellent"
United States
Carlton
The price is AED 217
AED 243 total
includes taxes & fees
1 Nov - 2 Nov
Days Inn & Suites by Wyndham Fort Pierce I-95
A multi-story hotel with a modern design, featuring a prominent sign for 'Springhill Suites Marriott'.

18. SpringHill Suites Port St. Lucie

SpringHill Suites Port St. Lucie
3.0 star property
17.2 km from Main Street Fort Pierce
8.6 out of 10, Excellent, (1,000 reviews)
"Loved our stay, great staff."
United States
Amy
The price is AED 377
AED 422 total
includes taxes & fees
25 Oct - 26 Oct
SpringHill Suites Port St. Lucie
A modern bar area with wooden tables and blue chairs, featuring black pendant lights and a large abstract mural on the wall.

19. TownePlace Suites by Marriott Port St. Lucie I-95

TownePlace Suites by Marriott Port St. Lucie I-95
3.0 star property
21.9 km from Main Street Fort Pierce
9.4 out of 10, Exceptional, (1,003 reviews)
"Location was convenient , staff was nice , hotel was clean"
United States
Demonica
The price is AED 426
AED 478 total
includes taxes & fees
6 Nov - 7 Nov
TownePlace Suites by Marriott Port St. Lucie I-95
An outdoor patio area with a fire pit, red and black wicker furniture, and string lights.

20. Residence Inn by Marriott Port St. Lucie

Residence Inn by Marriott Port St. Lucie
3.0 star property
17.8 km from Main Street Fort Pierce
9.0 out of 10, Wonderful, (1,004 reviews)
"Great place to stay"
United States
Eduardo
The price is AED 404
AED 453 total
includes taxes & fees
8 Nov - 9 Nov
Residence Inn by Marriott Port St. Lucie
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Main Street Fort Pierce

Find the best Main Street Fort Pierce areas and neighborhoods for the activities you enjoy most.
A coastal area with a narrow waterway, a beach, and residential buildings.

Lakewood Park

While Lakewood Park isn't home to many top sights, McKee Botanical Garden and Avalon State Park are some notable places to visit nearby.

Spanish Lakes Country Club Village

While there might not be top attractions in Spanish Lakes Country Club Village, you can explore the larger area and discover places like Harbor Branch Ocean Discovery Center and McKee Botanical Garden.

A calm lake reflecting trees and a clear sky.

Spanish Lakes Fairways

While Spanish Lakes Fairways might not have many sights to explore, venturing just a little farther will lead you to top things to see and do like Lakewood Park Regional Park / Pool and Indrio Road Park / Schoolhouse.

A coastal city with a bay, mangrove islands, and a clear blue sky.

Meadowood

If you're looking for some top things to see and do in Meadowood and surrounding area, you can visit Endless Summer Vineyard & Winery and Al's Family Farms.

A mosaic sign with 'Mainstreet Fort Pierce' written on it.

Panther Woods

If you're looking for some top things to see and do in Panther Woods and surrounding area, you can visit Endless Summer Vineyard & Winery and Al's Family Farms.

Top Main Street Fort Pierce Hotel Reviews

TownePlace Suites by Marriott Port St. Lucie I-95

TownePlace Suites by Marriott Port St. Lucie I-95

10/10 Excellent
"Service staff were very friendly and accommodating. Allowed us to check in early by finding a room that was already cleaned and ready to use."
STEVEN 1-night trip
Posted 12 hours ago
TownePlace Suites by Marriott Port St. Lucie I-95

Frequently asked questions

What is Main Street Fort Pierce like?
Main Street Fort Pierce is a neighborhood that travelers like for its waterfront, art, and shopping. Be sure to check out Sunrise Theater and Fort Pierce Farmer's Market as part of your Main Street Fort Pierce travel plans.
How many hotels can I expect to find in Main Street Fort Pierce?
Book one of Expedia's 7 hotels and other accommodations in Main Street Fort Pierce and start exploring everything Fort Pierce has to offer.
If I need to cancel my hotel reservation in Main Street Fort Pierce, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable provided that you cancel before the hotel's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of booking. Put your dates in and click on "Search", then use the filter option "fully refundable" to review the top deals on offer in Main Street Fort Pierce.
Where can I learn more about changing or cancelling my trip to Main Street Fort Pierce?
For additional details about changing or cancelling your trip to Main Street Fort Pierce, head over to our customer service page.
What is there to do in this Fort Pierce neighborhood?
Sights like Sunrise Theater and Official Highwaymen Art Gallery can be part of your cultural tour of Main Street Fort Pierce. Fort Pierce Farmer's Market and Fort Pierce City Marina are also a couple of places to visit in the neighborhood. A few places to visit in the area around Main Street Fort Pierce include Manatee Education and Observation Center, House of Seven Gables, and A.E. Backus Museum. Marina at Fort Pierce and Causeway Cove are also worth a visit when you're out sightseeing in Fort Pierce.