A water feature with multiple tiers and a circular viewing platform at the top.

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2 Oct - 4 Oct
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9 Oct - 11 Oct

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Our top choices for South Central Houston hotels

A rooftop pool area with lounge chairs and a view of a tall building at night.

1. The Westin Houston Medical Center/Museum District

The Westin Houston Medical Center/Museum District
4.0 star property
South Central Houston
9.2 out of 10, Wonderful, (1,222 reviews)
"great location and the hotel is quite comfortable"
United States
Juan
The price is AED 625
AED 778 total
includes taxes & fees
11 Oct - 12 Oct
The Westin Houston Medical Center/Museum District
A modern restaurant with a bar area, featuring a patterned floor, multiple dining tables, and contemporary lighting fixtures.

2. Houston Marriott Medical Center/Museum District

Houston Marriott Medical Center/Museum District
4.0 star property
South Central Houston
9.0 out of 10, Wonderful, (1,001 reviews)
"They are very accommodating. Easy access to Houston Methodist Hoptial."
United States
Melanie
The price is AED 658
AED 889 total
includes taxes & fees
11 Oct - 12 Oct
Houston Marriott Medical Center/Museum District
A spacious living area with a dining table, chairs, and a chandelier.

3. Hotel Zaza Houston Museum District

Hotel Zaza Houston Museum District
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (1,004 reviews)
"Great place!"
United States
Madiha
The price is AED 923
AED 1,252 total
includes taxes & fees
8 Oct - 9 Oct
Hotel Zaza Houston Museum District
A spacious lobby with modern furniture, large windows, and indoor plants.

4. InterContinental Houston by IHG

InterContinental Houston by IHG
4.0 star property
South Central Houston
9.4 out of 10, Exceptional, (1,006 reviews)
"Great stay!"
United States
Luke
The price is AED 621
AED 800 total
includes taxes & fees
25 Oct - 26 Oct
InterContinental Houston by IHG
A rooftop patio with outdoor seating, fire pits, and a view of the cityscape.

5. Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center
4.5 star property
South Central Houston
8.4 out of 10, Very good, (2,176 reviews)
"Beautiful Hotel and excellent Service"
United States
olga
The price is AED 368
AED 435 total
includes taxes & fees
11 Oct - 12 Oct
Hilton Houston Plaza/Medical Center
A modern hotel room with a large bed, a black leather sofa, a wooden coffee table, and a desk with a mirror.

6. Downtowner Inns - Houston Downtown

Downtowner Inns - Houston Downtown
2.0 star property
South Central Houston
9.2 out of 10, Wonderful, (250 reviews)
"Second time stay here. Lovely place"
United States
Jaelon
The price is AED 324
AED 380 total
includes taxes & fees
5 Oct - 6 Oct
Downtowner Inns - Houston Downtown
A spacious dining area with multiple tables and chairs, large windows, and hanging pendant lights.

7. DoubleTree by Hilton Houston Medical Center Hotel & Suites

DoubleTree by Hilton Houston Medical Center Hotel & Suites
4.0 star property
South Central Houston
8.4 out of 10, Very good, (687 reviews)
"Great hotel"
United States
Brandon
The price is AED 479
AED 560 total
includes taxes & fees
11 Oct - 12 Oct
DoubleTree by Hilton Houston Medical Center Hotel & Suites
A multi-story hotel with a brick facade, balconies, and a well-lit entrance.

8. La Maison in Midtown an urban B&B

La Maison in Midtown an urban B&B
3.5 star property
South Central Houston
9.8 out of 10, Exceptional, (601 reviews)
"Lovely welcoming staff, beautiful building with wonderful communal areas. We enjoyed the outside verandah. It's in a fairly noisy location but this didn't bother us. Walking distance to local bars/restaurants, 10 minutes drive to Downtown. Oh and let's not forget the lovely breakfast!"
United Kingdom
Joanna
The price is AED 631
AED 738 total
includes taxes & fees
4 Oct - 5 Oct
La Maison in Midtown an urban B&B
A modern kitchen with dark wood cabinets, a granite countertop, and a built-in island with a glass enclosure.

9. Americas Best Value Inn Medical Center Downtown

Americas Best Value Inn Medical Center Downtown
2.0 star property
South Central Houston
8.0 out of 10, Very good, (1,000 reviews)
"Clean room, comfortable stay"
United States
Susanne
The price is AED 272
AED 318 total
includes taxes & fees
4 Oct - 5 Oct
Americas Best Value Inn Medical Center Downtown
A high-rise hotel with a rooftop pool, multiple floors, and a cityscape view.

10. Sentral Forme Houston

Sentral Forme Houston
4.5 star property
South Central Houston
9.2 out of 10, Wonderful, (89 reviews)
"Great place to stay!"
United States
Keeshaun
The price is AED 590
AED 798 total
includes taxes & fees
5 Oct - 6 Oct
Sentral Forme Houston
A large, multi-story house with a swimming pool, outdoor seating, and a red umbrella.

11. Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only

Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
South Central Houston
9.6 out of 10, Exceptional, (221 reviews)
"The room was very clean, the staff was just great and the breakfast was very good! The Parking was a little difficult, but it was very safe!"
United States
Walter
The price is AED 646
AED 811 total
includes taxes & fees
4 Oct - 5 Oct
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
A spacious lobby with a high ceiling, a central seating area with sofas and armchairs, a staircase leading to an upper level, and a flat-screen TV mounted on the wall.

12. Extended Stay America Suites Houston Med Ctr Braeswood Bl

Extended Stay America Suites Houston Med Ctr Braeswood Bl
2.5 star property
South Central Houston
6.2 out of 10, (1,000 reviews)
"The perfect place to stay!"
Mexico
Maria Fernanda
The price is AED 284
AED 334 total
includes taxes & fees
8 Oct - 9 Oct
Extended Stay America Suites Houston Med Ctr Braeswood Bl
A modern kitchen with a large island, bar stools, and a stainless steel refrigerator.

13. Wanderstay Boutique Hotel

Wanderstay Boutique Hotel
3.0 star property
South Central Houston
9.8 out of 10, Exceptional, (80 reviews)
"Solo trip and it was a perfect location staff was nice and it was nice and clean!! Would stay there again. "
United States
Sharon
The price is AED 509
AED 596 total
includes taxes & fees
4 Oct - 5 Oct
Wanderstay Boutique Hotel
A hotel room with a bed, a desk, a chair, a mirror, a television, and a heater.

14. Scott Inn Suites - Downtown Houston

Scott Inn Suites - Downtown Houston
2.0 star property
South Central Houston
8.4 out of 10, Very good, (47 reviews)
"Nice staff, good clean room and close to public transportation"
United States
Sergio
The price is AED 224
AED 269 total
includes taxes & fees
8 Oct - 9 Oct
Scott Inn Suites - Downtown Houston
A spacious lobby with a large sectional sofa, a coffee table, and a reception desk.

15. Hilton University of Houston

Hilton University of Houston
3.5 star property
South Central Houston
9.0 out of 10, Wonderful, (983 reviews)
"Pretty amazing stay"
United States
DELISA
The price is AED 569
AED 666 total
includes taxes & fees
12 Oct - 13 Oct
Hilton University of Houston
A hotel room with a bed, bedside table, desk, and a mirror.

16. Southmore Boulevard Motel

Southmore Boulevard Motel
2.0 star property
South Central Houston
5.6 out of 10, (245 reviews)
"Very sweet lady I will be back"
United States
LaKeara
The price is AED 200
AED 234 total
includes taxes & fees
2 Nov - 3 Nov
Southmore Boulevard Motel
A modern reception area with a blackboard, a blue sofa, a yellow armchair, and a colorful rug.

17. Wanderstay Houston Hostel

Wanderstay Houston Hostel
2.0 star property
South Central Houston
8.2 out of 10, Very good, (214 reviews)
"Excellent stay experience"
United States
Binkeung
The price is AED 190
AED 222 total
includes taxes & fees
3 Oct - 4 Oct
Wanderstay Houston Hostel
A bedroom with a bed, a nightstand, a window with curtains, and a view of greenery outside.

18. Modern 3BR Near UH Downtown Toyota Center NRG

Modern 3BR Near UH Downtown Toyota Center NRG
2.0 star property
South Central Houston
The price is AED 408
AED 3,200 total
includes taxes & fees
5 Oct - 6 Oct
Modern 3BR Near UH Downtown Toyota Center NRG
A modern kitchen with stainless steel appliances, a granite countertop, and a dining area with a glass table and metal chairs.

19. Walkable Eado Condo Near Dtwn: Modern + Chic!

Walkable Eado Condo Near Dtwn: Modern + Chic!
3.0 star property
South Central Houston
The price is AED 455
AED 1,505 total
includes taxes & fees
4 Oct - 5 Oct
Walkable Eado Condo Near Dtwn: Modern + Chic!
A reception desk with a computer, a keyboard, a mouse, and a telephone. There are certificates and keys on the wall.

20. Golden Motel Near Houston Medical Center

Golden Motel Near Houston Medical Center
2.5 star property
South Central Houston
2.0 out of 10, (4 reviews)
"Room smelt like cigarettes burnt wholes in the wall and bed sheet all 6 walls had stains toilet seat look like someone stood on it "
United States
Jacari
The price is AED 239
AED 294 total
includes taxes & fees
3 Oct - 4 Oct
Golden Motel Near Houston Medical Center
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in South Central Houston

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
A modern kitchen with a large island, bar stools, and a stainless steel refrigerator.
Wanderstay Boutique Hotel
3.0 star property
9.8
Exceptional
80 reviews
View
A large, multi-story house with a swimming pool, outdoor seating, and a red umbrella.
Houston Towers Inn Downtown Museum District Med. Ctr NRG - Adults Only
3.5 star property
9.6
Exceptional
221 reviews
View
A modern hotel room with a large bed, a black leather sofa, a wooden coffee table, and a desk with a mirror.
Downtowner Inns - Houston Downtown
2.0 star property
9.2
Wonderful
250 reviews
View
A spacious lobby with modern furniture, large windows, and indoor plants.
InterContinental Houston by IHG
4.0 star property
9.4
Exceptional
1,006 reviews
View
A rooftop pool area with lounge chairs and a view of a tall building at night.
The Westin Houston Medical Center/Museum District
4.0 star property
9.2
Wonderful
1,222 reviews
View

Where to stay in South Central Houston

Find the best South Central Houston areas and neighborhoods for the activities you enjoy most.
A sculpture garden with abstract art pieces in a city park.

Downtown Houston

Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.

A tall, modern building with a unique, vertical design, surrounded by trees and a partly cloudy sky.

The Galleria

Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Williams Tower.

A cityscape with dense high-rise buildings, a river, and surrounding greenery.

Texas Medical Center

Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.

A modern building with a covered outdoor area and a circular garden feature.

Montrose

Unique features of Montrose include the theaters and museums. Make a stop by Rothko Chapel or Menil Collection while you're exploring the area.

A bridge with the words "Welcome to Downtown Houston" and a star emblem.

Houston Central Business District

If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.

Top South Central Houston Hotel Reviews

Hilton Houston Plaza/Medical Center

Hilton Houston Plaza/Medical Center

10/10 Excellent
"Enjoyed the stay, staff was very helpful and courteous."
Robert 1-night trip
Posted 12 hours ago
Hilton Houston Plaza/Medical Center

Frequently asked questions

What's it like in South Central Houston?
Travelers are sure to enjoy a stay in Houston's South Central Houston neighborhood. Be sure to check out TDECU Stadium and Children's Museum of Houston as part of your South Central Houston travel plans.
What's the best accommodation in South Central Houston?
Based on our traveler data, Hotel Zaza Houston Museum District is one of the top choices for your stay in South Central Houston. This hotel is a short 6-minute walk from Rice University, and it offers a full-service spa and a restaurant. Other good options for your stay in the area include Hilton Houston Plaza/Medical Center and The Westin Houston Medical Center/Museum District.
How many hotels can I expect to find in the South Central Houston area?
Expedia has 1272 hotels and other accommodations in South Central Houston to choose from, making this an ideal home base for exploring the greater Houston area.
If I need to cancel my hotel reservation in South Central Houston, will I receive a refund?
Yes, the majority of hotel room reservations are fully refundable provided that you cancel before the accommodation's cancellation deadline, which in most cases is within 24 or 48 hours of the scheduled arrival. If you have a non-refundable reservation, you might be able to cancel it and be given a refund within 24 hours of your booking. Enter dates in and click on "Search", then you can use the "fully refundable" filter to review the best options available in South Central Houston.
Where can I learn more about changing or cancelling my trip to South Central Houston?
To access more information about changing or cancelling your trip to South Central Houston, go to https://www.expedia.com/service/.
What is there to do around this Houston neighborhood?
Spend some time exploring the great outdoors at Hermann Park, Cullen Sculpture Garden, and Twilight Epiphany Skyspace. TDECU Stadium and Children's Museum of Houston are some other stops to visit in the neighborhood. Daikin Park and Toyota Center are some favorite places to visit in the area around South Central Houston. Shape Community Center and Project Row Houses are also worth a visit when you're out sightseeing in Houston.
How can I get around South Central Houston and the greater Houston area?
For a quick way to explore the city, catch a ride on metro transit at Elgin/Third Ward Station, TSU/UH Athletics District Station, or Ensemble/HCC Station. If you want to venture out of town, M. D. Anderson Station is the closest train station. You can also catch a ride at Kinder Station.