Find hotels in South Main, Houston
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Our top choices for South Main hotels
1. Comfort Suites Houston near Medical Center- NRG Stadium
Comfort Suites Houston near Medical Center- NRG StadiumSouth Main
8.8 out of 10, Excellent, (1,005 reviews)
"Great Staff, room and location!"
chris
The price is AED 371
AED 435 total
includes taxes & fees
8 Sep - 9 Sep
2. Wyndham Houston at Reliant Park & Medical Center
Wyndham Houston at Reliant Park & Medical CenterSouth Main
7.2 out of 10, Good, (1,406 reviews)
"Staff friendly rooms nice and clean."
Miguel
The price is AED 345
AED 404 total
includes taxes & fees
14 Sep - 15 Sep
3. Quality Inn & Suites NRG Park - Medical Center
Quality Inn & Suites NRG Park - Medical CenterSouth Main
6.6 out of 10, (1,002 reviews)
"Regular aceptable ."
Oscar
The price is AED 241
AED 282 total
includes taxes & fees
5 Oct - 6 Oct
4. Candlewood Suites Houston Medical Center by IHG
Candlewood Suites Houston Medical Center by IHGSouth Main
7.4 out of 10, Good, (896 reviews)
"Great amenities!"
Michelle
The price is AED 272
AED 318 total
includes taxes & fees
8 Sep - 9 Sep
5. Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG
Holiday Inn Express & Suites Houston S - Medical Ctr Area by IHG1.4 km from South Main
9.4 out of 10, Exceptional, (1,002 reviews)
"I’ll stay again"
Kevin
The price is AED 433
AED 510 total
includes taxes & fees
7 Sep - 8 Sep
6. Hotel Ylem
Hotel Ylem2.3 km from South Main
8.4 out of 10, Very Good, (1,561 reviews)
"We found a clean room, all amenities, tv and
a/c
The breakfast is so good and fresh"
GUSTAVO
The price is AED 232
AED 290 total
includes taxes & fees
10 Sep - 11 Sep
7. Courtyard By Marriott Houston Medical Center Reliant Park
Courtyard By Marriott Houston Medical Center Reliant Park2.7 km from South Main
8.6 out of 10, Excellent, (1,003 reviews)
"Great Hotel!"
Jorge
The price is AED 410
AED 485 total
includes taxes & fees
7 Sep - 8 Sep
8. Hyatt House Houston Medical Center
Hyatt House Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (1,283 reviews)
"Great lodging, staff, breakfast, and shuttle service to MD Anderson."
ALFRED
The price is AED 464
AED 546 total
includes taxes & fees
10 Sep - 11 Sep
9. Hyatt Place Houston Medical Center
Hyatt Place Houston Medical CenterTexas Medical Center, 3.1 km from South Main
9.2 out of 10, Wonderful, (2,651 reviews)
"Lovely stay!"
Lamarr
The price is AED 466
AED 549 total
includes taxes & fees
10 Sep - 11 Sep
10. Blossom Hotel Houston, Curio Collection by Hilton
Blossom Hotel Houston, Curio Collection by HiltonTexas Medical Center, 3.5 km from South Main
9.0 out of 10, Wonderful, (3,902 reviews)
"I loved staying here!"
Kamauri
The price is AED 525
AED 617 total
includes taxes & fees
7 Sep - 8 Sep
11. Hilton Houston Plaza/Medical Center
Hilton Houston Plaza/Medical CenterTexas Medical Center, 4.4 km from South Main
8.4 out of 10, Very Good, (2,135 reviews)
"Our stay was great"
Cindy
The price is AED 286
AED 339 total
includes taxes & fees
6 Sep - 7 Sep
12. The Westin Houston Medical Center/Museum District
The Westin Houston Medical Center/Museum DistrictTexas Medical Center, 4.4 km from South Main
9.2 out of 10, Wonderful, (1,196 reviews)
"Great place to stay"
Kevin
The price is AED 475
AED 591 total
includes taxes & fees
7 Sep - 8 Sep
13. Hilton Garden Inn Houston Medical Center, TX
Hilton Garden Inn Houston Medical Center, TXTexas Medical Center, 4.7 km from South Main
9.2 out of 10, Wonderful, (1,003 reviews)
"nice hotel"
Tameka
The price is AED 419
AED 490 total
includes taxes & fees
10 Sep - 11 Sep
14. Home2 Suites by Hilton Houston Medical Center, TX
Home2 Suites by Hilton Houston Medical Center, TXTexas Medical Center, 4.7 km from South Main
9.2 out of 10, Wonderful, (728 reviews)
"The staff, the suite and breakfast were great. Very nice hotel."
Charles
The price is AED 479
AED 560 total
includes taxes & fees
10 Sep - 11 Sep
15. Hotel Zaza Houston Museum District
Hotel Zaza Houston Museum District6.3 km from South Main
9.2 out of 10, Wonderful, (1,001 reviews)
"Loved the location, staff, and extra little amenities!"
Tina
The price is AED 825
AED 1,111 total
includes taxes & fees
6 Sep - 7 Sep
16. Crowne Plaza Houston Med Ctr-Galleria Area by IHG
Crowne Plaza Houston Med Ctr-Galleria Area by IHGGreenway Plaza-Upper Kirby, 6.5 km from South Main
7.8 out of 10, Good, (1,612 reviews)
"Stay was nice’! Will stay again"
Lanita
The price is AED 231
AED 270 total
includes taxes & fees
7 Sep - 8 Sep
17. DoubleTree by Hilton Hotel Houston - Greenway Plaza
DoubleTree by Hilton Hotel Houston - Greenway PlazaGreenway Plaza-Upper Kirby, 6.6 km from South Main
8.4 out of 10, Very Good, (1,851 reviews)
"Great stay"
Raphael
The price is AED 283
AED 331 total
includes taxes & fees
10 Sep - 11 Sep
18. Sonesta ES Suites Houston Galleria
Sonesta ES Suites Houston GalleriaThe Galleria, 8.4 km from South Main
8.4 out of 10, Very Good, (1,382 reviews)
"Clean room, helpful staff, and excellent breakfast."
Mikhail
The price is AED 400
AED 468 total
includes taxes & fees
5 Sep - 6 Sep
19. Holiday Inn Express Houston - Galleria Area by IHG
Holiday Inn Express Houston - Galleria Area by IHGThe Galleria, 8.6 km from South Main
9.4 out of 10, Exceptional, (1,006 reviews)
"Very good stay and amenities."
Michelle
The price is AED 433
AED 507 total
includes taxes & fees
7 Sep - 8 Sep
20. The Chifley Houston, Tapestry Collection by Hilton
The Chifley Houston, Tapestry Collection by HiltonThe Galleria, 8.7 km from South Main
9.2 out of 10, Wonderful, (1,350 reviews)
"This is a great hotel in the perfect location and close to everything."
Ronald
The price is AED 419
AED 490 total
includes taxes & fees
11 Sep - 12 Sep
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Where to stay in South Main
Find the best South Main areas and neighborhoods for the activities you enjoy most.
Downtown Houston
Largest central business district in Texas, this area boasts major league sports venues, a vibrant Theater District, and shopping options like GreenStreet. Easily navigate with public transportation options like METRORail and bus lines.
The Galleria
Travelers to The Galleria praise its popular shops. If you've got some more time to explore, be sure to make a stop by The Galleria and Gerald D. Hines Waterwall Park.
Texas Medical Center
Boasting the world's largest medical complex, this Houston neighborhood offers access to over 60 medical institutions and is served by the METRORail Red Line. Explore the John P. McGovern Historical Collections and Research Center for a unique experience.
Montrose
Unique features of Montrose include the theaters and museums. Make a stop by Menil Collection or Rothko Chapel while you're exploring the area.
Photo by George Zimzores
Open Photo by George Zimzores
Houston Central Business District
If you're spending time in Houston Central Business District, check out sights like Toyota Center or House of Blues Houston and hop on the metro to see more the city at Bell Station or Downtown Transit Center Station.
Top South Main Hotel Reviews
Hyatt Place Houston Downtown
10/10 Excellent
