In the heart of Jeffersonville, Deaconess Guesthouse combines historical charm with modern luxury. Enjoy stunning riverfront views from the front porch and balcony or unwind in the hot tub under starry skies. This spacious retreat boasts indoor gaming zones, a unique dome, fully-equipped kitchens, SMART ROKU TVs in every living room and bedroom.
Reviews
1010 out of 10
Exceptional
Entire home
8 bedrooms6 bathroomsSleeps 24539 sq m
Popular amenities
Hot Tub
Dryer
Kitchen
Fireplace
Washer
Barbecue grill
Add dates for prices
About this property
Entire place
You'll have the entire home to yourself and will only share it with other guests in your party.
★ Where Heritage Meets High-End Living: Welcome to Deaconess Guesthouse, an extraordinary 1800s landmark transformed into a modern luxury retreat. Once Jeffersonville’s first public hospital, this historic estate has been masterfully restored by Charming Vacation Homes to offer a one-of-a-kind blend of timeless elegance, boutique-hotel comfort and sweeping Ohio River views.
Just minutes from downtown Louisville, the Bourbon Trail and Jeffersonville’s vibrant riverfront district, this unparalleled residence invites guests to savor a stay that feels both meaningful and indulgent.
★ Designed for Elevated Gatherings & Unforgettable Moments: Featuring 8 designer bedrooms and 6 spa-style bathrooms arranged across four private suites, Deaconess comfortably hosts up to 24 guests. It’s the ideal setting for corporate retreats, multi-family getaways, wedding groups and milestone celebrations.
Every space—from the grand communal rooms to cozy nooks curated with rich textures, custom art and premium furnishings—has been thoughtfully crafted to inspire conversation, connection and cherished memories.
★ Signature Luxury Experiences: 1. Private Hot Tub & Fire Pit – Relax under the stars along your private stretch of riverfront 2. Wraparound Porches & Balconies – Enjoy sunrise coffee and sunset cocktails with breathtaking views 3. Stargazing Dome – A whimsical escape for dreamers, children, creatives, and romantics 4. Ample On-Site Parking – Ideal for executive travel, large groups, and event convenience
★ Unmatched Location for Exploration: - Walk to Downtown Jeffersonville – Boutiques, craft eateries, festivals, and waterfront entertainment - Only 2.5 Miles to Downtown Louisville – Distilleries, Churchill Downs, museums, sports, concerts, and nightlife - Adventure at Your Doorstep – Paddleboarding, cycling, and seasonal events just steps away
★ Your Private Luxury Riverfront Retreat: Whether you’re sharing stories around the fire pit, hosting an elegant celebration or simply unwinding with river views from a rocking chair, Deaconess Guesthouse offers an experience that encourages you to slow down, reconnect and savor the moment.
With its historic soul, elevated finishes and unmatched setting, Deaconess isn't just a place to stay—it’s a chapter of your story waiting to unfold.
Reserve your stay today at Louisville and Jeffersonville’s premier riverfront estate—where history, luxury, and unforgettable memories come together.
★ CONVENIENT LOCATION The house is centrally located and is within a 10-15 minute Uber/Lyft drive to most locations:
- Big Four Walking Bridge (Connecting KY and IN) - 0.4 miles (2 mins) - Churchill Downs (DERBY) - 7.7 miles (15 mins) - KFC Yum Center - 2.3 miles (7 mins) - Downtown Louisville/ 4th Street Live - 2.4 miles (6 mins) - Waterfront Park - 3.4 miles (9 mins) - Papa Johns Stadium (Cardinal Stadium) - 6.4 miles (11 mins) - University of Louisville - 6.5 miles (12 mins) - Kentucky Fairgrounds - 6.5 miles (10 min) - Kentucky Exposition Center - 6.7 miles (11 mins) - Kentucky Kingdom - 7.4 miles (13 mins) - Highland Festival Grounds - 8.5 miles (12 mins) - Louisville Airport - 8.6 miles (10 mins) - Louisville Mega Cavern - 10.2 miles (19 mins) - Ford LAP Plant - 10.9 miles (16 mins) - UPS Worldport - 11.2 miles (20 mins) - Waverly Hills Sanatorium - 17 miles (30 mins) - Valhalla Golf Club - 19 miles (27 mins)
PROPERTY HIGHLIGHTS ★ Unmatched Ohio Riverfront Setting: Begin each day with sweeping panoramic views of the Ohio River. Wander to the lively downtown districts of Jeffersonville and Louisville—home to boutique shopping, acclaimed dining, vibrant nightlife and year-round festivals just steps from your door. ★ Where History Meets Luxury: Meticulously restored and thoughtfully redesigned, this iconic landmark blends timeless craftsmanship with modern sophistication. Designer finishes, curated decor and preserved architectural details create an atmosphere that is both elegant and irresistibly inviting. ★ Inspiring Views & Peaceful Retreats: Enjoy your morning coffee or unwind with evening cocktails on covered porches and private balconies overlooking the sparkling river. Every outdoor space is crafted to capture the tranquility and magic of waterfront living. ★ Luxury Designed for Connection: With 8 beautifully styled bedrooms and 6 spa-inspired bathrooms, the home offers exceptional comfort for groups. Sun-filled living spaces and warm gathering areas encourage togetherness, storytelling and memories that linger long after check-out. ★ Elevated Culinary Experiences: Featuring four fully appointed gourmet kitchens, each with premium appliances and chef-forward layouts—perfect for hosting celebrations, preparing family meals or hiring a private chef for an unforgettable dining experience. ★ Thoughtful for Families & Pets: Cozy reading corners, kid-friendly nooks and pet-accommodating touches make every guest—big, small or four-legged—feel right at home. ★ Your Private Outdoor Sanctuary: Relax in the hot tub, gather around the riverfront fire pit, unwind beneath the gazebo or Hyperdome, enjoy alfresco dining or play lawn games under the stars. Every corner of the outdoor oasis is designed to inspire relaxation and connection. ★ Entertainment for Every Moment: Enjoy Smart Roku TVs throughout, indoor and outdoor games and multiple lounge spaces that offer endless ways to play, unwind, and enjoy your stay. ★ Ideal for Groups, Retreats & Celebrations: Perfect for family reunions, corporate retreats, milestone events or extended group getaways. The home includes generous parking, four washer/dryer sets and versatile indoor/outdoor spaces ideal for hosting. ★ Your Signature Riverfront Escape: Experience the perfect fusion of historic charm, elevated comfort and unbeatable location—where each sunrise over the Ohio River feels like a celebration and every stay becomes a cherished story.
★ OTHER 2025 UPCOMING EVENTS (Including TRADE SHOWS) -North American International Livestock Exposition: Nov 6th to 20th, 2025
NOTE: 1) Must be 25 or older to book. 2) Please review house rules before booking. Rental Agreement & Security Hold: Guests must e-sign our rental agreement and Must submit a $500 off-platform security hold that will be collected upon signing rental agreement but it will not be placed until 2 days prior to arrival and released 7 days after departure, if no damages are reported. Please note we are API Connected to a hotel-style software called OwnerRez to safely and securely take off-platform security deposits. 3) ** STRICT CANCELLATION for DERBY/ Bourbon & Beyond ** 4) Visitors are not permitted unless you make a special request to the host and receive approval. 5) We have exterior surveillance with voice and recording capabilities of the parking area and front door. They are in place for security of guests and the home. We do NOT have interior cameras nor camera in the backyard. 6) The Dome is not recommended for use during hot summer months. We suggest enjoying the other amenities during warmer months for optimal comfort. 7) We cannot accommodate early check-ins or late check-outs for same-day turnarounds. 8) For days without same-day turnarounds, we offer early check-ins and late check-outs at the following rates: $100 for up to 2 hours, $250 for 2 to 4 hours, and a full day's rate for more than 4 hours. 9) Please note that for cancellations of bookings made on platforms other than Airbnb, a Stripe card processing fee of 3% will be deducted from the total refund.
PLEASE REVIEW THE HOUSE RULES BEFORE BOOKING. THANK YOU!
Property amenities
Pool/Spa
Hot tub
Internet
Available in the house: Free WiFi
Parking and transportation
Car recommended
Parking on site
Kitchen
Coffee/tea maker
Cookware, dishware, and utensils
Dishwasher
Ice maker
Kitchen island
Microwave
Oven
Refrigerator
Spices
Stovetop
Toaster
Dining
Dining table
Bedrooms
8 bedrooms
Bedsheets provided
Sofa bed
Bathroom
6 bathrooms
Bathtub or shower
Hair dryer
Shower
Towels provided
Living spaces
Dining table
Fireplace
Living room
Entertainment
Books
Games
Smart TV
Outdoor areas
Balcony
Barbecue grill
Fenced yard
Firepit
Garden
Laundry
Laundry facilities
Washing machine
Work spaces
Desk
Desk chair
Comfort
Air conditioning
Heating
Pets
Pet friendly
Suitability/Accessibility
If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
Area rugs in public areas
Handrails in hallways
Handrails in stairways
Hardwood flooring in public areas
Smooth flooring in public areas
Thin carpet in public areas
Tile flooring in public areas
Well-lit path to entrance
Smoking not allowed
Services and conveniences
Iron/ironing board
Location highlights
In the city center
Near a hospital
Near a zoo
Near the marina
On a river
On the waterfront
Things to do
Arcade/game room
Water park
Casino nearby
Fishing nearby
Golfing nearby
Kayaking nearby
Motor boating nearby
Theme park nearby
Winery tours nearby
Safety features
Carbon monoxide detector (host has indicated there is a carbon monoxide detector on the property)
Smoke detector (host has indicated there is a smoke detector on the property)
First aid kit
Fire extinguisher
Deadbolt lock
General
At least 80% lighting from LEDs
Garden
Recycling
Unit size: 5,800 square feet
Water-efficient showers
Water-efficient toilets
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You will receive an email from the host with check-in and check-out instructions
Information provided by the property may be translated using automated translation tools
Rules
Must sign rental agreement upon booking which will be sent via email
A $500 security hold will be placed 2 days prior to arrival and released 7 days after departure, if no damages are reported
Must follow all house rules listed in the end of the description and also on the rental agreement.
Pets
Pets allowed
Service animals are welcome, and are exempt from fees
Note from host: Up to 2 pets 50lbs max.
Children and extra beds
Children are welcome
Events
No events allowed
Smoking
Smoking is not permitted
Important information
You need to know
Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
Onsite parties or group events are strictly prohibited
Host has indicated there is a carbon monoxide detector on the property
Host has indicated there is a smoke detector on the property
Safety features at this property include a fire extinguisher, a first aid kit, and a deadbolt lock
This property is managed through our partner, Vrbo. You will receive an email from Vrbo with a link to a Vrbo account, where you can change or cancel your reservation
We should mention
A car is recommended for transportation to and from this property
Property is also known as
orp5b65a95x
About the neighborhood
Jeffersonville, IN
What's nearby
Schimpffs Confectionery - 6 min walk - 0.6 km
Big Four Bridge - 12 min walk - 1.1 km
Louisville Waterfront Park - 17 min walk - 1.4 km
Nulu Market Place - 3 min drive - 2.8 km
Lynn Family Stadium - 3 min drive - 3.4 km
Getting around
Louisville, KY (LOU-Bowman Field) - 16 min drive
Restaurants
Parlour - 10 min walk
Cluckers - 5 min walk
Harry's Tap House and Kitchen - 6 min walk
Fresco Tea Bar - 9 min walk
Pearl Street Taphouse - 12 min walk
Frequently asked questions
Is 6000SF*Sleeps24*Views*Louisville*Dome*YardOasis*HotTub*Firepit*Pet*Lux Amenities pet-friendly?
Yes, pets are allowed at this property.
How much is parking?
Onsite parking is available at the property.
What time is check-in at 6000SF*Sleeps24*Views*Louisville*Dome*YardOasis*HotTub*Firepit*Pet*Lux Amenities?
Check-in begins at 4:00 PM.
What time is check-out at 6000SF*Sleeps24*Views*Louisville*Dome*YardOasis*HotTub*Firepit*Pet*Lux Amenities?
Check-out is at 10:00 AM.
Where is 6000SF*Sleeps24*Views*Louisville*Dome*YardOasis*HotTub*Firepit*Pet*Lux Amenities located?
This family-friendly Jeffersonville vacation home is located on the waterfront, within a 10-minute walk of Ohio River Valley, Ohio River, and Big Four Bridge. KFC Yum Center is 2.2 mi (3.6 km) away.
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