A cityscape with a prominent tower, a large body of water, and a sunset.

Find hotels in Medical Center District, San Antonio from AED 172

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
17 Jul - 19 Jul
Next weekend
24 Jul - 26 Jul

Filter by

Star rating

Guest rating

Selecting then applying a filter from this group will update the results on a new page

Our top choices for Medical Center District hotels

Free daily buffet breakfast

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
Medical Center District
8.4 out of 10, Very Good, (3,478 reviews)
"Was a nice hotel. Breakfast was good."
United States
Teresa
The price is AED 326
AED 386 total
includes taxes & fees
16 Jul - 17 Jul
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
Lobby

San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center
3.5 star property
Medical Center District
8.6 out of 10, Excellent, (1,126 reviews)
"Very nice hotel and the staff were alll very nice!"
United States
Kaniyah
The price is AED 362
AED 431 total
includes taxes & fees
15 Aug - 16 Aug
San Antonio Marriott Northwest Medical Center
Lobby

Drury Inn & Suites San Antonio Northwest Medical Center

Drury Inn & Suites San Antonio Northwest Medical Center
3.0 star property
Medical Center District
9.2 out of 10, Wonderful, (1,397 reviews)
"Staff very friendly"
United States
Luis
The price is AED 331
AED 391 total
includes taxes & fees
26 Jul - 27 Jul
Drury Inn & Suites San Antonio Northwest Medical Center
Property entrance

OYO Inn & Suites Medical Center San Antonio

OYO Inn & Suites Medical Center San Antonio
2.0 star property
Medical Center District
7.4 out of 10, Good, (243 reviews)
"It was quiet and clean and the staff was very friendly"
United States
Ronnie
The price is AED 206
AED 261 total
includes taxes & fees
31 Jul - 1 Aug
OYO Inn & Suites Medical Center San Antonio
Bar (on property)

Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio
3.0 star property
Medical Center District
8.8 out of 10, Excellent, (1,005 reviews)
"Our family loved this hotel. It's one of the best we've stayed at. We'll definately be back."
United States
Tiffani
The price is AED 327
AED 386 total
includes taxes & fees
1 Aug - 2 Aug
Courtyard by Marriott Medical Center San Antonio
Lobby lounge

Fairfield Inn & Suites by Marriott San Antonio Medical Center

Fairfield Inn & Suites by Marriott San Antonio Medical Center
3.0 star property
Medical Center District
9.0 out of 10, Wonderful, (1,030 reviews)
"Great Stay!"
United States
Matthew
The price is AED 318
AED 371 total
includes taxes & fees
26 Jul - 27 Jul
Fairfield Inn & Suites by Marriott San Antonio Medical Center
Free daily on-the-go breakfast

Park Inn by Radisson

Park Inn by Radisson
2.0 star property
Medical Center District
7.2 out of 10, Good, (1,000 reviews)
"Room was very clean, walking distance from hospitals. Ample parking"
United States
Gloria
The price is AED 247
AED 288 total
includes taxes & fees
29 Jul - 30 Jul
Park Inn by Radisson
Desk, laptop workspace, blackout drapes, free WiFi

Studio 6 San Antonio, Tx - Northwest Medical Center

Studio 6 San Antonio, Tx - Northwest Medical Center
2.0 star property
Medical Center District
7.4 out of 10, Good, (325 reviews)
"Good staff great room for the price Quiet area"
United States
RUDY AGUIRRE
The price is AED 172
AED 201 total
includes taxes & fees
22 Jul - 23 Jul
Studio 6 San Antonio, Tx - Northwest Medical Center
Free daily on-the-go breakfast

Country Inn & Suites by Radisson, San Antonio Medical Center, TX

Country Inn & Suites by Radisson, San Antonio Medical Center, TX
3.0 star property
Medical Center District
7.0 out of 10, Good, (1,000 reviews)
"It was a comfortable stay"
United States
Eric
The price is AED 228
AED 266 total
includes taxes & fees
22 Jul - 23 Jul
Country Inn & Suites by Radisson, San Antonio Medical Center, TX
WiFi (free), bed sheets

Motel 6 San Antonio, TX - Northwest Medical Center

Motel 6 San Antonio, TX - Northwest Medical Center
2.0 star property
Medical Center District
6.0 out of 10, (1,006 reviews)
"Everyone In that hotels Is pretty friendly and great service."
United States
José
The price is AED 174
AED 221 total
includes taxes & fees
19 Jul - 20 Jul
Motel 6 San Antonio, TX - Northwest Medical Center
Front of property

Atria Inn & Suites

Atria Inn & Suites
2.0 star property
Medical Center District
7.4 out of 10, Good, (301 reviews)
"Workspace met my needs, their people is so gentle and always in a good mood"
United States
Guillermo
The price is AED 206
AED 240 total
includes taxes & fees
17 Jul - 18 Jul
Atria Inn & Suites
Basic Room, 1 King Bed, Non Smoking | Desk, iron/ironing board, free WiFi, bed sheets

Flex Studios

Flex Studios
2.5 star property
Medical Center District
6.2 out of 10, (551 reviews)
"Yes I would stay again"
United States
Jasper
The price is AED 145
AED 172 total
includes taxes & fees
19 Jul - 20 Jul
Flex Studios
Desk, laptop workspace, WiFi (free), alarm clocks

Studio 6 Extended Stay - San Antonio, TX - Medical Center

Studio 6 Extended Stay - San Antonio, TX - Medical Center
2.0 star property
Medical Center District
6.8 out of 10, (939 reviews)
"Staff very friendly and keep property clean at all times while office is open."
United States
Bonnie
The price is AED 184
AED 224 total
includes taxes & fees
16 Jul - 17 Jul
Studio 6 Extended Stay - San Antonio, TX - Medical Center
Property entrance

Hampton Inn & Suites Schertz

Hampton Inn & Suites Schertz
2.5 star property
31.1 km from Medical Center District
8.8 out of 10, Excellent, (920 reviews)
"Great stay"
United States
Renaldo
The price is AED 325
AED 373 total
includes taxes & fees
9 Aug - 10 Aug
Hampton Inn & Suites Schertz
Lobby

Best Western Plus Atrium Inn

Best Western Plus Atrium Inn
2.5 star property
30.6 km from Medical Center District
8.6 out of 10, Excellent, (1,009 reviews)
"Always a great stay for the price"
United States
Felicia
The price is AED 347
AED 400 total
includes taxes & fees
19 Jul - 20 Jul
Best Western Plus Atrium Inn
Standard Studio, 1 King Bed, Refrigerator & Microwave | Premium bedding, laptop workspace, iron/ironing board, free WiFi

Extended Stay America Premier Suites - San Antonio - Schertz

Extended Stay America Premier Suites - San Antonio - Schertz
2.5 star property
29.4 km from Medical Center District
9.0 out of 10, Wonderful, (351 reviews)
"The place was awesome and will definitely stay again"
United States
Joshua
The price is AED 331
AED 380 total
includes taxes & fees
16 Jul - 17 Jul
Extended Stay America Premier Suites - San Antonio - Schertz
Exterior

Best Western Garden Inn

Best Western Garden Inn
2.5 star property
Uptown, 21.2 km from Medical Center District
8.2 out of 10, Very Good, (1,001 reviews)
"Very clean, really enjoyed our stay in this place"
United States
Frederick Magtibay
The price is AED 300
AED 350 total
includes taxes & fees
28 Jul - 29 Jul
Best Western Garden Inn
Lobby

Drury Inn & Suites San Antonio Northeast

Drury Inn & Suites San Antonio Northeast
3.0 star property
17.6 km from Medical Center District
9.4 out of 10, Exceptional, (1,002 reviews)
"We stay here every time we're in San Antonio"
United States
Gloria
The price is AED 331
AED 379 total
includes taxes & fees
29 Jul - 30 Jul
Drury Inn & Suites San Antonio Northeast
Free buffet breakfast

Holiday Inn Express & Suites San Antonio North - Windcrest by IHG

Holiday Inn Express & Suites San Antonio North - Windcrest by IHG
2.5 star property
17.5 km from Medical Center District
9.0 out of 10, Wonderful, (1,001 reviews)
"Clean rooms, friendly staff!! I love the fact that we get different breakfast options daily! Overall! Very clean establishment!!"
United States
Matilda
The price is AED 394
AED 457 total
includes taxes & fees
14 Aug - 15 Aug
Holiday Inn Express & Suites San Antonio North - Windcrest by IHG
Deluxe Suite, 2 Queen Beds, Non Smoking with Sofabed | 1 bedroom, desk, laptop workspace, blackout drapes

Comfort Suites San Antonio Ft. Sam Houston/SAMMC Area

Comfort Suites San Antonio Ft. Sam Houston/SAMMC Area
2.5 star property
17.2 km from Medical Center District
9.2 out of 10, Wonderful, (991 reviews)
"Great place to stay."
United States
Chance
The price is AED 337
AED 394 total
includes taxes & fees
26 Jul - 27 Jul
Comfort Suites San Antonio Ft. Sam Houston/SAMMC Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties

Compare popular hotels in Medical Center District

Property
Property class
Guest rating
Breakfast included
Pool
Spa
Pet friendly
WiFi included
Lobby lounge
Fairfield Inn & Suites by Marriott San Antonio Medical Center
3.0 star property
9.0
Wonderful
1,030 reviews
View
Lobby
San Antonio Marriott Northwest Medical Center
3.5 star property
8.6
Excellent
1,126 reviews
View
Bar (on property)
Courtyard by Marriott Medical Center San Antonio
3.0 star property
8.8
Excellent
1,005 reviews
View
Free daily buffet breakfast
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
3.0 star property
8.4
Very Good
3,478 reviews
View
Property entrance
OYO Inn & Suites Medical Center San Antonio
2.0 star property
7.4
Good
243 reviews
View

Where to stay in Medical Center District

Find the best Medical Center District areas and neighborhoods for the activities you enjoy most.
A boat tour on a canal with a bridge in the background.

Downtown San Antonio

Explore the heart of San Antonio with top attractions like the Alamo and River Walk, or enjoy kayaking and bicycling to the World Heritage Missions. Discover historic sites, theaters, and shopping at Rivercenter, all easily accessible by public transit.

A large, modern building with a blue and white color scheme, featuring a prominent circular window and a 'Welcome' sign.

Far West Side

While visiting Far West Side, you might make a stop by sights like Aquatica San Antonio Waterpark and Hill Country Golf Club.

A large, abstract sculpture with a flowing design, set against a dramatic sky.
Photo by Sarah C.
Open Photo by Sarah C.

Uptown

While visiting Uptown, you might make a stop by sights like San Antonio Zoo and Aquarium and San Antonio River.

A nighttime amusement park with roller coasters, a bridge, and a full moon.

La Cantera District

If you're spending some time in La Cantera District, Six Flags Fiesta Texas and The Shops of La Cantera are top sights worth seeing.

A historic stone building with a central arched doorway, a flagpole with a flag, and a paved courtyard.

Northwest Side

While visiting Northwest Side, you might make a stop by sights like Huebner Oaks and Crystal Ice Palace.

Top Medical Center District Hotel Reviews

Menger Hotel

Menger Hotel

10/10 Excellent
"Interesting historical but older property. Well maintained. Great location. Front office staff are friendly, helpful and supportive. Will surely stay again."
Venkateshwaran 3-night trip
Posted 1 hour ago
Menger Hotel

Explore a world of travel with Expedia

Frequently asked questions

What is Medical Center District like?
Travelers are sure to enjoy a stay in San Antonio's Medical Center District neighborhood. Are you looking for Medical Center District travel tips? Be sure to check out USAA Corporate Office Headquarters and The San Antonio Art Institute while you're in the neighborhood.
What's a favorite place to stay in Medical Center District?
Based on our traveler data, La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW is one of the top choices for your stay in Medical Center District. This hotel offers free breakfast and an outdoor pool. Other good options for your stay in the area include San Antonio Marriott Northwest Medical Center and Drury Inn & Suites San Antonio Northwest Medical Center.
How many hotels will I be able to find in Medical Center District?
Expedia has 131 hotels and other accommodations in Medical Center District to choose from, making this an ideal home base for exploring the greater San Antonio area.
If I need to cancel my hotel reservation in Medical Center District, will I receive a refund?
Yes! You'll find that most hotel bookings are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of the scheduled arrival. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of your booking. Enter your dates, click on "Search", then use the filter option "fully refundable" to view top deals in Medical Center District.
Where can I learn more about changing or cancelling my trip to Medical Center District?
For more information about changing or cancelling your trip to Medical Center District, go to https://www.expedia.com/service/.
What can I see and do in this San Antonio neighborhood?
USAA Corporate Office Headquarters, The San Antonio Art Institute, and Cinemark San Antonio 16 are just a few attractions to check out in Medical Center District. Wonderland of the Americas Mall and Regal Huebner Oaks are also worth a visit when you're out sightseeing in San Antonio.