Top 10 Hotels in Santa Fe, FL from AED 249 - Competitive Prices

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in Santa Fe

Pet friendly

Apartment

Pool

Condo

Hot tub

Family friendly

Cottage

Waterpark

Cabin

Check prices for these dates

Tonight

Tomorrow

This weekend

Next weekend

Our top choices for Santa Fe hotels

Suite, 2 Queen Beds (Walk-In Shower) | Premium bedding, down comforters, pillowtop beds, in-room safe

1. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Alachua

Tobias

AED 382

AED 430 total

includes taxes & fees

5 Oct - 6 Oct

Suite, 2 Queen Beds, Non Smoking | In-room safe, desk, laptop workspace, WiFi

2. Hampton Inn & Suites Alachua I-75

Alachua

Pamela

AED 389

AED 437 total

includes taxes & fees

11 Oct - 12 Oct

3. Best Western Gateway Grand

Gainesville

Jason

AED 340

AED 382 total

includes taxes & fees

29 Sep - 30 Sep

4. La Quinta by Wyndham Gainesville

Gainesville

Elizabeth

AED 364

AED 409 total

includes taxes & fees

29 Sep - 30 Sep

Desk, iron/ironing board, cribs (free), rollaway beds (surcharge)

Outdoor pool, open 9:00 AM to 9:00 PM, pool umbrellas, sun loungers

5. Quality Inn Alachua - Gainesville Area

Alachua

Deborah

AED 279

AED 314 total

includes taxes & fees

19 Oct - 20 Oct

6. Clarion Pointe Alachua - Gainesville Area

Alachua

María Teresa

AED 221

AED 267 total

includes taxes & fees

20 Oct - 21 Oct

Standard Room, 2 Double Beds | Blackout drapes, WiFi (free), bed sheets

7. Royal Inn

Alachua

Alec

AED 264

AED 298 total

includes taxes & fees

29 Sep - 30 Sep

8. BlueGem Motel

High Springs

Wesley

AED 355

AED 399 total

includes taxes & fees

29 Sep - 30 Sep

Double Room, Non Smoking | Laptop workspace, WiFi (free)

9. High Springs Country Inn

High Springs

Luis

AED 242

AED 273 total

includes taxes & fees

4 Oct - 5 Oct

Premium bedding, desk, blackout drapes, soundproofing

Studio, 1 King Bed | Bathroom | Combined shower/tub, free toiletries, hair dryer, towels

10. Palms Garden Inn

Lake City

Igor

AED 236

AED 265 total

includes taxes & fees

29 Oct - 30 Oct

11. Fairfield Inn & Suites by Marriott Gainesville I-75

Gainesville

Robert

AED 437

AED 492 total

includes taxes & fees

2 Oct - 3 Oct

40-inch Smart TV with digital channels, Netflix, streaming services

Cabin, 1 Queen Bed with Sofa bed, Kitchen | Private kitchen | Coffee/tea maker, full-size fridge, microwave, stovetop

12. Vista Verde Farm Retreat

Lake City

Stacy

AED 432

AED 744 total

includes taxes & fees

1 Oct - 2 Oct

Standard Room, 2 Queen Beds | WiFi (free)

13. Holiday Inn Express Starke by IHG

Starke

Judy

AED 404

AED 448 total

includes taxes & fees

4 Oct - 5 Oct

Outdoor pool, open 7:00 AM to 10:00 PM, sun loungers

14. Hyatt Place Gainesville Downtown

Downtown Gainesville

Claire

AED 360

AED 405 total

includes taxes & fees

4 Oct - 5 Oct

Desk, laptop workspace, iron/ironing board, cribs (free)

15. Drury Inn & Suites Gainesville

Gainesville

Joan

AED 386

AED 434 total

includes taxes & fees

4 Oct - 5 Oct

Suite, 1 Bedroom, Non Smoking | Pillowtop beds, desk, laptop workspace, blackout drapes

Pillowtop beds, desk, laptop workspace, blackout drapes

16. Country Inn & Suites by Radisson, Gainesville, FL

Gainesville

sherry

AED 325

AED 365 total

includes taxes & fees

4 Oct - 5 Oct

Suite, 1 King Bed, Accessible, Non Smoking (with Sofabed) | Pillowtop beds, in-room safe, desk, laptop workspace

17. Best Western Waldo Inn and Suites

Waldo

Ana Laura

AED 499

AED 562 total

includes taxes & fees

6 Oct - 7 Oct

Studio Suite, 1 King Bed with Sofa bed, Microwave | Premium bedding, down comforters, desk, laptop workspace

18. Hampton Inn Gainesville

Gainesville

Charles

AED 319

AED 358 total

includes taxes & fees

4 Oct - 5 Oct

Executive Suite, 1 King Bed, Non Smoking | Premium bedding, memory foam beds, desk, laptop workspace

19. Comfort Suites Gainesville near University

Gainesville

thomas

AED 289

AED 336 total

includes taxes & fees

18 Oct - 19 Oct

Studio, 2 Queen Beds (Mobility Accessible, Tub) | In-room safe, desk, laptop workspace, blackout drapes

20. TownePlace Suites by Marriott Gainesville Northwest

Gainesville

Tanya

AED 385

AED 433 total

includes taxes & fees

30 Sep - 1 Oct

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Top Santa Fe Hotel Reviews

HOM Hotel Gainesville, SureStay Collection by Best Western

10/10 Excellent

"Excellent and renovated hotel. Everything was nice, very clean and a great location. Highly recommend."

Drury Inn & Suites Gainesville

10/10 Excellent

"Clean room. Good friendly staff. Nice location."

Red Roof Inn PLUS+ Gainesville

8/10 Good

"The staff was excellent, prompt, and extremely helpful! We needed help with the TV and the staff was very attentive and quickly solved the problem. The room had an odd smell and felt damp, but understandable in humid Florida! It was a convenient location and the AC was cold!"

Hyatt Place Gainesville Downtown

10/10 Excellent

"Great service all around"

Sleep Inn & Suites University/Shands

8/10 Good

"We stayed here for UF Family weekend. We booked early, and the rate wasn’t too inflated. Things really book up around that time and there is price gouging, so we chose an affordable hotel. The staff was very kind and helpful and made us aware of amenities. They offered a shuttle for the UF football game. Your stay includes free breakfast. Coffee, fresh popcorn and cookies are available most of the day. The condition of the elevator and the carpet and chair in our room needed some attention. The hotel has a bit of a damp or musty smell. We went nose blind to it pretty quickly, though. I know moisture is a big challenge in Florida. The bed and pillows were quite comfortable, and my teenage son said he slept like a baby on the sofa bed, for which the front desk gave us clean sheets, blanket and pillow. Overall, a positive experience. We would stay here again."

Country Inn & Suites by Radisson, Gainesville, FL

10/10 Excellent

"All good"

Hilton University of Florida Conference Center Gainesville

10/10 Excellent

"Only thing I didn’t like was the breakfast vouchers that essentially cover nothing so don’t feel like you’re getting any perk all I really want you to do is go down and buy their breakfast"

Comfort Suites Gainesville near University

8/10 Good

"Good breakfast but the trash bins by the elevators weren't cleaned out regularly and therefore smelled a bit funky."

More cheap stays in Santa Fe

Red Roof Inn PLUS+ Gainesville

3500 Southwest 42nd St Gainesville FL

AED 221

AED 249 total

4 Oct - 5 Oct

includes taxes & fees

Days Inn by Wyndham Gainesville University I-75

920 Nw 69th Ter Gainesville FL

AED 265

AED 299 total

30 Sep - 1 Oct

includes taxes & fees

5.6/10 (1,007 reviews)

HOM Hotel Gainesville, SureStay Collection by Best Western

3905 Sw 43Rd St Gainesville FL

AED 266

AED 299 total

4 Oct - 5 Oct

includes taxes & fees

8.6/10 Excellent! (2,146 reviews)

Sleep Inn & Suites University/Shands

4110 SW 40th Boulevard Gainesville FL

AED 278

AED 333 total

18 Oct - 19 Oct

includes taxes & fees

8.8/10 Excellent! (1,303 reviews)

Comfort Suites Gainesville near University

2603 SW 13TH STREET Gainesville FL

AED 289

AED 336 total

18 Oct - 19 Oct

includes taxes & fees

9.2/10 Wonderful! (1,504 reviews)

Comfort Inn Gainesville - University Area

3440 SW 40th Blvd Gainesville FL

AED 281

AED 336 total

18 Oct - 19 Oct

includes taxes & fees

8.2/10 Very Good! (1,101 reviews)

Frequently asked questions

What's the best place for a stay in Santa Fe?

Located 18.6 mi (30 km) from the heart of Santa Fe, Drury Inn & Suites Gainesville is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Sleep Inn & Suites University/Shands and Country Inn & Suites by Radisson, Gainesville, FL. See all available top hotels, or vacation rentals in Santa Fe.

What are some of the best vacation rentals in Santa Fe?

Private Resort-Style Oasis, Pool, Lanai & Court – Backyard Paradise w/ BBQ: This vacation home rental outside of Santa Fe is located in the city center and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms as well as a kitchen with a dishwasher, a stovetop, and a microwave, so you can cook with friends or family. See all vacation rentals in Santa Fe.

If I need to cancel my hotel reservation in Santa Fe, will I receive a refund?

Yes, most hotel bookings are fully refundable if cancelled before the hotel's cancellation deadline, which is often 24 or 48 hours before check in. If you have a non-refundable reservation, you might still have the option to cancel and get a refund within 24 hours of booking. Filter your search by fully refundable to find flexible hotel deals in Santa Fe.

Where can I learn more about changing or cancelling my trip to Santa Fe?

To access more information about picking new dates or cancelling your trip to Santa Fe, go to https://www.expedia.com/service/.

What is staying in Santa Fe like?

Travelers to Santa Fe will find plenty to explore and enjoy. There are 802 hotels and other accommodations in the surrounding area. Find out more about Santa Fe.

What are the top places to visit in Santa Fe?

Places to visit in the wider area include O'Leno State Park, San Felasco Hammock Preserve State Park, and Devil's Milhopper Geological State Park. You'll also find Gainesville Raceway and Poe Springs Park in the area. Check out what more to see and do in Expedia's Santa Fe guide.

What's the seasonal weather like in Santa Fe?

The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 59°F. The rainiest months in Santa Fe are August, June, July, and September, with each month seeing an average of 7 inches of rainfall.

Find hotels in Santa Fe, FL from AED 249

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Santa Fe

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Santa Fe hotels

1. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

2. Hampton Inn & Suites Alachua I-75

3. Best Western Gateway Grand

4. La Quinta by Wyndham Gainesville

5. Quality Inn Alachua - Gainesville Area

6. Clarion Pointe Alachua - Gainesville Area

7. Royal Inn

8. BlueGem Motel

9. High Springs Country Inn

10. Palms Garden Inn

11. Fairfield Inn & Suites by Marriott Gainesville I-75

12. Vista Verde Farm Retreat

13. Holiday Inn Express Starke by IHG

14. Hyatt Place Gainesville Downtown

15. Drury Inn & Suites Gainesville

16. Country Inn & Suites by Radisson, Gainesville, FL

17. Best Western Waldo Inn and Suites

18. Hampton Inn Gainesville

19. Comfort Suites Gainesville near University

20. TownePlace Suites by Marriott Gainesville Northwest

Top Santa Fe Hotel Reviews

HOM Hotel Gainesville, SureStay Collection by Best Western

Drury Inn & Suites Gainesville

Red Roof Inn PLUS+ Gainesville

Hyatt Place Gainesville Downtown

Sleep Inn & Suites University/Shands

Country Inn & Suites by Radisson, Gainesville, FL

Hilton University of Florida Conference Center Gainesville

Comfort Suites Gainesville near University

More cheap stays in Santa Fe

Red Roof Inn PLUS+ Gainesville

Days Inn by Wyndham Gainesville University I-75

HOM Hotel Gainesville, SureStay Collection by Best Western

Sleep Inn & Suites University/Shands

Comfort Suites Gainesville near University

Comfort Inn Gainesville - University Area

Frequently asked questions

Go further with the Expedia app