Top La Quinta Inn & Suites in Southern Illinois, IL from AED 304

A forested valley with autumn foliage, a rocky cliff, and a sunset.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

Tonight

Tomorrow

Next weekend

In two weeks

Our top choices for Southern Illinois La Quinta Inn & Suites

Studio Suite, Non Smoking (1 King Bed) | Pillowtop beds, desk, blackout drapes, iron/ironing board

1. La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

Eastport

Taylor

AED 325

AED 373 total

includes taxes & fees

19 Aug - 20 Aug

Deluxe Room, 1 King Bed, Non Smoking, Jetted Tub | Desk, laptop workspace, blackout drapes, iron/ironing board

Indoor pool, open 6:00 AM to 11:00 PM, sun loungers

2. La Quinta Inn & Suites by Wyndham Effingham

Effingham

Alexis

AED 378

AED 423 total

includes taxes & fees

30 Aug - 31 Aug

Room, 2 Queen Beds, Non Smoking | Premium bedding, pillowtop beds, desk, iron/ironing board

3. La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

O'Fallon

Tahjae

AED 264

AED 304 total

includes taxes & fees

18 Aug - 19 Aug

4. La Quinta Inn & Suites by Wyndham Pontoon Beach

Granite City

Weldon

AED 415

AED 477 total

includes taxes & fees

18 Aug - 19 Aug

View all properties

Save an average of 15% on thousands of hotels when you're signed in

Top Southern Illinois Hotel Reviews

Drury Plaza Hotel Mt. Vernon

10/10 Excellent

"Very clean and pleasant stay."

Drury Inn & Suites Marion

10/10 Excellent

"Best hot tub experience and the staff were super friendly and helpful. "

Country Inn & Suites by Radisson, Effingham, IL

10/10 Excellent

"The staff was friendly the room was clean and the bed was super comfortable."

Comfort Suites Mount Vernon

10/10 Excellent

"We enjoyed one night stay there. Brea at the front desk was very helpful and friendly. The hotel was very clean. My room was great. Enjoyed the shower. I was on the second floor was very quiet. The breakfast wasn’t the best. It was OK thanks so much."

Comfort Suites Fairview Heights - St. Louis

8/10 Good

"The room had a staleness to it, when we first walked in. The ac was set to around 75, so we lowered the temperature and it helped a lot. The carpet was sticky in some places. The room itself seemed run down. The wooden furniture was all scuffed up and scratched. Only one light worked in the bathroom and the vent didn't work. The elevator didn't have the inspection sheet hanging in it. The breakfast reminded my husband of "field chow" from his time in the service. The staff was very friendly and the parking was good."

The Principal Hotel

10/10 Excellent

"The cutest hotel! Friendly staff and the restaurant there has thee best food! Highly recommend!!"

Holiday Inn Express Metropolis by IHG

8/10 Good

"Room was clean. Staff was friendly. Breakfast was very good."

Comfort Inn Edwardsville - St. Louis

10/10 Excellent

"I had a wonderful experience staying at the Comfort Inn during my daughter’s move-in day at SIUE. The hotel was clean, comfortable, and welcoming from the moment we arrived. The guests were friendly, and the team members were very nice and helpful. I highly recommend the Comfort Inn to anyone visiting the Edwardsville/SIUE area. Thank you to the entire team for making our stay such a pleasant one!"

Room 1

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Southern Illinois La Quinta Inn & Suites

1. La Quinta Inn & Suites by Wyndham Collinsville - St. Louis

2. La Quinta Inn & Suites by Wyndham Effingham

3. La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis

4. La Quinta Inn & Suites by Wyndham Pontoon Beach