Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Go beyond your typical stay in Upstate South Carolina

Spa

Apart hotel

Our top choices for Upstate South Carolina hotels

Fairfield Inn & Suites by Marriott Greenville Simpsonville

Simpsonville

henry

AED 356 total

includes taxes & fees

12 Apr - 13 Apr

Comfort Inn & Suites Greer - Greenville

Greer

susan

AED 383 total

includes taxes & fees

19 Apr - 20 Apr

Inn on the Square, an Ascend Collection Hotel

Uptown Greenwood

Sandra

AED 482 total

includes taxes & fees

10 May - 11 May

Suite, 1 King Bed with Sofa bed, Non Smoking (Efficiency) | Premium bedding, individually decorated, desk, laptop workspace

Comfort Inn & Suites Clemson - University Area

Clemson

HANS

AED 412 total

includes taxes & fees

11 May - 12 May

Best Western Plus Greenville I-385 Inn & Suites

Greenville

Karen

AED 342 total

includes taxes & fees

26 Apr - 27 Apr

Holiday Inn Express Gaffney by IHG

Gaffney

Kevin

AED 324 total

includes taxes & fees

3 May - 4 May

La Quinta by Wyndham Haywood Mall-Near Greenville Downtown

Greenville

Cody

AED 284 total

includes taxes & fees

12 Apr - 13 Apr

Hampton Inn Easley

Easley

Wesley

AED 542 total

includes taxes & fees

21 Apr - 22 Apr

The Inn at Patrick Square

Clemson

Eric

AED 648 total

includes taxes & fees

20 Apr - 21 Apr

Lakeside Lodge Clemson

Seneca

Jeffrey

AED 497 total

includes taxes & fees

12 Apr - 13 Apr

Clemson University's James F. Martin Inn

Clemson

Elliott

AED 607 total

includes taxes & fees

12 Apr - 13 Apr

The Abernathy of Clemson

Clemson

Linda

AED 608 total

includes taxes & fees

13 Apr - 14 Apr

Hyatt Place Greenville/Haywood

Greenville

Wesley

AED 428 total

includes taxes & fees

11 May - 12 May

Deluxe Inn

Mauldin

AED 235 total

includes taxes & fees

18 Apr - 19 Apr

Four Points by Sheraton Spartanburg

Spartanburg

Edsel

AED 485 total

includes taxes & fees

19 Apr - 20 Apr

Holiday Inn Express & Suites Greenwood Mall by IHG

Greenwood

Sarah

AED 465 total

includes taxes & fees

26 Apr - 27 Apr

Hampton Inn Greer Greenville, SC

Greer

Dawn

AED 557 total

includes taxes & fees

17 Apr - 18 Apr

Best Western Plus Clemson Hotel & Conference Center

Clemson

Jeff

AED 412 total

includes taxes & fees

13 Apr - 14 Apr

Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Greenville

Alysha

AED 416 total

includes taxes & fees

10 May - 11 May

Hampton Inn Simpsonville

Simpsonville

Robert

AED 492 total

includes taxes & fees

26 Apr - 27 Apr

View all properties

Vacation Rentals in Upstate South Carolina

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Excellent stay."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Aparthotel

Full-size fridge, microwave, oven, stovetop

stayAPT Suites Greenville-Haywood Mall

Greenville

"Nice gym, good breakfast and the rooms are clean and well appointed. Good hotel stayed one night with my family "

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Very clean, nice amenities. Plenty of space and a great location. "

Cottage

Lake Access & Boat Slip: Greenwood Cottage!

Greenwood

"Outstanding little cottage for my mom and daughter weekend! Super clean and comfortable. "

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Cottage

Greer Guest House < 1 Mi to Park & Downtown Area!

Greer

"Nice place en Greenville area "

Cottage

Stunning Lakefront Retreat w/ Dock Access!

Greenwood

Cottage

Cleveland Home w/ South Saluda Fishing Access

Cleveland

"This was a fishing trip that myself and a couple of my friends went on. The cabin was exactly as described in the listing and then some. Very clean and had every amenity you could think of. The host lives next door and went above and beyond making sure we had everything we needed and were comfortable. He even lent us his state pass to get into the parks and supplied his vast knowledge of where and what to use for fishing in the creeks. Will definitely be going back sometime in the near future."

Cottage

Cozy Greenville Bungalow ~ 2 Mi to Downtown!

Greenville

"Amazing place. Great host. "

Cottage

9 Mi to Devils Fork State Park: Getaway w/ Porch!

Tamassee

"Fall weekend getaway and this was perfect location. Loved the back porch for coffee and views of the sun through all the colorful leaves. Felt like we were away from it all but just a short drive to restaurants, stores, lakes and parks!!!"

Cottage

8 Mi to Clemson: Peaceful Family Home w/ Yard

Seneca

"The place was all out perfect the owner was polite and perfect. It was a very peaceful place to stay thank you so much."

Cottage

Waterfront Lake Hartwell Vacation Rental w/ Dock!

Townville

See all vacation rentals

Save an average of 15% on thousands of hotels when you're signed in

Stay near popular Southeastern United States attractions

Clemson University

4.8/5 (1,438 reviews)

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

See properties

Fred W. Symmes Chapel

4.9/5 (28 reviews)

You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area.

See properties

Learn more about Upstate South Carolina

Venture to sights like Discovery Island Water Park and Heritage Park as you discover Upstate South Carolina.

See all hotels in Upstate South Carolina

Top Upstate South Carolina Hotel Reviews

Embassy Suites Greenville Golf Resort & Conference Center

6/10 Okay

"Food was great first morning, second morning the food was a little over done bacon crumbing into little pieces. The pool was down and we had 6 kids to entertain with no pool and that’s the reason they picked Embassy for their vacation. Staff and housekeepers were great."

Comfort Inn Greenville - Haywood Mall

2/10 Terrible

"I am a regular customer of this hotel chain, but I do not recommend this specific location. They do not let you rest and keep bothering you at 11:00 AM—even if you have extended your stay. They show no respect for your rest, despite the fact that you are paying specifically to get some sleep."

Drury Inn & Suites Greenville

10/10 Excellent

"This hotel was very clean, the staff pleasant and friendly. Loved the indoor pool and the added bonus of breakfast every morning and a mixer with hors d’oeuvres every night. The location was great. This is one of the cleanest hotels I’ve ever stayed in. The rooms were spacious and comfortable."