Find hotels in Upstate South Carolina, SC from AED 244
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Go beyond your typical stay in Upstate South Carolina
Pet friendly
Apartment
Apart hotel
Villa
Condo
Cottage
Chalet
Family friendly
Check prices for these dates
Tonight
26 Aug - 27 AugTomorrow
27 Aug - 28 AugThis weekend
28 Aug - 30 AugNext weekend
4 Sep - 6 SepOur top choices for Upstate South Carolina hotels
1. Hampton Inn Greer Greenville, SC
Hampton Inn Greer Greenville, SCGreer
Teresa
AED 529
AED 577 total
includes taxes & fees
28 Aug - 29 Aug
2. Tru by Hilton Spartanburg
Tru by Hilton SpartanburgSpartanburg
Jeremy
AED 361
AED 400 total
includes taxes & fees
20 Sep - 21 Sep
3. Four Points by Sheraton Spartanburg
Four Points by Sheraton SpartanburgSpartanburg
Travis
AED 372
AED 412 total
includes taxes & fees
6 Sep - 7 Sep
4. Comfort Suites At WestGate Mall
Comfort Suites At WestGate MallSpartanburg
Diane
AED 329
AED 365 total
includes taxes & fees
20 Sep - 21 Sep
5. Best Western Plus Greenville I-385 Inn & Suites
Best Western Plus Greenville I-385 Inn & SuitesGreenville
Nancy
AED 304
AED 335 total
includes taxes & fees
30 Aug - 31 Aug
6. Best Western Spartanburg I-26
Best Western Spartanburg I-26Spartanburg
Jonathan
AED 340
AED 378 total
includes taxes & fees
2 Sep - 3 Sep
7. Hampton Inn & Suites Spartanburg-I-26-Westgate Mall
Hampton Inn & Suites Spartanburg-I-26-Westgate MallSpartanburg
michelle
AED 404
AED 448 total
includes taxes & fees
6 Sep - 7 Sep
8. Holiday Inn Express & Suites Greenville SE - Simpsonville by IHG
Holiday Inn Express & Suites Greenville SE - Simpsonville by IHGSimpsonville
Alicia
AED 470
AED 517 total
includes taxes & fees
29 Aug - 30 Aug
9. Embassy Suites Greenville Golf Resort & Conference Center
Embassy Suites Greenville Golf Resort & Conference CenterGreenville
Pedro
AED 376
AED 427 total
includes taxes & fees
6 Sep - 7 Sep
10. Spartanburg Marriott
Spartanburg MarriottSpartanburg
Sarah
AED 433
AED 481 total
includes taxes & fees
6 Sep - 7 Sep
11. Hampton Inn & Suites Greenville Airport, SC
Hampton Inn & Suites Greenville Airport, SCGreenville
Daniel
AED 385
AED 436 total
includes taxes & fees
4 Sep - 5 Sep
12. Hotel Hartness
Hotel HartnessGreenville
Cornelius
AED 639
AED 845 total
includes taxes & fees
14 Sep - 15 Sep
13. Fairfield Inn & Suites by Marriott Greenville Simpsonville
Fairfield Inn & Suites by Marriott Greenville SimpsonvilleSimpsonville
Carole
AED 309
AED 340 total
includes taxes & fees
13 Sep - 14 Sep
14. Comfort Suites Greenville Airport
Comfort Suites Greenville AirportGreenville
Chandler
AED 362
AED 410 total
includes taxes & fees
20 Sep - 21 Sep
15. La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.
La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.Greenville
Cole
AED 271
AED 307 total
includes taxes & fees
30 Aug - 31 Aug
16. Best Western Spartanburg Northwest
Best Western Spartanburg NorthwestSpartanburg
Porsche
AED 325
AED 368 total
includes taxes & fees
30 Aug - 31 Aug
17. Hampton Inn & Suites Greenville/Spartanburg I-85, SC
Hampton Inn & Suites Greenville/Spartanburg I-85, SCDuncan
Kathy
AED 389
AED 431 total
includes taxes & fees
10 Sep - 11 Sep
18. Holiday Inn Express Hotel & Suites Spartanburg-North by IHG
Holiday Inn Express Hotel & Suites Spartanburg-North by IHGSpartanburg
Michael
AED 370
AED 411 total
includes taxes & fees
6 Sep - 7 Sep
19. Microtel Inn by Wyndham Duncan/Spartanburg
Microtel Inn by Wyndham Duncan/SpartanburgDuncan
Bert
AED 261
AED 290 total
includes taxes & fees
30 Aug - 31 Aug
20. Courtyard by Marriott Greenville Mauldin
Courtyard by Marriott Greenville MauldinGreenville
LEEKYA
AED 437
AED 481 total
includes taxes & fees
6 Sep - 7 Sep
Vacation Rentals in Upstate South Carolina
Cabin
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy
Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott BonvoySeneca
"Me and my family had a great time"
Cabin
Carolina Camp Cedar
Carolina Camp CedarPickens
"The cottage was clean, staff was so friendly, our stay was quiet and peaceful… it was perfect! Definitely planning to stay there again!"
Aparthotel
stayAPT Suites Greenville-Haywood Mall
stayAPT Suites Greenville-Haywood MallGreenville
"The rooms are spacious and feels like a and apartment. This place is one of the best places to stay."
Cottage
Families Welcome, Fenced Yard: Inviting Greer Home
Families Welcome, Fenced Yard: Inviting Greer HomeGreer
"This property is such an amazing find. Three large bedrooms, very clean and well maintained. Close to town of Greer and all amenities. Very easy check-in. Beds very comfortable. Kitchen well equipped for the week we were there."
Aparthotel
The Station by Compo Hotels
The Station by Compo HotelsTravelers Rest
"Lovely place to stay. Very clean and well appointed. The host was responsive and welcoming. Comfortable bed and quiet. Highly recommend."
Apartment
Mint House Greenville Downtown by Kasa
Mint House Greenville Downtown by KasaGreenville Downtown
"Love the location. Room was great."
Cottage
Clemson Memorabilia House
Clemson Memorabilia HouseClemson
"We enjoyed our stay, it was the perfect size for our family of four. "
Mobile Home
Carolina Landing RV Resort - Caravan Park
Carolina Landing RV Resort - Caravan ParkFair Play
"Very nice stay with friendly staff"
Aparthotel
Landing Apartments - Lyman
Landing Apartments - LymanLyman
"Great room that was nice and clean. Smooth check-in."
Cottage
1 Mi to Downtown Greer: Family Home w/ Gazebo!
1 Mi to Downtown Greer: Family Home w/ Gazebo!Greer
"Very cute home close to everything. Super clean and spacious. Well furnished."
Cottage
Lake Access & Boat Slip: Greenwood Cottage!
Lake Access & Boat Slip: Greenwood Cottage!Greenwood
"Outstanding little cottage for my mom and daughter weekend! Super clean and comfortable. "
Apartment
Serene Travelers Rest Apartment: 7 Mi to Downtown!
Serene Travelers Rest Apartment: 7 Mi to Downtown!Travelers Rest
"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "
Cottage
Cozy Greenville Bungalow ~ 2 Mi to Downtown!
Cozy Greenville Bungalow ~ 2 Mi to Downtown!Greenville
"Amazing place. Great host. "
Cottage
Home w/ Lake Keowee Access: Sleeps 7, Coffee Bar
Home w/ Lake Keowee Access: Sleeps 7, Coffee BarSeneca
"The best, perfect "
Apartment
Designer Retreat w/ Pool, Golf + Beach Access!
Designer Retreat w/ Pool, Golf + Beach Access!Salem
"Property is in a great community, and it was very clean and beautifully decorated."
Save an average of 15% on thousands of hotels when you're signed in
Stay near popular Upstate South Carolina attractions
Clemson University
9.6/10 (1,439 reviews)
Walk around the campus of Clemson University, a top university in Clemson. Experience the area's theater scene or attend a football game.
Falls Park on the Reedy
9.6/10 (2,661 reviews)
Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the great live music or attend a sporting event in this family-friendly area.
Photo by Karyn Thompson
Fred W. Symmes Chapel
9.8/10 (29 reviews)
You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area.
Bon Secours Wellness Arena
8.6/10 (1,219 reviews)
Catch an event at Bon Secours Wellness Arena during your trip to Greenville. Stroll along the riverfront or experience the great live music in this family-friendly area.
Greenville Convention Center
8.4/10 (571 reviews)
Learn about the events happening at Greenville Convention Center during your trip to Greenville. Attend a sporting event or visit the shops in this family-friendly area.
Memorial Stadium
9.6/10 (410 reviews)
Catch an event at Memorial Stadium during your trip to Clemson. Experience the area's theater scene or attend a football game.
Haywood Mall
8.8/10 (1,681 reviews)
During your trip to Greenville, you can browse for the perfect souvenirs at Haywood Mall. Experience the great live music or attend a sporting event in this family-friendly area.
Learn more about Upstate South Carolina
Venture to sights like Martin Farm and Discovery Island Water Park as you discover Upstate South Carolina.
See all hotels in Upstate South Carolina
Photo by Ryan Watts
Top Upstate South Carolina Hotel Reviews
Best Western Plus Greenville I-385 Inn & Suites
8/10 Good
"I didn't like the noise in the room next door they was making a lot of noise"
Best Western Plus Clemson Hotel & Conference Center
8/10 Good
"The front desk woman was super sweet and welcoming. The hotel itself has a lot of character and is pretty cool, although it could definitely use some updating. Our room had a musty smell, and the bathroom floors—especially in the corners—could use a deeper cleaning. Overall, we just needed an affordable place to sleep for one night while visiting Clemson for a tour, and for around $100, it did the job. Not fancy, but perfectly fine for a quick overnight stay."
Comfort Inn & Suites Clemson - University Area
10/10 Excellent
"room was clean and modern, very nice"
Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG
10/10 Excellent
"The room eas clean and the staff eas outstanding especially fronk desk agent Isis we was very friendly and professional."
Courtyard Marriott Clemson
10/10 Excellent
"👍"
More cheap stays in Upstate South Carolina
Days Inn by Wyndham Greenville
60 Roper Mountain Rd Greenville SC
AED 222
AED 244 total
30 Aug - 31 Aug
includes taxes & fees
Best Western Plus Greenville I-385 Inn & Suites
831 Congaree Rd Greenville SC
AED 304
AED 335 total
30 Aug - 31 Aug
includes taxes & fees
9.2/10 Wonderful! (1,563 reviews)
Comfort Inn Greenville - Haywood Mall
246 Congaree Road Greenville SC
AED 295
AED 336 total
6 Sep - 7 Sep
includes taxes & fees
Holiday Inn Express Hotel & Suites Spartanburg-North by IHG
161 Sha Ln Spartanburg SC
AED 370
AED 411 total
6 Sep - 7 Sep
includes taxes & fees
Best Western Plus Clemson Hotel & Conference Center
1310 Tiger Blvd Clemson SC
AED 372
AED 412 total
29 Aug - 30 Aug
includes taxes & fees
8/10 Very Good! (1,001 reviews)
Lakeside Lodge Clemson
13500 Clemson Blvd Seneca SC
AED 400
AED 497 total
28 Aug - 29 Aug
includes taxes & fees
Hotels in Upstate South Carolina with star-rating
4 Star Hotels
29 properties
3 Star Hotels
200 properties
2 Star Hotels
153 properties
Explore a world of travel with Expedia
- Hodges Hotels
- Red Roof Inn Hotels in Una
- Extended Stay America Hotels in Lyman
- Hotels near Runway Park at GMU
- Rv Parks in Duncan
- Motel 6 Hotels in Roebuck
- Cabin Rentals in Duncan
- Red Roof Inn Hotels in Spartanburg Historic District
- Motel 6 Hotels in Fountain Inn
- Red Roof Inn Hotels in Fairforest
- Una Hotels
- Hotels near Beattie House
- Wyndham Hotels in Fingerville
- Best Western Hotels in Roebuck
- 2 Star Hotels in Fingerville
- Wyndham Hotels in Woodruff
- Hotels with an Indoor Pool in Spartanburg
- Hotels with Free Parking in Spartanburg
- La Quinta Inn & Suites Hotels in Fountain Inn
- Hilton Hotels in Woodruff
- 5 Star Hotels in Fairforest
- 5 Star Hotels in Woodruff
- B&B in Fountain Inn
- Extended Stay America Hotels in Roebuck
- Hotels near Frankie's Fun Park
- Hotels near Shriners Hospitals for Children Greenville
- 4 Star Hotels in Lyman
- Hotels near Bob Jones University
- Easley Hotels
- Extended Stay America Hotels in Duncan
- Hyattvacations Supechain Hotels in Fountain Inn
- 3 Star Hotels in Reidville
- Hotels near Haywood Mall
- La Quinta Inn & Suites Hotels in Fairforest
- Marriott Hotels & Resorts in Startex
- Hotels near Tyger River Park
- Beach Hotels in Spartanburg
- Hotels near Furman University Golf Club
- Independent Hotels in Pauline
- Starwood Capital Hotels in Fountain Inn
- Apartments in Woodruff
- Best Western Hotels in Woodruff
- Shopping Hotels in Duncan
- La Quinta Inn & Suites Hotels in Roebuck
- Motel 6 Hotels in Enoree
- Hilton Hotels in Enoree
- Motels in Fountain Inn
- Aimbridge Hospitality Hotels in Lyman
- Joanna Hotels
- Wyndham Hotels in Duncan
- Wyndham Hotels in Roebuck
- Red Roof Inn Hotels in Fountain Inn
- 5 Star Hotels in Una
- Hotels near Spartanburg Station
- Duncan Hotels
- Apartments in Duncan
- Pet-Friendly Hotels in Duncan
- Hilton Hotels in Spartanburg
- Hotels near Younts Center for Performing Arts
- B&B in Roebuck
- Hilton Hotels in Roebuck
- Extended Stay America Hotels in Woodruff
- Rv Parks in Una
- Hotels near McAlister Square
- Fingerville Hotels
- Business Hotels in Spartanburg
- Enoree Hotels
- Hotels near West Towne Plaza
- Gaffney Hotels
- Hotels near The Peace Center
- 4 Star Hotels in Cross Anchor
- Hotels near Gaffney Outlet Marketplace
- Premier Inn Hotels in Fountain Inn
- 2 Star Hotels in Duncan
- Marriott Hotels & Resorts in Roebuck
- 5 Star Hotels in Fountain Inn
- Rv Parks in Roebuck
- Extended Stay America Hotels in Fountain Inn
- 4 Star Hotels in Una
- Adventure Hotels in Lyman
- Hotels near BMW Performance Center
- Cottages in Woodruff
- Hotels near Wade Hampton Plaza Shopping Center
- Cabin Rentals in Woodruff
- Luxury Hotels in Spartanburg
- Cottages in Enoree
- Vacation Homes in Spartanburg Station
- Flights from Roebuck
- Flights from Appleton (ATW) to Spartanburg (SPA)
- Flights from Woodruff
- Flights from Oslo (OSL) to Spartanburg (SPA)
- Flights from Salisbury (SBY) to Spartanburg (SPA)
- Flights from Reidville
- Flights from Concord (CON) to Spartanburg (SPA)
- Flights from White Plains (HPN) to Spartanburg (SPA)
- Flights from Cross Anchor
- Flights from Huntsville (HSV) to Spartanburg (SPA)
- Flights from Enoree
- Flights from Duncan
- Flights from Startex
