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Vacation Rentals in Upstate South Carolina

Cottage

9 Mi to Devils Fork State Park: Getaway w/ Porch!

Tamassee

"Fall weekend getaway and this was perfect location. Loved the back porch for coffee and views of the sun through all the colorful leaves. Felt like we were away from it all but just a short drive to restaurants, stores, lakes and parks!!!"

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Spotless wonderful stay"

Aparthotel

Full-size fridge, microwave, oven, stovetop

stayAPT Suites Greenville-Haywood Mall

Greenville

"Great place!"

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Excellent stay."

Apartment

Designer Retreat w/ Pool, Golf + Beach Access!

Salem

"Property is in a great community, and it was very clean and beautifully decorated."

Cottage

Waterfront Seneca Cabin ~ 4 Mi to Boat Launch!

Seneca

"Beautiful and quaint cabin! Highly recommend, great view of the lake."

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Cottage

Waterfront Lake Hartwell Vacation Rental w/ Dock!

Townville

Cottage

Deck, Grill & Dock Access: Lake Keowee Retreat!

Seneca

"The best, perfect "

Cottage

Cozy Home in Historic Area ~ 2 Mi to Main St!

Greenville

"Absolutely adorable property. Little bit of an interesting part of town. We weren’t spending a bunch of time on property so it didn’t mater. Super close to down town and the house is well kept. "

Cottage

8 Mi to Clemson: Peaceful Family Home w/ Yard

Seneca

"The place was all out perfect the owner was polite and perfect. It was a very peaceful place to stay thank you so much."

Cottage

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

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Stay near popular Southeastern United States attractions

Clemson University

4.7/5 (738 reviews)

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

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Falls Park on the Reedy

4.7/5 (1,399 reviews)

Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

Top Upstate South Carolina Hotel Reviews

Embassy Suites Greenville Golf Resort & Conference Center

10/10 Excellent

"Everything is so clean and the staff was all very accommodating. It’s just a very nice hotel. My daughters loved the hot breakfast buffet and made to order omelets.Much better than any continental breakfasts elsewhere. We also enjoyed the indoor pool to ourselves all weekend which was well maintained. Highly recommend! "