Top 10 Hotels in Upstate South Carolina, SC - Competitive Prices

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Go beyond your typical stay in Upstate South Carolina

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Our top choices for Upstate South Carolina hotels

An indoor swimming pool with a tiled floor, a covered area, and a seating area with chairs.

A hotel room with two beds, a wooden headboard, a nightstand with a lamp, and a red accent wall.

A modern restaurant with high ceilings, large windows, and a mix of seating options including booths and tables.

A modern hotel lobby with a wooden cabinet, a flat-screen TV, a sofa, and a table.

1. Drury Inn & Suites Greenville

Greenville

Gohan

AED 422

AED 465 total

includes taxes & fees

1 Nov - 2 Nov

A modern restaurant interior with round tables and chairs, a kitchen area, and large windows offering a view of parked cars outside.

A hotel room with a large bed, a desk with a chair, a blue armchair, a wooden nightstand with a lamp, and a wardrobe with a mirror.

A modern kitchen with a central island, three bar stools, pendant lighting, and a decorative flower arrangement.

A pool area with lounge chairs and a sign for Best Western Plus.

2. Best Western Plus Greenville I-385 Inn & Suites

Greenville

Stephanie

AED 279

AED 307 total

includes taxes & fees

18 Oct - 19 Oct

A modern kitchen with hanging light fixtures and bar seating.

A modern lobby with a curved reception desk, comfortable seating, and a large wall-mounted TV.

A hotel patio with outdoor seating, stone pillars, and a modern building in the background.

A modern bar area with a central island, bar stools, and overhead lighting.

3. DoubleTree by Hilton Greenville Woodruff Road

Greenville

Jeffery

AED 408

AED 462 total

includes taxes & fees

1 Nov - 2 Nov

A multi-level hotel atrium with a central open area, multiple balconies, and a variety of seating arrangements.

A modern living room with a dining table, chairs, a sofa, a television, and bookshelves.

An outdoor patio with a stone fire pit, wicker chairs, and a pergola structure.

A large hotel with a central courtyard, surrounded by manicured lawns and trees.

4. Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Ethan

AED 389

AED 440 total

includes taxes & fees

11 Oct - 12 Oct

A hotel with a stone facade, multiple windows, and a sign indicating it's a Wyndham hotel.

A hotel room with a bed, a desk with a chair, a television, a window with curtains, and a bedside table with a lamp.

A laundry room with two stacked washing machines and a single dryer.

A modern kitchen with a granite countertop, a built-in grill, a microwave, and a coffee maker. There are two framed artworks on the wall and a refrigerator with a built-in ice maker.

5. Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

Greenville

Charles

AED 259

AED 285 total

includes taxes & fees

18 Oct - 19 Oct

A modern outdoor seating area with a glass-top coffee table, blue sofas, and orange patterned cushions.

A modern lobby with a blue sofa, teal armchairs, hanging lights, and a seating area with round chairs.

A modern lobby with a reception desk, seating areas, and a large window offering a view.

A snack bar with a variety of packaged foods and beverages, a refrigerated display case, and a counter with a sign that reads 'This and that and then some.'

6. Tru by Hilton Greenville Woodruff Road

Greenville

semhar

AED 347

AED 416 total

includes taxes & fees

1 Nov - 2 Nov

A spacious hotel lobby with a central bar area, seating arrangements, and large windows providing natural light.

A modern kitchen with a bar area, a seating area with a sofa and chairs, and a television mounted on the wall.

A conference room with a large flat-screen TV, multiple tables with chairs, and water bottles on each table.

A hotel room with a bed, desk, chair, TV, and a window with a geometric pattern.

7. Holiday Inn Greenville - Woodruff Road by IHG

Greenville

Diane

AED 378

AED 416 total

includes taxes & fees

1 Nov - 2 Nov

A modern hotel lobby with a bar area, seating, and a patterned floor.

A hotel lobby with a reception desk, computers, and a seating area.

A modern living room with a sofa, armchairs, a coffee table, and a patterned rug.

A hotel entrance with a welcoming sign, a covered walkway, and a landscaped area with benches and flowers.

8. Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

Greenville

Roderick

AED 334

AED 379 total

includes taxes & fees

1 Nov - 2 Nov

A multi-story hotel with a modern design, featuring a prominent 'La Quinta' sign, a parking lot, and a landscaped entrance area.

A La Quinta hotel with a covered outdoor seating area, stone pillars, and a parking lot.

A modern living room with a fireplace, a flat-screen TV, and comfortable seating.

A reception area with two reception desks, a large cityscape poster, and a plant.

9. La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

Greenville

Lissette

AED 375

AED 424 total

includes taxes & fees

4 Oct - 5 Oct

A modern hotel room with a large bed, a desk, and a seating area with chairs and a table.

A cafe with a checkered floor, wooden cabinets, and hanging pendant lights.

A hotel room with a large bed, a television on a dresser, a nightstand with a lamp, and a window with curtains.

A hotel pool area with lounge chairs, a flag, and a sunset view.

10. Hampton Inn Greenville I-385 - Woodruff Rd.

Greenville

David

AED 373

AED 423 total

includes taxes & fees

15 Oct - 16 Oct

A spacious living area with a fireplace, a beige sofa, and a modern chandelier.

A modern retail store named 'The Shop' with a variety of products including snacks, beverages, and household items.

An outdoor patio area with a fire feature, wicker furniture, and potted plants.

A multi-story hotel with a prominent entrance and a landscaped driveway.

11. Hilton Garden Inn Greenville

Greenville

Leroy

AED 373

AED 423 total

includes taxes & fees

31 Oct - 1 Nov

A modern lobby with a reception desk, seating area, and a kitchen in the background.

A modern hotel lobby with a large digital display, seating areas, and a view of the outdoors.

A Courtyard Marriott hotel with a modern design, featuring a prominent entrance with glass doors and a covered walkway.

A hotel exterior with large windows, outdoor seating, and potted plants.

12. Courtyard by Marriott Greenville Downtown

Greenville Downtown

Shellie

AED 509

AED 577 total

includes taxes & fees

4 Oct - 5 Oct

A spacious lobby with modern furniture, a chandelier, and potted plants.

A bar with a white countertop, multiple bar stools, and shelves stocked with bottles.

13. Hilton Greenville

Greenville

Edward

AED 419

AED 474 total

includes taxes & fees

11 Oct - 12 Oct

An outdoor patio with wicker furniture, a stone fire pit, and a pergola.

A modern kitchen with granite countertops, a central island, and a stone backsplash.

A compact kitchen with a refrigerator, microwave, coffee maker, and a flat-screen TV.

A hotel room with a sofa, a desk, a television, a chair, a small cabinet, and a bed.

14. Staybridge Suites Greenville I-85 Woodruff Road by IHG

Greenville

Kevin

AED 621

AED 683 total

includes taxes & fees

14 Oct - 15 Oct

A covered outdoor area with a stone facade, a bench, and a truck parked nearby.

A swimming pool with lounge chairs and umbrellas, surrounded by a building with a modern design and a fence.

A hotel reception area with a counter, computers, chairs, and a display case with pastries.

A hotel room with a large bed, a desk with a television, a chair, and a lamp.

15. Comfort Inn Greenville - Haywood Mall

Greenville

Doug

AED 299

AED 340 total

includes taxes & fees

18 Oct - 19 Oct

A hotel lobby with a reception desk, seating area, and a view of the outdoors.

A stone building with a sign for 'Sweets' and outdoor seating with blue umbrellas.

A modern interior with a round table and red chairs, large windows with a view of greenery, and a blue door.

16. Holiday Inn Express & Suites Greenville - Downtown by IHG

Greenville Downtown

Robyn

AED 477

AED 525 total

includes taxes & fees

1 Nov - 2 Nov

A circular outdoor seating area with a fire pit, surrounded by sofas and chairs, in front of a multi-story building.

A modern bar area with a curved counter, bar stools, and a wine glass.

A hotel room with two beds, a desk with a computer, a chair, and a large window with curtains.

A modern bar area with seating arrangements, a counter with various beverages, and a sports screen.

17. Courtyard by Marriott Greenville Haywood Mall

Greenville

Richard

AED 368

AED 417 total

includes taxes & fees

18 Oct - 19 Oct

A multi-story hotel with a modern design, featuring a mix of glass and brick facades, and a parking area with autumn-colored trees.

A modern hotel lobby with a reception desk, seating area, and a decorative wall.

A modern hotel lobby with a mix of seating areas, including sofas and tables, and a patterned carpet.

18. Hyatt Place Greenville Downtown

Greenville Downtown

Tamara

AED 477

AED 541 total

includes taxes & fees

11 Oct - 12 Oct

An outdoor patio area with a wooden pergola, barbecue grill, and seating.

A modern hotel lobby with a seating area featuring sofas and round tables, large windows, and a decorative wooden panel.

A modern hotel lobby with a reception desk, a large round rug, a sofa, and a unique chandelier.

An indoor swimming pool with a brick wall backdrop, a poolside area with tables and chairs, and a clear pool edge.

19. Homewood Suites by Hilton Greenville Downtown

Greenville Downtown

Michael

AED 539

AED 611 total

includes taxes & fees

11 Oct - 12 Oct

A multi-story hotel with a stone facade, large windows, and outdoor seating areas.

A modern building with a covered outdoor seating area and a sign reading "The Commons".

A spacious dining area with round tables and chairs, large windows with sheer curtains, and pendant lighting.

A modern dining area with a wooden ceiling, a sofa, a table, and chairs.

20. Hampton Inn & Suites Greenville-Downtown-RiverPlace

Greenville Downtown

James

AED 569

AED 645 total

includes taxes & fees

25 Oct - 26 Oct

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Vacation Rentals in Upstate South Carolina

Aparthotel

A reception desk with a blue wall, a white counter, and dark cabinets. There is a vase with white flowers on the counter.

A modern hotel with a sign reading "apt suites" and a parking lot with cars.

stayAPT Suites Greenville-Haywood Mall

Greenville

"Everything was great"

Cabin

A swimming pool with lounge chairs and a covered area with tables and chairs.

A covered porch with a welcome mat, two black Adirondack chairs, and a bench.

A modern bedroom with a large bed, a ceiling fan, and a view of the outdoors through a window.

Carolina Camp Cedar

Pickens

"The cottage was clean, staff was so friendly, our stay was quiet and peaceful… it was perfect! Definitely planning to stay there again!"

Cottage

A living room with a blue sofa, a round coffee table with a vase of flowers, a patterned rug, and a chair. There are paintings on the walls and a window with curtains.

A kitchen with a wooden countertop, a sink, a coffee maker, a toaster, and a window with a view of trees.

A dining area with a wooden table set for two, a blue chair, a small table with a lamp, and a kitchen in the background.

A bed with a white quilted cover, flanked by two wall-mounted nightstands with lamps.

Claires Cottage ~ 4 Mi to Downtown Greenville!

Greenville

"Great trip. The small cottage was perfect for my wife and I and the owner was very responsive."

Apartment

A modern living room with a sofa, a coffee table, a TV, and a balcony with a view of buildings.

A modern kitchen with granite countertops, double sinks, and a built-in dishwasher.

A modern kitchen with white cabinets, a stainless steel refrigerator, and a bar area with white stools.

A modern kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, and a granite countertop. There are three white bar stools and two pendant lights.

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Excellent location for our trip. Very clean, had everything we needed."

Aparthotel

A modern building with outdoor seating and a garden.

A two-story house with a dark roof and siding, a front porch with four yellow chairs, and a well-maintained garden with shrubs and mulch.

A modern kitchen with white cabinetry, a wooden dining table, and a black chair. There is a window with a view of greenery outside.

A modern living room with a sofa, coffee table, and dining table. There is a TV mounted on the wall, a coffee machine, and a bookshelf.

The Station by Compo Hotels

Travelers Rest

"Lovely place to stay. Very clean and well appointed. The host was responsive and welcoming. Comfortable bed and quiet. Highly recommend."

Cabin

A wooden interior with a table, chair, and a hanging lantern.

A cabin in a forest with a small deck and outdoor seating area.

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Me and my family had a great time"

Cottage

A cozy living room with a fireplace, a dining area with a table and chairs, and a large wooden door.

A room with wooden sliding doors, a small black table with a potted plant, and a circular sign with the words "stay awhile".

A bedroom with a bed, bedside tables, a nightstand, a wooden floor, a door, and a wall-mounted shelf.

Clemson Memorabilia House

Clemson

"We enjoyed our stay, it was the perfect size for our family of four. "

Mobile Home

A wooden dining table with green placemats, surrounded by chairs, in a cabin with large windows and wooden walls.

A rustic cabin with a porch, wooden steps, and a picnic table.

A cozy cabin interior with a wooden interior, a sofa, a television on a wooden stand, and a sign on the wall.

A wooden interior with a loft bed, a green chair, a wooden table, and a map on the wall.

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

A house with a grey siding exterior, a white front door, and a window with a white frame.

A dining area with a round table and six chairs, a kitchen with white cabinets, and a window with blinds.

A bedroom with a wooden bed, a dresser, a mirror, a window with blinds, and a door leading to a bathroom.

A living room with a striped sofa, a patterned armchair, and a dark sofa with a floral pillow. There is a wooden coffee table with a book and a plant. A lamp is on a side table next to the sofa.

Cozy Greenville Bungalow ~ 2 Mi to Downtown!

Greenville

"Amazing place. Great host. "

Cottage

A modern living room with a ceiling fan, a sofa, a chair, and a coffee table. There is a kitchen in the background with cabinets and a countertop.

A modern kitchen with white cabinets, stainless steel appliances, and a marble countertop.

A single-story house with a porch, a gravel driveway, and a well-maintained lawn.

A wooden bridge leading to a playground with green grass and trees.

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Cottage

A living room with a sofa, a dining table, chairs, a kitchen area, and a view through large windows.

A blue house with a wooden deck, a red door, and a fenced backyard with a small garden.

A cozy living room with a sofa, two side tables, a coffee table, and a patterned rug.

A two-story house with a front porch, a small garden, and a wooden fence.

Greer Guest House < 1 Mi to Park & Downtown Area!

Greer

"Nice place en Greenville area "

Apartment

A large house with a spacious driveway and a pond in the background.

A spacious living room with a high ceiling, a large leather sofa, a flat-screen TV, and a wooden coffee table.

A kitchen with wooden cabinets, stainless steel appliances, a granite countertop, and a bar stool.

A modern kitchen with a central island, wooden cabinets, and a dining area with bar stools.

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

A living room with a sofa, coffee table, and a dining area with chairs and a table.

A covered porch with wicker furniture, a round table with a bowl and a cup, and a view of a lush garden.

A modern kitchen with white cabinets, stainless steel appliances, and a patterned rug.

A living room with a fireplace, a round wooden table with chairs, a sofa, and a television.

1 Mi to Downtown Greer: Family Home w/ Gazebo!

Greer

"Very cute home close to everything. Super clean and spacious. Well furnished."

Cottage

A spacious living room with a dining area, a leather sofa, a TV, and artwork on the walls.

A white door with a brass knocker, a white bench, a potted plant, and a wicker basket outside a house with a brick foundation and a window with blinds.

A spacious living room with a brown leather sofa, a white shag rug, and a dining area with a table and chairs.

A dining area with a wooden table and grey upholstered chairs, a large mirror, and a painting on the wall.

Families Welcome, Fenced Yard: Inviting Greer Home

Greer

"This property is such an amazing find. Three large bedrooms, very clean and well maintained. Close to town of Greer and all amenities. Very easy check-in. Beds very comfortable. Kitchen well equipped for the week we were there."

Cottage

A wooden deck with a bench and a welcome mat, overlooking a well-maintained lawn and trees.

A bedroom with a large bed, a ceiling fan, a TV, and a window with blinds.

A spacious kitchen with green cabinets, a white refrigerator, and wooden countertops.

A spacious living room with hardwood floors, a fireplace, a sofa, a coffee table, and a television.

Serene Cabin w/ Pond & Creek on South Saluda River

Cleveland

"I chose this cabin due to its close proximity to the pretty place chapel. The property was BEAUTIFUL and tucked away. The silence and change of scenery was well needed and felt like we were at home. I honestly don’t have enough good things to say about the host Mr. Steve and his generosity and professionalism!"

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

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A pedestrian bridge with colorful lights, surrounded by trees and a distant building.

Falls Park on the Reedy

9.6/10 (2,661 reviews)

Falls Park on the Reedy is just one of the places to see in Greenville, so why not enjoy the other things to explore during your travels? Experience the acclaimed theater scene or attend a sporting event in this family-friendly area.

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A wooden cross with inscriptions, set against a mountainous landscape with a cloudy sky.

Fred W. Symmes Chapel

9.8/10 (29 reviews)

You can find out about the history of Cleveland when you stop by Fred W. Symmes Chapel. Wander the lakeside and forest in this relaxing area.

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Bon Secours Wellness Arena

8.6/10 (1,219 reviews)

Catch an event at Bon Secours Wellness Arena during your trip to Greenville. Stroll along the riverfront or experience the great live music in this family-friendly area.

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Memorial Stadium

9.6/10 (410 reviews)

Catch an event at Memorial Stadium during your trip to Clemson. Experience the area's theater scene or attend a football game.

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BMW Performance Center

9.0/10 (90 reviews)

You can spend an afternoon browsing the exhibits at BMW Performance Center during your travels in Greer. While in this family-friendly area, you can savor the charming coffeehouses.

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Greenville Convention Center

8.4/10 (571 reviews)

Learn about the events happening at Greenville Convention Center during your trip to Greenville. Attend a sporting event or visit the shops in this family-friendly area.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

Grand Bohemian Lodge Greenville, Autograph Collection

10/10 Excellent

"The room was very clean and comfortable. Staff was helpful and friendly. The lobby is to die for with the displays of Native American art and jewelry. A fun place e to stay with convenient location."

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

10/10 Excellent

"Good location...about 10 mins from downtown. Clean. Friendly staff. Fitness Center and breakfast was a nice plus and free parking."

Comfort Inn & Suites Clemson - University Area

8/10 Good

"Great stay. Clean and conveniently located."

Hotel Hartness

10/10 Excellent

"Great property"

Hyatt Place Greenville Downtown

10/10 Excellent

"Was very nice."

Find hotels in Upstate South Carolina, SC

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in Upstate South Carolina

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for Upstate South Carolina hotels

1. Drury Inn & Suites Greenville

2. Best Western Plus Greenville I-385 Inn & Suites

3. DoubleTree by Hilton Greenville Woodruff Road

4. Embassy Suites Greenville Golf Resort & Conference Center

5. Microtel Inn & Suites by Wyndham Greenville / Woodruff Rd

6. Tru by Hilton Greenville Woodruff Road

7. Holiday Inn Greenville - Woodruff Road by IHG

8. Crowne Plaza Hotel Greenville-I-385-Roper Mtn Rd by IHG

9. La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

10. Hampton Inn Greenville I-385 - Woodruff Rd.

11. Hilton Garden Inn Greenville

12. Courtyard by Marriott Greenville Downtown

13. Hilton Greenville

14. Staybridge Suites Greenville I-85 Woodruff Road by IHG

15. Comfort Inn Greenville - Haywood Mall

16. Holiday Inn Express & Suites Greenville - Downtown by IHG

17. Courtyard by Marriott Greenville Haywood Mall

18. Hyatt Place Greenville Downtown

19. Homewood Suites by Hilton Greenville Downtown

20. Hampton Inn & Suites Greenville-Downtown-RiverPlace

Vacation Rentals in Upstate South Carolina

stayAPT Suites Greenville-Haywood Mall

Carolina Camp Cedar

Claires Cottage ~ 4 Mi to Downtown Greenville!

Mint House Greenville Downtown by Kasa

The Station by Compo Hotels

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Clemson Memorabilia House

Carolina Landing RV Resort - Caravan Park

Cozy Greenville Bungalow ~ 2 Mi to Downtown!

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greer Guest House < 1 Mi to Park & Downtown Area!

Serene Travelers Rest Apartment: 7 Mi to Downtown!

1 Mi to Downtown Greer: Family Home w/ Gazebo!

Families Welcome, Fenced Yard: Inviting Greer Home

Serene Cabin w/ Pond & Creek on South Saluda River

Stay near popular Upstate South Carolina attractions

Clemson University

Falls Park on the Reedy

Fred W. Symmes Chapel

Bon Secours Wellness Arena

Memorial Stadium

BMW Performance Center

Greenville Convention Center

Learn more about Upstate South Carolina

Top Upstate South Carolina Hotel Reviews

Grand Bohemian Lodge Greenville, Autograph Collection

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

Comfort Inn & Suites Clemson - University Area

Hotel Hartness

Hyatt Place Greenville Downtown

Hotels in Upstate South Carolina with star-rating

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