A bench, a bicycle, and a lake surrounded by trees.

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Go beyond your typical stay in Upstate South Carolina

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Our top choices for Upstate South Carolina hotels

Hampton Inn Gaffney

Gaffney

Cristen

AED 352 total

includes taxes & fees

2 Aug - 3 Aug

Hampton Inn Greer Greenville, SC

Greer

Trina

AED 557 total

includes taxes & fees

12 Jul - 13 Jul

Best Western Plus Clemson Hotel & Conference Center

Clemson

Nancy

AED 388 total

includes taxes & fees

4 Jul - 5 Jul

Lakeside Lodge Clemson

Seneca

Kelly

AED 497 total

includes taxes & fees

4 Jul - 5 Jul

The Inn at Patrick Square

Clemson

Karyn

AED 608 total

includes taxes & fees

5 Jul - 6 Jul

Holiday Inn Express Gaffney by IHG

Gaffney

melvin

AED 368 total

includes taxes & fees

12 Jul - 13 Jul

Clemson University's James F. Martin Inn

Clemson

Melissa

AED 567 total

includes taxes & fees

5 Jul - 6 Jul

The Bleckley Inn

Anderson

Patrick

AED 722 total

includes taxes & fees

5 Jul - 6 Jul

Tru by Hilton Seneca Clemson

Seneca

Jason

AED 424 total

includes taxes & fees

19 Jul - 20 Jul

Embassy Suites Greenville Golf Resort & Conference Center

Greenville

Janet

AED 442 total

includes taxes & fees

2 Aug - 3 Aug

Hampton Inn & Suites Clinton - I-26

Clinton

Sarah

AED 452 total

includes taxes & fees

19 Jul - 20 Jul

Hampton Inn & Suites Greenville Airport, SC

Greenville

Thomas Christian

AED 423 total

includes taxes & fees

24 Jul - 25 Jul

Best Western Plus Greenville I-385 Inn & Suites

Greenville

Shabana

AED 372 total

includes taxes & fees

5 Jul - 6 Jul

The Abernathy of Clemson

Clemson

Samuel

AED 504 total

includes taxes & fees

5 Jul - 6 Jul

Outdoor pool, open 9:00 AM to 9:00 PM, sun loungers

Fairfield Inn & Suites by Marriott Anderson Clemson

Anderson

Salaeka

AED 395 total

includes taxes & fees

10 Jul - 11 Jul

Holiday Inn Express Hotel & Suites Anderson-I-85 by IHG

Anderson

Gina

AED 448 total

includes taxes & fees

26 Jul - 27 Jul

Four Points by Sheraton Spartanburg

Spartanburg

Susan

AED 485 total

includes taxes & fees

12 Jul - 13 Jul

3 restaurants; breakfast and dinner served

AC Hotel by Marriott Spartanburg

Spartanburg

Carla

AED 607 total

includes taxes & fees

5 Jul - 6 Jul

Tru by Hilton Spartanburg

Spartanburg

Hester L.

AED 374 total

includes taxes & fees

23 Jul - 24 Jul

Suite, 1 King Bed with Sofa bed, Non Smoking (Efficiency) | Premium bedding, individually decorated, desk, laptop workspace

Comfort Inn & Suites Clemson - University Area

Clemson

Lon

AED 412 total

includes taxes & fees

29 Jul - 30 Jul

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Vacation Rentals in Upstate South Carolina

Cabin

Postcard Cabins Lake Hartwell, Outdoor Collection by Marriott Bonvoy

Seneca

"Awesome place "

Cottage

< 3 Mi to Dtwn: Modern Cottage in Greenville!

Greenville

Apartment

Deluxe Two Bedroom (Self Check-in with Virtual Front Desk) | Living area | 55-inch flat-screen TV with digital channels, TV, streaming services

Mint House Greenville Downtown by Kasa

Greenville Downtown

"Great deal for the location. Apartment needed a little bit of love/attention."

Aparthotel

Full-size fridge, microwave, oven, stovetop

stayAPT Suites Greenville-Haywood Mall

Greenville

"This is a great hotel for the price!!"

Mobile Home

Cabin, 2 Bedrooms, Non Smoking (No Pets, Linens Included) | In-room dining

Carolina Landing RV Resort - Caravan Park

Fair Play

"Very nice stay with friendly staff"

Cottage

4 Seasons of Fun! Walhalla Home w/ Spacious Yard!

Walhalla

"Check-in and out was seamless. The rental operators were easily reachable and responsive. The house was well appointed and very comfortable. The house has been nicely renovated and the kitchen was amazing. The master bathroom was beautiful and the shower was enviable. The location was at once pleasantly remote, and yet very close to everything we wanted to explore. It happened to rain the whole holiday weekend we visited, but the comfortableness house made it so that wasn’t a loss at all....

Apartment

Lake Keowee Resort Condo: Waterfront Balcony

Salem

"Very clean. Amazing amenities. Lake view that takes your breath away."

Cottage

Home w/ Lake Keowee Access: Sleeps 7, Coffee Bar

Seneca

"The best, perfect "

Cottage

2 Mi to Downtown: Luxe Greenville Retreat!

Greenville

"Great house! Very clean and comfortable. Outstanding amenities. Conveniently located. "

Apartment

Designer Retreat w/ Pool, Golf + Beach Access!

Salem

"Property is in a great community, and it was very clean and beautifully decorated."

Apartment

Serene Travelers Rest Apartment: 7 Mi to Downtown!

Travelers Rest

"The best time ever. My wife and I enjoyed our Honeymoon and stay here. We will come back every year for our Anniversary now and also to vacation here. The area was beautiful, quiet, and safe. We had everything we needed. No other vacation spot in South Carolina can compete. Thank you for our wonderful stay and perfect memories! "

Cottage

Serene Cabin w/ Pond & Creek on South Saluda River

Cleveland

"I chose this cabin due to its close proximity to the pretty place chapel. The property was BEAUTIFUL and tucked away. The silence and change of scenery was well needed and felt like we were at home. I honestly don’t have enough good things to say about the host Mr. Steve and his generosity and professionalism!"

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Stay near popular Upstate South Carolina attractions

A historic building with a clock tower, surrounded by a well-maintained lawn with a paw print design.

Clemson University

9.6/10 (1,439 reviews)

Enjoy the collegiate vibe when you visit Clemson University, during your travels in Clemson. Experience the area's theater scene or attend a football game.

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Learn more about Upstate South Carolina

Experience the family-friendly area of Upstate South Carolina—live music, restaurants, and sights from Discovery Island Water Park to Frankie's Fun Park.

See all hotels in Upstate South Carolina

An aerial view of a park with a winding path, trees in autumn colors, and a bridge.

Top Upstate South Carolina Hotel Reviews

La Quinta Inn & Suites by Wyndham Greenville Woodruff Rd.

10/10 Excellent

"The property was very clean and the staff was very helpful."

Embassy Suites Greenville Golf Resort & Conference Center

10/10 Excellent

"We had a wonderful stay and would absolutely come back! The hotel was clean, comfortable, and well maintained. The staff was friendly and welcoming, making check-in and our entire stay easy and enjoyable. The room was spacious, the beds were comfortable, and everything we needed was provided. We especially enjoyed the pool—it was a great way to relax before heading home. Overall, this hotel exceeded our expectations. If you’re looking for a clean, comfortable place with great service, I highly recommend staying here!"

Drury Inn & Suites Greenville

10/10 Excellent

"Great breakfast. Pool was nice. The staff were very helpful. We asked for extra pillows & towels and they gladly gave them. Check in & out were super easy. Laundry facilities were easy to use bonus that it was on our floor. Location is right off the interstate & super easy to get in & out of."

The Shepherd Hotel Downtown Clemson

10/10 Excellent

"The hotel was very nice!! The staff was excellent. The valet that took care of me the minute I stopped my car, and the desk staff was awesome!!! I definitely recommend this hotel to anyone!!! Excellent service!!! Wasn't able to go to the restaurant and other areas the hotel offers due to short stay, but if I get back to Clemson, I will definitely stay here again."