A red train on tracks, palm trees, and modern buildings.

Find 4 Star Hotels in Central San Diego, CA from AED 550

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check availability on Central San Diego 4 Star Hotels

Tonight
10 Oct - 11 Oct
Tomorrow
11 Oct - 12 Oct
Next weekend
16 Oct - 18 Oct
In two weeks
23 Oct - 25 Oct

Our top choices for Central San Diego 4-star hotels

An outdoor lounge area with seating, a fire feature, and a pool in the background.
A hotel with a large pool surrounded by lounge chairs and umbrellas, palm trees, and a well-lit building facade.
A spacious lobby with a bar area, leather armchairs, and a reception desk.
A stone wall with a neon sign that reads "Tom & Jerry."

1. Town and Country San Diego

Town and Country San Diego
Mission Valley
United States
Alberto
AED 671
AED 898 total
includes taxes & fees
7 Nov - 8 Nov
Town and Country San Diego
A bar area with a glass ceiling, a central bar counter, and multiple stools.
A dimly lit room with patterned walls, a wooden table, and a chair.
A large swimming pool with lounge chairs and umbrellas, surrounded by palm trees and a building with a striped facade.
A luxurious interior with a large chandelier, patterned sofas, and a view of a cityscape through a large window.

2. Lafayette Hotel & Club

Lafayette Hotel & Club
University Heights
United States
katie
AED 1,003
AED 1,153 total
includes taxes & fees
19 Oct - 20 Oct
Lafayette Hotel & Club
An outdoor seating area with wicker chairs and a fire pit, surrounded by palm trees and string lights.
A modern dining area with a large table, chairs, and hanging plants.
A poolside area with a concrete pool, lounge chairs, and a wooden deck.
A spacious lobby with a central seating area, a staircase, and a view of the hallway leading to the entrance.

3. DoubleTree by Hilton Hotel San Diego - Mission Valley

DoubleTree by Hilton Hotel San Diego - Mission Valley
Mission Valley
United States
Alesi
AED 528
AED 606 total
includes taxes & fees
8 Nov - 9 Nov
DoubleTree by Hilton Hotel San Diego - Mission Valley
An outdoor dining area with tables and chairs, a fire feature, and a bar area with a stone wall and shelves.
A hotel entrance with a covered outdoor seating area, palm trees, and a car parked in front.
A swimming pool with lounge chairs and umbrellas, surrounded by trees and a tall building in the background.
A spacious gym with various exercise equipment, large windows, and a wooden floor.

4. San Diego Marriott La Jolla

San Diego Marriott La Jolla
University City
United States
Debra L
AED 680
AED 782 total
includes taxes & fees
6 Nov - 7 Nov
San Diego Marriott La Jolla
An outdoor dining area with tables set for two, string lights overhead, and a view of a building in the background.
A modern interior with a seating area featuring round tables and chairs, a large mirror, and a unique ceiling light fixture.
A modern lobby with a large window, two sofas, and two black planters with plants.
A spacious lobby with a modern staircase, comfortable seating, and large windows offering natural light.

5. Hilton San Diego Mission Valley

Hilton San Diego Mission Valley
Mission Valley
United States
Mary
AED 509
AED 585 total
includes taxes & fees
20 Oct - 21 Oct
Hilton San Diego Mission Valley
An outdoor patio with a stone fire pit, outdoor seating, string lights, and a tall, narrow heater.
A multi-level hotel lobby with dining areas, a reception desk, and a large TV screen.
A beach with clear skies, a rocky cliff, and a lighthouse in the distance.
A swimming pool with a visible water filtration system and a tiled edge.

6. Embassy Suites by Hilton San Diego La Jolla

Embassy Suites by Hilton San Diego La Jolla
University City
United States
Kunta
AED 621
AED 819 total
includes taxes & fees
31 Oct - 1 Nov
Embassy Suites by Hilton San Diego La Jolla
A spacious lobby with modern furniture, large windows, and a high ceiling with hanging lights.
A hotel room with a large bed, a wooden nightstand, a bench, a desk with a TV, and a chair.
A swimming pool with blue lounge chairs and umbrellas, surrounded by a building with balconies.
A pathway leading to a building labeled "LEGACY Hotel."

7. Legacy Resort Hotel & Spa

Legacy Resort Hotel & Spa
Mission Valley
United States
christopher
AED 591
AED 680 total
includes taxes & fees
8 Nov - 9 Nov
Legacy Resort Hotel & Spa
A spacious hotel lobby with a long reception desk, multiple seating areas, and large windows offering views of the outdoors.
A hotel room with two beds, a nightstand with a lamp, a framed picture on the wall, and a view through an open door.
A hotel room with two beds, a TV, a desk, and a chair.
A poolside area with a fire pit, lounge chairs, and a pool.

8. DoubleTree by Hilton San Diego - Hotel Circle

DoubleTree by Hilton San Diego - Hotel Circle
Mission Valley
United States
Ramiro
AED 479
AED 550 total
includes taxes & fees
15 Oct - 16 Oct
DoubleTree by Hilton San Diego - Hotel Circle
A swimming pool with lounge chairs and a waterfall feature, surrounded by palm trees and a building with multiple balconies.
A modern bar area with a long counter, multiple hanging pendant lights, and a bar stocked with bottles and glasses.
A modern hotel with a prominent tower, multiple floors, and a well-lit entrance.
A modern lobby with a round table and four chairs, a reception desk, and a large window.

9. San Diego Marriott Mission Valley

San Diego Marriott Mission Valley
Mission Valley
United States
John
AED 584
AED 671 total
includes taxes & fees
25 Oct - 26 Oct
San Diego Marriott Mission Valley
An outdoor seating area with sofas, a fire pit, and tables covered with blue tablecloths.
A gym with exercise equipment, mirrors, and a wall-mounted TV.
A hotel room with a flat-screen TV, a desk with a chair, a small table with a lamp, a framed picture on the wall, and a large window with curtains.
A rooftop swimming pool with sun loungers and umbrellas, surrounded by a landscaped area with trees and a tennis court.

10. Hyatt Regency La Jolla

Hyatt Regency La Jolla
University City
United States
lisa
AED 683
AED 906 total
includes taxes & fees
30 Oct - 31 Oct
Hyatt Regency La Jolla
An outdoor patio with tables and chairs, string lights, and umbrellas.
A hotel room with a large bed, a TV, a desk with a chair, and a view of the city through large windows.
A pool area with lounge chairs and umbrellas, surrounded by palm trees and a hilly landscape.
Property amenity

11. Sheraton Mission Valley San Diego Hotel

Sheraton Mission Valley San Diego Hotel
Mission Valley
United States
Leanna
AED 657
AED 756 total
includes taxes & fees
18 Oct - 19 Oct
Sheraton Mission Valley San Diego Hotel
A narrow, enclosed walkway with wooden railings and a metal grid barrier, leading to a building entrance.
A modern reception desk with a glass top, a large window offering a view, and a potted plant.
A modern bedroom with a large bed, a nightstand, a wall-mounted lamp, and a window with curtains.
An outdoor seating area with sofas and chairs, a wooden staircase, and potted plants.

12. City24 Hotel Little Italy Mission Hills

City24 Hotel Little Italy Mission Hills
Middletown
United States
Donavin
AED 422
AED 601 total
includes taxes & fees
4 Nov - 5 Nov
City24 Hotel Little Italy Mission Hills
BBQ/picnic area
Room
Room
Breakfast area

13. Residence Inn by Marriott San Diego Mission Valley

Residence Inn by Marriott San Diego Mission Valley
Mission Valley
United States
Kabnne
Residence Inn by Marriott San Diego Mission Valley
Save an average of 15% on thousands of hotels when you're signed in

Learn more about Central San Diego

Explore the seaside area of Central San Diego—a zoo, sports teams, and popular sights like San Diego Zoo.

See all hotels in Central San Diego
A historic cathedral with intricate architecture, a prominent bell tower, and a blue-domed structure.
Photo by Bilen Z

Top Central San Diego Hotel Reviews

Hilton San Diego Mission Valley

Hilton San Diego Mission Valley

10/10 Excellent
"Staff is helpful and always at arms reach if we needed anything"
Magdalena 2-night trip
Posted 10 hours ago
Hilton San Diego Mission Valley
Lafayette Hotel & Club

Lafayette Hotel & Club

10/10 Excellent
"If you love over the top, bougie decor and fabulous customer service The Lafayatte is a must stay at hotel!! We had a girls weekend, had so much fun and the ambiance is just beyond amazing!! You can spend an entire vacation in the hotel with the different restaurants, bars, bowling, pool etc!! We are going to make it an annual trip!!"
Marcella 1-night trip
Posted 11 hours ago
Lafayette Hotel & Club

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Central San Diego?
Expedia can help you easily locate the ideal 4-star hotel for your vacation in Central San Diego. Use our filter tool to tailor your search by things like price, conveniences and hotel star rating and get access to terrific deals in a couple of clicks.
  • Search for the lowest price from AED 550
What's the difference between 5-star and 4-star hotels in Central San Diego?
Offering a welcoming guest experience and upscale surroundings, 4-star hotels are a wonderful option for your Central San Diego escape. These kinds of stays generally feature loads of handy amenities that make it easy to unpack and unwind — think complimentary bathrobes, restaurants and pools. Or live in the lap of luxury at a 5-star hotel designed to spoil you with high-end perks and amenities. A personalized service, complimentary toiletries and gourmet dining are typically featured at these plush retreats.
Does Central San Diego have any 4-star all-inclusive resorts?
Use our "All inclusive" filter to search for your next getaway in Central San Diego where everything is taken care of, from your room to your meals, activities and entertainment. We can also help you find standard 4-star stays in and around this destination.

Explore a world of travel with Expedia