Find 5 Star Hotels in Southeast Missouri, MO

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Check availability on Southeast Missouri 5 Star Hotels

Tonight
31 Aug - 1 Sep
Tomorrow
1 Sep - 2 Sep
Next weekend
5 Sep - 7 Sep
In two weeks
12 Sep - 14 Sep

Compare Southeast Missouri 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Southeast Missouri.
Urban Lofts

Urban Lofts

104 North Jackson Street, Perryville, MO
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to K Bridge Recreation Area.

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Frequently asked questions

How much does it cost to stay in a 5-star hotel in Southeast Missouri?
How much you pay for a 5-star hotel in Southeast Missouri depends on factors like when you want to go and the length of your trip. A top tip for scoring the best deal? Use our pricing filters to check out all of the available accommodations for your preferred dates.

  • Search for the lowest price per night

What makes a hotel 5 stars in Southeast Missouri?
Flawless guest service is at the heart of every 5-star hotel in Southeast Missouri. From the minute you step through the door, staff are at your beck and call, whether recommending activities and tours or providing in-room beauty treatments. Additionally, hotels have to offer superior conveniences to be entitled to a 5-star rating. These can include luxury baths, an on-site spa, swimming pools, fine dining kitchens and knowledgeable concierge.
Are there any 5-star all-inclusive resorts in Southeast Missouri?
Our filter tool is the easiest way to find exactly what you're looking for. Check the "All inclusive" and "5-star" boxes to show the finest properties in Southeast Missouri where your meals, room, activities and entertainment are included in the upfront price. At these escapes, your trip is absolute indulgence from the moment you arrive.