An aerial view of a forested landscape with a river, a parking lot, and a bridge.

Vacation Homes in Anderson County

Compare and save
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
In two months
In three months
In four months

Our top choices for Anderson County vacation homes

1. Discover Your Vacation Haven in Greenville, SC – B5 Homes!

Discover Your Vacation Haven in Greenville, SC – B5 Homes!
Greenville
9.8 out of 10, Exceptional, (113 reviews)
"Very nice and comfy place. We really enjoyed our stay and the place was just right! Our host was very hospitable and helpful! I definitely recommend this place for your next stay! The back porch was our favorite to hang out and drink coffee."
United States
Danny
Discover Your Vacation Haven in Greenville, SC – B5 Homes!

2. Cozy 2-bedroom house on Lake Keowee with private dock

Cozy 2-bedroom house on Lake Keowee with private dock
West Union
10.0 out of 10, Exceptional, (21 reviews)
"We had a wonderful stay at Bonita's Lake Keowee house! With three kids, we had plenty of room. Access to the lake, with paddle boards, kayaks, and a paddle boat, along with beautiful views from the back porch made the trip. Highly recommend!"
United States
Peter I.
Cozy 2-bedroom house on Lake Keowee with private dock

3. Lake House Near Clemson Private Boat Dock WiFi 65" TV Grill Kayaks Deep Water

Lake House Near Clemson Private Boat Dock WiFi 65" TV Grill Kayaks Deep Water
Seneca
9.8 out of 10, Exceptional, (170 reviews)
"Great place with lake front access."
United States
Curt W.
Lake House Near Clemson Private Boat Dock WiFi 65" TV Grill Kayaks Deep Water

4. Steps Away Downtown Douthit Greenville Getaway!

Steps Away Downtown Douthit Greenville Getaway!
Greenville
8.6 out of 10, Excellent, (11 reviews)
"Absolutely a perfect home!"
United States
Andrea R.
Steps Away Downtown Douthit Greenville Getaway!

5. Brand New 6BR/6BA Luxury, 20min to Clemson. Wooded flat lot/firepit/pool table!

Brand New 6BR/6BA Luxury, 20min to Clemson. Wooded flat lot/firepit/pool table!
West Union
10.0 out of 10, Exceptional, (44 reviews)
"Hosts were delightful and the property exceeded expectations"
United States
Randy S.
Brand New 6BR/6BA Luxury, 20min to Clemson. Wooded flat lot/firepit/pool table!

6. CLOSE TO DOWNTOWN GREENVILLE

CLOSE TO DOWNTOWN GREENVILLE
Overbrook Historic District
10.0 out of 10, Exceptional, (33 reviews)
"This townhome was perfect for our weekend in Greenville. Property was clean and had everything we needed. Great location near downtown."
United States
Sarah B.
CLOSE TO DOWNTOWN GREENVILLE

7. Fall Chill! Mtn - Lake - Pools -Pickleball - Gym. Spacious townhome for groups

Fall Chill! Mtn - Lake - Pools -Pickleball - Gym. Spacious townhome for groups
Salem
10.0 out of 10, Exceptional, (39 reviews)
"Wonderful place to stay. It has everything!"
United States
John M.
Fall Chill! Mtn - Lake - Pools -Pickleball - Gym. Spacious townhome for groups

8. The Blue Bungalow by Unity Park - Newly Renovated

The Blue Bungalow by Unity Park - Newly Renovated
Woodside Cotton Mill Village Historic District
9.8 out of 10, Exceptional, (108 reviews)
"Fully equipped, comfortable beds…everything to make for an enjoyable stay. "
United States
Ron E.
The price is AED 271
AED 791 total
includes taxes & fees
27 Sep - 28 Sep
The Blue Bungalow by Unity Park - Newly Renovated

9. Downtown House steps to Falls Park, Baseball Stadium, Restaurants & Shopping

Downtown House steps to Falls Park, Baseball Stadium, Restaurants & Shopping
Greenville Downtown
9.4 out of 10, Exceptional, (22 reviews)
"This is a great location - we were able to walk to everything that we wanted - from the park to restaurants and the arena. "
United States
Jay K.
Downtown House steps to Falls Park, Baseball Stadium, Restaurants & Shopping

10. Private, pet-friendly adorable getaway mins to downtown

Private, pet-friendly adorable getaway mins to downtown
Greenville
9.8 out of 10, Exceptional, (133 reviews)
"A great getaway! Close enough to Clemson and close to Greenville. Perfect for our family."
United States
Deanna C.
Private, pet-friendly adorable getaway mins to downtown

11. Just updated! Downtown Greer house. Walk to downtown shops. Fenced in backyard

Just updated! Downtown Greer house. Walk to downtown shops. Fenced in backyard
Greer
10.0 out of 10, Exceptional, (23 reviews)
"The house was clean and had everything we needed for our stay. "
United States
Anneice T.
Just updated! Downtown Greer house. Walk to downtown shops. Fenced in backyard

12. 4/3, Waterfront Home w/ Covered Dock, Child Sand Play Pit, Pet Friendly!

4/3, Waterfront Home w/ Covered Dock, Child Sand Play Pit, Pet Friendly!
Seneca
9.8 out of 10, Exceptional, (390 reviews)
"Great house and host!"
United States
Deborah W.
4/3, Waterfront Home w/ Covered Dock, Child Sand Play Pit, Pet Friendly!

13. 6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.

6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.
Seneca
9.8 out of 10, Exceptional, (174 reviews)
"Exactly what we wanted. All around fantastic stay."
United States
Barbara A.
6 Bedrooms and 3 docks on a Lake Hartwell cove, 3 miles from Clemson by water.

14. 4 Mi to Dtwn: Home w/ Fire Pit in Greenville

4 Mi to Dtwn: Home w/ Fire Pit in Greenville
Greenville
9.8 out of 10, Exceptional, (17 reviews)
"Good location. Good communication with manager. We enjoyed our stay. "
United States
Jill N.
4 Mi to Dtwn: Home w/ Fire Pit in Greenville

15. NEW Spacious 4-Story 4-bedroom Townhome Retreat in Greenville

NEW Spacious 4-Story 4-bedroom Townhome Retreat in Greenville
Greenville
10.0 out of 10, Exceptional, (19 reviews)
"Wonderful stay! Beautiful property! Owner was a dream to work with and was very easy to communicate with. Quiet area with a 20 min walk to all the shops and restaurants on Main Street."
United States
Andrea L.
The price is AED 1,520
AED 2,642 total
includes taxes & fees
27 Sep - 28 Sep
NEW Spacious 4-Story 4-bedroom Townhome Retreat in Greenville

16. Le Downtown French Maison- LUXURY Greer Home w/Firepit

Le Downtown French Maison- LUXURY Greer Home w/Firepit
Greer
9.4 out of 10, Exceptional, (13 reviews)
"Great location and Irina is so responsive!"
United States
Steve C.
Le Downtown French Maison- LUXURY Greer Home w/Firepit

17. Lake Keowee Escape w/ Dock, Deck & Lake Access!

Lake Keowee Escape w/ Dock, Deck & Lake Access!
Six Mile
9.4 out of 10, Exceptional, (152 reviews)
"The house was perfect for our family to relax at the lake"
United States
Nicci K.
Lake Keowee Escape w/ Dock, Deck & Lake Access!

18. Vacation Rental, Spa & Salt Room Table Rock State Park Fire-Pit ,Pet Friendly

Vacation Rental, Spa & Salt Room Table Rock State Park Fire-Pit ,Pet Friendly
Pickens
10.0 out of 10, Exceptional, (23 reviews)
"Beautiful tiny home with all that you would need for a wonderful stay. We enjoyed celebrating our one- year marriage anniversary."
United States
Felicia T.
The price is AED 661
AED 828 total
includes taxes & fees
27 Sep - 28 Sep
Vacation Rental, Spa & Salt Room Table Rock State Park Fire-Pit ,Pet Friendly

19. The Rustic Rectangle

The Rustic Rectangle
Pendleton
10.0 out of 10, Exceptional, (13 reviews)
The price is AED 334
AED 856 total
includes taxes & fees
5 Oct - 6 Oct
The Rustic Rectangle

20. Charming pet-friendly Greenville house with mountain setting and fenced yard

Charming pet-friendly Greenville house with mountain setting and fenced yard
Greenville
10.0 out of 10, Exceptional, (31 reviews)
"Will definitely be staying here again! "
United States
Eric M.
Charming pet-friendly Greenville house with mountain setting and fenced yard
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Anderson County Hotel Reviews

Explore a world of travel with Expedia