Top Vacation Homes in Antofagasta Region in 2026

A road leading to snow-capped mountains in a barren landscape.

Change your mind
Book hotels with free cancellation
Treat yourself
Sign in to save 10% or more on thousands of hotels
Sign in
Be picky
Search almost a million properties worldwide

Check prices for these dates

In two weeks

In two months

In three months

In four months

Our top choices for Antofagasta Region vacation homes

1. Atacama Arriera - Origin Experience (Newly remodeled)

San Pedro de Atacama

Gonzalo I.

2. Casa Solena San Pedro De Atacama

San Pedro de Atacama

Fran

3. Arriendo Cabaña por Días en San Pedro de Atacama

San Pedro de Atacama

4. Cozy and comfortable apartment in the middle of the desert

San Pedro de Atacama

5. Tiny house container for stargazing; rental car optional, by artist @Paz_Sarrat,

San Pedro de Atacama

View all properties

Find vacation rentals that suit your style

Cabins

Apartments

Save an average of 15% on thousands of hotels when you're signed in

Top Antofagasta Region Hotel Reviews

Hotel Tulor

8/10 Good

"Great concept, very convenient location, really interesting story around the hotel and its owner. Unfortunately only downside is the included breakfast which is not well attended. Would still stay again"

Noi Casa Atacama

10/10 Excellent

"Amazing staff and location! Went on a family trip with cousins and extended in laws and stayed here solo. It was absolutely beautiful and clean. The staff was very friendly and accommodating with my little Spanish speaking abilities (thank you all for your patience!) Breakfast was convenient and available daily. Also coffee was available in my room (if you know you know this is a plus in Atacama!) If you’re considering this hotel, book!"

Hotel Takha Takha

10/10 Excellent

"The hotel and grounds was beautiful! The staff was very helpful and kind. Alejandra was especially helpful and welcoming. She helped us secure a transfer to the airport as well as recommendations for bike rentals and other information. The grounds has 3 lovely dogs on property who are adorable and sweet. The breakfast was delicious. We really enjoyed our stay!"

Diego de Almagro San Pedro de Atacama

8/10 Good

"Staff very helpful and friendly, although no English. Happy to converse using translation tools. Swimming pool was closed due to it being winter, which I didn’t reslise when I booked. A couple of times there was no water, no electricity and no wifi, but staff worked to resolve the issue. Breakfast was very good and there was free tea, coffee and iced drinking water available all day. I didn’t have supper at the hotel but did have some drinks at the bar by the open fire which was welcoming and warm."

Room 1

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Antofagasta Region vacation homes

1. Atacama Arriera - Origin Experience (Newly remodeled)

2. Casa Solena San Pedro De Atacama

3. Arriendo Cabaña por Días en San Pedro de Atacama

4. Cozy and comfortable apartment in the middle of the desert

5. Tiny house container for stargazing; rental car optional, by artist @Paz_Sarrat,

Find vacation rentals that suit your style

Top Antofagasta Region Hotel Reviews

Hotel Tulor

Noi Casa Atacama

Vientos - La Yareta

Hotel Takha Takha

Geotel Calama

Lodge Quelana

Vicuña lodge

Diego de Almagro San Pedro de Atacama

Park Hotel Calama

Explore a world of travel with Expedia