Find Luxury Hotels in Cape Girardeau, MO

Use Expedia to arrange your flight to Cape Girardeau, MO (CGI-Cape Girardeau Municipal) airport or Cairo, IL (CIR-Cairo Regional) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are important when you plan a vacation, so we make it easy to get what you’d like to make your stay relaxing and comfortable. If you want an upscale hotel that has fine dining, a spa, or several swimming pools, Expedia can help you find the best luxury hotel experience that Cape Girardeau offers. During your visit, you might want to enjoy the university which Cape Girardeau is known for.

Lie in the lap of luxury during your getaway to Cape Girardeau in one of Expedia’s 6 luxury hotels.

Planning for the weather is an important factor for making your trip to Cape Girardeau a success, especially when you’re splurging. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 40°F. Average annual precipitation for Cape Girardeau is 59 inches.

Enjoy all that Cape Girardeau has to offer and visit Isle Casino Cape Girardeau, Riverfront Bridge Park, and Show Me Center. If you have a bit of extra time while you’re in the area, you might want to check out Cape Splash Family Aquatic Center and Hunter Valley Winery.