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Find Luxury Hotels in Cape Girardeau, MO

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Check availability on Cape Girardeau Luxury Hotels

Top Cape Girardeau Luxury Hotels

Property grounds
Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Historical 'Kage House' Short Term Rental located in "Old Town Cape"

Cape Girardeau
10.0 out of 10, Exceptional, (223)
"Property location was perfect.Deck view was great.Very clean and comfortable place."
United States
Robert M.
Historical 'Kage House' Short Term Rental located in "Old Town Cape"
Lobby
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 star property
Cape Girardeau
9.0 out of 10, Wonderful, (1001)
"Nice place for a stay at a reasonable price."
United States
Arthur
The price is AED 257
AED 290 total
includes taxes & fees
23 Nov - 24 Nov
Pear Tree Inn Cape Girardeau Near the Medical Center
Lobby
Quality Inn

Quality Inn

2.5 star property
Cape Girardeau
7.2 out of 10, Good, (674)
"Overall was wonderful customer service and breakfast"
United States
Stephanie
The price is AED 212
AED 239 total
includes taxes & fees
24 Nov - 25 Nov
Quality Inn
Business center
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1000)
"Rooms are nice and big. Breakfast was above average and staff was very nice and friendly. "
United States
Sandra
The price is AED 331
AED 373 total
includes taxes & fees
30 Nov - 1 Dec
Drury Inn & Suites Cape Girardeau
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Cape Girardeau Hotel Reviews

Quality Inn

Quality Inn

10/10 Excellent
"Overall was wonderful customer service and breakfast"
Stephanie 1-night trip
Posted 6 days ago
Quality Inn

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Frequently asked questions

Are you searching for the perfect hotel for your luxury getaway to Cape Girardeau?
Use Expedia to arrange your flight to Cape Girardeau, MO (CGI-Cape Girardeau Municipal) airport or Cairo, IL (CIR-Cairo Regional) airport, and then select from a variety of places to stay that will deliver the luxury you want. Amenities are important when you plan a vacation, so we make it easy to get what you'd like to make your stay relaxing and comfortable. If you want an upscale hotel that has fine dining, a spa, or several swimming pools, Expedia can help you find the best luxury hotel experience that Cape Girardeau offers. During your visit, you might want to enjoy the university which Cape Girardeau is known for.
When can I expect good weather in Cape Girardeau?
Planning for the weather is an important factor for making your trip to Cape Girardeau a success, especially when you're splurging. The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 40°F. Average annual precipitation for Cape Girardeau is 59 inches.
What's there to see and do in Cape Girardeau?
Enjoy all that Cape Girardeau has to offer and visit Isle Casino Cape Girardeau, Show Me Center, and Cape Splash Family Aquatic Center. If you have a bit of extra time while you're in the area, you might want to check out Trail of Tears State Park and Shawnee National Forest.