A brick-paved street with a gazebo, a red car, and a white pickup truck.

Search Vacation Homes in Jefferson

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
20 Nov - 22 Nov
In two months
1 Jan - 3 Jan
In three months
29 Jan - 31 Jan
In four months
26 Feb - 28 Feb

Our top choices for Jefferson vacation homes

A modern kitchen with white cabinets, a wooden countertop, a microwave, a stove, and a refrigerator.

1. Sleeps 6. Pets welcome. Wi-Fi. 3 bedroom house

Sleeps 6. Pets welcome. Wi-Fi. 3 bedroom house
Jefferson
9.2 out of 10, Wonderful, (25 reviews)
"Location was perfect! Great bang for you buck. I'd stay there again."
United States
Anonymous traveler
Sleeps 6. Pets welcome. Wi-Fi. 3 bedroom house
A patio with a table and chairs, string lights, a barbecue grill, and hanging plants.

2. Historic Home in the Heart of Perry

Historic Home in the Heart of Perry
Perry
10.0 out of 10, Exceptional, (44 reviews)
"Grandma Helen’s was an absolute gem!! Extraordinary home in a small town atmosphere. Stayed here to take in the great bicycle trail system in the area."
United States
Debra K. B.
The price is AED 826
AED 1,674 total
includes taxes & fees
3 Dec - 4 Dec
Historic Home in the Heart of Perry
A kitchen with wooden cabinets, a stainless steel oven, and a dining table with chairs.

3. Railroad themed 3-bedroom house in Boone The Main Street Station is pet friendly

Railroad themed 3-bedroom house in Boone The Main Street Station is pet friendly
Boone
10.0 out of 10, Exceptional, (16 reviews)
"Great place! Thanks for a wonderful stay."
United States
Rebecca
Railroad themed 3-bedroom house in Boone The Main Street Station is pet friendly
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Jefferson Hotel Reviews

Railroad themed 3-bedroom house in Boone The Main Street Station is pet friendly

Railroad themed 3-bedroom house in Boone The Main Street Station is pet friendly

10/10 Excellent
"This was the perfect spot for our Iowa State Football game weekend getaway. Everything we needed and the perfect setting for our family. Shea and Amy were excellent hosts and provided unbeatable communication. Thanks for our unforgettable stay in Boone!!"
Erin Y. 2-night trip
Posted 2 days ago
Railroad themed 3-bedroom house in Boone The Main Street Station is pet friendly

Explore a world of travel with Expedia