A sunset over a mountainous landscape with scattered clouds.

Search Vacation Homes in La Mesa

  • Change your mind

    Book hotels with free cancellation

  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in

  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
16 Oct - 18 Oct
In two months
27 Nov - 29 Nov
In three months
25 Dec - 27 Dec
In four months
22 Jan - 24 Jan

Our top choices for La Mesa vacation homes

An outdoor patio with a table and chairs, string lights, and a grill.

1. 3 Bedroom House - Fire Pit Table, BBQ - 10 Guests

3 Bedroom House - Fire Pit Table, BBQ - 10 Guests
La Mesa
9.2 out of 10, Wonderful, (15 reviews)
"Adam was great! Communicated regularly and ensured I was good to go from the start. "
United States
Beth H.
The price is AED 432
AED 1,810 total
includes taxes & fees
7 Oct - 8 Oct
3 Bedroom House - Fire Pit Table, BBQ - 10 Guests
A neatly made bed with white bedding, a bedside table with a digital thermometer, two lit candles, a blue and white patterned lamp, and a small potted plant.

2. Entire Private Home w/ 4BR 3Bath, King Bed, Large Yard & Prime Area, Ranch Style

Entire Private Home w/ 4BR 3Bath, King Bed, Large Yard & Prime Area, Ranch Style
La Mesa
10.0 out of 10, Exceptional, (1 review)
"Great overall experience, clean room."
United States
Warren B.
The price is AED 588
AED 1,495 total
includes taxes & fees
7 Oct - 8 Oct
Entire Private Home w/ 4BR 3Bath, King Bed, Large Yard & Prime Area, Ranch Style
Beach

3. Entire Private Home with 4 Bedroom, 2 Bath, King Bed, Ranch Style, Prime Area

Entire Private Home with 4 Bedroom, 2 Bath, King Bed, Ranch Style, Prime Area
La Mesa
9.0 out of 10, Wonderful, (2 reviews)
The price is AED 588
AED 1,470 total
includes taxes & fees
19 Oct - 20 Oct
Entire Private Home with 4 Bedroom, 2 Bath, King Bed, Ranch Style, Prime Area
A modern kitchen with a central island, bar stools, and a built-in oven.

4. Cozy Mid-Century Charmer - Huge Backyard - Firepit

Cozy Mid-Century Charmer - Huge Backyard - Firepit
La Mesa
9.8 out of 10, Exceptional, (12 reviews)
"Clean and great host"
United States
Michelle D.
Cozy Mid-Century Charmer - Huge Backyard - Firepit
A modern living room with a sofa, a dining area, and a kitchen.

5. 25% off, Chic Casita • Hot tub • BBQ • 4 min to SDSU

25% off, Chic Casita • Hot tub • BBQ • 4 min to SDSU
La Mesa
10.0 out of 10, Exceptional, (8 reviews)
"Great stay. Clean, beautiful and great communication with property manager."
United States
Kate K.
25% off, Chic Casita • Hot tub • BBQ • 4 min to SDSU
A modern kitchen with wooden cabinets, stainless steel appliances, and a dining area set for a meal.

6. Entire Private House with 4 Beds, Gated Yard, Parking, Ranch Style in La Mesa

Entire Private House with 4 Beds, Gated Yard, Parking, Ranch Style in La Mesa
La Mesa
The price is AED 727
AED 1,590 total
includes taxes & fees
19 Oct - 20 Oct
Entire Private House with 4 Beds, Gated Yard, Parking, Ranch Style in La Mesa
A modern living room with a flat-screen TV, a dining area with a white table and green chairs, and a hallway with a door.

7. Entire Private House with 4 Bedroom 3 Bath Ranch Style w Gated Yard, Parking

Entire Private House with 4 Bedroom 3 Bath Ranch Style w Gated Yard, Parking
La Mesa
7.0 out of 10, Good, (2 reviews)
Entire Private House with 4 Bedroom 3 Bath Ranch Style w Gated Yard, Parking
A modern kitchen with a large island, stainless steel appliances, and pendant lighting.

8. Modern SD Escape: SDSU/Downtown <10 Min, GameRoom, Fire Pit, Easy Freeway Access

Modern SD Escape: SDSU/Downtown <10 Min, GameRoom, Fire Pit, Easy Freeway Access
La Mesa
9.0 out of 10, Wonderful, (10 reviews)
"We had a wonderful stay! The home is lovely, clean and exactly as described. Jonathan is very nice and easy to communicate with. We loved staying here to celebrate our son’s graduation from SDSU!"
United States
Anonymous traveler
The price is AED 863
AED 1,859 total
includes taxes & fees
4 Oct - 5 Oct
Modern SD Escape: SDSU/Downtown <10 Min, GameRoom, Fire Pit, Easy Freeway Access
A hallway with a wooden floor, a red door, and a door with a sign.

9. L U C K A Room at Relax Inn

L U C K A Room at Relax Inn
El Cajon
The price is AED 264
AED 393 total
includes taxes & fees
3 Oct - 4 Oct
L U C K A Room at Relax Inn
A modern kitchen with white cabinets, stainless steel appliances, and a wooden dining table with upholstered chairs.

10. La Mesa Family Retreat - 20 minutes to Beaches & More!

La Mesa Family Retreat - 20 minutes to Beaches & More!
La Mesa
9.0 out of 10, Wonderful, (11 reviews)
"The property was well located for us. "
United States
Ann D.
La Mesa Family Retreat - 20 minutes to Beaches & More!
A modern living room with a sofa, a small table, a baby playpen, and a wall-mounted TV.

11. Mid-Century Treehouse with Yard and Views! AMAZING Location! Pet-friendly!

Mid-Century Treehouse with Yard and Views! AMAZING Location! Pet-friendly!
Spring Valley
9.2 out of 10, Wonderful, (9 reviews)
"Location was perfect for our needs. Great space for the dogs too. "
United States
Hayley G.
Mid-Century Treehouse with Yard and Views! AMAZING Location! Pet-friendly!
A living room with a beige sofa, two armchairs, a coffee table, and a rug. There are two lamps, a painting on the wall, and a window with a view of greenery and a blue car outside.

12. 'Ted' 2-bedroom cozy house in central location! 10 minutes to Balboa!

'Ted' 2-bedroom cozy house in central location! 10 minutes to Balboa!
Encanto
8.8 out of 10, Excellent, (40 reviews)
"Beds were very comfortable."
United States
Paula
The price is AED 349
AED 969 total
includes taxes & fees
1 Nov - 2 Nov
'Ted' 2-bedroom cozy house in central location! 10 minutes to Balboa!
A gravel pathway with red bricks leading to a gate.

13. La Casita Guest House, private fenced yard & with heat and AC, pet friendly

La Casita Guest House, private fenced yard & with heat and AC, pet friendly
Mount Helix
9.8 out of 10, Exceptional, (13 reviews)
"Thank you so much for the hospitality and your kindness"
United States
Lisa D.
The price is AED 477
AED 1,198 total
includes taxes & fees
1 Nov - 2 Nov
La Casita Guest House, private fenced yard & with heat and AC, pet friendly
A modern living room with a grey sofa, a small round coffee table, and a ceiling fan.

14. Charming 1-bedroom house in Beautiful San Diego with WiFi, AC

Charming 1-bedroom house in Beautiful San Diego with WiFi, AC
Mid-City
10.0 out of 10, Exceptional, (2 reviews)
"Our stay was excellent. We enjoyed the space. Used TV, sofa and bed… nothing else. Quiet and easy access to property. "
United States
Socorro C.
Charming 1-bedroom house in Beautiful San Diego with WiFi, AC
A deck with two wicker chairs and a small table, overlooking a mountainous landscape and a body of water.

15. Luxury Studio with Lake Views and Spacious Balcony

Luxury Studio with Lake Views and Spacious Balcony
Spring Valley
7.8 out of 10, Good, (7 reviews)
"It was beautiful and very modern. We loved it and hope to come back again!! "
United States
Ronette B.
Luxury Studio with Lake Views and Spacious Balcony
A living room with a flat-screen TV on a wooden wall, a sofa, a coffee table with a tray, and a door leading to another room.

16. SanDiego Insider's Coastal Bliss and Urban Wonders. Near SDSU Chollas Lake.

SanDiego Insider's Coastal Bliss and Urban Wonders. Near SDSU Chollas Lake.
Mid-City
9.4 out of 10, Exceptional, (19 reviews)
"The location was great for getting to all the top attractions in San Diego. The back yard and garden was very peaceful and great for kids to explore!"
United States
Jenna T.
The price is AED 536
AED 1,398 total
includes taxes & fees
2 Nov - 3 Nov
SanDiego Insider's Coastal Bliss and Urban Wonders. Near SDSU Chollas Lake.
A living room with a blue sofa, a round coffee table, and a world map on the wall.

17. Charming 2 bedroom San Diego home-Close to Downtown/Balboa Park/SeaWorld/Beaches

Charming 2 bedroom San Diego home-Close to Downtown/Balboa Park/SeaWorld/Beaches
Mid-City
8.0 out of 10, Very good, (4 reviews)
"We thoroughly appreciated the communications provided by the host. Initially had a few teething issues, with the keylock code not working, and a smell in the bedroom and the living area, but this was rectified and a cleaning crew came in twice for it. Place is perfectly situated (with car use) but a bit less so if on foot, or public transportation. The laundry in the shed and the kitchen are always welcome especially as our booking was over 2 weeks long! Thanks again for a suitable stay for us!"
United States
Carlo Luis
Charming 2 bedroom San Diego home-Close to Downtown/Balboa Park/SeaWorld/Beaches
A modern living room with a fireplace, a ceiling fan, and a large sliding glass door leading to an outdoor area.

18. Palm & Peace Retreat

Palm & Peace Retreat
La Mesa
9.8 out of 10, Exceptional, (20 reviews)
"The host is very responsive and the house is nice in a great location! "
United States
Demi B.
The price is AED 942
AED 2,389 total
includes taxes & fees
4 Oct - 5 Oct
Palm & Peace Retreat
A backyard with a pergola, outdoor seating, and a brick pathway.

19. 3-bedroom and 3-bathroom home in the heart of San Diego, 12 minutes to downtown

3-bedroom and 3-bathroom home in the heart of San Diego, 12 minutes to downtown
Mid-City
9.4 out of 10, Exceptional, (8 reviews)
"We LOVED the backyard and the location. Thank you for a wonderful time. The property was clean, beds were comfortable, and the showers were amazing!"
United States
Angie G.
3-bedroom and 3-bathroom home in the heart of San Diego, 12 minutes to downtown
A poolside area with wicker chairs, a table with a bottle and glasses, and a view of a building and pool at dusk.

20. Ultimate Group Getaway—Pool, Spa, Views, Games!

Ultimate Group Getaway—Pool, Spa, Views, Games!
San Carlos
9.6 out of 10, Exceptional, (33 reviews)
"Wonderful little oasis - so great for our family gathering with young children"
United States
Steven N.
The price is AED 1,084
AED 3,160 total
includes taxes & fees
18 Oct - 19 Oct
Ultimate Group Getaway—Pool, Spa, Views, Games!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
View all properties
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top La Mesa Hotel Reviews

The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld

10/10 Excellent
"My favorite place to stay for a quick trip to San Diego. Very comfortable and clean rooms. The pool and hot tub add a special touch to your stay. Front desk customer service is superb. Very friendly and helpful. Breakfast is also delicious with hot coffee station."
JoHanna 2-night trip
Posted 1 hour ago
The Alcala Hotel Mission Valley/Seaworld

Explore a world of travel with Expedia