Photo by Michael Schuier

Search Vacation Homes in Ladys Island

Start date: Check-in selected.
To Date
End date: Check-out
  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks
In one month
In two months

Vacation Homes in Ladys Island

Vacation Home in Sea Pines

3.5 star property
9.0 out of 10, Wonderful, (60)
"The staff was extremely inviting, professional, and kind. Parking was extremely easy we stayed in villa 3939. It was very large, clean, and had a great view. The property was conveniently located within the area and very walkable. It is very dark at night but we felt safe walking back from dinner. I’d definitely recommend this property for a quiet and peaceful getaway."
United States
ANGELEE
The price is AED 584
AED 642 total
includes taxes & fees
14 Dec - 15 Dec
Marriott's Harbour Club

Vacation Home in Fripp Island

3.0 star property
The price is AED 499
AED 1,261 total
includes taxes & fees
2 Dec - 3 Dec
504 Sunsuite

Vacation Home in Mid Island

3.5 star property
9.6 out of 10, Exceptional, (127)
"While the rooms are overdue a refurbishment, this place is a wondeful resort. "
United States
Chad
Disney's Hilton Head Island Resort

Vacation Home in Port Royal

8.8 out of 10, Excellent, (11)
"Port Royal is charming & this was a great place to stay. Right next to a park, very clean and super comfy!"
United States
Julie S.
The price is AED 215
AED 802 total
includes taxes & fees
7 Dec - 8 Dec
Experience USMC History: 10 min to Parris Island

Vacation Home in Edisto Beach

10.0 out of 10, Exceptional, (15)
"Great vacation home!"
United States
Samuel J.
The price is AED 643
AED 1,662 total
includes taxes & fees
1 Dec - 2 Dec
Gentleman Pirate (Ocean Views!)

Vacation Home in Port Royal

9.4 out of 10, Exceptional, (11)
"Family was impressed with the sleeping accommodations, Wished the stay was longer. "
United States
YVONNE S.
The price is AED 389
AED 1,337 total
includes taxes & fees
1 Dec - 2 Dec
4 mi. to Beaufort Waterfront and Parris Island 🇺🇸- 🧲 Pit - Porch w/ Grill

Vacation Home in Saint Helena Island

10.0 out of 10, Exceptional, (15)
"Beautiful marsh views. Close to the beach and state park. Peaceful and well taken care of. "
United States
Dorothy T.
The price is AED 621
AED 1,168 total
includes taxes & fees
1 Dec - 2 Dec
The Offbeat Oasis by the Marsh- State Park Pass Included🏖

Vacation Home in Beaufort

8.8 out of 10, Excellent, (18)
"This was our 2nd stay at this property so there we no surprises. The home is comfortable with plenty of room for a larger family. It has everything you need and is close to Beaufort. "
United States
Faye B.
The price is AED 562
AED 937 total
includes taxes & fees
1 Dec - 2 Dec
Historic Beaufort, South Carolina Near Hilton Head, SC, New Renovation, Sleeps 8

Vacation Home in Northwest Quadrant

9.8 out of 10, Exceptional, (29)
"Beautiful house. Near downtown. Friendly neighbors. Will definitely stay here again."
United States
Kerry F.
The price is AED 375
AED 1,228 total
includes taxes & fees
9 Dec - 10 Dec
Sleeps 10•5 Beds•3 min to DT Beaufort•12 min to Parris Island 🇺🇸•Shaded Deck

Vacation Home in Saint Helena Island

10.0 out of 10, Exceptional, (24)
"The property owner was great to work with. The house was clean and everything was as described in the listing. "
United States
Scott F.
The price is AED 643
AED 1,495 total
includes taxes & fees
30 Dec - 31 Dec
Coastline Cottage with Breathtaking Ocean Views On Fripp Island Wi-Fi, Golf Cart

Vacation Home in Sea Pines

3.5 star property
9.4 out of 10, Exceptional, (67)
"Another great Marriott, super clean and spacious with the comforts we needed to finish out a long trip (e.g. hot tub, laundry, kitchen). Friendly staff and convenient to the forest reserve."
United States
Landry
The price is AED 584
AED 642 total
includes taxes & fees
14 Dec - 15 Dec
Marriott's Heritage Club

Vacation Home in Beaufort

8.6 out of 10, Excellent, (4)
"The check in process was easy and the owner is very friendly. However we had no idea it was a trailer park. The yard is full clutter and the other mobile homes are too close to the house. The couch and the bed were horrible! We could feel the springs in the cushions and the washer and dryer clearly need to be replaced. The dryer didn't dry. The stay was short and it didn't rain but rain would have been mud puddles. All in all the description of the property feels a little crafted and what we got...
United States
Kijana A.
The price is AED 529
AED 840 total
includes taxes & fees
1 Dec - 2 Dec
Tucked Away Newly Renovated 2 Bedroom/ 1 Bath, Sleep 8

Vacation Home in Saint Helena Island

10.0 out of 10, Exceptional, (11)
"Really cool A frame tiny home off the beaten path. "
United States
Kelly M.
The price is AED 514
AED 925 total
includes taxes & fees
31 Dec - 1 January 2026
"A" Secluded Quiet Oasis Treehouse w/ Beach Pass

Vacation Home in Mid Island

2.0 star property
Family-Friendly 2BR Home w/ Sofa Bed – Hilton Head

Vacation Home in Edisto Beach

9.6 out of 10, Exceptional, (174)
"Very nice and relaxing. We gad a great stay."
United States
Stephanie D.
The price is AED 496
AED 1,012 total
includes taxes & fees
2 Dec - 3 Dec
Relax on Huge Porch Overlooking Marsh- Short Walk to Beach

Vacation Home in Fripp Island

10.0 out of 10, Exceptional, (4)
"Everything as distributed. Host was responsive and quickly helped out when we reached out."
United States
JARELL M.
The price is AED 679
AED 2,088 total
includes taxes & fees
29 Dec - 30 Dec
Relax and Unwind at 709 Ocean Cottage – Golf Cart and Resort Access Included!

Vacation Home in Fripp Island

3.5 star property
The price is AED 873
AED 2,028 total
includes taxes & fees
2 Dec - 3 Dec
709 Ocean Cottage

Vacation Home in Old Town Bluffton

9.2 out of 10, Wonderful, (23)
"Definitely stay here!"
United States
Gregory T.
The price is AED 2,133
AED 3,594 total
includes taxes & fees
31 Dec - 1 January 2026
Historic Old Town + Modern 4 BR Retreat + Fire Pit

Vacation Home in Mid Island

9.6 out of 10, Exceptional, (90)
"We were looking for a place to stay on our honeymoon and this spot was perfect! We were able to go to the beach every day without worrying about parking, but we were still able to explore all aspects of the island. Would definitely come back!"
United States
Brooke B.
The price is AED 253
AED 921 total
includes taxes & fees
25 Dec - 26 Dec
Beach. View. Suite. 1 br. 1 ba. Sleeps 5

Vacation Home in Bluffton

10.0 out of 10, Exceptional, (20)
"The property was very spacious and centrally located. Would stay again."
United States
Lynne
The price is AED 716
AED 1,273 total
includes taxes & fees
1 Dec - 2 Dec
Bluffton Retreat, Pet Friendly
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Black Friday Sale

Limited-time deals: Save up to 50% on select hotels
Save an average of 15% on thousands of hotels when you're signed in

Top Ladys Island Hotel Reviews