A calm river with clear water, surrounded by dense trees and rocky banks.

Find hotels in O Brien, FL from AEDĀ 153

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Check prices for these dates

This weekend
26 Jun - 28 Jun
Next weekend
3 Jul - 5 Jul

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Star rating

Our top choices for O Brien hotels

Individually decorated, desk, laptop workspace, iron/ironing board

Days Inn by Wyndham Lake City I-10

Days Inn by Wyndham Lake City I-10
2.0 star property
Lake City
7.0 out of 10, Good, (1,003 reviews)
"Nice and restful place to stay"
United States
Frederick
The price is AEDĀ 231
AEDĀ 260 total
includes taxes & fees
30 Jun - 1 Jul
Days Inn by Wyndham Lake City I-10
Down comforters, pillowtop beds, blackout drapes, free WiFi

Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.4 out of 10, Good, (730 reviews)
"The room was clean, staff were very nice and the breakfast was outstanding."
United States
Michelle
The price is AEDĀ 240
AEDĀ 270 total
includes taxes & fees
20 Jul - 21 Jul
Super 8 by Wyndham Lake City
Exterior

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 star property
Alachua
9.4 out of 10, Exceptional, (1,001 reviews)
"The staff were amazing, great location, big rooms, great breakfast"
United States
Brittani
The price is AEDĀ 382
AEDĀ 430 total
includes taxes & fees
12 Jul - 13 Jul
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Suite, Multiple Beds, Accessible, Non Smoking | Pillowtop beds, desk, laptop workspace, iron/ironing board

Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,000 reviews)
"Great stay - easy - accommodating - quiet!"
United States
Paula
The price is AEDĀ 382
AEDĀ 430 total
includes taxes & fees
29 Jun - 30 Jun
Comfort Suites Lake City
Premium bedding, desk, blackout drapes, soundproofing

Palms Garden Inn

Palms Garden Inn
2.0 star property
Lake City
7.6 out of 10, Good, (626 reviews)
"REALLY NICE PLACE, VERY CLEAN, WONDERFUL STAFF"
United States
Caroline
The price is AEDĀ 239
AEDĀ 268 total
includes taxes & fees
30 Jun - 1 Jul
Palms Garden Inn
Breakfast area

Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
2.5 star property
Alachua
9.4 out of 10, Exceptional, (525 reviews)
"Wonderful place to stay"
United States
Tamela
The price is AEDĀ 389
AEDĀ 437 total
includes taxes & fees
1 Jul - 2 Jul
Hampton Inn & Suites Alachua I-75
Lobby sitting area

Motel 6 ā€“ Lake City, Fl ā€“ Medical Center

Motel 6 ā€“ Lake City, Fl ā€“ Medical Center
2.0 star property
Lake City
7.6 out of 10, Good, (196 reviews)
"Clean room hot water nice upgrades and friendly staff"
United States
Pennee
The price is AEDĀ 268
AEDĀ 302 total
includes taxes & fees
2 Jul - 3 Jul
Motel 6 ā€“ Lake City, Fl ā€“ Medical Center
Outdoor pool, open 9:00 AM to 10:00 PM, sun loungers

Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,000 reviews)
"Breakfast menu was fresh, the room was clean, and the staff friendly and professional."
United States
Claire
The price is AEDĀ 419
AEDĀ 471 total
includes taxes & fees
5 Jul - 6 Jul
Hampton Inn & Suites Lake City
BBQ/picnic area

Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.6 out of 10, Excellent, (1,000 reviews)
"We stopped for one night. We have stayed here before when visiting. The staff is always helpful and accommodating ."
United States
William
The price is AEDĀ 261
AEDĀ 294 total
includes taxes & fees
28 Jun - 29 Jun
Americas Best Value Inn Lake City
Pillowtop beds, desk, iron/ironing board, free WiFi

Quality Inn Lake City

Quality Inn Lake City
2.5 star property
Lake City
8.0 out of 10, Very Good, (1,003 reviews)
"It was clean and comfortable bed !"
United States
Glenda
The price is AEDĀ 266
AEDĀ 299 total
includes taxes & fees
21 Jul - 22 Jul
Quality Inn Lake City
Pillowtop beds, in-room safe, desk, blackout drapes

Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
2.0 star property
Lake City
7.6 out of 10, Good, (1,000 reviews)
"Great for a short stay and clean"
United States
Brizheet
The price is AEDĀ 247
AEDĀ 277 total
includes taxes & fees
1 Jul - 2 Jul
Days Inn by Wyndham Lake City I-75
Exterior

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
3.0 star property
Lake City
8.6 out of 10, Excellent, (1,130 reviews)
"Enjoyed our stay"
United States
Tammie
The price is AEDĀ 347
AEDĀ 391 total
includes taxes & fees
29 Jun - 30 Jun
La Quinta Inn & Suite by Wyndham Lake City
Lobby

Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,062 reviews)
"The location was great have many restaurants around, and the staff was very friendly"
United States
Carla
The price is AEDĀ 338
AEDĀ 380 total
includes taxes & fees
29 Jun - 30 Jun
Best Western Plus Lake City
Lobby

Econo Lodge Live Oak

Econo Lodge Live Oak
2.0 star property
Live Oak
7.0 out of 10, Good, (309 reviews)
"The room was fairly cheap and staff was friendly."
United States
James
The price is AEDĀ 283
AEDĀ 311 total
includes taxes & fees
28 Jun - 29 Jun
Econo Lodge Live Oak
Outdoor spa tub

Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75
2.5 star property
Lake City
5.0 out of 10, (1,001 reviews)
"Desk & housekeeping staff were super helpful & friendly!"
United States
Cameron
The price is AEDĀ 212
AEDĀ 239 total
includes taxes & fees
29 Jun - 30 Jun
Baymont by Wyndham Lake City I-75
Desk, blackout drapes, iron/ironing board, rollaway beds

Americas Best Value Inn Alachua

Americas Best Value Inn Alachua
2.0 star property
Alachua
5.0 out of 10, (629 reviews)
"It was a place to stay"
United States
Jennifer
Americas Best Value Inn Alachua
Indoor pool

Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
3.0 star property
Lake City
9.0 out of 10, Wonderful, (246 reviews)
"Great place..great breakfast"
United States
Michelle
The price is AEDĀ 437
AEDĀ 492 total
includes taxes & fees
2 Jul - 3 Jul
Fairfield Inn & Suites Lake City
Snack bar

Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1,000 reviews)
"Clean helpful staff and breakfast was good.parking good also"
United States
John
The price is AEDĀ 400
AEDĀ 450 total
includes taxes & fees
5 Jul - 6 Jul
Tru by Hilton Lake City
Reception

The Blanche

The Blanche
2.0 star property
Lake City
9.4 out of 10, Exceptional, (194 reviews)
"Great property! Beautiful renovated!"
United States
Brandi
The price is AEDĀ 472
AEDĀ 530 total
includes taxes & fees
30 Jun - 1 Jul
The Blanche
Lobby

Regal Inn

Regal Inn
2.5 star property
Lake City
8.4 out of 10, Very Good, (605 reviews)
"Surprisingly well maintained and clean for the price. Lady at the front desk was kind and sweet."
United States
Johnny
The price is AEDĀ 228
AEDĀ 256 total
includes taxes & fees
28 Jun - 29 Jun
Regal Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida

Top O Brien Hotel Reviews

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

8/10 Good
"Clean room."
Thomas 1-night trip
Posted 2 hours ago
La Quinta Inn & Suite by Wyndham Lake City

More cheap stays in O Brien

Baymont by Wyndham Lake City I-75

Baymont by Wyndham Lake City I-75

3598 W Us Highway 90 Lake City FL
The price is AEDĀ 212 per night from Jun 29 to Jun 30
AEDĀ 212
AEDĀ 239 total
29 Jun - 30 Jun
includes taxes & fees
5/10 (1,001 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?
La Quinta Inn & Suite by Wyndham Lake City, located 18.2 mi (29.3 km) from the heart of O Brien, is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy. See all available top hotels, or vacation rentals in O Brien.
What's the top vacation rental in O Brien?
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: Visitors give good reviews to this O Brien vacation home rental, which is located on the beach and has a balcony, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. Our travelers also rate MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY as a favorite home for rent in O Brien. See all vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
Where can I learn more about changing or cancelling my trip to O Brien?
To access more information about picking new dates or cancelling your trip to O Brien, click here.
Where is the best hotel to stay near Ichetucknee Springs State Park?
Escape to Nature - 2 miles from Ichetucknee park is one of the top choices for your stay based on our traveler data, and this property features in-room kitchens and fireplaces. It's located 2.3 mi (3.8 km) from Ichetucknee Springs State Park. Another good choice is A Riverview of a Magical Sunrise every morning, located 5.6 mi (9.1 km) away.
What are some accommodations with pools in O Brien?
La Quinta Inn & Suite by Wyndham Lake City: Features on-the-go, an indoor pool, and free self parking. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and Little River Spring Cave divers poolside Hideaway are two additional hotels that feature an onsite pool. View all hotels with pools in O Brien.
What's the best hotel for staying near Gainesville Regional Airport (GNV)?
Hampton Inn & Suites Gainesville Downtown is one of the top choices for your stay and is a popular hotel, featuring free breakfast and an outdoor pool. It's located 3.7 mi (6 km) from Gainesville Regional Airport. Other good choices close to the airport include Sweetwater Branch Inn and Travelers Inn.
How is it to stay in O Brien?
Visitors to O Brien are sure to find plenty to explore and enjoy. In O Brien, there are 10 hotels and other accommodations to choose from. Find out more about O Brien.
What should I see while I'm in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River, and Ichetucknee Springs State Park. You'll also find Wes Skiles Peacock Springs State Park and First Federal Sportsplex in the area. Check out what more to see and do in Expedia's O Brien guide.
What's the seasonal weather like in O Brien?
The hottest months are usually July and August with an average temp of 80Ā°F, while the coldest months are January and February with an average of 58Ā°F. Average annual precipitation for O Brien is 50 inches.