Top 10 Hotels in O Brien, FL from AED 239 - Competitive Prices

A calm river with clear water, surrounded by dense trees and rocky banks.

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Go beyond your typical stay in O Brien

Pet friendly

Apartment

Pool

Cottage

Cabin

Family friendly

Waterpark

Condo

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Our top choices for O Brien hotels

Outdoor pool, open 9:00 AM to 10:00 PM, sun loungers

1. Hampton Inn & Suites Lake City

Lake City

James

AED 368

AED 414 total

includes taxes & fees

27 Sep - 28 Sep

Premium bedding, pillowtop beds, desk, laptop workspace

2. Best Western Plus Lake City

Lake City

Gerri

AED 300

AED 338 total

includes taxes & fees

28 Sep - 29 Sep

Suite, Multiple Beds, Accessible, Non Smoking | Pillowtop beds, desk, laptop workspace, iron/ironing board

3. Comfort Suites Lake City

Lake City

Carma

AED 342

AED 385 total

includes taxes & fees

6 Oct - 7 Oct

4. Tru by Hilton Lake City

Lake City

Carolina

AED 356

AED 401 total

includes taxes & fees

4 Oct - 5 Oct

Studio Suite, 1 King Bed, Non Smoking | Living area | LCD TV

Suite, 1 Bedroom, Non Smoking | Private kitchen | Coffee/tea maker, fridge, microwave, dishwasher

5. Home2 Suites by Hilton Lake City

Lake City

William

AED 385

AED 433 total

includes taxes & fees

27 Sep - 28 Sep

Desk, laptop workspace, blackout drapes, iron/ironing board

6. La Quinta Inn & Suite by Wyndham Lake City

Lake City

Peggy

AED 331

AED 372 total

includes taxes & fees

28 Sep - 29 Sep

Standard Room, 2 Double Beds, Non Smoking | Pillowtop beds, desk, iron/ironing board, WiFi (free)

7. Quality Inn Lake City

Lake City

Justin

AED 283

AED 318 total

includes taxes & fees

27 Sep - 28 Sep

8. Fairfield Inn & Suites Lake City

Lake City

Jordan

AED 345

AED 389 total

includes taxes & fees

4 Oct - 5 Oct

Down comforters, pillowtop beds, blackout drapes, WiFi (free)

9. Super 8 by Wyndham Lake City

Lake City

Scott

AED 240

AED 270 total

includes taxes & fees

4 Oct - 5 Oct

10. Americas Best Value Inn Lake City

Lake City

Larissa

AED 237

AED 267 total

includes taxes & fees

27 Sep - 28 Sep

3 outdoor pools, open 10:00 AM to 10:00 PM, sun loungers

Basic Tent | WiFi (free), individually decorated, individually furnished, bed sheets

Classic Cabin, Resort View | Terrace/patio

Basic House, 2 Bedrooms, Patio, River View | Terrace/patio

11. Suwannee River Rendezvous

Mayo

Beth

AED 331

AED 443 total

includes taxes & fees

26 Sep - 27 Sep

Desk, blackout drapes, iron/ironing board, cribs (free)

12. Holiday Inn & Suites Lake City by IHG

Lake City

C.jeffery

AED 371

AED 417 total

includes taxes & fees

28 Sep - 29 Sep

Camper with Kitchenette & Queen Size Bed | Private kitchen | Coffee/tea maker, microwave

Desk, laptop workspace, blackout drapes, iron/ironing board (on request)

Single Room | Desk, laptop workspace, blackout drapes, iron/ironing board (on request)

13. Cindys Motel

Mayo

Diane

AED 313

AED 338 total

includes taxes & fees

26 Oct - 27 Oct

14. Quality Inn White Springs Suwanee

White Springs

Pennee

AED 237

AED 261 total

includes taxes & fees

27 Sep - 28 Sep

Pillowtop beds, in-room safe, desk, blackout drapes

15. Days Inn by Wyndham Lake City I-75

Lake City

Wilberd

AED 232

AED 261 total

includes taxes & fees

27 Sep - 28 Sep

16. TownePlace Suites by Marriott Lake City

Lake City

Jennifer

AED 437

AED 492 total

includes taxes & fees

27 Sep - 28 Sep

17. Holiday Inn Express & Suites Live Oak by IHG

Live Oak

Tammy

AED 433

AED 477 total

includes taxes & fees

18 Oct - 19 Oct

18. Suwannee River Retreat: Pet Friendly, Private Dock

Branford

AED 1,183

AED 2,227 total

includes taxes & fees

28 Sep - 29 Sep

Room, 2 Double Beds, Accessible, Non Smoking | WiFi (free), bed sheets

Room, 2 Double Beds, Accessible, Smoking | WiFi (free), bed sheets

19. Econo Lodge Live Oak

Live Oak

James

AED 269

AED 296 total

includes taxes & fees

28 Sep - 29 Sep

Premium bedding, desk, laptop workspace, blackout drapes

20. Courtyard By Marriott Lake City

Lake City

Angel

AED 393

AED 443 total

includes taxes & fees

11 Oct - 12 Oct

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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien

A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

Americas Best Value Inn Lake City

10/10 Excellent

"Im a truck driver and when I can I stop here to have some rest. Everything is clean and the bes are amazing to have a food sleep"

Quality Inn Lake City

8/10 Good

"We enjoyed chatting with the lady who checked us in. The room was very nice and quiet. The bathroom needed some maintenance. The fan didn’t work in the bathroom. The toilet lid needed replacing. There should have been a nonslip mat for the tub or a non slip surface. I didn’t feel safe. The towels were thin from frequent washing. We were happy to find a Gideon Bible to read. The breakfast was substantial and tasty. The eating area was very tidy and clean."

BlueGem Motel

10/10 Excellent

"N/a"

Tru by Hilton Lake City

10/10 Excellent

"Great stay, very comfy and great staff"

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

8/10 Good

"Lugar muy lindo y acogedor pura naturaleza y mucha paz todo era muy limpio y con muy buena atención"

Courtyard By Marriott Lake City

10/10 Excellent

"Wonderful place, clean and conform beds."

Days Inn by Wyndham Lake City I-10

8/10 Good

"Clean and convenient"

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

10/10 Excellent

"Great for my sons and grandsons to play for a long weekend. Lots of room and games inside and huge yard to play in. Ideal if you have a boat to enjoy the river."

Baymont by Wyndham Lake City I-75

8/10 Good

"For the money, no complaints. Staff was very courteous"

More cheap stays in O Brien

Baymont by Wyndham Lake City I-75

3598 W Us Highway 90 Lake City FL

AED 212

AED 239 total

27 Sep - 28 Sep

includes taxes & fees

5/10 (1,000 reviews)

Quality Inn Lake City

285 Sw Commerce Dr Lake City FL

AED 283

AED 318 total

27 Sep - 28 Sep

includes taxes & fees

8.2/10 Very Good! (1,003 reviews)

Best Western Plus Lake City

350 SW Florida Gateway Dr Lake City FL

AED 300

AED 338 total

28 Sep - 29 Sep

includes taxes & fees

Comfort Suites Lake City

3690 W Us Highway 90 Lake City FL

AED 342

AED 385 total

6 Oct - 7 Oct

includes taxes & fees

Tru by Hilton Lake City

284 NW Centurion Court Lake City FL

AED 356

AED 401 total

4 Oct - 5 Oct

includes taxes & fees

9.2/10 Wonderful! (1,000 reviews)

Holiday Inn Express & Suites Live Oak by IHG

6694 Us Highway 129 Live Oak FL

AED 433

AED 477 total

18 Oct - 19 Oct

includes taxes & fees

Frequently asked questions

Where is the best place to stay in O Brien?

La Quinta Inn & Suite by Wyndham Lake City, located 18.2 mi (29.3 km) from the heart of O Brien, is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy. See all available top hotels, or vacation rentals in O Brien.

What's the top vacation rental in O Brien?

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: Visitors give good reviews to this O Brien vacation home rental, which is located on the beach and has a balcony, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. Our travelers also rate MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY as a favorite home for rent in O Brien. See all vacation rentals in O Brien.

If I need to cancel my hotel reservation in O Brien, will I receive a refund?

Yes! You'll find that most hotel reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.

Where can I learn more about changing or cancelling my trip to O Brien?

To access more information about picking new dates or cancelling your trip to O Brien, click here.

Where is the best hotel to stay near Ichetucknee Springs State Park?

Escape to Nature - 2 miles from Ichetucknee park is one of the top choices for your stay based on our traveler data, and this property features in-room kitchens and fireplaces. It's located 2.3 mi (3.8 km) from Ichetucknee Springs State Park. Another good choice is A Riverview of a Magical Sunrise every morning, located 5.6 mi (9.1 km) away.

What are some accommodations with pools in O Brien?

La Quinta Inn & Suite by Wyndham Lake City: Provides buffet, an indoor pool, and free self parking. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and Holiday Inn Express & Suites Alachua - Gainesville Area by IHG are two additional hotels that feature an onsite pool. View all hotels with pools in O Brien.

What's the best hotel for staying near Gainesville Regional Airport (GNV)?

Hampton Inn & Suites Gainesville Downtown is one of the top choices for your stay and is a popular hotel, featuring free breakfast and an outdoor pool. It's located 3.7 mi (6 km) from Gainesville Regional Airport. Other good choices close to the airport include Sweetwater Branch Inn and Travelers Inn.

How is it to stay in O Brien?

Visitors to O Brien are sure to find plenty to explore and enjoy. In O Brien, there are 9 hotels and other accommodations to choose from. Find out more about O Brien.

What should I see while I'm in O Brien?

Natural beauty is on display at Suwannee River, Ichetucknee River, and Ichetucknee Springs State Park. You'll also find Troy Spring State Park and Lake City Mall in the area. Check out what more to see and do in Expedia's O Brien guide.

What's the seasonal weather like in O Brien?

The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 58°F. Average annual precipitation for O Brien is 50 inches.

Find hotels in O Brien, FL from AED 239

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in O Brien

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for O Brien hotels

1. Hampton Inn & Suites Lake City

2. Best Western Plus Lake City

3. Comfort Suites Lake City

4. Tru by Hilton Lake City

5. Home2 Suites by Hilton Lake City

6. La Quinta Inn & Suite by Wyndham Lake City

7. Quality Inn Lake City

8. Fairfield Inn & Suites Lake City

9. Super 8 by Wyndham Lake City

10. Americas Best Value Inn Lake City

11. Suwannee River Rendezvous

12. Holiday Inn & Suites Lake City by IHG

13. Cindys Motel

14. Quality Inn White Springs Suwanee

15. Days Inn by Wyndham Lake City I-75

16. TownePlace Suites by Marriott Lake City

17. Holiday Inn Express & Suites Live Oak by IHG

18. Suwannee River Retreat: Pet Friendly, Private Dock

19. Econo Lodge Live Oak

20. Courtyard By Marriott Lake City

Learn more about O Brien

Top O Brien Hotel Reviews

Americas Best Value Inn Lake City

Quality Inn Lake City

BlueGem Motel

Tru by Hilton Lake City

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Courtyard By Marriott Lake City

Days Inn by Wyndham Lake City I-10

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

Baymont by Wyndham Lake City I-75

More cheap stays in O Brien

Baymont by Wyndham Lake City I-75

Quality Inn Lake City

Best Western Plus Lake City

Comfort Suites Lake City

Tru by Hilton Lake City

Holiday Inn Express & Suites Live Oak by IHG

Frequently asked questions

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