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7 Feb - 8 Feb
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8 Feb - 9 Feb
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13 Feb - 15 Feb
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Our top choices for O Brien hotels

Exterior

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
3.5 star property
Alachua
9.4 out of 10, Exceptional, (1,000 reviews)
  • cleanliness
    Relaxing retreat near Gainesville with pool, hot tub, and free breakfast.
"Staff and hotel were wonderful!"
United States
Sandra
The price is AED 397
AED 446 total
includes taxes & fees
22 Feb - 23 Feb
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Exterior

Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (199 reviews)
  • cleanliness
    Visit Lake City with a tranquil pool and modern amenities at this business hotel.
"Nice and clean. Friendly staff."
United States
Jennifer
The price is AED 393
AED 442 total
includes taxes & fees
15 Feb - 16 Feb
Courtyard By Marriott Lake City
3 outdoor pools, open 10:00 AM to 10:00 PM, sun loungers

Suwannee River Rendezvous

Suwannee River Rendezvous
2.5 star property
Mayo
8.8 out of 10, Excellent, (22 reviews)
  • cleanliness
    Serene riverside resort with 3 outdoor pools for a refreshing Florida retreat.
"Awesome place to stay, beautiful location and great accommodations. Friendly staff and lots to do!"
United States
Lauren
The price is AED 99
AED 159 total
includes taxes & fees
8 Feb - 9 Feb
Suwannee River Rendezvous
Terrace/patio

Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
3.0 star property
Lake City
9.4 out of 10, Exceptional, (759 reviews)
  • cleanliness
    Restful retreat in Lake City with outdoor pool and modern fitness center.
"This is an excellent hotel while you roadtrip:)"
United States
Desiree Moreno
The price is AED 450
AED 506 total
includes taxes & fees
15 Feb - 16 Feb
Home2 Suites by Hilton Lake City
Exterior

Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
3.0 star property
Lake City
8.6 out of 10, Excellent, (1,001 reviews)
  • cleanliness
    Lakefront getaway with indoor pool, dining, and fitness options near city attractions.
"Great place"
United States
John
The price is AED 360
AED 405 total
includes taxes & fees
15 Feb - 16 Feb
Holiday Inn & Suites Lake City by IHG
Lobby

Regal Inn

Regal Inn
2.5 star property
Lake City
8.6 out of 10, Excellent, (558 reviews)
  • cleanliness
    Convenient Lake City hotel offers easy access to Regal UA Cinema 90 and Mall.
"Friendly staff, clean rooms, convenient location"
United States
Keith
The price is AED 228
AED 256 total
includes taxes & fees
9 Feb - 10 Feb
Regal Inn
Individually decorated, desk, laptop workspace, blackout drapes

Cindys Motel

Cindys Motel
2.5 star property
Mayo
8.8 out of 10, Excellent, (129 reviews)
  • cleanliness
    Enjoy the quiet comfort of this well-maintained motel in Mayo with free parking.
"Easy parking next to your door and easy check in.beds are comfy and as a single parent traveler i felt safe"
United States
Diane
Cindys Motel
Breakfast area

Hampton Inn & Suites Alachua I-75

Hampton Inn & Suites Alachua I-75
2.5 star property
Alachua
9.4 out of 10, Exceptional, (484 reviews)
  • cleanliness
    Enjoy comfortable stays near Alachua Sports Complex with pool and fitness access.
"We visited family in the area and stayed here, hotel was clean, quiet, staff was great and room was so comfortable and spacious for our family of 5. Will definitely stay again!"
United States
Libbi
The price is AED 383
AED 430 total
includes taxes & fees
15 Feb - 16 Feb
Hampton Inn & Suites Alachua I-75
Suite, Multiple Beds, Accessible, Non Smoking | Pillowtop beds, desk, laptop workspace, iron/ironing board

Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.6 out of 10, Exceptional, (1,002 reviews)
  • cleanliness
    Modern hotel near Lake City attractions with a welcoming outdoor pool.
"The staff is great"
United States
Tana
The price is AED 428
AED 482 total
includes taxes & fees
22 Feb - 23 Feb
Comfort Suites Lake City
Free daily on-the-go breakfast

Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1,001 reviews)
  • cleanliness
    Contemporary Lake City hotel offers an outdoor pool and fitness center experience.
"Clean and staff was very kind "
United States
Rosemary
The price is AED 392
AED 441 total
includes taxes & fees
22 Feb - 23 Feb
Tru by Hilton Lake City
Property amenity

TownePlace Suites by Marriott Lake City

TownePlace Suites by Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (125 reviews)
  • cleanliness
    Modern stay with outdoor pool near Gainesville and Lake City attractions.
"Good hotel"
United States
Frank
The price is AED 621
AED 698 total
includes taxes & fees
22 Feb - 23 Feb
TownePlace Suites by Marriott Lake City
Free WiFi, bed sheets

Gateway Inn

Gateway Inn
2.5 star property
Lake City
7.8 out of 10, Good, (142 reviews)
  • cleanliness
    Discover Gateway Inn in Lake City with free amenities and daily housekeeping.
"Always enjoy our stay "
United States
Teresa
Gateway Inn
Lobby

Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (193 reviews)
  • cleanliness
    Relax and rejuvenate at this Lake City hotel with indoor pool and friendly staff.
"Friendly staff, convenient location, clean rooms, excellent breakfast"
United States
Keith
The price is AED 393
AED 442 total
includes taxes & fees
15 Feb - 16 Feb
Fairfield Inn & Suites Lake City
Exterior

La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
2.5 star property
Lake City
8.8 out of 10, Excellent, (1,069 reviews)
  • cleanliness
    Modern rooms with a serene indoor pool in the heart of Lake City, Florida.
"Excellent place to stay."
United States
Donovan
The price is AED 383
AED 431 total
includes taxes & fees
8 Feb - 9 Feb
La Quinta Inn & Suite by Wyndham Lake City
Lobby

Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,049 reviews)
  • cleanliness
    Step into stylish comfort at this Best Western Plus Lake City, close to cinemas and mall.
"Great place to stay"
United States
Jack
The price is AED 366
AED 412 total
includes taxes & fees
8 Feb - 9 Feb
Best Western Plus Lake City
Lobby

Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.8 out of 10, Excellent, (1,004 reviews)
  • cleanliness
    Enjoy a refreshing stay in Lake City with free perks and a cooling outdoor pool.
"Nice quiet and comfortable hotel a little gem."
Canada
Tim
The price is AED 247
AED 277 total
includes taxes & fees
8 Feb - 9 Feb
Americas Best Value Inn Lake City
Outdoor pool, open 9:00 AM to 10:00 PM, sun loungers

Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,004 reviews)
  • cleanliness
    Enjoy Lake City with free breakfast, pool access, and nearby attractions.
"The room was very clean and comfortable. Excellent breakfast and staff was very friendly and helpful."
United States
Kenneth
The price is AED 437
AED 492 total
includes taxes & fees
8 Feb - 9 Feb
Hampton Inn & Suites Lake City
Pillowtop beds, desk, iron/ironing board, free WiFi

Quality Inn Lake City

Quality Inn Lake City
2.5 star property
Lake City
8.0 out of 10, Very Good, (977 reviews)
  • cleanliness
    Discover Lake City's clean, convenient lodging with outdoor pool and fitness center.
"Staff were great and room was clean and comfortable "
Canada
Ethan
The price is AED 312
AED 351 total
includes taxes & fees
8 Mar - 9 Mar
Quality Inn Lake City
Free WiFi, bed sheets

Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center
2.0 star property
Lake City
8.2 out of 10, Very Good, (106 reviews)
  • cleanliness
    Modern Lake City motel near medical center with free WiFi and parking.
"Dog friendly and price."
United States
John
The price is AED 221
AED 249 total
includes taxes & fees
5 Mar - 6 Mar
Motel 6 – Lake City, Fl – Medical Center
Coffee service

Driftwood Inn

Driftwood Inn
2.0 star property
Lake City
7.8 out of 10, Good, (769 reviews)
  • cleanliness
    Lake City hotel with clean rooms near Regal UA Cinema and mall for a relaxing stay.
"Room was great and bed was very comfortable. Price was wonderful. "
United States
Brittani
Driftwood Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien
kayakers at Rock Bluff Spring on the Suwanneee River, Gilchrist County, Florida

Top O Brien Hotel Reviews

Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City

10/10 Excellent
"Clean room and friendly staff"
Regina 1-night trip
Posted 3 days ago
Home2 Suites by Hilton Lake City

More cheap stays in O Brien

Motel 6 – Lake City, Fl – Medical Center

Motel 6 – Lake City, Fl – Medical Center

3340 W US Highway 90 Lake City FL
The price is AED 221 per night from Mar 5 to Mar 6
AED 221
AED 249 total
5 Mar - 6 Mar
includes taxes & fees
8/10 Very Good! (106 reviews)

Frequently asked questions

Where is the best place to stay in O Brien?
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG, located 29.9 mi (48.2 km) from the heart of O Brien, is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are La Quinta Inn & Suite by Wyndham Lake City and Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy. See all available top hotels, or vacation rentals in O Brien.
What's the top vacation rental in O Brien?
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: Visitors like this O Brien vacation home rental. It is located on the beach and has a balcony, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. See all vacation rentals in O Brien.
If I need to cancel my hotel reservation in O Brien, will I receive a refund?
Yes! You'll find that most hotel reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.
Where can I learn more about changing or cancelling my trip to O Brien?
To access more information about picking new dates or cancelling your trip to O Brien, click here.
Where is the best hotel to stay near Ichetucknee Springs State Park?
Escape to Nature - 2 miles from Ichetucknee park is one of the top choices for your stay based on our traveler data, and this property features in-room kitchens and fireplaces. It's located 2.3 mi (3.8 km) from Ichetucknee Springs State Park. Another good choice is A Riverview of a Magical Sunrise every morning, located 5.6 mi (9.1 km) away.
What are some accommodations with pools in O Brien?
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG: Offers buffet, an outdoor pool, and complimentary wired internet access. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and La Quinta Inn & Suite by Wyndham Lake City are two additional hotels that feature an onsite pool. View all hotels with pools in O Brien.
What's the best hotel for staying near Gainesville Regional Airport (GNV)?
Hampton Inn & Suites Gainesville Downtown is one of the top choices for your stay and is a popular hotel, featuring free breakfast and an outdoor pool. It's located 3.7 mi (6 km) from Gainesville Regional Airport. Other good choices close to the airport include Sweetwater Branch Inn and Travelers Inn.
How is it to stay in O Brien?
Visitors to O Brien are sure to find plenty to explore and enjoy. In O Brien, there are 11 hotels and other accommodations to choose from. Find out more about O Brien.
What should I see while I'm in O Brien?
Natural beauty is on display at Suwannee River, Ichetucknee River, and Ichetucknee Springs State Park. You'll also find Troy Spring State Park and Wes Skiles Peacock Springs State Park in the area. Check out what more to see and do in Expedia's O Brien guide.
What's the seasonal weather like in O Brien?
The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 58°F. Average annual precipitation for O Brien is 50 inches.