Top 10 Hotels in O Brien, FL from AED 239 - Competitive Prices

A calm river with clear water, surrounded by dense trees and rocky banks.

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Cottage

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Our top choices for O Brien hotels

Suite, 2 Queen Beds, Non Smoking | In-room safe, desk, laptop workspace, WiFi

1. Hampton Inn & Suites Alachua I-75

Alachua

Jasmine

AED 389

AED 437 total

includes taxes & fees

17 Aug - 18 Aug

Standard Room, 2 Double Beds | Blackout drapes, WiFi (free), bed sheets

2. Royal Inn

Alachua

Alec

AED 238

AED 268 total

includes taxes & fees

13 Aug - 14 Aug

Suite, 2 Queen Beds (Walk-In Shower) | Premium bedding, down comforters, pillowtop beds, in-room safe

3. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Alachua

Blake

AED 320

AED 359 total

includes taxes & fees

30 Aug - 31 Aug

1 bedroom, laptop workspace, WiFi (free), bed sheets

40-inch Smart TV with digital channels, Netflix, streaming services

4. Vista Verde Farm Retreat

Lake City

Stacy

AED 418

AED 726 total

includes taxes & fees

12 Aug - 13 Aug

5. BlueGem Motel

High Springs

REINIER

AED 441

AED 496 total

includes taxes & fees

11 Aug - 12 Aug

Double Room, Non Smoking | Laptop workspace, WiFi (free)

Single Room, Non Smoking | Laptop workspace, WiFi (free)

6. High Springs Country Inn

High Springs

Antonio

AED 231

AED 260 total

includes taxes & fees

12 Aug - 13 Aug

Premium bedding, desk, blackout drapes, soundproofing

Studio, 1 King Bed | Bathroom | Combined shower/tub, free toiletries, hair dryer, towels

7. Palms Garden Inn

Lake City

Teresa

AED 239

AED 268 total

includes taxes & fees

11 Aug - 12 Aug

8. The Blanche

Lake City

Brandi

AED 529

AED 595 total

includes taxes & fees

11 Aug - 12 Aug

Desk, laptop workspace, iron/ironing board, cribs (free)

Studio Suite, Multiple Beds, Non Smoking | Desk, laptop workspace, iron/ironing board, cribs (free)

9. Days Inn by Wyndham Lake City I-10

Lake City

Serhii

AED 217

AED 245 total

includes taxes & fees

11 Aug - 12 Aug

Cabin, 1 Queen Bed (View) | Breakfast meal

Cabin, 1 Queen Bed | Private kitchen | Mini-fridge, stovetop, cookware/dishes/utensils, paper towels

10. Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

High Springs

Jakeline

AED 433

AED 800 total

includes taxes & fees

8 Sep - 9 Sep

Down comforters, pillowtop beds, blackout drapes, WiFi (free)

Outdoor pool, open 9:00 AM to 10:00 PM, sun loungers

11. Super 8 by Wyndham Lake City

Lake City

Mari

AED 240

AED 270 total

includes taxes & fees

12 Aug - 13 Aug

Basic 2 Queen Beds Non Smoking | Soundproofing, bed sheets

12. Driftwood Inn

Lake City

Dmitriy

AED 183

AED 206 total

includes taxes & fees

11 Aug - 12 Aug

Basic Single Room | Bathroom | Hair dryer, towels

Iron/ironing board, WiFi (free), bed sheets

13. Regal Inn

Lake City

Samuel

AED 216

AED 244 total

includes taxes & fees

11 Aug - 12 Aug

14. Courtyard By Marriott Lake City

Lake City

Tonya

AED 393

AED 443 total

includes taxes & fees

16 Aug - 17 Aug

15. Knights Inn Lake City

Lake City

Melissa

AED 189

AED 213 total

includes taxes & fees

23 Aug - 24 Aug

16. Holiday Inn & Suites Lake City by IHG

Lake City

Renee

AED 356

AED 401 total

includes taxes & fees

16 Aug - 17 Aug

Standard Room, 2 Double Beds, Non Smoking | Pillowtop beds, desk, iron/ironing board, WiFi (free)

17. Quality Inn Lake City

Lake City

Lucille

AED 269

AED 302 total

includes taxes & fees

7 Sep - 8 Sep

Desk, laptop workspace, blackout drapes, iron/ironing board

18. La Quinta Inn & Suite by Wyndham Lake City

Lake City

Priscilla J

AED 344

AED 387 total

includes taxes & fees

6 Sep - 7 Sep

Pillowtop beds, in-room safe, desk, blackout drapes

19. Days Inn by Wyndham Lake City I-75

Lake City

Brizheet

AED 232

AED 261 total

includes taxes & fees

11 Aug - 12 Aug

Blackout drapes, WiFi (free), bed sheets

20. Rodeway Inn Lake City I-75

Lake City

Norma

AED 215

AED 242 total

includes taxes & fees

16 Aug - 17 Aug

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Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

See all hotels in O Brien

A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

Comfort Suites Lake City

10/10 Excellent

"The rooms were clean, the staff were kind, and the breakfast had plenty of choices. We will definitely be staying here again."

La Quinta Inn & Suite by Wyndham Lake City

8/10 Good

"na"

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

10/10 Excellent

"It was a great place to stay. Best hotel experience in a long time."

Hampton Inn & Suites Alachua I-75

10/10 Excellent

"Conveniently located near I-75, with plenty of dining options nearby, this is a great place to stay when you’re just minutes away from your next outdoor adventure. The rooms are clean and comfortable, and the breakfast is a great way to fuel up and get ready for the road."

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

10/10 Excellent

"Everything worked great"

Holiday Inn Express & Suites Live Oak by IHG

10/10 Excellent

"The rate per night was reasonable, the breakfast was amazing, and unlimited free coffee was prefect, and the staff was very helpful and accommodating when we had an issue after the rain."

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

8/10 Good

"Christine was absolutely wonderful from beginning to end. She even came by to say hello on our first day. Very responsive. I do wish the river was closer and not quite a small walk because my in laws are elderly and couldn’t enjoy it. The walk to the river is quite tough, hard to get kayaks out to the water, It’s a very steep walk. The ac wouldn’t go any colder than 70. Only one television which is in the livingroom so that was rough. Kitchen and home Fully stocked with all the things we needed and the kids enjoyed the play room. Overall the home and the host was great for the price"

MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

10/10 Excellent

"A great get away for Labor Day weekend to do a little jet skiing with friends on the river and visiting all the local springs!"

More cheap stays in O Brien

Days Inn by Wyndham Lake City I-10

3430 N Us Highway 441 Lake City FL

AED 217

AED 245 total

11 Aug - 12 Aug

includes taxes & fees

Quality Inn Lake City

285 Sw Commerce Dr Lake City FL

AED 269

AED 302 total

7 Sep - 8 Sep

includes taxes & fees

Best Western Plus Lake City

350 SW Florida Gateway Dr Lake City FL

AED 301

AED 338 total

16 Aug - 17 Aug

includes taxes & fees

Comfort Suites Lake City

3690 W Us Highway 90 Lake City FL

AED 360

AED 405 total

18 Aug - 19 Aug

includes taxes & fees

9.4/10 Exceptional! (1,009 reviews)

Hampton Inn & Suites Alachua I-75

15930 Northwest 163rd Lane Alachua FL

AED 389

AED 437 total

17 Aug - 18 Aug

includes taxes & fees

9.4/10 Exceptional! (545 reviews)

Tru by Hilton Lake City

284 NW Centurion Court Lake City FL

AED 400

AED 450 total

16 Aug - 17 Aug

includes taxes & fees

Frequently asked questions

Where is the best place to stay in O Brien?

Best Western Plus Lake City, located 17.9 mi (28.8 km) from the heart of O Brien, is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and La Quinta Inn & Suite by Wyndham Lake City. See all available top hotels, or vacation rentals in O Brien.

What's the top vacation rental in O Brien?

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: Visitors like this O Brien vacation home rental. It is located on the beach and has a balcony, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. See all vacation rentals in O Brien.

If I need to cancel my hotel reservation in O Brien, will I receive a refund?

Yes! You'll find that most hotel reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.

Where can I learn more about changing or cancelling my trip to O Brien?

To access more information about picking new dates or cancelling your trip to O Brien, click here.

Where is the best hotel to stay near Ichetucknee Springs State Park?

Escape to Nature - 2 miles from Ichetucknee park is one of the top choices for your stay based on our traveler data, and this property features in-room kitchens and fireplaces. It's located 2.3 mi (3.8 km) from Ichetucknee Springs State Park. Another good choice is A Riverview of a Magical Sunrise every morning, located 5.6 mi (9.1 km) away.

What are some accommodations with pools in O Brien?

Best Western Plus Lake City: Features a snack bar/deli, an indoor pool, and buffet. Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks! and Holiday Inn Express & Suites Alachua - Gainesville Area by IHG are two additional hotels that feature an onsite pool. View all hotels with pools in O Brien.

What's the best hotel for staying near Gainesville Regional Airport (GNV)?

Hampton Inn & Suites Gainesville Downtown is one of the top choices for your stay and is a popular hotel, featuring free breakfast and an outdoor pool. It's located 3.7 mi (6 km) from Gainesville Regional Airport. Other good choices close to the airport include Sweetwater Branch Inn and Travelers Inn.

How is it to stay in O Brien?

Visitors to O Brien are sure to find plenty to explore and enjoy. In O Brien, there are 9 hotels and other accommodations to choose from. Find out more about O Brien.

What should I see while I'm in O Brien?

Natural beauty is on display at Suwannee River, Ichetucknee River, and Ichetucknee Springs State Park. You'll also find Troy Spring State Park and Wes Skiles Peacock Springs State Park in the area. Check out what more to see and do in Expedia's O Brien guide.

What's the seasonal weather like in O Brien?

The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 58°F. Average annual precipitation for O Brien is 50 inches.

Find hotels in O Brien, FL from AED 239

Change your mind

Treat yourself

Be picky

Go beyond your typical stay in O Brien

Check prices for these dates

Filter by

Star rating

Guest rating

Our top choices for O Brien hotels

1. Hampton Inn & Suites Alachua I-75

2. Royal Inn

3. Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

4. Vista Verde Farm Retreat

5. BlueGem Motel

6. High Springs Country Inn

7. Palms Garden Inn

8. The Blanche

9. Days Inn by Wyndham Lake City I-10

10. Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

11. Super 8 by Wyndham Lake City

12. Driftwood Inn

13. Regal Inn

14. Courtyard By Marriott Lake City

15. Knights Inn Lake City

16. Holiday Inn & Suites Lake City by IHG

17. Quality Inn Lake City

18. La Quinta Inn & Suite by Wyndham Lake City

19. Days Inn by Wyndham Lake City I-75

20. Rodeway Inn Lake City I-75

Learn more about O Brien

Top O Brien Hotel Reviews

Comfort Suites Lake City

La Quinta Inn & Suite by Wyndham Lake City

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Hampton Inn & Suites Alachua I-75

Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy

Holiday Inn Express & Suites Live Oak by IHG

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY

More cheap stays in O Brien

Days Inn by Wyndham Lake City I-10

Quality Inn Lake City

Best Western Plus Lake City

Comfort Suites Lake City

Hampton Inn & Suites Alachua I-75

Tru by Hilton Lake City

Frequently asked questions

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