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Find hotels in O Brien, FL from AED 204
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Compare 337 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
Holiday Inn Express & Suites Alachua - Gainesville Area by IHG
9.4 out of 10, Exceptional, (1004)
The price is AED 448
AED 504 total
includes taxes & fees
5 Nov - 6 Nov

La Quinta Inn & Suite by Wyndham Lake City
La Quinta Inn & Suite by Wyndham Lake City
8.8 out of 10, Excellent, (1006)
The price is AED 354
AED 398 total
includes taxes & fees
16 Nov - 17 Nov

Americas Best Value Inn Alachua
Americas Best Value Inn Alachua
4.8 out of 10, (592)
The price is AED 247
AED 277 total
includes taxes & fees
3 Nov - 4 Nov

Hampton Inn & Suites Alachua I-75
Hampton Inn & Suites Alachua I-75
9.4 out of 10, Exceptional, (464)
The price is AED 413
AED 464 total
includes taxes & fees
30 Nov - 1 Dec

Best Western Plus Lake City
Best Western Plus Lake City
9.2 out of 10, Wonderful, (1045)
The price is AED 305
AED 343 total
includes taxes & fees
9 Nov - 10 Nov

Courtyard By Marriott Lake City
Courtyard By Marriott Lake City
9.6 out of 10, Exceptional, (164)
The price is AED 393
AED 442 total
includes taxes & fees
16 Nov - 17 Nov
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Learn more about O Brien
Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

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Top O Brien Hotel Reviews

Motel 6 – Lake City, Fl – Medical Center
10/10 Excellent
More cheap stays in O Brien

Best Western Plus Lake City
350 SW Florida Gateway Dr, Lake City, FL
The price is AED 305 per night from Nov 9 to Nov 10
AED 305
AED 343 total
9 Nov - 10 Nov
includes taxes & fees
9/10 Wonderful! (1,042 reviews)
Hotels in O Brien with star-rating

3 Star Hotels
19 properties

2 Star Hotels
53 properties
Frequently asked questions
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Stay near popular O Brien attractions
- Hotels near Ichetucknee Springs State Park
- Hotels near Ginnie Spring
- Hotels near Ruth B. Kirby Gilchrist Blue Springs State Park
- Hotels near Ichetucknee River
- Hotels near Suwannee River State Park
- Hotels near Santa Fe River
- Hotels near Poe Springs Park
- Hotels near Florida Department of Transportation
- Hotels near Southside Sports Complex
- Hotels near Lake City Mall
- Hotels near Lake City Veterans Affairs Medical Center
- Hotels near O'Leno State Park
- Hotels near North Florida Speedway
- Hotels near Big Shoals State Park
- Hotels near Columbia County Courthouse
- Hotels near Wes Skiles Peacock Springs State Park
- Hotels near Southside Recreation Complex
- Hotels near Troy Spring State Park
- Hotels near Lafayette Blue Springs State Park
- Hotels near Epiphany Catholic Church
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