Find hotels in Otay Mesa, San Diego from AED 307

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

This weekend
Next weekend

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Otay Mesa hotels

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.2 out of 10, Very Good, (1,699 reviews)
"The location is great if you are crossing late from Tijuana to San Diego and you need to rest, the room is super clean, and very comfortable. "
United States
Rafael Moreno
The price is AED 441
AED 501 total
includes taxes & fees
26 Apr - 27 Apr
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.0 out of 10, Good, (1,000 reviews)
"The only hotel in otay mesa and overall the service was good"
United States
MARIA
The price is AED 379
AED 431 total
includes taxes & fees
3 May - 4 May
Quality Suites San Diego Otay Mesa

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,862 reviews)
"Staff is welcoming and so helpful. Room was very clean, spacious, and the bed was comfortable. The casino downstairs had 3 restaurants and 2 corner delis so getting food was not a problem. Will be coming back."
United States
Maria
The price is AED 518
AED 614 total
includes taxes & fees
28 Apr - 29 Apr
Sycuan Casino Resort

Days Inn by Wyndham San Diego-East/El Cajon

Days Inn by Wyndham San Diego-East/El Cajon
2.0 star property
27.3 km from Otay Mesa
7.6 out of 10, Good, (1,003 reviews)
"My room was perfect in every way. The complimentary breakfast was excellent, plenty of variety and quantity with nice seating. Day’s Inn has a great location for traveling on foot, bus or trolley to many locations. I will stay here again on my next trip. "
United States
Marla
The price is AED 340
AED 375 total
includes taxes & fees
26 Apr - 27 Apr
Days Inn by Wyndham San Diego-East/El Cajon

Courtyard by Marriott San Diego El Cajon

Courtyard by Marriott San Diego El Cajon
3.0 star property
26.3 km from Otay Mesa
9.2 out of 10, Wonderful, (1,000 reviews)
"Clean room, good food at the Bistro, excellent drinks at the bar. Wonderful service with everyone we came in contact with, especially the young man at the front desk who was working when we checked out at about noon today (12/14). Thank you!"
United States
Adriane
The price is AED 557
AED 614 total
includes taxes & fees
10 May - 11 May
Courtyard by Marriott San Diego El Cajon

Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego
2.5 star property
24.6 km from Otay Mesa
8.4 out of 10, Very Good, (1,001 reviews)
"The staff was so nice! Made request to stay more super easy!!! Good job!!!"
United States
Betsy
The price is AED 515
AED 567 total
includes taxes & fees
29 Apr - 30 Apr
Best Western Plus La Mesa San Diego

SpringHill Suites by Marriott Chula Vista Eastlake

SpringHill Suites by Marriott Chula Vista Eastlake
3.5 star property
10.5 km from Otay Mesa
9.6 out of 10, Exceptional, (631 reviews)
"This was the perfect stay for being in San Diego. It was just outside the city and we were able to stay at a cheaper price, super nice hotel, that had amazing amenities and a mall, restaurants, and more right next door. I'll stay here again! "
United States
Joshua
The price is AED 691
AED 761 total
includes taxes & fees
10 May - 11 May
SpringHill Suites by Marriott Chula Vista Eastlake

Lamplighter Inn & Suites at SDSU

Lamplighter Inn & Suites at SDSU
2.5 star property
24.4 km from Otay Mesa
9.0 out of 10, Wonderful, (1,406 reviews)
"This is a really nice motel. Grounds very clean, flowers are beautiful. Room much much bigger then I thought. Separate bedroom kitchenette living room area. We'll definitely stay here again.And actually, looking into staying for a month to get out of that Arizona heat. Close to attractions like the zoo. "
United States
DIANE
The price is AED 591
AED 666 total
includes taxes & fees
11 May - 12 May
Lamplighter Inn & Suites at SDSU

Best Western Chula Vista/Otay Valley Hotel

Best Western Chula Vista/Otay Valley Hotel
2.5 star property
7.1 km from Otay Mesa
8.0 out of 10, Very Good, (1,712 reviews)
"It was peaceful, clean, convenient and the staff was very friendly "
United States
Jennifer
The price is AED 403
AED 443 total
includes taxes & fees
10 May - 11 May
Best Western Chula Vista/Otay Valley Hotel

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,597 reviews)
"The room was nice and clean. The staff was very friendly. Our needs were met. As a landmark, they are located adjacent/behind Denny's. Google Maps sent us around through the back which was the long way."
United States
Rachel
The price is AED 372
AED 409 total
includes taxes & fees
10 May - 11 May
La Quinta Inn by Wyndham San Diego Chula Vista

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.2 out of 10, Very Good, (1,442 reviews)
"Front desk personnel were very friendly. Check process was smooth and fast. Breakfast was ok, the served Mexican "
United States
Mary
The price is AED 382
AED 420 total
includes taxes & fees
21 May - 22 May
Comfort Inn Chula Vista San Diego South

Studio 6 Suites San Ysidro, CA -San Diego South Bay

Studio 6 Suites San Ysidro, CA -San Diego South Bay
2.5 star property
6.9 km from Otay Mesa
8.0 out of 10, Very Good, (1,616 reviews)
"Clean room super convenient if crossing to Tijuana outlets down the street "
United States
Michael
The price is AED 283
AED 322 total
includes taxes & fees
26 Apr - 27 Apr
Studio 6 Suites San Ysidro, CA -San Diego South Bay

Hotel Palmeras Chula Vista

Hotel Palmeras Chula Vista
2.0 star property
14.4 km from Otay Mesa
7.2 out of 10, Good, (2,203 reviews)
"It's impossible to find a better place to stay at this low cost price. The staff was friendly and helpful. I highly recommend this place."
United States
Ivan
The price is AED 279
AED 307 total
includes taxes & fees
26 Apr - 27 Apr
Hotel Palmeras Chula Vista

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,104 reviews)
"Great hotel choice in Chulla Vista. It’s quiet, clean, variety in breakfast items, close driving distance to amenities, staff is attentive and friendly. Don’t look any further. Great hotel. : ) "
United States
Mayra
The price is AED 493
AED 543 total
includes taxes & fees
10 May - 11 May
Holiday Inn Express San Diego South - Chula Vista by IHG

Hercor Hotel - Urban Boutique

Hercor Hotel - Urban Boutique
3.0 star property
13.6 km from Otay Mesa
8.6 out of 10, Excellent, (1,425 reviews)
"My room was clean, staff members were friendly, parking was simple. Hotel is located super close to shuttle stop that takes you to the Gaylord Pacific Convention Center. I do recommend renting a car if you plan to visit nearby attractions. It’s easy to hop on the highway and get anywhere you want to go. The 7/11 store next door and nearby fast food joints were convenient. "
United States
Shantelle
The price is AED 391
AED 431 total
includes taxes & fees
27 Apr - 28 Apr
Hercor Hotel - Urban Boutique

Quality Inn San Diego I-5 Naval Base

Quality Inn San Diego I-5 Naval Base
2.5 star property
18.8 km from Otay Mesa
7.8 out of 10, Good, (927 reviews)
"Laura was the best. Super kind and helpful. Room was clean and great location to the zoo. "
United States
Katrina
The price is AED 356
AED 402 total
includes taxes & fees
19 May - 20 May
Quality Inn San Diego I-5 Naval Base

SureStay Hotel by Best Western Chula Vista San Diego Bay

SureStay Hotel by Best Western Chula Vista San Diego Bay
3.0 star property
14.7 km from Otay Mesa
8.0 out of 10, Very Good, (1,669 reviews)
"Room was fine, and pretty clean. The area is okay, too. Stayed for a couple of days during a busy week. The staff was very nice and friendly."
United States
kassandra
The price is AED 327
AED 361 total
includes taxes & fees
29 Apr - 30 Apr
SureStay Hotel by Best Western Chula Vista San Diego Bay

Berkshire Motor Hotel

Berkshire Motor Hotel
2.5 star property
North Park, 26.7 km from Otay Mesa
8.4 out of 10, Very Good, (1,002 reviews)
"Clean room. Quiet experience. Friendly staff. Lots of amenities in the surrounding area too. "
United States
Walter
The price is AED 347
AED 391 total
includes taxes & fees
29 Apr - 30 Apr
Berkshire Motor Hotel

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,264 reviews)
"This was a last minute booking for one night. The front desk staff was excellent. Very friendly and very accommodating. The hotel has plenty of parking (you will likely be able to park right in front of your room), the location is quiet and really close to the border (if you're using CBX), the room was very clean and had all the AC and tv channels you would expect. "
United States
Josefina
The price is AED 449
AED 511 total
includes taxes & fees
28 Apr - 29 Apr
Best Western Americana Inn

The Rambler Hotel

The Rambler Hotel
3.0 star property
14.8 km from Otay Mesa
9.0 out of 10, Wonderful, (2,118 reviews)
"Any time I visit San Diego this is my stay location. I really like the cool summer vibe of the building and the rooms. The staff as always are very friendly and welcoming. Love this place. Thank you"
United States
George
The price is AED 389
AED 450 total
includes taxes & fees
27 Apr - 28 Apr
The Rambler Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most.

Downtown San Diego

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Pacific Beach

Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

Mission Beach

Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

Ocean Beach

Ocean Beach is known for its stunning beaches, and with sights like Dog Beach and Sunset Cliffs Natural Park, you won't get bored spending a day wandering around this part of San Diego.

Top Otay Mesa Hotel Reviews

Find out more about Otay Mesa

Top reasons to visit Otay Mesa

  • Family-Friendly Attractions: Otay Mesa offers a range of activities perfect for families, including shopping centers, theaters, and a water park.
  • Vibrant Cultural Events: Exciting events like Comic-Con and various local festivals create a lively atmosphere for visitors.
  • Diverse Outdoor Activities: Nearby Mission Bay provides scenic views and opportunities for outdoor adventures.
  • Convenient Shopping and Dining: The Otay Town Center Mall features a variety of shopping and dining options for all tastes.
  • Variety of Accommodations: Otay Mesa offers diverse lodging options, catering to families, couples, and budget travelers.

Find great hotels near Otay Mesa

Otay Mesa offers a diverse selection of accommodations, catering to various preferences and budgets. From comfortable hotels to charming guesthouses, you'll find options that are perfect for pet owners, business travelers, and families alike. Whether you're seeking the best-rated hotels, affordable stays, or reviews to guide your choice, Otay Mesa has something to make your visit enjoyable and memorable.

  • Best Western Plus Marina Gateway Hotel: This welcoming hotel is perfect for families and pet lovers seeking a memorable vacation experience. Situated 17.7km from Otay Mesa, the Best Western Plus Marina Gateway Hotel offers a delightful blend of comfort and inclusivity, proudly catering to LGBTQIA travelers. Families will appreciate the child-friendly amenities, including a mini-golf course, children's pool, and free cribs. Additionally, the hotel’s pet policy allows for dogs onsite, ensuring that your furry friends are part of your getaway.
  • Ramada by Wyndham San Diego National City: Ideal for business travelers and adventure seekers, the Ramada by Wyndham San Diego National City is located 17.7km from Otay Mesa. This 3-star hotel boasts a variety of recreation options that include nearby boat tours, surfing, and hiking, making it a fantastic choice for those looking to blend work with play. Families will find conveniences like free cribs, ensuring a comfortable stay for younger guests. Enjoy a balanced mix of relaxation and excitement at this versatile property.
  • Hard Rock Hotel San Diego: Located 24.1km from Otay Mesa, the Hard Rock Hotel San Diego offers a vibrant atmosphere for adventure enthusiasts and LGBTQIA travelers alike. This 4-star hotel is renowned for its exciting recreation opportunities, including nearby water sports and rentals for bicycles and scooters. Guests can indulge in a lively experience while enjoying stylish accommodations. The hotel's commitment to inclusivity and adventure makes it a standout choice for those looking to create unforgettable memories in San Diego.

Where to stay near Otay Mesa

Otay Mesa offers a delightful mix of family-friendly attractions and vibrant cultural experiences. Visitors can explore the Otay Town Center Mall for shopping and dining, or venture to nearby Mission Bay for scenic views and outdoor activities. With its friendly atmosphere and proximity to diverse neighborhoods like Point Loma, Otay Mesa is a perfect base for a memorable vacation, catering to families, couples, and budget travelers alike.

  • San Diego: San Diego is a vibrant city that embodies the quintessential Southern California lifestyle. Located adjacent to Otay Mesa, it offers a mix of family-friendly activities, outdoor adventures, and stunning beaches. Visitors can explore renowned attractions like theme parks and family beaches, making it an ideal destination for all ages. The city is known for its pleasant climate year-round, with peak travel times in March to April and July, ensuring a lively atmosphere for tourists. Don't miss out on the diverse shopping centers and malls that add to the San Diego experience.
  • San Ysidro: Just 6.4km away from Otay Mesa, San Ysidro is a bustling city known for its shopping and cultural experiences. Travelers flock here for both family-oriented and business-themed activities, especially during peak months like June to July and November. The city features popular shopping centers and a water park, making it a fun spot for families. Additionally, local attractions like theme parks and symbolic landmarks offer visitors a taste of the area's rich culture. San Ysidro’s proximity to the border with Mexico also allows for unique cross-cultural experiences.
  • South Bay: Located 8.0km from Otay Mesa, South Bay is a delightful area perfect for outdoor enthusiasts and families alike. With peak travel seasons occurring from June to August, visitors can enjoy the sun-soaked beaches and amusement parks. South Bay is characterized by its beautiful bay views and vibrant beach culture. The area is home to several shopping centers and local attractions, including theme parks, making it a well-rounded destination for a fun-filled vacation. South Bay’s inviting atmosphere and access to outdoor activities make it a must-visit during your stay.

Things to do near Otay Mesa

Otay Mesa offers a fantastic blend of family-friendly activities and entertainment options, making it an ideal vacation spot. Visitors can enjoy a variety of attractions, including shopping centers and theaters. Exciting activities such as arcade fun, family outings, and a water park promise memorable experiences, while events like Comic-Con add to the vibrant atmosphere. Whether you're seeking adventure or relaxation, Otay Mesa has something for everyone.

Shopping

For shopping in Otay Mesa, explore Las Americas Premium Outlets and Otay Ranch Town Center, both 6.4km away, offering a mix of family-friendly and business vibes. Chula Vista Center, 12.9km away, also provides a lively atmosphere with various entertainment options.

Recreation

The Chula Vista Elite Athlete Training Center offers a vibrant sports atmosphere with top-notch facilities, perfect for fitness enthusiasts. Eastlake Country Club provides a relaxing outdoor golf experience amidst lush landscapes. For luxury and wellness, the Salvation Army Kroc Center features upscale amenities and various recreational activities.

Adventure

Experience a splashing good time at Sesame Place San Diego, a vibrant waterpark 4.8km from Otay Mesa, perfect for family fun. For a thrilling indoor adventure, visit Sky Zone San Diego Indoor Trampoline Park, located 11.3km away, where you can bounce to your heart's content.

Enjoy the excitement at White Water Canyon, another waterpark situated 4.8km from Otay Mesa, offering entertainment and adventure vibes for the whole family.

Nightlife

The nightlife in Otay Mesa offers a mix of entertainment and adventure. Catch a concert at North Island Credit Union Amphitheatre, just 4.8km away, or enjoy family fun at Len Moore Skate Park and Atlantis Laser Tag, both within a short drive, perfect for an exciting evening out.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Otay Mesa

To save money during your trip to Otay Mesa, consider visiting from November to January when hotel prices drop. Tuesdays are the cheapest days to stay, while Saturdays are the most expensive. Use Expedia to compare hotel prices and filter for eco-friendly options. You can also save by booking a hotel package that includes flights and activities. For transportation, utilize local public transit options to keep costs low. Explore free attractions in the area to enhance your experience without breaking the bank.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Otay Mesa are November to January, where the prices are slightly lower. This is in comparison to June to August, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Otay Mesa is Tuesday. The most expensive day to stay around Otay Mesa is Saturday.
  • Find cheap hotels on Expedia: Expedia’s search tool enables you to customize your travel preferences, including your budget and desired location. You can easily sort the results from lowest to highest price, allowing you to view the most affordable hotel options first. Additionally, you have the ability to refine your search by hotel category; for instance, selecting the Eco-certified filter will showcase sustainable and environmentally-friendly hotels that are available for booking.
  • Consider bundling your trip: You can save money by combining your Otay Mesa hotel reservation with your flights and activities through an Expedia package.

Find the best attractions near Otay Mesa

Otay Mesa is an ideal destination for family-friendly and entertainment-focused vacations. Visitors can explore a variety of attractions including beautiful beaches, urban parks, and event venues. Whether you're seeking cultural experiences or outdoor adventures, Otay Mesa offers a range of points of interest that cater to families and travelers looking for memorable experiences in this vibrant area of San Diego.

  • San Ysidro Border Crossing: Experience the vibrant atmosphere at one of the busiest border crossings in the world. Just 4.8km from Otay Mesa, it offers a unique glimpse into cultural exchanges, with friendly locals and a sunny vibe perfect for family outings.
  • San Diego Convention Center: Located 24.1km away, this premier event venue hosts various conferences and conventions. Its modern architecture and lively business atmosphere make it an exciting stop for networking and entertainment.
  • Coronado Beach: Also 24.1km from Otay Mesa, this stunning beach is known for its golden sands and relaxed beach vibes. It's ideal for sunbathing, swimming, and enjoying breathtaking ocean views.

Best time to go to Otay Mesa

The best time to visit Otay Mesa is dependent on what kind of holiday you are seeking. August is its hottest month on average. At this time, visitor numbers are average and weather is sunny with no rain. February is its coolest month on average. At this time, visitor numbers are average and weather is sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January57.4°F (14.1°C)Light RainSunnySlightly LowSlightly Low
February56.8°F (13.8°C)Light RainSunnyAverageAverage
March58.1°F (14.5°C)No RainMostly SunnyAverageAverage
April60.6°F (15.9°C)No RainSunnyAverageAverage
May62.6°F (17.0°C)No RainSunnyAverageAverage
June66.4°F (19.1°C)No RainSunnySlightly HighSlightly High
July70.5°F (21.4°C)No RainSunnySlightly HighSlightly High
August72.3°F (22.4°C)No RainSunnyAverageSlightly High
September72.0°F (22.2°C)No RainSunnySlightly HighAverage
October68.2°F (20.1°C)No RainSunnySlightly LowAverage
November62.6°F (17.0°C)No RainSunnyAverageSlightly Low
December57.4°F (14.1°C)Light RainMostly SunnySlightly LowSlightly Low

The nearest major airports for your trip to Otay Mesa

When visiting Otay Mesa, you have convenient access to two major airports. San Diego International Airport (SAN) is located 29.0km away, with notable hotels nearby such as the 5-star Pendry San Diego and The US Grant, both within 4.8km, and The Lodge at Torrey Pines, 19.3km away. Tijuana's General Abelardo L. Rodriguez International Airport (TIJ) is even closer, just 1.4km from Otay Mesa, offering options like the 4.5-star Quartz Hotel & SPA and Real Inn Tijuana, both 4.8km away. Additionally, Carlsbad's McClellan-Palomar Airport (CLD) is 44.8km from Otay Mesa, with luxurious stays such as the Park Hyatt Aviara Resort nearby.

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on Expedia customer reviews, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is the highest ranked property in Otay Mesa. This hotel offers free breakfast and an outdoor pool. Another top choice in the area is Quality Suites San Diego Otay Mesa.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.
Where can I learn more about changing or cancelling my trip to Otay Mesa?
To find more details about changing or cancelling your trip to Otay Mesa, go to https://www.expedia.com/service/.
What is there to do in this San Diego neighborhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.