Find hotels in Otay Mesa, San Diego from AED 280

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
In two weeks

Filter by

Guest rating
Guest rating
Star rating

Our top choices for Otay Mesa hotels

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG
2.5 star property
Otay Mesa
8.2 out of 10, Very Good, (1,747 reviews)
"Clean, friendly staff, great breakfast!!"
United States
Flor
The price is AED 514
AED 585 total
includes taxes & fees
14 Jun - 15 Jun
Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG

Quality Suites San Diego Otay Mesa

Quality Suites San Diego Otay Mesa
2.5 star property
Otay Mesa
7.0 out of 10, Good, (1,001 reviews)
"Breakfast was good. Staff was excellent rooms were clean."
United States
jacqueline
The price is AED 437
AED 497 total
includes taxes & fees
4 Jun - 5 Jun
Quality Suites San Diego Otay Mesa

Best Western Americana Inn

Best Western Americana Inn
2.5 star property
8 km from Otay Mesa
9.0 out of 10, Wonderful, (1,286 reviews)
"Everything was very pleasant,the place was super clean, and the breakfast was delicious👍"
United States
Nancy
The price is AED 449
AED 511 total
includes taxes & fees
7 Jun - 8 Jun
Best Western Americana Inn

Sycuan Casino Resort

Sycuan Casino Resort
4.0 star property
28.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,954 reviews)
"Always a great stay"
United States
Jeanette
The price is AED 393
AED 477 total
includes taxes & fees
1 Jun - 2 Jun
Sycuan Casino Resort

Comfort Inn Chula Vista San Diego South

Comfort Inn Chula Vista San Diego South
2.5 star property
13 km from Otay Mesa
8.2 out of 10, Very Good, (1,529 reviews)
"Laundry room was extremely clean breakfast pretty nice staff was excellent "
United States
Victoria
The price is AED 420
AED 463 total
includes taxes & fees
7 Jun - 8 Jun
Comfort Inn Chula Vista San Diego South

Holiday Inn Express San Diego South - Chula Vista by IHG

Holiday Inn Express San Diego South - Chula Vista by IHG
2.5 star property
14.5 km from Otay Mesa
9.4 out of 10, Exceptional, (1,199 reviews)
"Very nice place to stay"
United States
Lingzhi
The price is AED 559
AED 615 total
includes taxes & fees
7 Jun - 8 Jun
Holiday Inn Express San Diego South - Chula Vista by IHG

Valli Hi Motel

Valli Hi Motel
2.5 star property
7.9 km from Otay Mesa
8.4 out of 10, Very Good, (1,010 reviews)
"Great place to stay."
United States
Allan
The price is AED 245
AED 280 total
includes taxes & fees
1 Jun - 2 Jun
Valli Hi Motel

Best Western San Diego Pacific Beach/Mission Bay

Best Western San Diego Pacific Beach/Mission Bay
2.5 star property
Bay Park, 33.6 km from Otay Mesa
8.2 out of 10, Very Good, (403 reviews)
"The stay was good and close to the zoo and beach also shopping"
United States
Carol
The price is AED 352
AED 405 total
includes taxes & fees
8 Jun - 9 Jun
Best Western San Diego Pacific Beach/Mission Bay

Best Western Plus Marina Gateway Hotel

Best Western Plus Marina Gateway Hotel
3.5 star property
16.9 km from Otay Mesa
9.2 out of 10, Wonderful, (3,847 reviews)
"Great stay"
United States
Cameron
The price is AED 621
AED 684 total
includes taxes & fees
1 Jun - 2 Jun
Best Western Plus Marina Gateway Hotel

San Diego Mission Bay Resort

San Diego Mission Bay Resort
4.0 star property
Mission Bay, 33.1 km from Otay Mesa
8.6 out of 10, Excellent, (1,455 reviews)
"Great resort!"
United States
Jean-Michelle
The price is AED 849
AED 1,170 total
includes taxes & fees
3 Jun - 4 Jun
San Diego Mission Bay Resort

Howard Johnson by Wyndham National City/San Diego South

Howard Johnson by Wyndham National City/San Diego South
2.0 star property
18.3 km from Otay Mesa
7.4 out of 10, Good, (1,032 reviews)
"Check in was easy & staff was friendly"
United States
Lorie
The price is AED 287
AED 317 total
includes taxes & fees
2 Jun - 3 Jun
Howard Johnson by Wyndham National City/San Diego South

Crowne Plaza San Diego - Mission Valley by IHG

Crowne Plaza San Diego - Mission Valley by IHG
3.5 star property
29.8 km from Otay Mesa
8.2 out of 10, Very Good, (1,011 reviews)
"Amazing stay"
United States
Neshaye
The price is AED 433
AED 500 total
includes taxes & fees
29 Jun - 30 Jun
Crowne Plaza San Diego - Mission Valley by IHG

Lafayette Hotel & Club

Lafayette Hotel & Club
4.0 star property
26.8 km from Otay Mesa
9.4 out of 10, Exceptional, (1,675 reviews)
"Lovely hotel, very aesthetic place"
United States
Roxana
The price is AED 915
AED 1,051 total
includes taxes & fees
29 Jun - 30 Jun
Lafayette Hotel & Club

The Alcala Hotel Mission Valley/Seaworld

The Alcala Hotel Mission Valley/Seaworld
2.5 star property
30.2 km from Otay Mesa
8.2 out of 10, Very Good, (139 reviews)
"The breakfast was great and I enjoyed my stay!"
United States
Felix
The price is AED 334
AED 384 total
includes taxes & fees
1 Jun - 2 Jun
The Alcala Hotel Mission Valley/Seaworld

La Quinta Inn by Wyndham San Diego Chula Vista

La Quinta Inn by Wyndham San Diego Chula Vista
3.0 star property
12.9 km from Otay Mesa
8.6 out of 10, Excellent, (1,627 reviews)
"Comfy, clean, updated and free breakfast"
United States
Nicholas
The price is AED 421
AED 464 total
includes taxes & fees
11 Jun - 12 Jun
La Quinta Inn by Wyndham San Diego Chula Vista

Holiday Inn Express San Diego Airport - Old Town by IHG

Holiday Inn Express San Diego Airport - Old Town by IHG
2.5 star property
28.8 km from Otay Mesa
9.2 out of 10, Wonderful, (1,065 reviews)
"Staff was so great nice rooms really great stay"
United States
Amelia
The price is AED 551
AED 633 total
includes taxes & fees
8 Jun - 9 Jun
Holiday Inn Express San Diego Airport - Old Town by IHG

Days Inn by Wyndham San Diego-East/El Cajon

Days Inn by Wyndham San Diego-East/El Cajon
2.0 star property
27.3 km from Otay Mesa
7.8 out of 10, Good, (1,006 reviews)
"Great place definitely recommend"
United States
Trenton
The price is AED 340
AED 375 total
includes taxes & fees
9 Jun - 10 Jun
Days Inn by Wyndham San Diego-East/El Cajon

Kings Inn San Diego

Kings Inn San Diego
2.5 star property
29.1 km from Otay Mesa
8.8 out of 10, Excellent, (3,721 reviews)
"Clean room, friendly staff, and my kid loved the pool!"
United States
Mark
The price is AED 320
AED 367 total
includes taxes & fees
1 Jun - 2 Jun
Kings Inn San Diego

Best Western Plus La Mesa San Diego

Best Western Plus La Mesa San Diego
2.5 star property
24.6 km from Otay Mesa
8.4 out of 10, Very Good, (1,004 reviews)
"We enjoyed our stay."
United States
Lauren
The price is AED 566
AED 622 total
includes taxes & fees
1 Jun - 2 Jun
Best Western Plus La Mesa San Diego

Wyndham Garden San Diego Near SeaWorld

Wyndham Garden San Diego Near SeaWorld
3.0 star property
31.3 km from Otay Mesa
7.4 out of 10, Good, (4,234 reviews)
"Nice stay, clean room"
United States
Luis
The price is AED 415
AED 477 total
includes taxes & fees
7 Jun - 8 Jun
Wyndham Garden San Diego Near SeaWorld
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Where to stay in Otay Mesa

Find the best Otay Mesa areas and neighborhoods for the activities you enjoy most.

Downtown San Diego

Cultural and financial hub, Downtown San Diego boasts the Symphony, Opera, theaters, museums, and historic sites like Gaslamp Quarter. Enjoy diverse shops, dining, nightlife, and convenient public transport options.

Pacific Beach

Boasting a lively nightlife scene, Pacific Beach offers miles of sandy shores, a bustling 3.2-mile boardwalk, and attractions like Crystal Pier and Kate Sessions Park. Enjoy local shops, bars, and eateries along the vibrant walkway.

Mission Beach

Spanning nearly two miles of oceanfront, this sandbar community offers sunbathing, surfing, and beach volleyball, with nearby attractions like Belmont Park's Giant Dipper Roller Coaster and SeaWorld in Mission Bay Park.

Gaslamp Quarter

Downtown San Diego's historic district boasts Victorian-era buildings, now housing vibrant restaurants, shops, and entertainment venues. Stroll from Broadway to Harbor Drive, and 4th to 6th Avenue, admiring the newly installed gaslamps at Market Street.

Mission Bay

If you're spending some time in Mission Bay, Mission Bay and Mission and Pacific Beaches are top sights worth seeing.

Top Otay Mesa Hotel Reviews

Find out more about Otay Mesa

Top reasons to visit Otay Mesa

  • Family-Friendly Attractions: Otay Mesa offers a range of activities perfect for families, including shopping centers, theaters, and a water park.
  • Vibrant Cultural Events: Exciting events like Comic-Con and various local festivals create a lively atmosphere for visitors.
  • Diverse Outdoor Activities: Nearby Mission Bay provides scenic views and opportunities for outdoor adventures.
  • Convenient Shopping and Dining: The Otay Town Center Mall features a variety of shopping and dining options for all tastes.
  • Variety of Accommodations: Otay Mesa offers diverse lodging options, catering to families, couples, and budget travelers.

Find great hotels near Otay Mesa

Otay Mesa offers a diverse selection of accommodations, catering to various preferences and budgets. From comfortable hotels to charming guesthouses, you'll find options that are perfect for pet owners, business travelers, and families alike. Whether you're seeking the best-rated hotels, affordable stays, or reviews to guide your choice, Otay Mesa has something to make your visit enjoyable and memorable.

  • Best Western Plus Marina Gateway Hotel: This welcoming hotel is perfect for families and pet lovers seeking a memorable vacation experience. Situated 17.7km from Otay Mesa, the Best Western Plus Marina Gateway Hotel offers a delightful blend of comfort and inclusivity, proudly catering to LGBTQIA travelers. Families will appreciate the child-friendly amenities, including a mini-golf course, children's pool, and free cribs. Additionally, the hotel’s pet policy allows for dogs onsite, ensuring that your furry friends are part of your getaway.
  • Ramada by Wyndham San Diego National City: Ideal for business travelers and adventure seekers, the Ramada by Wyndham San Diego National City is located 17.7km from Otay Mesa. This 3-star hotel boasts a variety of recreation options that include nearby boat tours, surfing, and hiking, making it a fantastic choice for those looking to blend work with play. Families will find conveniences like free cribs, ensuring a comfortable stay for younger guests. Enjoy a balanced mix of relaxation and excitement at this versatile property.
  • Hard Rock Hotel San Diego: Located 24.1km from Otay Mesa, the Hard Rock Hotel San Diego offers a vibrant atmosphere for adventure enthusiasts and LGBTQIA travelers alike. This 4-star hotel is renowned for its exciting recreation opportunities, including nearby water sports and rentals for bicycles and scooters. Guests can indulge in a lively experience while enjoying stylish accommodations. The hotel's commitment to inclusivity and adventure makes it a standout choice for those looking to create unforgettable memories in San Diego.

Where to stay near Otay Mesa

Otay Mesa offers a delightful mix of family-friendly attractions and vibrant cultural experiences. Visitors can explore the Otay Town Center Mall for shopping and dining, or venture to nearby Mission Bay for scenic views and outdoor activities. With its friendly atmosphere and proximity to diverse neighborhoods like Point Loma, Otay Mesa is a perfect base for a memorable vacation, catering to families, couples, and budget travelers alike.

  • San Diego: San Diego is a vibrant city that embodies the quintessential Southern California lifestyle. Located adjacent to Otay Mesa, it offers a mix of family-friendly activities, outdoor adventures, and stunning beaches. Visitors can explore renowned attractions like theme parks and family beaches, making it an ideal destination for all ages. The city is known for its pleasant climate year-round, with peak travel times in March to April and July, ensuring a lively atmosphere for tourists. Don't miss out on the diverse shopping centers and malls that add to the San Diego experience.
  • San Ysidro: Just 6.4km away from Otay Mesa, San Ysidro is a bustling city known for its shopping and cultural experiences. Travelers flock here for both family-oriented and business-themed activities, especially during peak months like June to July and November. The city features popular shopping centers and a water park, making it a fun spot for families. Additionally, local attractions like theme parks and symbolic landmarks offer visitors a taste of the area's rich culture. San Ysidro’s proximity to the border with Mexico also allows for unique cross-cultural experiences.
  • South Bay: Located 8.0km from Otay Mesa, South Bay is a delightful area perfect for outdoor enthusiasts and families alike. With peak travel seasons occurring from June to August, visitors can enjoy the sun-soaked beaches and amusement parks. South Bay is characterized by its beautiful bay views and vibrant beach culture. The area is home to several shopping centers and local attractions, including theme parks, making it a well-rounded destination for a fun-filled vacation. South Bay’s inviting atmosphere and access to outdoor activities make it a must-visit during your stay.

Things to do near Otay Mesa

Otay Mesa offers a fantastic blend of family-friendly activities and entertainment options, making it an ideal vacation spot. Visitors can enjoy a variety of attractions, including shopping centers and theaters. Exciting activities such as arcade fun, family outings, and a water park promise memorable experiences, while events like Comic-Con add to the vibrant atmosphere. Whether you're seeking adventure or relaxation, Otay Mesa has something for everyone.

Shopping

For shopping in Otay Mesa, explore Las Americas Premium Outlets and Otay Ranch Town Center, both 6.4km away, offering a mix of family-friendly and business vibes. Chula Vista Center, 12.9km away, also provides a lively atmosphere with various entertainment options.

Recreation

The Chula Vista Elite Athlete Training Center offers a vibrant sports atmosphere with top-notch facilities, perfect for fitness enthusiasts. Eastlake Country Club provides a relaxing outdoor golf experience amidst lush landscapes. For luxury and wellness, the Salvation Army Kroc Center features upscale amenities and various recreational activities.

Adventure

Experience a splashing good time at Sesame Place San Diego, a vibrant waterpark 4.8km from Otay Mesa, perfect for family fun. For a thrilling indoor adventure, visit Sky Zone San Diego Indoor Trampoline Park, located 11.3km away, where you can bounce to your heart's content.

Enjoy the excitement at White Water Canyon, another waterpark situated 4.8km from Otay Mesa, offering entertainment and adventure vibes for the whole family.

Nightlife

The nightlife in Otay Mesa offers a mix of entertainment and adventure. Catch a concert at North Island Credit Union Amphitheatre, just 4.8km away, or enjoy family fun at Len Moore Skate Park and Atlantis Laser Tag, both within a short drive, perfect for an exciting evening out.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Otay Mesa

To save money during your trip to Otay Mesa, consider visiting from November to January when hotel prices drop. Tuesdays are the cheapest days to stay, while Saturdays are the most expensive. Use Expedia to compare hotel prices and filter for eco-friendly options. You can also save by booking a hotel package that includes flights and activities. For transportation, utilize local public transit options to keep costs low. Explore free attractions in the area to enhance your experience without breaking the bank.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Otay Mesa are November to January, where the prices are slightly lower. This is in comparison to June to August, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Otay Mesa is Tuesday. The most expensive day to stay around Otay Mesa is Saturday.
  • Find cheap hotels on Expedia: Expedia’s search tool enables you to customize your travel preferences, including your budget and desired location. You can easily sort the results from lowest to highest price, allowing you to view the most affordable hotel options first. Additionally, you have the ability to refine your search by hotel category; for instance, selecting the Eco-certified filter will showcase sustainable and environmentally-friendly hotels that are available for booking.
  • Consider bundling your trip: You can save money by combining your Otay Mesa hotel reservation with your flights and activities through an Expedia package.

Find the best attractions near Otay Mesa

Otay Mesa is an ideal destination for family-friendly and entertainment-focused vacations. Visitors can explore a variety of attractions including beautiful beaches, urban parks, and event venues. Whether you're seeking cultural experiences or outdoor adventures, Otay Mesa offers a range of points of interest that cater to families and travelers looking for memorable experiences in this vibrant area of San Diego.

  • San Ysidro Border Crossing: Experience the vibrant atmosphere at one of the busiest border crossings in the world. Just 4.8km from Otay Mesa, it offers a unique glimpse into cultural exchanges, with friendly locals and a sunny vibe perfect for family outings.
  • San Diego Convention Center: Located 24.1km away, this premier event venue hosts various conferences and conventions. Its modern architecture and lively business atmosphere make it an exciting stop for networking and entertainment.
  • Coronado Beach: Also 24.1km from Otay Mesa, this stunning beach is known for its golden sands and relaxed beach vibes. It's ideal for sunbathing, swimming, and enjoying breathtaking ocean views.

Best time to go to Otay Mesa

The best time to visit Otay Mesa is dependent on what kind of holiday you are seeking. August is its hottest month on average. At this time, visitor numbers are average and weather is sunny with no rain. February is its coolest month on average. At this time, visitor numbers are average and weather is sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January57.4°F (14.1°C)Light RainSunnySlightly LowSlightly Low
February56.8°F (13.8°C)Light RainSunnyAverageAverage
March58.1°F (14.5°C)No RainMostly SunnyAverageAverage
April60.6°F (15.9°C)No RainSunnyAverageAverage
May62.6°F (17.0°C)No RainSunnyAverageAverage
June66.4°F (19.1°C)No RainSunnySlightly HighSlightly High
July70.5°F (21.4°C)No RainSunnySlightly HighSlightly High
August72.3°F (22.4°C)No RainSunnyAverageSlightly High
September72.0°F (22.2°C)No RainSunnySlightly HighAverage
October68.2°F (20.1°C)No RainSunnySlightly LowAverage
November62.6°F (17.0°C)No RainSunnyAverageSlightly Low
December57.4°F (14.1°C)Light RainMostly SunnySlightly LowSlightly Low

The nearest major airports for your trip to Otay Mesa

When visiting Otay Mesa, you have convenient access to two major airports. San Diego International Airport (SAN) is located 29.0km away, with notable hotels nearby such as the 5-star Pendry San Diego and The US Grant, both within 4.8km, and The Lodge at Torrey Pines, 19.3km away. Tijuana's General Abelardo L. Rodriguez International Airport (TIJ) is even closer, just 1.4km from Otay Mesa, offering options like the 4.5-star Quartz Hotel & SPA and Real Inn Tijuana, both 4.8km away. Additionally, Carlsbad's McClellan-Palomar Airport (CLD) is 44.8km from Otay Mesa, with luxurious stays such as the Park Hyatt Aviara Resort nearby.

Explore a world of travel with Expedia

Frequently asked questions

What's it like in Otay Mesa?
Otay Mesa is a neighborhood that travelers like for its beaches, restaurants, and shopping.
Where is the best hotel for a stay in Otay Mesa?
Based on our traveler data, Holiday Inn Express Hotel & Suites San Diego Otay Mesa by IHG is one of the top choices for your stay in Otay Mesa. This hotel offers free breakfast and an outdoor pool.
If I need to cancel my hotel reservation in Otay Mesa, will I receive a refund?
Yes! The majority of hotel reservations are fully refundable if you cancel prior to the hotel's cancellation deadline, which in most cases is within 24 or 48 hours of your check-in date. If you have a non-refundable reservation, you might still have the option to cancel and receive a refund within a 24-hour period of booking. Put your dates in and click on "Search", then you can use the "fully refundable" filter to view the best deals available in Otay Mesa.
Where can I learn more about changing or cancelling my trip to Otay Mesa?
To find more details about changing or cancelling your trip to Otay Mesa, go to https://www.expedia.com/service/.
What is there to do in this San Diego neighborhood?
A few places to visit in the area around Otay Mesa include High Performance Center in Tijuana, Parque Industrial FINSA Tijuana, and Otay Sports Fields. While you're out sightseeing, Caliente Casino and Alameda Otay are a couple of additional sights to visit in San Diego.