A city skyline with high-rise buildings, a calm waterfront, and a sunset sky.

Find Resorts & Hotels with Spas in Panama City

Dates

November 2026

December 2026

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Our top choices for Panama City hotels with a spa

A view from a balcony with a cityscape in the background, featuring tall buildings and a body of water.

1. Plaza Paitilla Inn Hotel

San Francisco

Unwind with hot stone massages and facials at this hotel spa with pool views and plush treatment rooms.

AED 440 total

includes taxes & fees

11 Nov - 12 Nov

A high-rise building with a modern architectural design, featuring a grid of windows and balconies.

2. Megapolis Hotel Panamá

San Francisco

Immerse in therapeutic bliss with 2 spa rooms, steam, and sauna at this full-service wellness hotel.

AED 609 total

includes taxes & fees

11 Nov - 12 Nov

A room with two beds, a desk, a chair, and a window with a view of greenery.

3. Riande Aeropuerto Hotel & Casino

Tocumen Airport

Rejuvenate at this tranquil resort with pampering spa services, a stunning pool with swim-up bar, and lush gardens perfect for unwinding.

AED 454 total

includes taxes & fees

1 Dec - 2 Dec

4. Hilton Panama

Bella Vista

Indulge in blissful wellness at this Panama hotel with a full-service spa, casino, and outdoor pool to restore and rejuvenate.

AED 777 total

includes taxes & fees

13 Nov - 14 Nov

5. Central Hotel Panama Casco Viejo

Casco Viejo

Discover revitalizing massages and soothing facials at this historic hotel with a rooftop pool and steam room in Panama's vibrant center.

AED 663 total

includes taxes & fees

23 Nov - 24 Nov

A modern living room with a large window, a wooden bookshelf, and a dining area with bar stools.

6. JW Marriott Panama

San Francisco

Immerse in waterfront tranquility with bay views, rejuvenating in-room massages, and four outdoor pools for a complete spa getaway.

AED 1,290 total

includes taxes & fees

27 Nov - 28 Nov

A spacious outdoor patio with wicker furniture, potted plants, and umbrellas providing shade.

7. Hotel San Felipe

Casco Viejo

Recharge with daily aromatherapy, couples massages, and a garden-view spa at this stylish Panama City retreat.

AED 621 total

includes taxes & fees

11 Nov - 12 Nov

A modern building facade with large glass windows and a visible sign for 'AQUA SPA'.

8. Decapolis Hotel Panama City

San Francisco

Revive in Panama's premier hotel spa with Turkish hammam, hydrotherapy, and multiple treatment rooms for total rejuvenation.

AED 384 total

includes taxes & fees

11 Dec - 12 Dec

A hotel courtyard with a central lawn, surrounded by buildings with balconies and outdoor seating areas.

9. Hotel La Compañía Casco Antiguo

Casco Viejo

Soak in this colonial retreat's full-service spa sanctuary with rooftop pool and historic charm, creating a rejuvenating wellness escape.

AED 1,322 total

includes taxes & fees

1 Dec - 2 Dec

A hotel room with a checkered floor, a window with white curtains, and a lounge area with chairs and tables.

10. Sofitel Legend Casco Viejo, Panama City

Casco Viejo

Indulge in a waterfront spa retreat with outdoor treatment areas and hot stone massages at this beautifully restored Colonial hotel.

AED 1,909 total

includes taxes & fees

3 Dec - 4 Dec

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Choose what matters most at spa hotels in Panama City

Pool

Hot tub

Spa hotels with pools in Panama City

A rooftop pool with sun loungers and a city skyline in the background.

Waymore Hotel Spa & Casino

Bella Vista

AED 560 total

includes taxes & fees

11 Nov - 12 Nov

A balcony with two chairs, a city skyline, and a view of the ocean.

Yoo Panamá by Boutique Apartments

Bella Vista

AED 664 total

includes taxes & fees

11 Nov - 12 Nov

A resort with a large swimming pool, thatched-roof structures, and palm trees.

Dreams Playa Bonita Panama - All Inclusive

Veracruz

AED 964 total

includes taxes & fees

1 Dec - 2 Dec

View all properties

Spa hotels with hot tubs in Panama City

Waymore Hotel Spa & Casino

Bella Vista

AED 560 total

includes taxes & fees

11 Nov - 12 Nov

Dreams Playa Bonita Panama - All Inclusive

Veracruz

AED 964 total

includes taxes & fees

1 Dec - 2 Dec

View all properties

Spa hotels with free breakfast in Panama City

A pool area with lounge chairs, umbrellas, and a bridge over the water.

Riande Aeropuerto Hotel & Casino

Tocumen Airport

AED 454 total

includes taxes & fees

1 Dec - 2 Dec

Hotel La Compañía Casco Antiguo

Casco Viejo

AED 1,322 total

includes taxes & fees

1 Dec - 2 Dec

View all properties

Top Panama City Hotel Reviews

Hotel La Compañía Casco Antiguo

Casco Viejo

10/10 Excellent

The hotel was BEAUTIFUL and in such a great area (Casco Vieja). I love the fact that you could totally hang out at the hotel at the bar, spa, or at one of the many restaurants. The only suggestion that I would make is for the rooms with terraces, to chairs to the terrace. We loved going out on the terrace, but there was no seating. However, even with this suggestion, it would only bring my rating down to a 9.5.

Andrea

Sofitel Legend Casco Viejo, Panama City

Casco Viejo

10/10 Excellent

Dylan

A lobby with a central table, potted plants, and a modern ceiling design.

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

Juan Diaz

10/10 Excellent

John

A modern reception area with a chandelier, a large black and white rose artwork, and green climbing plants.

La Concordia Boutique Hotel

Casco Viejo

10/10 Excellent

This hotel was great. Its location is perfect for a loop around the historic area. The staff is friendly, and most are fluent in English. Everything was clean and the room was spacious with a great balcony. They staff the front door 24/7 so no one unwelcome can enter. The rooftop bar and food was great. It isn't open 24/7 but there are plenty of other options for places to eat, and it is open at meal times. Wifi worked well.

Michael

Plaza Paitilla Inn Hotel

San Francisco

10/10 Excellent

Natalie

Hotel San Felipe

Casco Viejo

10/10 Excellent

Carmen

A hotel room with a large window offering a city view, a bed, a chair, and a small table with a tray.

Bristol Panama, a Registry Collection Hotel

Bella Vista

10/10 Excellent

David

JW Marriott Panama

San Francisco

10/10 Excellent

My husband and I stayed at this property for my birthday, and it was a wonderful decision. Top notch service with great restaurants and proximity to many attractions. One highlight was the friendly willingness and capability of James to coordinate a last-minute private trip to Portobelo for us. Our booked excursion was cancelled at the last minute. We informed James and he made sure my birthday wish came true. We had a wonderful visit!

Crystal

Central Hotel Panama Casco Viejo

Casco Viejo

10/10 Excellent

Lourdes

Hilton Panama

Bella Vista

10/10 Excellent

Shirley

Waymore Hotel Spa & Casino

Bella Vista

10/10 Excellent

I loved my stay at this hotel. I stayed at this location when it was the Veneto over 12 years ago, & it wasn’t very good for a number of reasons. I am so glad to report that The Waymore is now my favorite hotel in Panama City & I’ve been going to Panama City 1-2xs a year for over 20 years. The location near the metro, good restaurants, markets, Via Argentina (& all it has to offer) are huge advantages. The staff was extremely courteous & spoke English well. The room was spectacular (a junior...

Manuel

A modern hotel lobby with a pool area, seating arrangements, and a reception desk.

Waldorf Astoria Panama

Bella Vista

10/10 Excellent

My family and I--6 people, in total--traveled to Panama City for a week. Here are what I think are the pros and cons to staying here: PROS: (1) The hotel itself is exceptionally clean. From the lobby to the bathrooms to the actual rooms to the pool/spa area to the dining/bar area, all were clean. (2) The hotel staff are what make this hotel stand out. I have traveled all over the world and I have never encountered such KIND, HELPFUL, PLEASANT, KNOWLEDGABLE hotel staff. They always greeted us...

Damian Joseph

A modern hotel pool area with a circular hot tub, lounge chairs, and a view of the city skyline.

Wanders Panama by Boutique Apartments

San Francisco

10/10 Excellent

Roberto

A spacious lobby with a large potted plant, two armchairs, a decorative wall, and a large window.

Sheraton Grand Panama

San Francisco

10/10 Excellent

John

A modern reception area with a large window, a geometric patterned floor, and two potted plants.

Sortis Hotel, Spa & Casino, Autograph Collection by Marriott

Bella Vista

10/10 Excellent

Before arrival my husband was in contact with the manager Sam. He explained how we needed three rooms, one needed to be a handicap room. At check in Sam came right up to us to advise us everything was taken care of. The check in process went very smooth and quick. Our rooms were very clean and exactly what we asked for. Everyone at the hotel was so friendly and accommodating. I wish I remembered everyone’s name to personally thank them. I worked with Flora the concierge. She was very patient...

Mandy

Frequently Asked Questions

Looking to vacation at a spa hotel in Panama City?

Forget the stress of everyday life and book yourself a hotel with a spa. Travelers highly recommend Panama City for its array of shops and gourmet restaurants—your day tour starts here. Be sure to enjoy the cafes during your stay. Spa hotels are a great way to break away from your routine and add a layer of luxury to your weekend away.

What is the best spa hotel in Panama City?

Megapolis Hotel Panamá is a top luxury spa hotel featuring 3 bars, a casino, a shopping mall, and a fitness center. Enjoy a facial, body scrub, or detox wrap at the onsite spa. Other popular spa hotels in Panama City include Waymore Hotel Spa & Casino and Decapolis Hotel Panama City.

How many spa hotels are there in Panama City?

Expedia has 21 spa hotels to choose from in Panama City.

What's there to see and do in Panama City?

Enjoy Panama City with a stop at Albrook Shopping Mall, Via Espana, and Iglesia del Carmen. If you have a little extra time during your trip, you might want to check out Uruguay Street and Avenida Balboa.

What is a Panama City spa hotel?

Spa hotels in Panama City have full on-site spas which offer services like massages and a range of beauty treatments. Some also provide a selection of in-room treatments for the ultimate luxury. Spa hotels are great for rest, rejuvenation, and relaxation.

Find Resorts & Hotels with Spas in Panama City

Change your mind

Treat yourself

Be picky

Check prices for these dates

Our top choices for Panama City hotels with a spa

1. Plaza Paitilla Inn Hotel

2. Megapolis Hotel Panamá

3. Riande Aeropuerto Hotel & Casino

4. Hilton Panama

5. Central Hotel Panama Casco Viejo

6. JW Marriott Panama

7. Hotel San Felipe

8. Decapolis Hotel Panama City

9. Hotel La Compañía Casco Antiguo

10. Sofitel Legend Casco Viejo, Panama City

Choose what matters most at spa hotels in Panama City

Spa hotels with pools in Panama City

Waymore Hotel Spa & Casino

Spa hotels with hot tubs in Panama City

Waymore Hotel Spa & Casino

Spa hotels with free breakfast in Panama City

Riande Aeropuerto Hotel & Casino

Top Panama City Hotel Reviews

Hotel La Compañía Casco Antiguo

10/10 Excellent

Frequently Asked Questions

Looking to vacation at a spa hotel in Panama City?

What is the best spa hotel in Panama City?

How many spa hotels are there in Panama City?

What's there to see and do in Panama City?

What is a Panama City spa hotel?