Panama City Vacations

Book a Hotel + Flight together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to AED 5,000 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Where to stay in Panama City

Find the best Panama City areas and neighborhoods for the activities you enjoy most. Learn more about Panama City
A waterfront cityscape with historic buildings and a prominent clock tower.

Casco Viejo

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo
A cityscape with modern skyscrapers, including a distinctive twisting tower.

Bella Vista

2 out of top 10 points of interest in this area

Bella Vista is highly notable for its popular shops, and you might want to visit top sights like Via Espana and Iglesia del Carmen. See more of Panama City by jumping on the metro at Iglesia del Carmen Station or Vía Argentina Station.

Find hotels in Bella Vista
A city skyline with modern high-rise buildings and a river in the foreground.

El Cangrejo

The abundant dining options and casinos are top of the list for many visitors to El Cangrejo. A stop by Via Espana or Crown Casino might round out your trip.

Find hotels in El Cangrejo
A bridge over a body of water with several boats.

San Francisco

1 out of top 10 points of interest in this area

San Francisco is noteworthy for its restaurants, and you can make a stop at top attractions like Multiplaza Pacific Mall and Calle 50.

Find hotels in San Francisco
A building with three arched windows, a balcony with wrought iron railings, and a tiled roof.

San Felipe

If you're spending some time in San Felipe, Independence Square and Interoceanic Canal Museum are top sights worth seeing.

Find hotels in San Felipe

Find the Best Panama City Vacation Packages

Panama City Hotel Deals

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
AED 506
AED 556 total
15 Sep - 16 Sep
includes taxes & fees
9/10 Wonderful! (5,895 reviews)
"Largest spread of a breakfast buffet, everyday was something different. Special acknowledgement to the restaurant staff Melissa and Erick who worked the breakfast shift. Excellent service!"

Reviewed on 27 August 2026

Hotel Riu Plaza Panama
Central Hotel Panama Casco Viejo

Central Hotel Panama Casco Viejo

Plaza de la Independencia Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
AED 674
AED 741 total
27 Sep - 28 Sep
includes taxes & fees
Central Hotel Panama Casco Viejo
Waymore Hotel Spa & Casino

Waymore Hotel Spa & Casino

Calle Augusto Samuel Boyd y Calle Eusebi Panama City
Fully refundableReserve now, pay when you stay
AED 290
AED 422 total
30 Aug - 31 Aug
includes taxes & fees
Waymore Hotel Spa & Casino
See all 1,730 properties in Panama City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Panama City attractions

A modern building facade with vertical reflective panels and the word "GUCCI" prominently displayed.
Photo by Fabiola Tile

Multiplaza Pacific Mall

9.0/10 (4,497 reviews)
Panama's premier shopping destination houses over 500 stores, from luxury brands like Gucci to popular retailers like Apple. Obtain the Panama Shopping Card at reception for exclusive discounts throughout the mall.
See properties
A marina with numerous boats, a bridge in the background, and lush green hills.

Amador Causeway

9.0/10 (1,902 reviews)
This man-made causeway connects Panama City to four islands using excavated material from the Panama Canal. Rent a bicycle to explore its entire length, stopping for waterfront dining with skyline views.
See properties
A city skyline with tall buildings along a waterfront.
Photo by Rob Gosse

Cinta Costera

9.2/10 (3,823 reviews)
This scenic 7 km waterfront promenade showcases Panama City's dramatic skyline against the Pacific Ocean. Stroll through gardens, cycle along dedicated paths, or sample fresh seafood at the nearby Mercado de Mariscos.
See properties
A nighttime cityscape with illuminated skyscrapers and a river reflecting the lights.

Avenida Balboa

8.8/10 (3,608 reviews)
Panama City's iconic waterfront boulevard offers spectacular views of the Pacific Ocean and skyline. Stroll along the Cinta Costera at sunset for a perfect blend of urban energy and coastal tranquility.
See properties
A historic stone tower amidst ruins, surrounded by grassy terrain.

Panama Viejo

9.2/10 (3,752 reviews)
Panama Viejo stands as the oldest European settlement on the Pacific coast of the Americas, founded in 1519. Wander among colonial ruins and climb the cathedral tower for a unique perspective on Panama's layered history.
See properties

Albrook Shopping Mall

8.6/10 (4,561 reviews)
One of Central America's largest shopping destinations, Albrook Mall features animal-themed corridors with matching statues. Explore 600+ stores, dine at diverse restaurants, or enjoy cinema and bowling.
See properties

Via Espana

8.4/10 (2,902 reviews)
Vía España pulses as Panama City's commercial backbone, lined with shops and diverse dining options. Explore this vibrant thoroughfare during late morning when the urban energy is at its peak.
See properties

Fuerte Amador Resort & Marina

9.4/10 (169 reviews)
This bustling marina at the Panama Canal's entrance offers premier yacht services and spectacular city skyline views. Enjoy waterfront dining or book a sunset cruise to experience the canal from a privileged perspective.
See properties

Frequently asked questions

How much does a Panama City vacation package cost?
Offering great value package deals on Expedia, you'll be thrilled with how little a vacation to Panama City costs! Expedia's packages make travel planning easier and your savings go further.
What are the cheapest months to go to Panama City?
You're likely to find reduced prices and better availability in September, October and November. Take a look at our cheap Panama City vacation packages and you could land some excellent off-season deals.
How to find the best Panama City package deals?
Finding a cheap Panama City package deal is a cinch with Expedia. After you've entered your destination and travel dates under our "Packages" tab, set your budget, add a few filters and see what's available. You can fine-tune your search by "Popular locations," "Property type," "Guest rating" and more. Sort the results by "Price: low to high" to discover the most economical Panama City package deals. Want a simple trick to get the biggest savings? Be flexible with your departure dates and consider traveling on a weekday, when prices are typically lower.
Is it cheaper to book a Panama City vacation as a package?
Expedia vacation packages are designed to help you keep more cash in your pocket. Bundle your car rental, hotel and flight into one great-value price and enjoy significant savings. You'll typically get a better deal than booking each component individually. And you'll still have the flexibility to create a tailored Panama City vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Panama City?
Enjoy incredible bargains by reserving your flights in advance with Expedia. If being spontaneous is more your style, grab one of our last-minute deals for an impromptu Panama City escape.
How to plan a trip to Panama City?
  1. Choose the ideal time to travel: Your schedule, favorite season and the type of weather you enjoy can all impact your decision on when to go to Panama City.
  2. Budget wisely: On top of the price of your stay, you should factor in other expenses too. These include transportation, food and flights. Also, set aside a little extra for unexpected costs that could crop up during your trip to Panama City.
  3. Decide how long to go away for: Now that you're up to speed on Panama City, you can figure out the right length of your vacation. Pull together a rough plan and give yourself enough time to get through everything on your must-do list.
  4. Bundle your bookings: With your travel dates in place, you can combine your flights, car rental, hotels and more into a personalized Panama City vacation package.

Explore a world of travel with Expedia