Panama City Vacations

Book a Hotel + Flight together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to AED 148 when you book a flight and hotel together*

  • Find the right fit

    With over 300,000 hotels worldwide, it's easy to create a perfect package

  • Rest easy

    Plan, book, and manage your trip all in one place

Eid al-Fitr Sale

Members save up to 40% on hotels. Plan this year’s big trip and save.
Book now

Where to stay in Panama City

Find the best Panama City areas and neighborhoods for the activities you enjoy most. Learn more about Panama City
View of the Panama City Old Town

Casco Viejo

4.5/5(178 area reviews)

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Find the Best Panama City Vacation Packages

Panama City Hotel Deals

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is AED 485 per night from Mar 10 to Mar 11
AED 485
AED 533 total
10 Mar - 11 Mar
includes taxes & fees
9/10 Wonderful! (4,927 reviews)
Very nice and clean hotel. Excellent breakfast which was included. We will return

Reviewed on 12 February 2026

Hotel Riu Plaza Panama
Hotel El Panama by Faranda Grand, a member of Radisson Individuals

Hotel El Panama by Faranda Grand, a member of Radisson Individuals

4 out of 5
Via Espana 111 Panama City Panama
Fully refundableReserve now, pay when you stay
The price is AED 397 per night from Feb 23 to Feb 24
AED 397
AED 436 total
23 Feb - 24 Feb
includes taxes & fees
7.8/10 Good! (1,028 reviews)
Very friendly staff but the hotel is a bit worn. Room 43 has an odor but

Reviewed on 11 February 2026

Hotel El Panama by Faranda Grand, a member of Radisson Individuals
W Panama

W Panama

5 out of 5
Calle Aquilino de la Guardia & Calle 50 Panama City
Fully refundableReserve now, pay when you stay
The price is AED 673 per night from Mar 7 to Mar 8
AED 673
AED 740 total
7 Mar - 8 Mar
includes taxes & fees
9/10 Wonderful! (1,002 reviews)
Room

Reviewed on 10 February 2026

W Panama
See all 1,465 properties in Panama City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Panama City

Causeway, Amador, Panama

Amador Causeway

4.5/5(757 reviews)

You can learn about the history of Ancon with a stop at Amador Causeway. Stroll along the seaside or visit the shops in this vibrant area.

Amador Causeway
Old and traditional Yatch Club at Cinta Costera, Panama City, Panama.

Cinta Costera

4.5/5(456 reviews)

Explore the great outdoors at Cinta Costera, a lovely green space in Panama City. While you're in the area, stroll along the seaside.

Cinta Costera
Panama City skyline during the day #seetheworld

Uruguay Street

4/5(59 reviews)

During your visit to Panama City, you can do some window-shopping at Uruguay Street. While in this family-friendly area, you can savor the top-notch restaurants.

Uruguay Street

Frequently asked questions

How do I find cheap flights to Panama City that have flexible change policies?
By using our clever "No change fee" filter, that's how. Simply type in your travel details, click the "Search" button, then tick the checkbox under the "Flexible change policies" heading (left-hand side of your screen). Expedia makes it a snap to find flexible and affordable airfares to Panama City.
Which airlines fly to Panama City?
Book a seat with one of these airlines and exciting Panama City will be yours to explore:

  • Copa Airlines - 915 flights to or near Panama City each month, including 915 flights to Tocumen Intl. Airport (PTY) per month.
  • United Airlines - 152 flights to or near Panama City each month, including 152 flights to Tocumen Intl. Airport (PTY) per month.
  • American Airlines - 30 flights to or near Panama City each month, including 30 flights to Tocumen Intl. Airport (PTY) per month.

How can I find cheap tickets to Panama City?
You'll always find a terrific deal with Expedia, but our "flexible dates" search function makes it that much easier. Enter your preferred travel date, then click on the flexible dates link above to compare prices for nearby days. was the best price for a flight to Panama City in the last seven days.
How much is a flight to Panama City?
In the last seven days, round-trip airfares to Panama City sold from just and reached a maximum price of . For one-way trips leaving (), the cheapest seat during this same period was .
What are the most popular airports to fly into in Panama City?
Jet into Tocumen Intl. Airport (PTY) and sample the best that Panama City has to offer. As the region's primary entry point, about 1,097 flights touch down here every month.
When is the cheapest time to fly to Panama City?
Take off to Panama City early on in the week and you'll usually be rewarded with more affordable fares. Tuesday is known for being the cheapest day to fly out, with Monday a close second. If you're eager to avoid the most expensive flights, keep clear of Saturdays.
How much is a plane ticket to Panama City?
In the last seven days, fares to Panama City ranged from to .
What months are the cheapest to book a flight to Panama City?
The ideal month to snare a fabulous deal to Panama City is February, while prices are at a premium in December. Try to avoid this month if you're watching your pennies.
How long is a flight to Panama City?
The time it takes will largely depend on the place you're traveling from. This list of the most popular routes to Panama City will give you an idea of what to expect:

  • Miami, FL (MIA-Miami Intl.) to Tocumen Intl. Airport (PTY) - 3 hours and 13 minutes
  • Orlando, FL (MCO-Orlando Intl.) to Tocumen Intl. Airport (PTY) - 3 hours and 30 minutes
  • Los Angeles, CA (LAX-Los Angeles Intl.) to Tocumen Intl. Airport (PTY) - 6 hours and 23 minutes

What are the best things to do in Panama City?

  • Begin your Panama City vacation in the happening city of Ancon. There's plenty to keep you occupied here, from top attractions like Soberania National Park to spectacular food, shopping, arts and more.
  • When deciding what kind of clothing to bring on your trip, bear in mind that Ancon has a tropical monsoon climate. To give you a better idea of what to expect, check out the weather conditions before you leave.
  • Be sure to make Juan Diaz your next port of call. It's approximately 14 kilometers to the east of Ancon and home to Los Pueblos Commercial Center, one of the destination's best sights.