Panama City Vacations

Book a Hotel + Flight together to unlock savings

  • Plan, book, travel with confidence

  • Better together

    Save up to AEDĀ 5,000 when you book a flight and hotel together*

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    With over 300,000 hotels worldwide, it's easy to create a perfect package

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    Plan, book, and manage your trip all in one place

Where to stay in Panama City

Find the best Panama City areas and neighborhoods for the activities you enjoy most. Learn more about Panama City
A waterfront cityscape with historic buildings and a prominent clock tower.

Casco Viejo

4.5/5(179 area reviews)

Unique features of Casco Viejo include the historic sites and bars. Make a stop by Independence Square or Interoceanic Canal Museum while you're exploring the area.

Find hotels in Casco Viejo

Find the Best Panama City Vacation Packages

Panama City Hotel Deals

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5 out of 5
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
The price is AEDĀ 540 per night from Jul 28 to Jul 29
AEDĀ 540
AEDĀ 594 total
28 Jul - 29 Jul
includes taxes & fees
9/10 Wonderful! (5,728 reviews)
"Satisfied"

Reviewed on 12 July 2026

Hotel Riu Plaza Panama
Waldorf Astoria Panama

Waldorf Astoria Panama

5 out of 5
47th St. & Uruguay Street Panama City Panama
Fully refundableReserve now, pay when you stay
The price is AEDĀ 1,010 per night from Aug 1 to Aug 2
AEDĀ 1,010
AEDĀ 1,111 total
1 Aug - 2 Aug
includes taxes & fees
9/10 Wonderful! (1,001 reviews)
"Convenient location and a wonderful staff. Very friendly and helpful. The hotel is modern with good amenities."

Reviewed on 8 July 2026

Waldorf Astoria Panama
Principe Hotel and Suites

Principe Hotel and Suites

3 out of 5
Via Argentina Panama City Panama
Fully refundableReserve now, pay when you stay
The price is AEDĀ 208 per night from Jul 14 to Jul 15
AEDĀ 208
AEDĀ 229 total
14 Jul - 15 Jul
includes taxes & fees
9/10 Wonderful! (1,953 reviews)
"Very clean, safe, convenient location and helpful staff."

Reviewed on 12 July 2026

Principe Hotel and Suites
See all 1,634 properties in Panama City
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Panama City attractions

A modern building facade with vertical reflective panels and the word "GUCCI" prominently displayed.
Photo by Fabiola Tile
Open Photo by Fabiola Tile

Multiplaza Pacific Mall

9.0/10 (4,497 reviews)
Panama's premier shopping destination houses over 500 stores, from luxury brands like Gucci to popular retailers like Apple. Obtain the Panama Shopping Card at reception for exclusive discounts throughout the mall.
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Frequently asked questions

How much does a Panama City vacation package cost?
Offering great value package deals on Expedia, you'll be thrilled with how little a vacation to Panama City costs! Expedia's packages make travel planning easier and your savings go further.
What are the cheapest months to go to Panama City?
You're likely to find reduced prices and better availability in September, October and November. Take a look at our cheap Panama City vacation packages and you could land some excellent off-season deals.
How to find the best Panama City package deals?
Finding a cheap Panama City package deal is a cinch with Expedia. After you've entered your destination and travel dates under our "Packages" tab, set your budget, add a few filters and see what's available. You can fine-tune your search by "Popular locations," "Property type," "Guest rating" and more. Sort the results by "Price: low to high" to discover the most economical Panama City package deals. Want a simple trick to get the biggest savings? Be flexible with your departure dates and consider traveling on a weekday, when prices are typically lower.
Is it cheaper to book a Panama City vacation as a package?
Expedia vacation packages are designed to help you keep more cash in your pocket. Bundle your car rental, hotel and flight into one great-value price and enjoy significant savings. You'll typically get a better deal than booking each component individually. And you'll still have the flexibility to create a tailored Panama City vacation by choosing your favorite airline, accommodation type and car class.
When to book a vacation package to Panama City?
Enjoy incredible bargains by reserving your flights in advance with Expedia. If being spontaneous is more your style, grab one of our last-minute deals for an impromptu Panama City escape.
How to plan a trip to Panama City?

  1. Choose the ideal time to travel: Your schedule, favorite season and the type of weather you enjoy can all impact your decision on when to go to Panama City.
  2. Budget wisely: On top of the price of your stay, you should factor in other expenses too. These include transportation, food and flights. Also, set aside a little extra for unexpected costs that could crop up during your trip to Panama City.
  3. Decide how long to go away for: Now that you're up to speed on Panama City, you can figure out the right length of your vacation. Pull together a rough plan and give yourself enough time to get through everything on your must-do list.
  4. Bundle your bookings: With your travel dates in place, you can combine your flights, car rental, hotels and more into a personalized Panama City vacation package.