Find 5 Star Hotels in Santa Ana from AED 444

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Check availability on Santa Ana 5 Star Hotels

Tonight
8 Dec - 9 Dec
Tomorrow
9 Dec - 10 Dec
This weekend
12 Dec - 14 Dec
Next weekend
19 Dec - 21 Dec

Compare Santa Ana 5 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Outdoor pool, sun loungers
Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (4631)
"Awesome great place to stay "
United States
Herbert
The price is AED 450
AED 495 total
includes taxes & fees
9 Dec - 10 Dec
Hotel Riu Plaza Panama
View from property
Waldorf Astoria Panama

Waldorf Astoria Panama

5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1002)
"I loved everything about my stay "
United States
Stephanie
The price is AED 660
AED 726 total
includes taxes & fees
16 Dec - 17 Dec
Waldorf Astoria Panama
2 restaurants, local cuisine
W Panama

W Panama

5.0 star property
Bella Vista
9.0 out of 10, Wonderful, (1006)
"Clean room, great views, great staff!"
United States
Ashley
The price is AED 732
AED 805 total
includes taxes & fees
19 Dec - 20 Dec
W Panama
4 outdoor pools, free cabanas, pool umbrellas
JW Marriott Panama

JW Marriott Panama

5.0 star property
San Francisco
9.0 out of 10, Wonderful, (1007)
"Bedroom was very comfy, also the staff were very on point. I will definitely recommend this hotel and there services, there is so much to do at this hotel."
United States
Sarran
The price is AED 889
AED 978 total
includes taxes & fees
4 Jan - 5 January 2026
JW Marriott Panama
Exterior
Sofitel Legend Casco Viejo, Panama City

Sofitel Legend Casco Viejo, Panama City

5.0 star property
Casco Viejo
9.8 out of 10, Exceptional, (554)
"Great hotel and location "
United Kingdom
Russell
The price is AED 1,504
AED 1,654 total
includes taxes & fees
15 Dec - 16 Dec
Sofitel Legend Casco Viejo, Panama City
Outdoor pool
Hilton Panama

Hilton Panama

5.0 star property
Bella Vista
8.8 out of 10, Excellent, (1001)
"Great place to stay."
United States
Salvador
The price is AED 684
AED 752 total
includes taxes & fees
2 Jan - 3 January 2026
Hilton Panama
3 outdoor pools, pool umbrellas, sun loungers
The Westin Playa Bonita Panama

The Westin Playa Bonita Panama

5.0 star property
Veracruz
8.0 out of 10, Very Good, (1003)
"Clean rooms , friendly staff , had great experience "
United States
Saro
The price is AED 643
AED 708 total
includes taxes & fees
18 Dec - 19 Dec
The Westin Playa Bonita Panama
40-inch Smart TV with cable channels, TV
Renaissance Panama City Hotel

Renaissance Panama City Hotel

5.0 star property
Bella Vista
8.8 out of 10, Excellent, (93)
"Great location and amazing staff"
United States
Aziz
The price is AED 426
AED 469 total
includes taxes & fees
15 Dec - 16 Dec
Renaissance Panama City Hotel
Couples treatment rooms, sauna, steam room, body treatments
Bristol Panama, a Registry Collection Hotel

Bristol Panama, a Registry Collection Hotel

5.0 star property
Bella Vista
9.4 out of 10, Exceptional, (1000)
"Love this hotel. Busy area, but hotel and restaurant make up for it."
United States
Allen
The price is AED 706
AED 777 total
includes taxes & fees
4 Jan - 5 January 2026
Bristol Panama, a Registry Collection Hotel
Suite, 1 Bedroom, Golf View (Terrace) | Premium bedding, minibar, in-room safe, desk
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City

5.0 star property
Juan Diaz
9.6 out of 10, Exceptional, (636)
"As usual the stay was amazing in this hotel"
United States
Jose
The price is AED 851
AED 936 total
includes taxes & fees
12 Dec - 13 Dec
The Santa Maria, A Luxury Collection Hotel & Golf Resort, Panama City
View from property
Megapolis Hotel Panamá

Megapolis Hotel Panamá

5.0 star property
San Francisco
8.4 out of 10, Very Good, (1000)
"Great stay! Very safe!"
United States
MARVIN
Megapolis Hotel Panamá
Outdoor pool
Waymore Hotel Spa and Casino

Waymore Hotel Spa and Casino

5.0 star property
Bella Vista
6.2 out of 10, (1000)
"It has a nice casino and it's very conveniently located. Breakfast was very good as well. Staff very helpful and attention oriented. Good experience "
United States
Aldo
Waymore Hotel Spa and Casino
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Santa Ana.
Crowne Plaza Panama Airport by IHG

Crowne Plaza Panama Airport by IHG

Ave. Domingo Diaz Tocumen Panama
The price is AED 404 per night from Dec 18 to Dec 19
AED 404
AED 444 total
18 Dec - 19 Dec
includes taxes & fees
8.4/10 Very Good! (2,320 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Santa Ana Hotel Reviews

Hotel Riu Plaza Panama

Hotel Riu Plaza Panama

10/10 Excellent
"Very good breakfast and very nice hotel and close to lots of restaurants "
Michele 4-night trip
Posted 2 days ago
Hotel Riu Plaza Panama

Frequently asked questions

What are the best 5-star hotels in Santa Ana?
According to reviews by our customers, Villa Palma Boutique Hotel is one of the best properties for an indulgent stay in the Panama City neighborhood of Santa Ana. Want more 5-star hotels around the area? Waldorf Astoria Panama and Hilton Panama will cater to your upscale desires.
How much does it cost to stay in a 5-star hotel in Santa Ana?
The amount you pay for a 5-star hotel in Santa Ana can vary according to when you prefer to travel and how long you plan to be away, among a range of factors. Use our price per night filter and other search tools to land the best deal on a high-end getaway.

  • Search for the lowest price per night from AED 444

What makes a hotel 5 stars in Santa Ana?
From high-end dining venues and 24-hour fitness centers to swimming pools and premium bedding, the 5-star experience in Santa Ana is all about luxury and comfort. But it requires more than just upscale conveniences to receive a 5-star rating. Hotels must also offer superior guest services like in-room massages, laundry and dry cleaning and room service any time day or night.

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