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Check prices for these dates

Next weekend
13 Nov - 15 Nov
In two weeks
20 Nov - 22 Nov
In one month
4 Dec - 6 Dec
In two months
1 Jan - 3 Jan

Our top choices for Perryville apartments

A modern kitchen with dark wood cabinets, a central island, and a brick wall.

1. Downtown Urban Loft #9

Downtown Urban Loft #9
Perryville
10.0 out of 10, Exceptional, (8 reviews)
"The Zen atmosphere made it really relaxing and the spa bathroom was incredible"
United States
Hunter
Downtown Urban Loft #9
A spacious loft with exposed brick walls, large windows, a kitchen with bar seating, and a ceiling fan.

2. Downtown Urban Loft #1

Downtown Urban Loft #1
Perryville
The price is AED 716
AED 1,124 total
includes taxes & fees
8 Nov - 9 Nov
Downtown Urban Loft #1
A modern kitchen with stainless steel appliances, a large window, and a breakfast setup on the counter.

3. Gorgeous, downtown house!

Gorgeous, downtown house!
Perryville
10.0 out of 10, Exceptional, (1 review)
"Our stay was excellent and our host Carisa was a Great person to work with. The house was beautiful. The house worked out great for us. We had 6 people staying and we all had very comfortable beds and our own bathrooms. Great for a large family. "
United States
Doyle or Cheryl D.
Gorgeous, downtown house!
A white two-story house with a covered porch, a chimney, and a small garden area with chairs and a table.

4. Beautiful Modern Loft In Wine Country!

Beautiful Modern Loft In Wine Country!
Ste. Genevieve
10.0 out of 10, Exceptional, (296 reviews)
"Absolutely beautiful place to stay!! Very clean!"
United States
Jimmy B.
The price is AED 544
AED 711 total
includes taxes & fees
17 Nov - 18 Nov
Beautiful Modern Loft In Wine Country!
A compact kitchen with wooden cabinets and a dining area with a table and chairs.

5. Villa B offers peace and quiet with beautiful views of the countryside.

Villa B offers peace and quiet with beautiful views of the countryside.
Jackson
9.8 out of 10, Exceptional, (16 reviews)
"We were only there for 1 night for a business trip but it was perfect for our stay. Very clean and comfortable and the host was onsite to welcome us. She even gave us a tip on the best place nearby for dinner that we will be going to any time we can in the future. I would gladly stay here again for future trips."
United States
Terry H.
The price is AED 551
AED 630 total
includes taxes & fees
18 Nov - 19 Nov
Villa B offers peace and quiet with beautiful views of the countryside.
A modern living room with a sectional sofa, a coffee table, a TV mounted on the wall, and a window with blinds.

6. The Lab! Come stay in our brand new space.

The Lab! Come stay in our brand new space.
Murphysboro
9.6 out of 10, Exceptional, (35 reviews)
"We enjoyed our visit"
United States
Tim P.
The price is AED 446
AED 726 total
includes taxes & fees
10 Nov - 11 Nov
The Lab! Come stay in our brand new space.
A kitchen with wooden cabinets, a black refrigerator, a microwave, a stove, and a ceiling fan. There are three stools at the island.

7. Relax in the country at Countryside Villas! - Villa A

Relax in the country at Countryside Villas! - Villa A
Jackson
10.0 out of 10, Exceptional, (39 reviews)
"Great place to stay, felt like home away from home. "
United States
Brittany
The price is AED 551
AED 630 total
includes taxes & fees
18 Nov - 19 Nov
Relax in the country at Countryside Villas! - Villa A
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Perryville and related destinations

Historic battlefields and the charming downtown district tell stories of Missouri's Civil War past. Visit Perry County Heritage Tourism Center and enjoy local wineries along the Mississippi Hills Wine Trail for a perfect weekend.

See all hotels in Perryville
A forest of tall pine trees at sunset.

Top reviews in Perryville

A modern kitchen with a large island, stainless steel appliances, and exposed brick walls.
Urban Lofts

Urban Lofts

Urban Lofts
Perryville

10/10 Excellent

Beautiful, clean property in the heart of city center. Many options for food and shopping within short walking distance.
United States
Gregory
Reviewed June 11, 2026
Urban Lofts

Frequently Asked Questions

What's it like to stay at an apartment in Perryville?

There are 7 apartments to choose from in Perryville for your vacation.

Why choose apartments instead of traditional hotels?

Often offering more space than a traditional hotel room, an apartment includes a kitchen for convenient home-cooked meals. Apartments are ideal for families who want the conveniences of home, and also for solo travelers who want to stay in at night and plan out their next day.

What's a favorite apartment for my stay in Perryville?

Downtown Urban Loft #4: Includes private balconies. Gorgeous, downtown house!: Private balconies and fireplaces are included. Access to onsite laundry facilities is available on site. Downtown Urban Loft #5: Includes private balconies.

How many apartments will I be able to find in Perryville?

Expedia has 7 apartments to book in Perryville.

What will the weather be like during my trip to Perryville?

Though weather is just one factor, it can really affect your travel plans, especially when you're planning an extended stay in Perryville. The hottest months are usually July and August with an average temp of 75°F, while the coldest months are January and February with an average of 39°F. Average annual precipitation for Perryville is 48 inches.

What are the must-see places to visit in Perryville?

Mark Twain National Forest and Mississippi River are a couple of lovely local spots to get outside and enjoy nature. National Shrine of Our Lady of the Miraculous Medal and Saint Marys Lake are other places to visit while you're in town.

What's the best way to get to and around Perryville?

Knowing a bit about the transportation options can make your trip smoother when you get to your destination. Fly into Cape Girardeau, MO (CGI-Cape Girardeau Municipal), which is located 38.3 mi (61.7 km) from the city center. If you'd like to explore around the area, you may want a rental car for your journey.