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Find Resorts & Hotels with Spas in Poplar Bluff, MO

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Check availability on Poplar Bluff Resorts & Hotels with Spas

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Recommended hotels in Poplar Bluff

Lobby lounge
Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (853)
"Very clean, great check in"
United States
Teresa
The price is AED 382
AED 432 total
includes taxes & fees
4 Jan - 5 January 2026
Fairfield Inn & Suites by Marriott Poplar Bluff
Lobby
Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (960)
"Nice room helpful staff. "
United States
Deborah
The price is AED 345
AED 390 total
includes taxes & fees
23 Dec - 24 Dec
Drury Inn & Suites Poplar Bluff
Reception
Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (796)
"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is AED 335
AED 375 total
includes taxes & fees
4 Jan - 5 January 2026
Hampton Inn Poplar Bluff
Blackout drapes, free WiFi, bed sheets
Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
7.8 out of 10, Good, (1004)
"Love the updated rooms and the vending area."
United States
Kathi
The price is AED 279
AED 294 total
includes taxes & fees
12 Dec - 13 Dec
Motel 6 Poplar Bluff, MO
Breakfast, lunch, dinner served; Italian cuisine
Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (697)
"Amazing place"
United States
Mladen
The price is AED 371
AED 419 total
includes taxes & fees
21 Dec - 22 Dec
Holiday Inn Poplar Bluff by IHG
Courtyard
Bullwinkles Rustic Lodge

Bullwinkles Rustic Lodge

Bullwinkles Rustic Lodge
2.5 star property
Poplar Bluff
8.4 out of 10, Very Good, (212)
"Had to "
United States
Brenda
Bullwinkles Rustic Lodge
Lobby
Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North

Comfort Inn Poplar Bluff North
2.5 star property
Poplar Bluff
7.8 out of 10, Good, (398)
"Good breakfast selection for the price and clean room. "
United States
Jared
The price is AED 333
AED 376 total
includes taxes & fees
4 Jan - 5 January 2026
Comfort Inn Poplar Bluff North
Lobby
Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri

Super 8 by Wyndham Poplar Bluff Missouri
2.0 star property
Poplar Bluff
6.6 out of 10, (622)
"The lady at the front was very nice. "
United States
Travis
The price is AED 206
AED 233 total
includes taxes & fees
18 Dec - 19 Dec
Super 8 by Wyndham Poplar Bluff Missouri
Exterior detail
Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff

Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff

Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff
Poplar Bluff
8.8 out of 10, Excellent, (9)
"The house was very clean and nicely decorated. The huge TV in the living room was a plus and the mattress was very comfortable. We would stay again!"
United States
Brian
The price is AED 367
AED 933 total
includes taxes & fees
11 Jan - 12 January 2026
Charming 2-bedroom house with 2 KING BEDS in Pleasant Poplar Bluff
Reception
Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
10.0 out of 10, Exceptional, (1)
"Staff was helpful and professional. The rooms were clean and comfortable "
United States
Michael
The price is AED 358
AED 402 total
includes taxes & fees
21 Dec - 22 Dec
Hampton Inn By Hilton Dexter
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Poplar Bluff Hotel Reviews

Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff

10/10 Excellent
"Staff was fantastic, especially John. All very friendly, helpful, & courteous."
Judy 1-night trip
Posted 4 days ago
Drury Inn & Suites Poplar Bluff

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Frequently asked questions

Looking for a spa hotel in Poplar Bluff?
Treat yourself to some time in a luxurious spa hotel and you won't regret it. Check out the opera and restaurants in Poplar Bluff—your day trip starts here. Enjoy the waterfalls during your vacation. Hotels with spas are the perfect way to take a break from your daily routine and add a layer of luxury to your holiday.
What's there to see and do in Poplar Bluff?
Experience Poplar Bluff with a stop at Black River Coliseum, Mark Twain National Forest, and Margaret Harwell Art Museum. If you have spare time during your trip, you might want to make a stop at Mo-Ark Regional Railroad Museum and North Main Street Historic District.
What is a Poplar Bluff spa hotel?
Spa hotels in Poplar Bluff provide lodging and have a full on-site spa which offers services like massages as well as beauty treatments. Some also offer in-room treatments. Spa hotels are great for rest, rejuvenation, and relaxation.