Photo by Bill Dillard

Find hotels in Southeast Missouri, MO from AED 227

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Compare 617 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Fairfield Inn & Suites by Marriott Poplar Bluff

2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (848)
"Very clean, great check in"
United States
Teresa
The price is AED 382
AED 432 total
includes taxes & fees
7 Dec - 8 Dec
Fairfield Inn & Suites by Marriott Poplar Bluff

Motel 6 Poplar Bluff, MO

2.0 star property
Poplar Bluff
7.8 out of 10, Good, (1002)
"Check in was smooth and facilities are excellent "
United States
Hector
The price is AED 279
AED 294 total
includes taxes & fees
7 Dec - 8 Dec
Motel 6 Poplar Bluff, MO

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1002)
"We like to stay at this hotel on our way to New Orleans and on our return trip to Wisconsin. It is convenient, clean, breakfast options are excellent and the 8 pm cookie time is always a hit. Staff are also very friendly. "
United States
Brian
The price is AED 349
AED 394 total
includes taxes & fees
22 Dec - 23 Dec
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Hampton Inn Poplar Bluff

2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (796)
"Staff was kind and provided a lot of information during check out."
United States
Shea
The price is AED 358
AED 401 total
includes taxes & fees
4 Jan - 5 January 2026
Hampton Inn Poplar Bluff

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

2.5 star property
Sikeston
8.4 out of 10, Very Good, (715)
"Stayed one night. Good rate for the Hotel "
United States
Paul
The price is AED 202
AED 230 total
includes taxes & fees
7 Dec - 8 Dec
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Drury Inn & Suites Sikeston, MO

3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
"Clean room, great location and friendly staff"
United States
Mark
The price is AED 331
AED 380 total
includes taxes & fees
10 Dec - 11 Dec
Drury Inn & Suites Sikeston, MO

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

3.0 star property
Jackson
8.8 out of 10, Excellent, (659)
"Great place "
United States
GUY
The price is AED 287
AED 311 total
includes taxes & fees
4 Jan - 5 January 2026
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

Drury Inn & Suites Poplar Bluff

3.0 star property
Poplar Bluff
9.2 out of 10, Wonderful, (955)
"Delicious, well-ran breakfast and quiet peaceful hotel. "
United States
Janene
The price is AED 378
AED 427 total
includes taxes & fees
27 Dec - 28 Dec
Drury Inn & Suites Poplar Bluff

Holiday Inn Poplar Bluff by IHG

3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (695)
"Amazing place"
United States
Mladen
The price is AED 364
AED 412 total
includes taxes & fees
7 Dec - 8 Dec
Holiday Inn Poplar Bluff by IHG

Honeysuckle Inn - Mountain View

3.0 star property
Mountain View
8.6 out of 10, Excellent, (331)
"Staff was very friendly."
United States
Joyce
The price is AED 350
AED 380 total
includes taxes & fees
17 Dec - 18 Dec
Honeysuckle Inn - Mountain View

Courtyard by Marriott Cape Girardeau Downtown

3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (466)
"The staff was very helpful and friendly. The rooms were modern and clean. The downtown location was perfect for us. "
United States
Deborah
The price is AED 426
AED 483 total
includes taxes & fees
21 Dec - 22 Dec
Courtyard by Marriott Cape Girardeau Downtown

Echo Bluff State Park

2.5 star property
Eminence
9.6 out of 10, Exceptional, (216)
"Beautiful location…excellent service and facilities / grounds were clean and well kept."
United States
William
The price is AED 549
AED 580 total
includes taxes & fees
7 Dec - 8 Dec
Echo Bluff State Park

Holiday Inn Express & Suites Perryville by IHG

2.5 star property
Perryville
9.2 out of 10, Wonderful, (536)
"Clean room and pleasant staff"
United States
David
The price is AED 320
AED 366 total
includes taxes & fees
7 Dec - 8 Dec
Holiday Inn Express & Suites Perryville by IHG

Hampton Inn Sikeston

2.5 star property
Sikeston
9.0 out of 10, Wonderful, (438)
"Room was clean and cozy, the check in-out staff were really nice and asked about our stay as well and the breakfast was a nice variety."
United States
Doncheial
The price is AED 350
AED 396 total
includes taxes & fees
14 Dec - 15 Dec
Hampton Inn Sikeston

Shepherd Mountain Inn

2.5 star property
Ironton
9.4 out of 10, Exceptional, (304)
" Nice room, nice bed, convenient location"
United States
Burton
Shepherd Mountain Inn

Best Western Plus Sikeston

2.5 star property
Sikeston
8.4 out of 10, Very Good, (1006)
"Nice location. Great staff. "
United States
Carla
The price is AED 293
AED 334 total
includes taxes & fees
14 Dec - 15 Dec
Best Western Plus Sikeston

The Farmstead Hotel

2.5 star property
Caruthersville
8.8 out of 10, Excellent, (460)
"Clean rooms and really comfortable beds!"
United States
Andrea
The price is AED 298
AED 339 total
includes taxes & fees
20 Dec - 21 Dec
The Farmstead Hotel

La Quinta Inn & Suites by Wyndham Festus - St. Louis South

3.0 star property
Festus
8.0 out of 10, Very Good, (883)
"Staff was very nice ans helpful. Our room was clean and pleasant. "
United States
ELLEN
The price is AED 347
AED 396 total
includes taxes & fees
4 Jan - 5 January 2026
La Quinta Inn & Suites by Wyndham Festus - St. Louis South

Drury Inn & Suites Jackson MO

3.0 star property
Jackson
9.6 out of 10, Exceptional, (1002)
"Breakfast was great- staff was welcoming. Will stay there again."
United States
Laura
The price is AED 305
AED 322 total
includes taxes & fees
8 Dec - 9 Dec
Drury Inn & Suites Jackson MO

Fort Davidson Hotel

2.5 star property
Ironton
9.2 out of 10, Wonderful, (173)
"Friendly staff, spacious room, nice pool!!"
United States
SHARON
The price is AED 441
AED 481 total
includes taxes & fees
7 Dec - 8 Dec
Fort Davidson Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Great weekend hotel deals in Southeast Missouri, MO

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Stay near popular Central United States attractions

Learn more about Southeast Missouri

Explore the family-friendly area of Southeast Missouri—restaurants, wineries, and sights from Sam A. Baker State Park to Walnut Hollow Lake.

Mini Takes the States 2014 Road Rally Memphis to St.Louis Leg:

Moark Regional Railroad Museum
HOURS: Saturdays 1 p.m. - 4 p.m.

It was not open when I stopped by but there are a few rail cars outside. Poplar has a train rich history.

This was a cool little town to stop in and take pictures. Lot's of wall murals for some reason, and some very cool architecture. Worth the stop and be sure and enjoy a lunch at Hayden's Drive-In ! 

#MTTS2014 #minitakesthestates #go11
#train
Photo by Bill Dillard
Open Photo by Bill Dillard

Top Southeast Missouri Hotel Reviews

More cheap stays in Southeast Missouri

Hotels in Southeast Missouri with star-rating

Find out more about Southeast Missouri

Top reasons to visit Southeast Missouri

  • Outdoor Adventures: Southeast Missouri is perfect for outdoor enthusiasts, offering hiking, scenic retreats, and recreational activities.
  • Family-Friendly Experiences: The region provides numerous activities suitable for families, ensuring fun for all ages.
  • Cultural Attractions: Explore historic civic buildings and nearby sites, including Southeast Missouri State University.
  • Inviting Parks: Enjoy picturesque urban and state parks for leisurely strolls and nature exploration.
  • Diverse Accommodations: Choose from a range of lodging options, from cozy motels to well-equipped hotels to fit any traveler’s needs.

Find great hotels near Southeast Missouri

Explore the diverse hotel accommodations in Southeast Missouri, where options range from cozy motels to well-equipped hotels tailored for business travelers and adventure seekers alike. Whether you're looking for pet-friendly places or the best-reviewed stays, this region offers a variety of choices to suit every traveler's needs. Discover the perfect lodging to make your visit memorable, conveniently located near popular attractions and activities.

  • Madison Inn Lodge: Ideal for pet lovers and business travelers, Madison Inn Lodge is a welcoming motel located 25.7km from Southeast Missouri. This lodge embraces a pet-friendly atmosphere, allowing guests to bring their furry companions along for the adventure. Offering essential amenities like complimentary Wi-Fi and comfortable accommodations, it ensures a hassle-free stay. The property also features a welcoming environment for service animals, making it a perfect choice for those traveling for work or leisure with pets in tow.
  • Shepherd Mountain Inn: Located 33.8km from Southeast Missouri, Shepherd Mountain Inn stands out as a reliable choice for business travelers. This hotel provides a focused and comfortable environment, making it easy for guests to unwind or catch up on work. With modern amenities and convenient services, it caters to the needs of professionals seeking a productive stay. The inn's strategic location allows easy access to nearby business hubs and local attractions, ensuring that guests can balance work and leisure seamlessly.
  • Alpaca Farm Stay: For those yearning for adventure or a romantic getaway, Alpaca Farm Stay is a charming lodge just 12.9km away from Southeast Missouri. Nestled in nature, it offers various outdoor activities including mountain biking, kayaking, and hiking, catering to families and thrill-seekers alike. With amenities designed for children, such as a shared playground, it’s perfect for family vacations. Guests can also enjoy stunning views of the lake and mountains while indulging in romance packages, creating unforgettable memories amidst beautiful surroundings.

Where to stay near Southeast Missouri

Southeast Missouri offers an inviting blend of outdoor adventures and family-friendly experiences. Enjoy leisurely strolls through picturesque parks, or embark on scenic retreats to explore lush landscapes. With friendly locals and convenient access to attractions, visitors can indulge in recreational activities suitable for all ages. Don’t miss the chance to soak in the region's vibrant atmosphere during its wettest month, making it an unforgettable getaway for nature lovers and families alike.

  • Annapolis: Located 22.5km from Southeast Missouri, Annapolis is a charming city that attracts visitors year-round, especially during the warmer months of June to July and September. Known for its outdoor adventures and scenic beauty, this city offers a variety of recreational areas and an entertainment arena. Nature lovers will appreciate the proximity to a national state park, rivers, and picturesque parks, making Annapolis an ideal spot for those seeking adventure and outdoor experiences.
  • Central Fredericktown: Just 16.1km from Southeast Missouri, Central Fredericktown is a quaint village that draws family-oriented travelers looking for a city-themed experience. The peak travel times from June to August make it a lively destination during the summer months. Visitors can enjoy educational venues, shopping mall centers, and urban parks. The local history museum provides a glimpse into the region's past, while the various parks offer a relaxing escape for families and outdoor enthusiasts alike.
  • Des Arc: A mere 17.7km from Southeast Missouri, Des Arc is a vibrant city known for its seasonal influx of visitors, peaking from June to August. This city is perfect for those who enjoy outdoor activities and stunning scenery. Des Arc features an array of recreational areas, a water park, and an entertainment arena, ensuring fun for all ages. Outdoor enthusiasts will love the nearby national state park, lake, and rivers, making it a fantastic destination for adventure seekers and nature lovers.

Things to do near Southeast Missouri

Southeast Missouri is perfect for outdoor enthusiasts and adventure seekers, offering a variety of activities. Visitors can enjoy campus tours, outdoor sports tournaments, and brewery tours. The region also boasts recreational areas and educational experiences, making it an ideal destination for those looking to explore nature and engage in fun activities. Whether you're interested in sports or learning, there's something for everyone in Southeast Missouri.

Shopping

Experience shopping at Red's Flea Market, located 41.8km from Southeast Missouri, where you'll find a variety of unique gifts and treasures. Additionally, visit the Farmington Mineral Area Shopping Center, 48.3km away, offering a mix of family-friendly entertainment, shops, and dining options.

Recreation

Crane Lake Recreation Area offers a peaceful retreat with serene surroundings, perfect for relaxation and rejuvenation. Arcadia Valley Golf Club provides an invigorating outdoor experience with its scenic golf course. Silver Mine Recreation Area combines wellness and nature, featuring tranquil trails and beautiful landscapes for ultimate relaxation.

Adventure

Shepherd Mountain Bike Park and Hiking Trails offers thrilling outdoor adventures only 33.8km from Southeast Missouri. Experience scenic biking paths and hiking trails that wind through lush landscapes, perfect for both adrenaline seekers and nature lovers looking to immerse themselves in the beautiful surroundings.

Nightlife

Southeast Missouri's nightlife offers a mix of cozy bars and lively venues. Enjoy live music at The Blue Note in Columbia or sip craft beers at a local brewery. For dancing, head to The Parlor in Cape Girardeau, where vibrant crowds and energetic beats create an unforgettable atmosphere.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Southeast Missouri

To save money during your trip to Southeast Missouri, plan to visit between November and January, when accommodation prices are lower. Tuesdays are the cheapest days to book, while Saturdays tend to be the most expensive. Use Expedia's search tool to find budget-friendly hotels by sorting prices and applying filters for eco-certified options. Additionally, consider booking package deals that combine flights, hotels, and activities for extra savings. Take advantage of free local attractions and affordable public transport to explore the area without overspending.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay around Southeast Missouri are November to January, where the prices are slightly lower. This is in comparison to April, June and August, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay around Southeast Missouri is Tuesday. The most expensive day to stay around Southeast Missouri is Saturday.
  • Find cheap hotels on Expedia: Expedia's search tool enables you to set your budget, choose your desired location, and much more. You can organize your results to display prices from lowest to highest, ensuring you see the most affordable hotels first. Additionally, you have the option to narrow down your choices by hotel type. For instance, by selecting the Eco-certified filter, you'll find a selection of sustainable and environmentally-friendly hotels available for booking.
  • Consider bundling your trip: You can save money by combining your hotel reservations in Southeast Missouri with your flights and activities by choosing an Expedia package.

Find the best attractions near Southeast Missouri

Southeast Missouri offers a fantastic blend of outdoor adventures and scenic beauty, making it an ideal destination for families and nature lovers. Visitors can explore urban parks, state parks, and historic civic buildings. Notable attractions include nearby sites and Southeast Missouri State University, providing a mix of educational and recreational experiences. Whether you're hiking, sightseeing, or enjoying family-friendly activities, Southeast Missouri has something for everyone.

  • Walnut Hollow Lake: Nestled 20.9km away, Walnut Hollow Lake offers a serene escape with its picturesque beaches and stunning scenery. Ideal for a romantic day out or a peaceful retreat, this lake is perfect for swimming, picnicking, or simply enjoying the natural beauty.
  • K Bridge Recreation Area: Located 27.4km from Southeast Missouri, this urban park is a family-friendly destination featuring open spaces for picnics, walking trails, and playgrounds. It’s a great spot to unwind and enjoy the city vibes while spending quality time with loved ones.
  • Millstream Gardens Conservation Area: Just 24.1km away, this conservation area is rich in history and adventure. With friendly locals and relaxing trails, it’s ideal for families seeking outdoor fun, making it a perfect place to connect with nature and explore.

Best time to go to Southeast Missouri

The best time to visit Southeast Missouri can depend on the weather and when visitor numbers rise and fall. The hottest average temperature around Southeast Missouri falls in July, when visitor numbers are slightly high and weather is mostly sunny with light rain. The coolest average temperature around Southeast Missouri falls in January, visitor numbers are slightly low and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January34.9°F (1.6°C)Light RainMostly SunnySlightly LowSlightly Low
February38.1°F (3.4000000000000004°C)Light RainMostly SunnySlightly LowAverage
March48.0°F (8.9°C)Light RainMostly SunnyAverageAverage
April57.6°F (14.2°C)Light RainMostly SunnyAverageSlightly High
May67.3°F (19.6°C)Light RainMostly SunnyAverageAverage
June76.5°F (24.700000000000003°C)Light RainMostly SunnySlightly HighSlightly High
July79.2°F (26.200000000000003°C)Light RainMostly SunnySlightly HighAverage
August77.2°F (25.1°C)Light RainMostly SunnySlightly HighSlightly High
September71.6°F (22.0°C)Light RainMostly SunnyAverageAverage
October59.9°F (15.5°C)Light RainMostly SunnyAverageAverage
November47.5°F (8.6°C)Light RainMostly SunnyAverageSlightly Low
December39.4°F (4.1000000000000005°C)Light RainMostly SunnySlightly LowSlightly Low

The nearest major airports for your trip to Southeast Missouri

When visiting Southeast Missouri, you can fly into several major airports. St. Louis Lambert International Airport (STL) is located 154.5km away, with nearby hotels like The Ritz-Carlton and Ameristar Casino Resort, both about 11.3km from the airport. Fort Leonard Wood Regional Airport (TBN) is also 154.5km away, offering accommodations such as the Z Loft Extended Stay Hotel, just 9.7km from the airport. Additionally, Barkley Regional Airport (PAH) in Paducah, KY is 152.9km away, with options like The Respite Bed and Breakfast located 14.5km from the airport. Each of these airports provides accessible transport to nearby hotels for a convenient stay.

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