Search Vacation Homes in Santo Domingo

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Find vacation rentals that suit your style

Check prices for these dates

Our top choices for Santo Domingo vacation homes

1. Cozy and Quiet Corner to Rest

Cozy and Quiet Corner to Rest
Los Frailes
Cozy and Quiet Corner to Rest

2. House by Aut. Las Américas 10 minutes from the airport

House by Aut. Las Américas 10 minutes from the airport
Los Frailes
House by Aut. Las Américas 10 minutes from the airport

3. Room-malecon Cozy Private Room 6

Room-malecon Cozy Private Room 6
3.0 star property
Ciudad Universitaria
4.0 out of 10, (1 review)
"There was no hot water option in the shower or sink house cleaning was extra and towels were not regularly available had to ask for new ones and they didn’t want to give me more then one at a time "
United States
Matthew
The price is AED 114
AED 180 total
includes taxes & fees
12 Nov - 13 Nov
Room-malecon Cozy Private Room 6

4. Comfort & ancient beauty meet

Comfort & ancient beauty meet
Zona Colonial
8.0 out of 10, Very good, (3 reviews)
"Love the location"
United States
tysean
Comfort & ancient beauty meet

5. ★Designer LOFT 1BR Piantini | CityViews-YellowKey

★Designer LOFT 1BR Piantini | CityViews-YellowKey
Piantini
10.0 out of 10, Exceptional, (5 reviews)
"It was amazing"
United States
Miguel Ángel M.
★Designer LOFT 1BR Piantini | CityViews-YellowKey

6. Short Term Studio Apartment in Gascue, Central Zone of the City

Short Term Studio Apartment in Gascue, Central Zone of the City
Gascue
8.8 out of 10, Excellent, (3 reviews)
"Very friendly staff. The room was clean and comfortable. "
United States
Jorge R.
Short Term Studio Apartment in Gascue, Central Zone of the City

7. Short Term Rooms in Central Zone of the City

Short Term Rooms in Central Zone of the City
Gascue
6.6 out of 10, (4 reviews)
"The room is OK, very spacious, and very comodable. Only issue is that the wifi is intermittent."
United States
Benjamin
Short Term Rooms in Central Zone of the City

8. Luxury Morden house with Jacuzzi Zona Colonial.!

Luxury Morden house with Jacuzzi Zona Colonial.!
Zona Colonial
10.0 out of 10, Exceptional, (8 reviews)
"Everything was perfect, the host was very friendly and accessible. I definitely will stay again."
United States
Robert J.
Luxury Morden house with Jacuzzi Zona Colonial.!

9. Modern Apartment in Santo Domingo – Near the Colonial District & Malecón

Modern Apartment in Santo Domingo – Near the Colonial District & Malecón
Gascue
Modern Apartment in Santo Domingo – Near the Colonial District & Malecón

10. Acogedora Casita en el corazón de la Zona Colonial

Acogedora Casita en el corazón de la Zona Colonial
Zona Colonial
Acogedora Casita en el corazón de la Zona Colonial

11. 2-Bedroom Family Apartment in Downtown with Gym and Rooftop Terrace

2-Bedroom Family Apartment in Downtown with Gym and Rooftop Terrace
Downtown Santo Domingo
10.0 out of 10, Exceptional, (4 reviews)
"This apartment has all that you need, spacious, clean, modern and welcoming.The location is perfect and easy to get around Santo Domingo. Great communication with host."
United States
José J.
2-Bedroom Family Apartment in Downtown with Gym and Rooftop Terrace

12. Getaway 1BR-WiFi-AC-View-Gym-BlueMall-YellowKey

Getaway 1BR-WiFi-AC-View-Gym-BlueMall-YellowKey
Piantini
Getaway 1BR-WiFi-AC-View-Gym-BlueMall-YellowKey

13. Room-malecon Cozy - Premium Plus 12

Room-malecon Cozy - Premium Plus 12
2.5 star property
Ciudad Universitaria
The price is AED 233
AED 321 total
includes taxes & fees
18 Nov - 19 Nov
Room-malecon Cozy - Premium Plus 12

14. Santo Domingo GETAWAY OASIS

Santo Domingo GETAWAY OASIS
Ciudad Universitaria
10.0 out of 10, Exceptional, (1 review)
"Awesome stay would stay here again highly recommend "
United States
Moolah E.
Santo Domingo GETAWAY OASIS

15. Heart of DR, 20 Min from Airport

Heart of DR, 20 Min from Airport
Santo Domingo Este
10.0 out of 10, Exceptional, (2 reviews)
"The place is quiet and Miguel the person who assist you with the check in he’s so nice"
United States
Yaisel L.
Heart of DR, 20 Min from Airport

16. In The City Center Modern Apartment! Pool&Gym

In The City Center Modern Apartment! Pool&Gym
Downtown Santo Domingo
9.0 out of 10, Wonderful, (7 reviews)
"Great location! Around a few restaurants and stores an uber to almost every location. Soler the front guy was amazing and friendly. "
United States
Lucia M.
In The City Center Modern Apartment! Pool&Gym

17. Regatta Living Prime Location, Stunning Amenities

Regatta Living Prime Location, Stunning Amenities
Piantini
Regatta Living Prime Location, Stunning Amenities

18. Upscale 1BR apartment near Blue mall with rooftop by Yellowkey

Upscale 1BR apartment near Blue mall with rooftop by Yellowkey
Piantini
10.0 out of 10, Exceptional, (2 reviews)
"Great weekend getaway. Would highly recommend."
United States
Andres A.
Upscale 1BR apartment near Blue mall with rooftop by Yellowkey

19. Armonia Piantini, A/C, Wifi, Smart tv-YellowKey

Armonia Piantini, A/C, Wifi, Smart tv-YellowKey
Piantini
10.0 out of 10, Exceptional, (1 review)
"Great stay"
United States
Christopher R.
Armonia Piantini, A/C, Wifi, Smart tv-YellowKey

20. Stunning Views, Pool, AC, WiFi - Perfect Getaway by Yellowkey

Stunning Views, Pool, AC, WiFi - Perfect Getaway by Yellowkey
Downtown Santo Domingo
6.0 out of 10, (1 review)
"The apartment is nice and the social area was beautiful. I had an issue and try to contact the host. It took from the morning until evening to get in contact with the host."
United States
Jairo
Stunning Views, Pool, AC, WiFi - Perfect Getaway by Yellowkey
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Santo Domingo and related destinations

Colonial architecture and vibrant plazas define the Zona Colonial, where cobblestone streets lead to the oldest cathedral in the Americas. Spend mornings exploring historic sites, then head to the Malecón for sunset strolls where locals fish alongside tourists enjoying fresh seafood.

A large, symmetrical building with a central entrance and multiple plaques on its facade.

Top reviews in Santo Domingo

Explore a world of travel with Expedia