Find hotels in Seneca, SC from AED 212

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Compare 1,629 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

Our top choices for Seneca hotels

Rodeway Inn

2.0 star property
7.6 out of 10, Good, (291)
"The walk-in shower was great. The room was clean and the bed was very comfortable."
The price is AED 248
AED 275 total
includes taxes & fees
21 Sep - 22 Sep
Rodeway Inn

Days Inn by Wyndham Royston

2.0 star property
7.2 out of 10, Good, (226)
"M"
The price is AED 338
AED 390 total
includes taxes & fees
12 Oct - 13 Oct
Days Inn by Wyndham Royston

Fairfield Inn & Suites by Marriott Anderson Clemson

2.5 star property
9.0 out of 10, Wonderful, (559)
"Clean room staff was verynice!"
The price is AED 327
AED 363 total
includes taxes & fees
21 Sep - 22 Sep
Fairfield Inn & Suites by Marriott Anderson Clemson

Tru by Hilton Seneca Clemson

2.5 star property
9.2 out of 10, Wonderful, (765)
"Staff and property were top-notch! "
The price is AED 403
AED 443 total
includes taxes & fees
21 Sep - 22 Sep
Tru by Hilton Seneca Clemson

Quality Inn Seneca Clemson Area US-123

2.5 star property
8.0 out of 10, Very Good, (637)
"Ok hotel for a quick stay "
The price is AED 294
AED 360 total
includes taxes & fees
18 Sep - 19 Sep
Quality Inn Seneca Clemson Area US-123

Postcard Cabins Lake Hartwell

2.0 star property
9.8 out of 10, Exceptional, (30)
"Lovely stay! Highly recommend!!!"
The price is AED 278
AED 447 total
includes taxes & fees
16 Sep - 17 Sep
Postcard Cabins Lake Hartwell

Fairfield Inn & Suites Seneca Clemson Univ Area

2.5 star property
9.4 out of 10, Exceptional, (190)
"Nice hotel by the lake"
The price is AED 511
AED 562 total
includes taxes & fees
14 Sep - 15 Sep
Fairfield Inn & Suites Seneca Clemson Univ Area

Lakeside Lodge Clemson

2.5 star property
9.0 out of 10, Wonderful, (1000)
"Very pleasant stay!"
The price is AED 400
AED 502 total
includes taxes & fees
13 Sep - 14 Sep
Lakeside Lodge Clemson

Best Western Seneca-Clemson

2.5 star property
8.4 out of 10, Very Good, (610)
"Liked location "
The price is AED 328
AED 361 total
includes taxes & fees
21 Sep - 22 Sep
Best Western Seneca-Clemson

Hampton Inn & Suites Seneca-Clemson Area

2.5 star property
9.4 out of 10, Exceptional, (633)
"The staff were very friendly and helpful. The room was clean and the breakfast was great!"
The price is AED 445
AED 490 total
includes taxes & fees
14 Sep - 15 Sep
Hampton Inn & Suites Seneca-Clemson Area

Days Inn by Wyndham Seneca / Clemson Area

2.0 star property
6.8 out of 10, (697)
"Friendly staff easy check-in. "
The price is AED 259
AED 285 total
includes taxes & fees
14 Sep - 15 Sep
Days Inn by Wyndham Seneca / Clemson Area

Hampton Inn Hartwell

2.5 star property
9.2 out of 10, Wonderful, (319)
"Great stay"
The price is AED 455
AED 541 total
includes taxes & fees
14 Sep - 15 Sep
Hampton Inn Hartwell

Hilton Garden Inn Anderson

3.0 star property
9.0 out of 10, Wonderful, (643)
"Breakfast was good staff was great "
The price is AED 343
AED 381 total
includes taxes & fees
22 Sep - 23 Sep
Hilton Garden Inn Anderson

Microtel Inn & Suites by Wyndham Anderson/Clemson

2.0 star property
8.2 out of 10, Very Good, (1000)
"Great place to stay!"
The price is AED 309
AED 343 total
includes taxes & fees
14 Sep - 15 Sep
Microtel Inn & Suites by Wyndham Anderson/Clemson

Rodeway Inn & Suites Walhalla

2.0 star property
7.6 out of 10, Good, (169)
"We only spent one night, for a show at the PAC. Room was nice, and well kept.. bed was comfortable.. "
The price is AED 265
AED 296 total
includes taxes & fees
12 Oct - 13 Oct
Rodeway Inn & Suites Walhalla

The Shepherd Hotel Downtown Clemson

4.0 star property
9.8 out of 10, Exceptional, (681)
"Great staff, location, comfortable and well maintained property."
The price is AED 694
AED 771 total
includes taxes & fees
14 Sep - 15 Sep
The Shepherd Hotel Downtown Clemson

Days Inn by Wyndham Anderson

2.0 star property
7.4 out of 10, Good, (1000)
"Super nice place -nice people"
The price is AED 231
AED 256 total
includes taxes & fees
14 Sep - 15 Sep
Days Inn by Wyndham Anderson

Hampton Inn Anderson/ Alliance Business Park

2.5 star property
9.2 out of 10, Wonderful, (777)
"Friendly staff, clean facility, decent amount of options for breakfast, kids loved the pool "
The price is AED 403
AED 447 total
includes taxes & fees
11 Oct - 12 Oct
Hampton Inn Anderson/ Alliance Business Park

Woodspring Suites Anderson North I-85

2.5 star property
6.8 out of 10, (28)
"Very nice and clean property. Staff was so nice and helpful. Made check in so easy"
The price is AED 290
AED 322 total
includes taxes & fees
14 Sep - 15 Sep
Woodspring Suites Anderson North I-85

Hartwell Suites

2.0 star property
9.2 out of 10, Wonderful, (21)
"Great location, nice place"
The price is AED 631
AED 744 total
includes taxes & fees
14 Sep - 15 Sep
Hartwell Suites
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Where to stay in Seneca

Find the best Seneca areas and neighborhoods for the activities you enjoy most.

Downtown

2 out of top 10 points of interest in this area

Downtown Seneca captures the essence of small-town Southern charm with its well-preserved railroad heritage and historic brick buildings. Tree-lined streets lead to charming shops and local eateries housed in structures dating back to the 1800s. Ram Cat Alley's colorful murals tell stories of local history while the old courthouse square hosts community gatherings. This walkable district offers a peaceful retreat from big city life. Visitors can browse antique stores for railroad memorabilia, sample authentic Southern comfort food, or explore the cultural exhibits at the Bertha Lee Strickland Museum. The nearby Lake Keowee provides outdoor recreation just minutes away.

Serenity Bay

Serenity Bay offers a peaceful retreat within Saxony Forest's coastal embrace. The quiet residential streets wind through mature trees, creating a tranquil atmosphere away from tourist crowds. Nature lovers can explore nearby Lake Keowee or enjoy the neighborhood's forest trails. The area perfectly balances woodland serenity with beach proximity. Visitors should plan for self-contained vacation rentals rather than hotels. While dining options are limited within the neighborhood, the natural surroundings provide ideal conditions for relaxation and outdoor recreation.

Pine Ridge Point

Lake Keowee's serene waters lap against the shores of Pine Ridge Point, a tranquil residential haven in Seneca. Private docks stretch into crystal-clear waters where boats gently bob. Towering pines create natural privacy between lakefront homes. Visitors enjoy peaceful mornings watching mist rise over the water. This neighborhood offers an authentic lakeside living experience without tourist crowds. Vacation rentals range from cozy cabins to luxury estates with private boat slips. Days revolve around swimming, fishing, and water sports on Lake Keowee. Nature trails wind through mature forests for hiking and birdwatching.

Indian Oaks

Indian Oaks offers a tranquil retreat in suburban Seneca where mature oak trees create natural canopies over peaceful residential streets. This family-oriented community provides an authentic glimpse into American suburban living without tourist crowds. Landscaped yards and community green spaces showcase South Carolina's native beauty. Visitors can enjoy quiet morning walks on spacious sidewalks while listening to birdsong. Lake Keowee lies just beyond the neighborhood boundaries for those seeking water activities. With minimal commercial presence, Indian Oaks delivers a genuinely restful experience away from urban bustle.

Learn more about Seneca

Nestled along Lake Keowee's shoreline, this charming town offers spectacular waterfront activities from kayaking to fishing at South Cove County Park. Nearby Stumphouse Tunnel and Issaqueena Falls provide fascinating historical exploration and refreshing natural beauty, especially during summer's humid afternoons.

View from the dike in Clemson, SC. This trail is used by runners, bikers, and lots of dog walkers.
Photo by Cindy Keese
Open Photo by Cindy Keese

Top Seneca Hotel Reviews

More cheap stays in Seneca

More cheap stays in Seneca

Hotels in Seneca with star-rating

Hotels in Seneca with star-rating

Explore a world of travel with Expedia

Explore a world of travel with Expedia

Frequently asked questions

Where is the best place for a stay in Seneca?

Tru by Hilton Seneca Clemson is ranked highly by Expedia customers. This hotel is a short 5-minute walk from Lake Hartwell, and it offers free breakfast and free parking. Traveler reviews also recommend Lakeside Lodge Clemson and Hampton Inn & Suites Seneca-Clemson Area as top choices for your visit. See all available top hotels, or vacation rentals in Seneca.

What's the top vacation rental in Seneca?

Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock: Visitors give good reviews to this Seneca vacation home rental, which is located on a lake and has a patio, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 4 bedrooms and a kitchen with a dishwasher. Some other homes for rent in Seneca include Large family home with dock on Lake Keowee! and 4/3 Waterfront Home w/ Covered Dock, 2 Decks, Pet Friendly. Long view on lake. . See all vacation rentals in Seneca.

If I need to cancel my hotel reservation in Seneca, will I receive a refund?

Yes, the majority of hotel reservations are refundable provided that you cancel before the accommodation's cancellation deadline, which often is within 24-48 hours of your check-in date. If your reservation is non-refundable, it might still be possible to cancel it and be given a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in Seneca.

Where can I learn more about changing or cancelling my trip to Seneca?

To find more details about updating your trip to Seneca or cancelling it, click here.

What's the best place to stay for a family vacation to Seneca?

Fairfield Inn & Suites Seneca Clemson Univ Area is a hotel with an outdoor pool and free parking, and it's a top choice on Expedia for families. Attractions in the area like Ultimate Action Sports are also fun for the whole family. Find more child-friendly accommodations in Seneca.

What's the best LGBTQ-friendly place to stay in Seneca?

Hampton Inn & Suites Seneca-Clemson Area is a top LGBTQ-friendly hotel that features free breakfast and free WiFi. Tru by Hilton Seneca Clemson is another good choice for your stay.

What's the best pet-friendly accommodation in Seneca?

Lakeside Lodge Clemson is a top hotel for people traveling with their pets, and offers a restaurant and a seasonal outdoor pool for its human guests. Other good choices to stay with your pet include Tru by Hilton Seneca Clemson and Days Inn by Wyndham Seneca / Clemson Area. See more pet-friendly hotel accommodations in Seneca.

What are some hotels with pools in Seneca?

Quality Inn Seneca Clemson Area US-123: Features daily, a seasonal outdoor pool, and free self parking. Lakeside Lodge Clemson and Hampton Inn & Suites Seneca-Clemson Area are two additional hotels with an onsite pool. View all hotels with pools in Seneca.

What is the best accommodation for staying close to Greenville-Spartanburg International Airport (GSP)?

Wyndham Garden Greenville Airport is one of the top choices for your stay and is a popular 3-star hotel featuring free breakfast and a restaurant. It's located 3.8 mi (6.1 km) from Greenville-Spartanburg Intl. Airport. Other good options near the airport include Best Western Greenville Airport Inn and Extended Stay America - Greenville - Airport.

What is staying in Seneca like?

Visitors to Seneca are sure to enjoy the sporting events, lakeside setting, and university setting. Welcoming and scenic, this city also attracts tourists with its coffeehouses. In Seneca, there are 289 hotels and other accommodations to choose from. Find out more about Seneca.

What should I do while I'm visiting Seneca?

Cultural venues include The Gauntlet and Oconee Community Theatre. Natural beauty is on display at Keowee Reservoir, Lake Keowee, and Lake Hartwell. Exploring the waterfront is a great activity, and Keowee Key Golf Course is one place to visit. Check out what more to see and do in Expedia's Seneca guide.

What's the weather like in Seneca?

The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 46°F. Average annual precipitation for Seneca is 62 inches.