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Compare 1,629 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.
Our top choices for Seneca hotels

Rodeway Inn
Rodeway Inn

Days Inn by Wyndham Royston
Days Inn by Wyndham Royston

Fairfield Inn & Suites by Marriott Anderson Clemson
Fairfield Inn & Suites by Marriott Anderson Clemson

Tru by Hilton Seneca Clemson
Tru by Hilton Seneca Clemson

Quality Inn Seneca Clemson Area US-123
Quality Inn Seneca Clemson Area US-123

Postcard Cabins Lake Hartwell
Postcard Cabins Lake Hartwell
Where to stay in Seneca

Downtown
Downtown Seneca captures the essence of small-town Southern charm with its well-preserved railroad heritage and historic brick buildings. Tree-lined streets lead to charming shops and local eateries housed in structures dating back to the 1800s. Ram Cat Alley's colorful murals tell stories of local history while the old courthouse square hosts community gatherings. This walkable district offers a peaceful retreat from big city life. Visitors can browse antique stores for railroad memorabilia, sample authentic Southern comfort food, or explore the cultural exhibits at the Bertha Lee Strickland Museum. The nearby Lake Keowee provides outdoor recreation just minutes away.
Serenity Bay
Serenity Bay offers a peaceful retreat within Saxony Forest's coastal embrace. The quiet residential streets wind through mature trees, creating a tranquil atmosphere away from tourist crowds. Nature lovers can explore nearby Lake Keowee or enjoy the neighborhood's forest trails. The area perfectly balances woodland serenity with beach proximity. Visitors should plan for self-contained vacation rentals rather than hotels. While dining options are limited within the neighborhood, the natural surroundings provide ideal conditions for relaxation and outdoor recreation.

Pine Ridge Point
Lake Keowee's serene waters lap against the shores of Pine Ridge Point, a tranquil residential haven in Seneca. Private docks stretch into crystal-clear waters where boats gently bob. Towering pines create natural privacy between lakefront homes. Visitors enjoy peaceful mornings watching mist rise over the water. This neighborhood offers an authentic lakeside living experience without tourist crowds. Vacation rentals range from cozy cabins to luxury estates with private boat slips. Days revolve around swimming, fishing, and water sports on Lake Keowee. Nature trails wind through mature forests for hiking and birdwatching.
Indian Oaks
Indian Oaks offers a tranquil retreat in suburban Seneca where mature oak trees create natural canopies over peaceful residential streets. This family-oriented community provides an authentic glimpse into American suburban living without tourist crowds. Landscaped yards and community green spaces showcase South Carolina's native beauty. Visitors can enjoy quiet morning walks on spacious sidewalks while listening to birdsong. Lake Keowee lies just beyond the neighborhood boundaries for those seeking water activities. With minimal commercial presence, Indian Oaks delivers a genuinely restful experience away from urban bustle.
Learn more about Seneca
Nestled along Lake Keowee's shoreline, this charming town offers spectacular waterfront activities from kayaking to fishing at South Cove County Park. Nearby Stumphouse Tunnel and Issaqueena Falls provide fascinating historical exploration and refreshing natural beauty, especially during summer's humid afternoons.

More cheap stays in Seneca
More cheap stays in Seneca

Days Inn by Wyndham Anderson
Hotels in Seneca with star-rating
Hotels in Seneca with star-rating

4 Star Hotels
Explore a world of travel with Expedia
Explore a world of travel with Expedia
Hotels in Seneca Neighborhoods
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Seneca Hotels by Brand
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- Fall fun at the cabin! Convenient to Lake Keowee and Clemson
- 4/3 Waterfront Home w/ Covered Dock, 2 Decks, Pet Friendly. Long view on lake.
- Charming 3-bedroom house with WiFi and AC in serene Seneca on Lake Hartwell
- New to VRBO! Big water views, private dock, pool table, 15 min Clemson!
- Incredible 10 BR home with pool
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