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Our top choices for Seneca vacation homes

1. Peaceful 3-bedroom home 4 miles from Clemson.

Peaceful 3-bedroom home 4 miles from Clemson.
Seneca
10.0 out of 10, Exceptional, (1 review)
"We were very comfortable for our stay and the property was everything we expected and more."
United States
Justin K.
The price is AED 415
AED 1,038 total
includes taxes & fees
11 Nov - 12 Nov
Peaceful 3-bedroom home 4 miles from Clemson.

2. Walk to Boat Ramp Lake Keowee w/ Parking + Firepit

Walk to Boat Ramp Lake Keowee w/ Parking + Firepit
Seneca
6.0 out of 10, (2 reviews)
"The house was immaculate and welcoming. It was well stocked with everything you could possibly need. We would definitely stay again."
United States
Stacey W.
The price is AED 520
AED 1,627 total
includes taxes & fees
12 Nov - 13 Nov
Walk to Boat Ramp Lake Keowee w/ Parking + Firepit

3. Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!
Downtown
10.0 out of 10, Exceptional, (23 reviews)
"This home was cozy and convenient. Communication was great; they are kind folks that enjoy what they do! We are grateful we could stay there!"
United States
Krystine F.
The price is AED 771
AED 1,501 total
includes taxes & fees
23 Nov - 24 Nov
Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson!

4. Renovated 3BR near Lake Keowee & Clemson

Renovated 3BR near Lake Keowee & Clemson
Seneca
10.0 out of 10, Exceptional, (2 reviews)
"Fantastic location and really nicely done home. It was a perfect touch having a desk in one of the rooms to be able to get work done."
United States
Brenda B.
The price is AED 685
AED 1,346 total
includes taxes & fees
11 Nov - 12 Nov
Renovated 3BR near Lake Keowee & Clemson

5. 3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson
Seneca
9.8 out of 10, Exceptional, (13 reviews)
"Easy check in, pet-friendly, great location!!"
United States
Jason M.
The price is AED 918
AED 1,450 total
includes taxes & fees
11 Dec - 12 Dec
3 bedroom 2 bath home located minutes from Keowee Mariana, shopping and Clemson

6. Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock

Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock
Seneca
8.4 out of 10, Very good, (8 reviews)
"Adorable and clean house! The yard is beautiful "
United States
Diana H.
The price is AED 630
AED 1,057 total
includes taxes & fees
29 Nov - 30 Nov
Lake Retreat- Mins to CU- Kayaks, Fire Pit, Dock

7. Lakefront Retreat l Near Clemson, Hot Tub, Game Room, Kayaks, Private Dock

Lakefront Retreat l Near Clemson, Hot Tub, Game Room, Kayaks, Private Dock
Seneca
9.6 out of 10, Exceptional, (13 reviews)
"We had a great time at Seneca Lake House. We would definitely stay here again. "
United States
Scott M.
The price is AED 1,425
AED 3,018 total
includes taxes & fees
17 Nov - 18 Nov
Lakefront Retreat l Near Clemson, Hot Tub, Game Room, Kayaks, Private Dock

8. The Big Golf House- 10 miles to Clemson

The Big Golf House- 10 miles to Clemson
Seneca
10.0 out of 10, Exceptional, (4 reviews)
"Great house and host!"
United States
David E.
The price is AED 1,083
AED 2,300 total
includes taxes & fees
23 Nov - 24 Nov
The Big Golf House- 10 miles to Clemson

9. Waterfront 3br home on Lake Hartwell near Clemson

Waterfront 3br home on Lake Hartwell near Clemson
Seneca
9.8 out of 10, Exceptional, (19 reviews)
"We enjoyed our stay. Had everything we needed. "
United States
Diane S.
The price is AED 944
AED 1,895 total
includes taxes & fees
11 Nov - 12 Nov
Waterfront 3br home on Lake Hartwell near Clemson

10. Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium
Seneca
9.6 out of 10, Exceptional, (15 reviews)
"Everything was lovely."
United States
Allison C.
The price is AED 1,199
AED 2,330 total
includes taxes & fees
11 Nov - 12 Nov
Beautiful Updated Clemson Lake House - 4 Miles from Downtown Clemson and the Stadium

11. Clemson Memorabilia House Frank Howard III’s Home

Clemson Memorabilia House Frank Howard III’s Home
Clemson
8.6 out of 10, Excellent, (21 reviews)
"Great location!"
United States
Libby S.
The price is AED 309
AED 921 total
includes taxes & fees
1 Dec - 2 Dec
Clemson Memorabilia House Frank Howard III’s Home

12. Modern and Spacious 2-floor Townhome Close to CU!

Modern and Spacious 2-floor Townhome Close to CU!
Clemson
The price is AED 329
AED 1,171 total
includes taxes & fees
11 Nov - 12 Nov
Modern and Spacious 2-floor Townhome Close to CU!

13. The Rustic Rectangle

The Rustic Rectangle
Pendleton
10.0 out of 10, Exceptional, (13 reviews)
"Cozy, clean and quiet! Loved that we could have our dogs stay with us! "
United States
Jennifer T.
The price is AED 324
AED 812 total
includes taxes & fees
17 Nov - 18 Nov
The Rustic Rectangle

14. Dream Weaver Cottage • Private Hot Tub • Fenced Yard • Pets Stay Free

Dream Weaver Cottage • Private Hot Tub • Fenced Yard • Pets Stay Free
Westminster
10.0 out of 10, Exceptional, (33 reviews)
"Loved this house for a quick get away. Everything you needed was there and more"
United States
Anneli v.
Dream Weaver Cottage • Private Hot Tub • Fenced Yard • Pets Stay Free

15. Our Nest, a well loved quiet retreat in Foxwood Hills Resort near Lake Hartwell.

Our Nest, a well loved quiet retreat in Foxwood Hills Resort near Lake Hartwell.
Westminster
9.8 out of 10, Exceptional, (10 reviews)
"Outstanding place and host. Will definitely stay here again. "
United States
William H. J.
The price is AED 364
AED 824 total
includes taxes & fees
8 Dec - 9 Dec
Our Nest, a well loved quiet retreat in Foxwood Hills Resort near Lake Hartwell.

16. Lakefront Private Cove Retreat w/ Sandy Beach, Dock, Hot Tub + Boat & Ski Option

Lakefront Private Cove Retreat w/ Sandy Beach, Dock, Hot Tub + Boat & Ski Option
West Union
9.6 out of 10, Exceptional, (17 reviews)
"We had a great stay and all agreed it was an incredible week (ages 1-69.) The house was clean and well maintained, the amenities were terrific, very easy check in and check out, and we had great communication with the host. The lake view is beautiful and it is an easy walk down to the dock. One child said the place was better than Disney World."
United States
Helen B.
The price is AED 2,341
AED 4,551 total
includes taxes & fees
16 Nov - 17 Nov
Lakefront Private Cove Retreat w/ Sandy Beach, Dock, Hot Tub + Boat & Ski Option

17. Large 3 Bedroom Townhome Downtown Clemson and garage! Walk to Clemson Stadium!

Large 3 Bedroom Townhome Downtown Clemson and garage! Walk to Clemson Stadium!
Clemson
The price is AED 735
AED 1,704 total
includes taxes & fees
1 Dec - 2 Dec
Large 3 Bedroom Townhome Downtown Clemson and garage! Walk to Clemson Stadium!

18. Clemson|SUPs|ParkPass|PizzaOven|PortmanMarina|EV

Clemson|SUPs|ParkPass|PizzaOven|PortmanMarina|EV
Anderson
10.0 out of 10, Exceptional, (13 reviews)
"We had a wonderful stay! The vacation rental was exceptionally clean, well-maintained, and had everything we needed to feel comfortable throughout our visit. The host was incredibly attentive, responsive, and made sure we had a great experience from start to finish. We would definitely stay here again and highly recommend it to anyone looking for a relaxing, hassle-free getaway!"
United States
Leah N.
The price is AED 463
AED 1,708 total
includes taxes & fees
11 Nov - 12 Nov
Clemson|SUPs|ParkPass|PizzaOven|PortmanMarina|EV

19. Walk to Lake Keowee: Salem Townhome w/ Deck

Walk to Lake Keowee: Salem Townhome w/ Deck
Salem
9.8 out of 10, Exceptional, (20 reviews)
"Beautiful place to stay w family not too far from Clemson"
United States
raquel
Walk to Lake Keowee: Salem Townhome w/ Deck

20. Home on Lake Hartwell! Dock, Decks & Endless Fun

Home on Lake Hartwell! Dock, Decks & Endless Fun
Martin
10.0 out of 10, Exceptional, (4 reviews)
"We had a great time at your lake front home. Even with the lower lake levels, we were still able to get out on the water. The house was very clean and had everything we needed. It was nice to have the water views off the deck and grilling porch. It made the morning coffee that much more enjoyable. The grocery store was only about 15 minutes away. We’ll definitely be back!"
United States
Rich
The price is AED 606
AED 1,700 total
includes taxes & fees
15 Nov - 16 Nov
Home on Lake Hartwell! Dock, Decks & Endless Fun
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about Seneca

Nestled along Lake Keowee's shoreline, this charming town offers spectacular waterfront activities from kayaking to fishing at South Cove County Park. Nearby Stumphouse Tunnel and Issaqueena Falls provide fascinating historical exploration and refreshing natural beauty, especially during summer's humid afternoons.

A sunset over a lake surrounded by dense forests and residential areas.

Top reviews in Seneca