Photo by Cindy Keese

Search Vacation Homes in Seneca

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check prices for these dates

Next weekend
8 Aug - 10 Aug
In two weeks
15 Aug - 17 Aug
In one month
29 Aug - 31 Aug
In two months
26 Sep - 28 Sep

Vacation Homes in Seneca

The Brick House At Currahee
Fridge, microwave, oven, stovetop

The Brick House At Currahee

9.6 out of 10, Exceptional, (67)
"We had a fabulous stay! It was very convenient to the event we attended at Flat Rock Farm. The house was so clean and quaint. It was perfect for our family."
The price is AED 393
AED 745 total
includes taxes & fees
4 Aug - 5 Aug
The Brick House At Currahee
Keowee Key Townhome - Pet Friendly, View of Golf Course plus Amenities
Outdoor dining

Keowee Key Townhome - Pet Friendly, View of Golf Course plus Amenities

9.8 out of 10, Exceptional, (71)
"Had a great stay, Ann and team thought and provided everything!"
Keowee Key Townhome - Pet Friendly, View of Golf Course plus Amenities
Lake Living at its finest!
Exterior

Lake Living at its finest!

10.0 out of 10, Exceptional, (48)
"We loved the cabin and Trish was a wonderful host! We will definitely stay again next time we are in the area! "
Lake Living at its finest!
Close to Lake Hartwell, Clemson, and Anderson
Smart TV

Close to Lake Hartwell, Clemson, and Anderson

10.0 out of 10, Exceptional, (53)
"Our entire group enjoyed this property and our stay. It was very clean, nice, comfortable, spacious, and felt like home. Everyone was pleased with our choice and we had a great time. "
Close to Lake Hartwell, Clemson, and Anderson
NEW LakeHome On The Water, LUXURY Sleeps 18, Pool, Dock, Beach, Close To Clemson
Property grounds

NEW LakeHome On The Water, LUXURY Sleeps 18, Pool, Dock, Beach, Close To Clemson

NEW LakeHome On The Water, LUXURY Sleeps 18, Pool, Dock, Beach, Close To Clemson
A charming lakefront Lake Keowee home!
Smart TV, fireplace, DVD player, video library

A charming lakefront Lake Keowee home!

10.0 out of 10, Exceptional, (118)
"Perfect set up for us. Private location."
A charming lakefront Lake Keowee home!
Lake Keowee Lakefront Cove, Private Dock, Deep Water Access, Kayaks & more
Outdoor dining

Lake Keowee Lakefront Cove, Private Dock, Deep Water Access, Kayaks & more

10.0 out of 10, Exceptional, (2)
"We really enjoyed this property! The house was very clean and convenient to boat access. Comfortable beds. Property manager is responsive. Would stay here again!"
Lake Keowee Lakefront Cove, Private Dock, Deep Water Access, Kayaks & more
Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock
Exterior

Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock

10.0 out of 10, Exceptional, (2)
"The kitchen is spacious, kitchen is fully stocked, plenty of towels, and a PERFECT location to anchor down and enjoy the fireworks on the lake. We entered the lake through Cane Creek Landing Boat Ramp which is only 7 minutes away. If you prefer more privacy with your family, this location in the cove is ideal."
Luxury 4BR/4BA Lake Keowee Retreat- Mountain Cabin Vibes + Private Dock
Lake Front, Quiet, Private cove on 4.75 acres, Canoe, 2 Kayak, 2 boat docks
Property grounds

Lake Front, Quiet, Private cove on 4.75 acres, Canoe, 2 Kayak, 2 boat docks

10.0 out of 10, Exceptional, (224)
"Excellent host and lovely place."
Lake Front, Quiet, Private cove on 4.75 acres, Canoe, 2 Kayak, 2 boat docks
Lakehouse Retreat with dock, paddle boat, canoe & kayaks! Now have Gas Grill
Terrace/patio

Lakehouse Retreat with dock, paddle boat, canoe & kayaks! Now have Gas Grill

10.0 out of 10, Exceptional, (174)
"Had a great time on the dock each night "
Lakehouse Retreat with dock, paddle boat, canoe & kayaks! Now have Gas Grill
Gameday Getaway! - Less than 2 miles from Death Valley!
Terrace/patio

Gameday Getaway! - Less than 2 miles from Death Valley!

2.0 star property
10.0 out of 10, Exceptional, (5)
"House was in perfect location.very clean.we have stayed there before and will definitely be back.would recommended to anyone looking for a place not far from downtown and great family spot."
Gameday Getaway! - Less than 2 miles from Death Valley!
Historic Seneca Bungalow
Exterior

Historic Seneca Bungalow

9.8 out of 10, Exceptional, (16)
"We would definitely stay here again. Great price for a football weekend & not too far from stadium. "
Historic Seneca Bungalow
Lake Jocassee ~ Easy Lake Access ~ Loved By Our Guests ~ Pet Friendly
Beach

Lake Jocassee ~ Easy Lake Access ~ Loved By Our Guests ~ Pet Friendly

9.8 out of 10, Exceptional, (86)
"This charming house was the perfect getaway for our trip! Plenty of room for our two trucks and trailers, clean and cozy with all the things we needed. Clear instructions for checking in and out. Minutes from the boat ramp at Devils Fork State Park!"
Lake Jocassee ~ Easy Lake Access ~ Loved By Our Guests ~ Pet Friendly
Blues Brothers Hideaway - Lakefront - Fenced yard - Pets Welcome - Clemson 20 mi
Dining

Blues Brothers Hideaway - Lakefront - Fenced yard - Pets Welcome - Clemson 20 mi

8.6 out of 10, Excellent, (47)
"Older folks may find it difficult to get up and down the hill to the lake. Everything else was superb. "
Blues Brothers Hideaway - Lakefront - Fenced yard - Pets Welcome - Clemson 20 mi
Private setting close to Clemson University
Outdoor dining

Private setting close to Clemson University

9.8 out of 10, Exceptional, (90)
"It was a good place to come back to and relax after spending time on campus. Very nice and quiet, with all the amenities of being at home."
Private setting close to Clemson University
Cozy Lake Hartwell Cabin - Beautiful dock views! Bring your boat and your pet!
Terrace/patio

Cozy Lake Hartwell Cabin - Beautiful dock views! Bring your boat and your pet!

10.0 out of 10, Exceptional, (53)
"Great for a family getaway. Loved the house and the dock!"
Cozy Lake Hartwell Cabin - Beautiful dock views! Bring your boat and your pet!
Charming 3-bedroom house with WiFi and AC in serene Seneca on Lake Hartwell
Property grounds

Charming 3-bedroom house with WiFi and AC in serene Seneca on Lake Hartwell

10.0 out of 10, Exceptional, (6)
Charming 3-bedroom house with WiFi and AC in serene Seneca on Lake Hartwell
Cozy Pet Friendly Cottage, 2 story Deep Water Dock - bring your boat!
Terrace/patio

Cozy Pet Friendly Cottage, 2 story Deep Water Dock - bring your boat!

10.0 out of 10, Exceptional, (97)
"This small but clean and comfortable ranch house also has wonderful views of Lake Hartwell."
Cozy Pet Friendly Cottage, 2 story Deep Water Dock - bring your boat!
Lake Keowee Retreat! Swim, Boat, Kayak & Relax on Dock Just Steps from the Water
Exterior

Lake Keowee Retreat! Swim, Boat, Kayak & Relax on Dock Just Steps from the Water

10.0 out of 10, Exceptional, (77)
"Our stay from beginning to end was amazing. The house and property are beautiful. All amenities and necessities of a long weekend were available from cooking utensils to linens! Beds were extremely comfortable! This was an amazing home away from home. Plan on staying here again! "
Lake Keowee Retreat! Swim, Boat, Kayak & Relax on Dock Just Steps from the Water
Lakefront Lake Keowee Home with flat lawn & private dock. 14 miles to Clemson!
Exterior

Lakefront Lake Keowee Home with flat lawn & private dock. 14 miles to Clemson!

10.0 out of 10, Exceptional, (111)
"We had a great 7 day stay. Beautiful weather, great property and fantastic communication the entire trip with Sharon! "
Lakefront Lake Keowee Home with flat lawn & private dock. 14 miles to Clemson!
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Top Seneca Hotel Reviews

Lake House Near Clemson Private Boat Dock WiFi 65" TV Grill Kayaks Deep Water

Lake House Near Clemson Private Boat Dock WiFi 65" TV Grill Kayaks Deep Water

10/10 Excellent
"This lake house was amazing! The perfect location with a non-busy cove. Great for swimming and kayaking! The house was cozy and perfect for our family! From check-in to check-out, our stay was amazing. We will be back! "
Stephanie S. 3-night trip
Posted 2 days ago
Lake House Near Clemson Private Boat Dock WiFi 65" TV Grill Kayaks Deep Water