Photo by Carl Anderson
Find Family Hotels in Southwest Illinois, IL
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Southwest Illinois Family Hotels
Top Southwest Illinois Family Hotels
Comfort Suites Mount Vernon
Mount Vernon
9.0 out of 10, Wonderful, (1004)
"Rooms have been painted great breakfast close to interstate and restaurants"
Stephen
The price is AED 410
AED 463 total
includes taxes & fees
4 Jan - 5 January 2026
Drury Plaza Hotel Mt. Vernon
Mount Vernon
9.6 out of 10, Exceptional, (1573)
"Great place to stay. Check in is easy and the hotel people are very nice."
Duane
The price is AED 345
AED 390 total
includes taxes & fees
4 Jan - 5 January 2026
Quality Inn Mount Vernon, IL
Mount Vernon
7.8 out of 10, Good, (531)
"It was nice and clean. It was a great place to just stop and sleep. The staff was very friendly, and it was located next to a lot of places to eat"
Christopher
The price is AED 250
AED 285 total
includes taxes & fees
4 Jan - 5 January 2026
Best Western Plus Centralia Hotel & Suites
Centralia
9.6 out of 10, Exceptional, (597)
"Very beautiful place to stay "
Valerie
The price is AED 443
AED 496 total
includes taxes & fees
1 Jan - 2 January 2026
Quality Inn & Suites Vandalia near I-70 and Hwy 51
Vandalia
8.4 out of 10, Very Good, (1000)
"Nice place to stay"
Aaron
The price is AED 232
AED 253 total
includes taxes & fees
14 Dec - 15 Dec
Baymont by Wyndham Marion
Marion
8.4 out of 10, Very Good, (1063)
"This place was nice for the money and our 1 night stay. "
Charles
The price is AED 259
AED 311 total
includes taxes & fees
7 Dec - 8 Dec
Super 8 by Wyndham Mt. Vernon IL
Mount Vernon
7.8 out of 10, Good, (1003)
"Clean comfortable room and bed. Great location to many restaurants and shopping. "
Patricia
The price is AED 209
AED 239 total
includes taxes & fees
14 Dec - 15 Dec
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Murphysboro
9.4 out of 10, Exceptional, (508)
"great property, great breakfast, friendly and knowledgable staff."
Ronald
The price is AED 394
AED 437 total
includes taxes & fees
8 Dec - 9 Dec
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Top Southwest Illinois Hotel Reviews
Drury Inn & Suites St. Louis O'Fallon, IL
10/10 Excellent
Explore a world of travel with Expedia
Top neighborhoods for Family Hotels
Find More Hotels near Southwest Illinois
More Hotel Options in Southwest Illinois
- Adults Only Resorts & Hotels in Southwest Illinois
- Adventure Hotels in Southwest Illinois
- Beach Hotels in Southwest Illinois
- Business Hotels in Southwest Illinois
- Casinos in Southwest Illinois
- Cheap Hotels in Southwest Illinois
- Golf Hotels in Southwest Illinois
- Historic Hotels in Southwest Illinois
- Hotel Wedding Venues in Southwest Illinois
- Hotel with a Concierge in Southwest Illinois
- Hotels with Bars in Southwest Illinois
- Hotels with Early Check-in in Southwest Illinois
- Hotels with Free Parking in Southwest Illinois
- Hotels with Hot Tubs in Southwest Illinois
- Hotels with WiFi in Southwest Illinois
- Hotels with a Pool in Southwest Illinois
- Hotels with an Indoor Pool in Southwest Illinois
- Hotels with smoking rooms in Southwest Illinois
- Luxury Hotels in Southwest Illinois
- Pet-friendly Hotels in Southwest Illinois
- Resorts & Hotels with Spas in Southwest Illinois
- Romantic Hotels in Southwest Illinois
- Shopping Hotels in Southwest Illinois
- Waterpark Hotels in Southwest Illinois
- Winery Hotels in Southwest Illinois
More Accommodation Types in Southwest Illinois
- Apartments in Illinois
- Vacation Homes in Illinois
- Condo Rentals in Illinois
- Motels in Illinois
- Cabin Rentals in Illinois
- Cottages in Illinois
- Aparthotels in Illinois
- B&B in Illinois
- RV Parks in Illinois
- Villas in Illinois
- Guest Houses in Illinois
- Lodges in Illinois
- Resorts in Illinois
- Hostels in Illinois
- Inns in Illinois
- Country Houses in Illinois
- Holiday Park Resorts in Illinois
- Residences in Illinois
Hotels near popular Southwest Illinois Attractions
- Hotels near Southern Illinois University
- Hotels near Lake of Egypt
- Hotels near Giant City State Park
- Hotels near Scott Air Force Base
- Hotels near Rend Lake
- Hotels near Marion Cultural and Civic Center
- Hotels near World Wide Technology Raceway
- Hotels near Carlyle Lake
- Hotels near Cahokia Mounds State Historic Site
- Hotels near O'Fallon Family Sports Park
Southwest Illinois Hotels by Star Rating
Explore more hotels
- The Principal Hotel
- La Quinta Inn & Suites by Wyndham O'Fallon, IL - St. Louis
- Days Inn by Wyndham Collinsville/St. Louis
- Hampton Inn O'Fallon
- Sleep Inn O'Fallon near I-64
- Comfort Suites Fairview Heights - St. Louis
- Quality Inn O'Fallon IL - St. Louis
- Baymont by Wyndham O'Fallon St. Louis Area
- Country Inn & Suites by Radisson, Fairview Heights, IL
- Drury Inn & Suites Marion
- Radisson Hotel Fairview Heights - St. Louis
- Comfort Inn Collinsville near St. Louis
- Holiday Inn Express & Suites Edwardsville by IHG
- Motel 6 Caseyville, IL - Caseyville Il
- DoubleTree by Hilton Collinsville - St. Louis
- Hampton Inn St. Louis - Columbia
- Comfort Inn Edwardsville - St. Louis
- Holiday Inn Express Troy by IHG
- Drury Inn & Suites St. Louis Collinsville
- Holiday Inn Express & Suites Mount Vernon by IHG