St. Charles, MN Vacation Homes from AED 315

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Our top choices for St. Charles vacation homes

A two-story house with a covered patio and a pathway leading to the entrance.

1. Magical Nest Hideaway

Rochester

Pam N.

AED 660 total

includes taxes & fees

9 Nov - 10 Nov

A dining room with a white table, white chairs, a chandelier, and a potted plant.

2. Discounted Charming 2-bedroom main-level TRIPLEX in Rochester

East Side Pioneers

Nadaley W.

AED 828 total

includes taxes & fees

11 Nov - 12 Nov

A modern kitchen with white cabinets, a built-in oven, and a coffee maker.

3. UrbanCottage | 1mi Mayo Clinic, No Stairs, Dogs OK

East Side Pioneers

AED 846 total

includes taxes & fees

14 Nov - 15 Nov

A living room with a television, sofa, coffee table, and shelves with decorative items.

4. Vintage Lustron Home Piece of History

Minnesota City

Jocelyn R.

AED 720 total

includes taxes & fees

16 Nov - 17 Nov

A living room with a brown armchair, a grey sofa, a small table with a lamp, and a window with curtains.

5. 1mile Mayo 2 step entry Encourage CoveredByFaith

Parkway

Philip

AED 1,058 total

includes taxes & fees

22 Nov - 23 Nov

A modern kitchen with stainless steel appliances, white cabinetry, and a window with a view of greenery.

6. The Little House | 1 mi from downtown, Love Pets!

Slatterly Park

Cheryl P.

AED 1,001 total

includes taxes & fees

22 Nov - 23 Nov

A living room with a dark blue armchair, a black entertainment unit with a TV displaying a scenic view, a white door, and a window with a view of a car outside.

7. 1mile to Mayo 2 step entry Brave Covered By Faith

Parkway

Kristin T.

AED 982 total

includes taxes & fees

9 Nov - 10 Nov

A modern dining area with a round wooden table, white chairs, and a central vase.

8. Lux 3 BR mins to Mayo & Dwtwn I Charming Haven

Rochester

Kay L.

A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a dishwasher, and a window with a view of greenery.

9. ColorHouse | 1 mi to Mayo Clinic, No Stairs Entry

East Side Pioneers

Jeremiah E.

AED 1,229 total

includes taxes & fees

11 Nov - 12 Nov

A neatly arranged bedroom with a bed, bedside table, lamp, and a dresser with a mirror.

10. Cozy 3BR near Mayo and downtown. Charming, spotless, and designed for comfort with restful bedrooms, a stocked kitchen, and two welcoming living spaces. Perfect for Mayo visits, business trips, or family stays. Dogs allowed, too.

Rochester

Kimberly K.

AED 1,732 total

includes taxes & fees

9 Nov - 10 Nov

A modern kitchen with a central island, bar stools, and a view of the backyard through large sliding doors.

11. Meet Don - A Modern, Zero-step, Pet-friendly home in Rochester

Slatterly Park

Sarah F.

AED 916 total

includes taxes & fees

15 Nov - 16 Nov

A living room with a flat-screen TV on a wooden stand, a gray sofa, and a blue armchair.

12. Close to Mayo/Shops, 1 step entry Covered By Faith

Rochester

Anonymous traveler

AED 1,091 total

includes taxes & fees

11 Nov - 12 Nov

A living room with a sectional sofa, a dining table, and a kitchen in the background.

13. Meet Bev, a charming 2-bedroom, pet-friendly home in Rochester

Washington

Ann G.

AED 831 total

includes taxes & fees

20 Nov - 21 Nov

A residential deck with a glass railing, a covered area with a sloped roof, and a view of a tree-lined landscape.

14. Quiet 3 BDR Home- private sauna & skyline view- close to downtown & Mayo Clinic

Rochester

Jonathan P.

AED 1,514 total

includes taxes & fees

10 Nov - 11 Nov

A bedroom with a large bed, a ceiling light, a window with curtains, a wall-mounted TV, and a bookshelf.

15. Mayo Clinic Cottage - Power Bed & Recliners

Northrup

A small, single-story house with a red door, surrounded by trees and a garden.

16. 2 bed/2 bath Beautiful Home in Historic Rochester· 2 Mins to Mayo Clinic Campus

Folwell

"Property was OK and location was good, but lacking in basic amenities: no ice maker or ice trays; no facial tissues; limited kitchen supplies (1 coffee mug, no Tupperware-type of food storage, limited place settings),The water heater was incapable of supplying 2 successive showers.One bedroom had a motion sensor that repeatedly turned off the overhead unless you were moving in the room.The downstairs washer and dryer worked OK, but getting to them required navigating steep, uneven stairs with a...

Bruce T.

A two-story house with a covered porch, a small garden with yellow flowers, and a bird feeder.

17. The Hen House Retreat - A Comfortable Place to Roost

Highland

Lydia F.

AED 694 total

includes taxes & fees

9 Nov - 10 Nov

A dining area with a wooden floor, a table with chairs, a rug, and a window with blinds.

18. HartHouse | 5 Min Walk to Mayo St Marys, Historic Kutzky

Kutzky Park

David M.

A wooden tray with a bottle and a remote control on a table, with a sofa and decorative pillows in the background.

19. Little Nest | 2 mi to Mayo Clinic, 2 bed w/Lg Yard

Rochester

pat o.

AED 1,438 total

includes taxes & fees

11 Nov - 12 Nov

A two-story house with a wooden staircase leading to a yellow door, a brick wall, and a window with a white frame.

20. Charming 1BR house with WiFi, AC, Private Patio + Cruiser Bikes & Grill Add-Ons

Historic Downtown Winona

Amy B.

AED 761 total

includes taxes & fees

23 Nov - 24 Nov

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Learn more about St. Charles

St. Charles awaits: its natural setting and more!

See all hotels in St. Charles

An aerial view of a town with industrial buildings, roads, and green areas.

Top reviews in St. Charles

A spacious living area with a high ceiling, wooden beams, a blue armchair, a sofa, and a glass coffee table.

Stone Mill Hotel & Suites

Lanesboro

10/10 Excellent

Shari

A swimming pool with clear blue water, surrounded by lounge chairs and a view of residential buildings through large windows.

Residence Inn by Marriott Rochester Mayo Clinic Area South

Rochester

10/10 Excellent

Jaci

An outdoor patio area with a concrete floor, wooden fence, and string lights.

Fairfield Inn & Suites Rochester Mayo Clinic Area/St. Marys

Kutzky Park

10/10 Excellent

Donald

An outdoor seating area with wooden pillars, colorful striped cushions, and potted plants.

Home2 Suites by Hilton Rochester Mayo Clinic Area

Rochester

10/10 Excellent

Mary

A modern kitchen with a central island, wooden cabinets, and pendant lighting.

TownePlace Suites by Marriott Rochester Mayo Clinic Area

Kutzky Park

10/10 Excellent

Neil

A modern hotel lobby with a reception desk, seating area, and a dining space.

Holiday Inn Express Rochester South - Mayo Area by IHG

Rochester

10/10 Excellent

Craig

A hotel room with a large bed, a desk, a chair, a television, and a window with curtains.

Econo Lodge Mayo Clinic Area

Rochester

10/10 Excellent

Eileen

A reception area with a wooden reception desk, a "Welcome to the Bread & Butter State" sign, and a "Please Center" sign.

Hampton Inn Rochester-South

Rochester

10/10 Excellent

Clean and stocked...the rooms were clean and the coffee area was stocked well. The rooms are really small. Not great if you need to spend a lot of time there, but they use the space well. No dressers but they have a wire drawer thing for your clothes. No safe in the rooms, which we are used to. Nice pull out shelf on night stand. Perfect for those that have a CPAP machine. The bathroom was pretty outdated-tub looked tired and lots of limescale on shower head. Zero counter space for doing...

Ross

A modern living room with a fireplace, comfortable seating, and large windows.

Staybridge Suites Rochester - Mayo Clinic Area by IHG

Kutzky Park

10/10 Excellent

Rachel

A modern living room with a flat-screen TV, a fireplace, a sofa, a coffee table, and a view of a cityscape through large windows.

Hilton Rochester Mayo Clinic Area

Downtown Rochester

10/10 Excellent

Ryan

An outdoor seating area with a fire feature, blue cushioned chairs, and a modern building with large windows in the background.

Hyatt House Rochester/Mayo Clinic Area

Downtown Rochester

10/10 Excellent

Chad

A Comfort Inn & Suites hotel with a modern design, featuring a prominent signage and a parking lot.

Comfort Inn & Suites Rochester South Mayo Clinic

Rochester

10/10 Excellent

Wendy

A modern indoor patio with a fire feature, seating, and large windows.

EVEN Hotel Rochester - Mayo Clinic Area by IHG

Kutzky Park

10/10 Excellent

ryan

A hotel room with a large bed, a separate bathroom with a bathtub, a desk with a chair, and a large mirror.

AmericInn by Wyndham Winona

Winona

10/10 Excellent

MARY

A modern living room with a sofa, coffee table, and a TV mounted on a stone wall.

Quality Inn & Suites Mayo Clinic Area

Rochester

10/10 Excellent

Beth

A grand staircase with a floral carpet, wooden balustrades, and a chandelier.

Alexander Mansion Bed and Breakfast

Historic Downtown Winona

10/10 Excellent

We stayed in the Alexander Suite, which was ideal for us. King size bed, Victorian charm, tidy bathroom with tub, shower and amenities. Enjoyed the Watkins lotion. The room has an adjacent sitting room perfect for coffee, tea, or relaxing. Don't forget to write something in the journal. The host, Richard, is super nice and so knowledgeable about the area. The huge breakfast consists of 5 courses. Fruit parfait, fresh baked bread that is to die for. The blueberry was our favorite. The main...

Laila and David

An outdoor patio area with tables and chairs under umbrellas, surrounded by flower beds and greenery.

Centerstone Plaza Hotel Soldiers Field - Mayo Clinic Area

Historic Southwest

10/10 Excellent

Shelley

Search Vacation Homes in St. Charles

Change your mind

Treat yourself

Be picky

Find vacation rentals that suit your style

Check prices for these dates

Our top choices for St. Charles vacation homes

1. Magical Nest Hideaway

2. Discounted Charming 2-bedroom main-level TRIPLEX in Rochester

3. UrbanCottage | 1mi Mayo Clinic, No Stairs, Dogs OK

4. Vintage Lustron Home Piece of History

5. 1mile Mayo 2 step entry Encourage CoveredByFaith

6. The Little House | 1 mi from downtown, Love Pets!

7. 1mile to Mayo 2 step entry Brave Covered By Faith

8. Lux 3 BR mins to Mayo & Dwtwn I Charming Haven

9. ColorHouse | 1 mi to Mayo Clinic, No Stairs Entry

10. Cozy 3BR near Mayo and downtown. Charming, spotless, and designed for comfort with restful bedrooms, a stocked kitchen, and two welcoming living spaces. Perfect for Mayo visits, business trips, or family stays. Dogs allowed, too.

11. Meet Don - A Modern, Zero-step, Pet-friendly home in Rochester

12. Close to Mayo/Shops, 1 step entry Covered By Faith

13. Meet Bev, a charming 2-bedroom, pet-friendly home in Rochester

14. Quiet 3 BDR Home- private sauna & skyline view- close to downtown & Mayo Clinic

15. Mayo Clinic Cottage - Power Bed & Recliners

16. 2 bed/2 bath Beautiful Home in Historic Rochester· 2 Mins to Mayo Clinic Campus

17. The Hen House Retreat - A Comfortable Place to Roost

18. HartHouse | 5 Min Walk to Mayo St Marys, Historic Kutzky

19. Little Nest | 2 mi to Mayo Clinic, 2 bed w/Lg Yard

20. Charming 1BR house with WiFi, AC, Private Patio + Cruiser Bikes & Grill Add-Ons

Learn more about St. Charles

Top reviews in St. Charles

Stone Mill Hotel & Suites

10/10 Excellent