Find 5 Star Hotels in Downtown St. Louis, MO from AED 364

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Check availability on Downtown St. Louis 5 Star Hotels

Our top choices for Downtown St. Louis 5-star hotels

Terrace/patio
Four Seasons Hotel St Louis

Four Seasons Hotel St Louis

Four Seasons Hotel St Louis
5.0 star property
Downtown St. Louis
9.4 out of 10, Exceptional, (1002)
"Everything exceeded my expectations from the welcoming staff to the luxuriously appointed room, to the 4 feet deep bathtub in which to soak my cares away--it was a total dream come true. I would come back in a heartbeat at this home away from home. "
United States
Lynne
The price is AED 1,524
AED 1,782 total
includes taxes & fees
1 Jan - 2 January 2026
Four Seasons Hotel St Louis
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Explore similar 4-star hotels

Many 4-star hotels have the same amenities as 5-star hotels. See all 4-star hotels in Downtown St. Louis.
Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

Magnolia Hotel St. Louis, a Tribute Portfolio Hotel

421 N 8th St St. Louis MO
The price is AED 321 per night from Dec 19 to Dec 20
AED 321
AED 381 total
19 Dec - 20 Dec
includes taxes & fees
8.6/10 Excellent! (1,149 reviews)
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Downtown St. Louis Hotel Reviews

Four Seasons Hotel St Louis

Four Seasons Hotel St Louis

10/10 Excellent
"Big, beautiful rooms and incredible service. Can’t beat it"
Lyle 1-night trip
Posted 10 days ago
Four Seasons Hotel St Louis

Frequently asked questions

What are the best 5-star hotels in Downtown St. Louis?
Experience top-class amenities and refined service at Four Seasons Hotel St Louis. Located around the St. Louis neighborhood of Downtown St. Louis, this 5-star hotel is a leading choice based on reviews by Expedia guests.
How much does it cost to stay in a 5-star hotel in Downtown St. Louis?
How much you pay for a 5-star hotel in Downtown St. Louis can vary depending on when you want to travel and how long you plan to be away, among several factors. Use our price per night filter and other search tools to land the best rate on an indulgent stay.

  • Search for the lowest price per night from AED 364

What makes a hotel 5 stars in Downtown St. Louis?
In Downtown St. Louis, a hotel needs to provide a certain amount of upscale conveniences to earn a 5-star rating. These can include on-site gyms, spas and saunas, gourmet restaurants, luxury bathroom products, premium bedding and more. What also sets 5-star hotels apart is their guest-focused standard of service. You can look forward to things like in-room massages, nightly turn-down services and concierge services. Some may also offer additional touches like welcome gifts.

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