Find hotels in O Brien, FL from AED 220

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Our top choices for O Brien hotels

1. Comfort Suites Lake City

Comfort Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,002 reviews)
"Overall great stay!"
United States
Jim
The price is AED 349
AED 392 total
includes taxes & fees
6 Dec - 7 Dec
Comfort Suites Lake City

2. La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City
3.0 star property
Lake City
8.8 out of 10, Excellent, (1,208 reviews)
"Very nice visit, very clean room, excellent staff, great breakfast, easy parking"
United States
Emory
The price is AED 344
AED 387 total
includes taxes & fees
2 Dec - 3 Dec
La Quinta Inn & Suite by Wyndham Lake City

3. Tru by Hilton Lake City

Tru by Hilton Lake City
2.5 star property
Lake City
9.2 out of 10, Wonderful, (1,004 reviews)
"Clean and well maintained hotel"
United States
Carlos
The price is AED 342
AED 384 total
includes taxes & fees
6 Dec - 7 Dec
Tru by Hilton Lake City

4. Best Western Plus Lake City

Best Western Plus Lake City
2.5 star property
Lake City
9.0 out of 10, Wonderful, (1,136 reviews)
"Nice staff great rooms"
United States
Ashlee
The price is AED 294
AED 331 total
includes taxes & fees
1 Dec - 2 Dec
Best Western Plus Lake City

5. Hampton Inn & Suites Lake City

Hampton Inn & Suites Lake City
2.5 star property
Lake City
9.4 out of 10, Exceptional, (1,000 reviews)
"I have stayed here several times. Staff is at least very friendly and accommodating properties very clean. We enjoyed our stay."
United States
Eileen
The price is AED 369
AED 415 total
includes taxes & fees
6 Dec - 7 Dec
Hampton Inn & Suites Lake City

6. Home2 Suites by Hilton Lake City

Home2 Suites by Hilton Lake City
3.0 star property
Lake City
9.4 out of 10, Exceptional, (834 reviews)
"Big, clean room and the staff was very friendly"
United States
Laurie
The price is AED 436
AED 490 total
includes taxes & fees
22 Nov - 23 Nov
Home2 Suites by Hilton Lake City

7. TownePlace Suites by Marriott Lake City

TownePlace Suites by Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (152 reviews)
"Very clean! Comfy beds!"
United States
John
The price is AED 474
AED 533 total
includes taxes & fees
15 Nov - 16 Nov
TownePlace Suites by Marriott Lake City

8. Fairfield Inn & Suites Lake City

Fairfield Inn & Suites Lake City
3.0 star property
Lake City
9.0 out of 10, Wonderful, (300 reviews)
"Stayed here on the way to Disney so wouldn't have to drive so far one way for the family. It was a nice place to stay."
United States
Anthony
The price is AED 345
AED 389 total
includes taxes & fees
4 Dec - 5 Dec
Fairfield Inn & Suites Lake City

9. Courtyard By Marriott Lake City

Courtyard By Marriott Lake City
3.0 star property
Lake City
9.6 out of 10, Exceptional, (315 reviews)
"Nice overnight stay."
United States
Zanza
The price is AED 426
AED 480 total
includes taxes & fees
22 Nov - 23 Nov
Courtyard By Marriott Lake City

10. Quality Inn Lake City

Quality Inn Lake City
2.5 star property
Lake City
8.2 out of 10, Very good, (1,000 reviews)
"Very nice hotel!"
United States
Mary
The price is AED 261
AED 294 total
includes taxes & fees
1 Dec - 2 Dec
Quality Inn Lake City

11. Holiday Inn & Suites Lake City by IHG

Holiday Inn & Suites Lake City by IHG
3.0 star property
Lake City
8.6 out of 10, Excellent, (1,000 reviews)
"Next time I am needing motel in Lake City, will plan to stay at this location."
United States
William
The price is AED 371
AED 417 total
includes taxes & fees
15 Nov - 16 Nov
Holiday Inn & Suites Lake City by IHG

12. Super 8 by Wyndham Lake City

Super 8 by Wyndham Lake City
2.0 star property
Lake City
7.4 out of 10, Good, (767 reviews)
"Complimentary dinner and cooked to order eggs at breakfast. Neat and clean. Comfy bed."
United States
Allan
The price is AED 225
AED 253 total
includes taxes & fees
1 Dec - 2 Dec
Super 8 by Wyndham Lake City

13. Americas Best Value Inn Lake City

Americas Best Value Inn Lake City
2.0 star property
Lake City
8.6 out of 10, Excellent, (1,000 reviews)
"This is a great hotel for the price. Clean, room was small. Close to restaurants and parking lot is well lite."
United States
Brenda
The price is AED 261
AED 294 total
includes taxes & fees
15 Nov - 16 Nov
Americas Best Value Inn Lake City

14. Cindys Motel

Cindys Motel
2.5 star property
Mayo
8.8 out of 10, Excellent, (142 reviews)
"It was a clean room. We could park outside our room door."
United States
Keith
The price is AED 322
AED 348 total
includes taxes & fees
12 Nov - 13 Nov
Cindys Motel

15. Holiday Inn Express & Suites Live Oak by IHG

Holiday Inn Express & Suites Live Oak by IHG
2.5 star property
Live Oak
8.4 out of 10, Very good, (901 reviews)
"Nice place"
United States
Andrew
The price is AED 386
AED 424 total
includes taxes & fees
6 Dec - 7 Dec
Holiday Inn Express & Suites Live Oak by IHG

16. Days Inn by Wyndham Lake City I-75

Days Inn by Wyndham Lake City I-75
2.0 star property
Lake City
7.6 out of 10, Good, (1,002 reviews)
"Nice breakfast."
United States
Nathan
The price is AED 247
AED 277 total
includes taxes & fees
1 Dec - 2 Dec
Days Inn by Wyndham Lake City I-75

17. Quality Inn White Springs Suwanee

Quality Inn White Springs Suwanee
2.5 star property
White Springs
7.2 out of 10, Good, (710 reviews)
"Great breakfast options quiet clean place to stay"
United States
Pennee
The price is AED 220
AED 242 total
includes taxes & fees
9 Dec - 10 Dec
Quality Inn White Springs Suwanee

18. Econo Lodge Live Oak

Econo Lodge Live Oak
2.0 star property
Live Oak
7.0 out of 10, Good, (327 reviews)
"I definitely will not recommend anyone to book a room there. The rooms are in bad sharp. The whole hotel need remodel."
United States
Alexia
The price is AED 269
AED 296 total
includes taxes & fees
15 Nov - 16 Nov
Econo Lodge Live Oak

19. Regal Inn

Regal Inn
2.5 star property
Lake City
8.4 out of 10, Very good, (623 reviews)
"This is the second time I’ve stayed at this hotel. Convenient to restaurants and gas stations. Look forward to staying again."
United States
Gerardo
The price is AED 228
AED 256 total
includes taxes & fees
13 Nov - 14 Nov
Regal Inn

20. Quality Inn & Suites Live Oak I-10 Exit 283

Quality Inn & Suites Live Oak I-10 Exit 283
2.5 star property
Live Oak
7.0 out of 10, Good, (600 reviews)
"Everything good"
United States
Guillermo
The price is AED 307
AED 338 total
includes taxes & fees
18 Nov - 19 Nov
Quality Inn & Suites Live Oak I-10 Exit 283
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Learn more about O Brien

Escape to this rural Florida gem where the Suwannee River offers peaceful kayaking trips and fishing adventures. Nearby Spirit of the Suwannee Music Park hosts live concerts, while O'Brien's local farms welcome visitors for fresh produce and family-friendly activities.

A calm river surrounded by trees reflecting in the water.

Top O Brien Hotel Reviews

Frequently Asked Questions

What's the top vacation rental in O Brien?

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!: Visitors give good reviews to this O Brien vacation home rental, which is located on the beach and has a balcony, a garden, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. You and your friends and family can relax into your vacation with amenities like a selection of games. Our travelers also rate MARGARITAVILLE BY THE SUWANNEE RIVER & ROYAL SPRINGS PET FRIENDLY as a favorite home for rent in O Brien. See all vacation rentals in O Brien.

If I need to cancel my hotel reservation in O Brien, will I receive a refund?

Yes! You'll find that most hotel reservations are fully refundable as long as you cancel prior to the hotel's cancellation deadline, which is usually within 24-48 hours of the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and get a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in O Brien.

Where can I learn more about changing or cancelling my trip to O Brien?

To access more information about picking new dates or cancelling your trip to O Brien, click here.

Where is the best hotel to stay near Ichetucknee Springs State Park?

Escape to Nature - 2 miles from Ichetucknee park is one of the top choices for your stay based on our traveler data, and this property features in-room kitchens and fireplaces. It's located 2.3 mi (3.8 km) from Ichetucknee Springs State Park. Another good choice is A Riverview of a Magical Sunrise every morning, located 5.6 mi (9.1 km) away.

What are some accommodations with pools in O Brien?

What's the best hotel for staying near Gainesville Regional Airport (GNV)?

Hampton Inn & Suites Gainesville Downtown is one of the top choices for your stay and is a popular hotel, featuring free breakfast and an outdoor pool. It's located 3.7 mi (6 km) from Gainesville Regional Airport. Other good choices close to the airport include Sweetwater Branch Inn and Travelers Inn.

How is it to stay in O Brien?

Visitors to O Brien are sure to find plenty to explore and enjoy. In O Brien, there are 9 hotels and other accommodations to choose from. Find out more about O Brien.

What should I see while I'm in O Brien?

Natural beauty is on display at Suwannee River, Ichetucknee River, and Ichetucknee Springs State Park. You'll also find Lafayette Blue Springs State Park and Lake City Mall in the area. Check out what more to see and do in Expedia's O Brien guide.

What's the seasonal weather like in O Brien?

The hottest months are usually July and August with an average temp of 80°F, while the coldest months are January and February with an average of 58°F. Average annual precipitation for O Brien is 50 inches.

Where is the best place to stay in O Brien?

La Quinta Inn & Suite by Wyndham Lake City, located 18.2 mi (29.3 km) from the heart of O Brien, is a top choice for your stay based on our traveler data. Other good choices for your visit to the area are Holiday Inn Express & Suites Alachua - Gainesville Area by IHG and Postcard Cabins Gilchrist Springs, Outdoor Collection by Marriott Bonvoy. See all available top hotels, or vacation rentals in O Brien.