Find hotels in Panacea, FL from AEDĀ 312

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Compare 497 hotels, room rates, hotel reviews and availability. Most hotels are fully refundable.

The Panacea Motel

2.0 star property
Panacea
9.0 out of 10, Wonderful, (134)
"A v nice place to stay "
United States
Harry
The Panacea Motel

The Lodge at Wakulla Springs

3.0 star property
Crawfordville
9.4 out of 10, Exceptional, (1005)
"Everything about our stay was great! Location, The Lodge, Staff, The food was excellent, and the staff. We only stayed one night as a halfway trip to Disney, but we will definitely be back because our family loved it so much!"
United States
Kaitlyn
The Lodge at Wakulla Springs

Wildwood Inn

3.0 star property
Crawfordville
8.6 out of 10, Excellent, (1002)
"Clean, friendly staff, good location. "
United States
Jennifer
The price is AEDĀ 422
AEDĀ 485 total
includes taxes & fees
17 Dec - 18 Dec
Wildwood Inn

Best Western Wakulla Inn & Suites

2.5 star property
Crawfordville
8.8 out of 10, Excellent, (945)
"Great hotel. Very good customer service and very clean"
United States
claudina
The price is AEDĀ 408
AEDĀ 455 total
includes taxes & fees
1 Jan - 2 January 2026
Best Western Wakulla Inn & Suites

St James Bay Golf & Pickleball Resort

3.5 star property
Carrabelle
9.0 out of 10, Wonderful, (366)
"The facility and amenities were wonderful! Everyone was so friendly and helpful. Our pup enjoyed his stay also. We will be back for sure! "
United States
Amy
The price is AEDĀ 518
AEDĀ 572 total
includes taxes & fees
1 Jan - 2 January 2026
St James Bay Golf & Pickleball Resort

The Moorings Hotel and Marina

2.5 star property
Carrabelle
8.4 out of 10, Very Good, (39)
"Hotel was really nice and convenient to everything we wanted to do in the area. Very quiet and peaceful. Bed was a little uncomfortable, but that's a personal preference thing and I won't fault them for that. Really nice staff and easy check in and check out. Would definitely return!"
United States
Cheryl
The price is AEDĀ 487
AEDĀ 538 total
includes taxes & fees
3 Dec - 4 Dec
The Moorings Hotel and Marina

The Old Carrabelle Hotel

2.0 star property
Carrabelle
The price is AEDĀ 523
AEDĀ 578 total
includes taxes & fees
1 Jan - 2 January 2026
The Old Carrabelle Hotel

Franklin Inn

2.0 star property
Carrabelle
7.8 out of 10, Good, (453)
"JJ was great great location clean room comfortable bed and good value. "
United States
Crystal
The price is AEDĀ 295
AEDĀ 326 total
includes taxes & fees
11 Dec - 12 Dec
Franklin Inn
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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Stay near popular Panacea attractions

Learn more about Panacea

Kayak through pristine coastal marshes at Panacea's Woolley Park, where fishing piers and boardwalks offer prime spots for catching redfish. Nearby St. Marks National Wildlife Refuge invites visitors to spot migratory birds and explore the historic lighthouse along scenic hiking trails.

Sunset over a lake at Panacea, northern Florida, USA | NONE |

Top Panacea Hotel Reviews

More cheap stays in Panacea

Hotels in Panacea with star-rating

Find out more about Panacea

Top reasons to visit Panacea

  • Stunning Beaches: Panacea features beautiful beaches perfect for sunbathing and relaxation.
  • Outdoor Adventures: The area offers numerous recreational activities, including hiking and fishing in the scenic surroundings.
  • Charming Accommodations: Enjoy a variety of cozy lodgings, from beachside motels to inviting guesthouses.
  • Natural Beauty: Explore nearby state parks and islands showcasing the region's lush landscapes and wildlife.
  • Friendly Locals: Experience the warm hospitality of the community, enhancing your vacation experience.

Find great hotels near Panacea

Discover a variety of cozy accommodations in Panacea, Florida, perfect for every type of traveler. From charming motels to inviting guesthouses, you'll find options that cater to adventure seekers, business travelers, and pet owners alike. Explore the local beachside motels and enjoy stunning views, along with essential amenities to make your stay memorable. Whether you're looking for a peaceful retreat or a base for exploration, Panacea has the perfect lodging for your vacation experience.

  • Hyatt House Tallahassee Capitol – University: Perfect for families, business travelers, and pet owners, Hyatt House Tallahassee Capitol – University offers a welcoming atmosphere with a variety of amenities. Located 46.7km from Panacea, this 3-star hotel is designed to cater to the needs of all types of travelers. Families will appreciate features such as window guards for children, complimentary cribs, and a first aid kit. The hotel also has a pet-friendly policy, allowing certain pets on-site with variable fees. Guests can enjoy a comfortable stay while having access to services that cater to both adults and kids.
  • Best Western Wakulla Inn & Suites: Just 9.7km from Panacea, Best Western Wakulla Inn & Suites is the ideal destination for adventure seekers and business travelers alike. This hotel is surrounded by opportunities for outdoor exploration, making it perfect for those looking to engage in activities like hiking, biking, snorkeling, sailing, and boat tours. With its convenient location and friendly service, guests can easily experience the vibrant local landscape while enjoying the comforts of a reliable stay.
  • Wildwood Inn: Located 11.3km from Panacea, Wildwood Inn combines business-friendly accommodations with a touch of adventure. This 3-star hotel caters to guests who desire to explore the great outdoors, with activities such as kayaking, mountain biking, and snorkeling available nearby. The property is also pet-friendly, ensuring that your furry companions can join in on the fun. With a focus on adventure and comfort, Wildwood Inn is a great choice for those looking to experience the best of both worlds during their stay.

Where to stay in and around Panacea

Panacea, Florida, offers a delightful blend of serene getaways and coastal charm, perfect for beach and outdoor enthusiasts. With its relaxing atmosphere and friendly locals, visitors can enjoy tranquil beach days, explore nearby family-friendly neighborhoods, and immerse themselves in the stunning natural scenery. Whether you seek a peaceful retreat or an oceanfront escape, Panacea and its surrounding areas provide an ideal setting for an unforgettable vacation experience.

  • Saint Teresa: Nestled within the Panacea region, Saint Teresa is a charming village that offers a delightful escape for beach lovers and outdoor enthusiasts. The area experiences moderately seasonal traveler arrivals, with peak times in March and from June to July. Visitors flock to enjoy picturesque scenery, recreational areas, and local resorts. Highlights include the beautiful beaches, a nearby national state park, and a unique nudist beach, making it a perfect spot for those seeking both relaxation and adventure.
  • Sopchoppy: Located just 9.7km from Panacea, Sopchoppy is a quaint city that attracts visitors with its outdoor adventures and scenic landscapes. The city sees seasonal visitor spikes, especially during March to April and July. Travelers come to explore the area's recreational parks, resorts, and golf venues. Notable attractions include the stunning beaches, a national state park, and a picturesque lake, providing ample opportunities for hiking, fishing, and enjoying nature's beauty.
  • Crawfordville: Situated 16.1km away from Panacea, Crawfordville is a vibrant city that offers a mix of outdoor activities and cultural experiences. While its visitor numbers are less seasonal, the city enjoys peak visits in March to April and September. Adventure seekers can explore recreational areas, educational sites, and golf courses. The local landmarks, including pristine beaches, a national state park, and a historic college university, create a diverse backdrop for unforgettable experiences.

Things to do in and around Panacea

Panacea, Florida, is perfect for beach lovers and outdoor enthusiasts, offering stunning scenery and recreational activities. Enjoy the local resorts and golf courses, where you can experience the best of outdoor seating and relaxation. Whether you're exploring the natural beauty or engaging in outdoor experiences, Panacea promises a memorable vacation filled with sun and adventure.

Shopping

In Panacea, visit the Flea Market Tallahassee, just 40.2km away, for a vibrant selection of local goods. If you're up for a drive, check out the Tallahassee Downtown Market and Governor's Square Mall, both 46.7km away, offering an array of shops and family-friendly entertainment.

Recreation

Experience a round of golf at St. James Bay Golf Club, where lush landscapes and serene outdoor vibes enhance your game. For relaxation, Woolley Park offers tranquil spaces to unwind, while Myron B Hodge City Park provides a peaceful retreat for leisurely strolls and rejuvenation.

Adventure

Explore the Tallahassee-Saint Marks Historic Railroad Trail State Park, located 43.5km from Panacea, where scenic hiking immerses you in nature. Venture to Saint Marks Trail, 45.1km away, for another picturesque hike. For a sporty challenge, enjoy tennis at Tom Brown Tennis Center, situated 49.9km from Panacea.

Nightlife

For a lively night out, head to Theatre Tallahassee, located 49.9km from Panacea. Enjoy a mix of romance, entertainment, and culture as you immerse yourself in a captivating performance. It's the perfect spot to experience the local arts scene and enjoy a memorable evening.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for Panacea

To save money on your trip to Panacea, plan your visit during the cheapest months of July and December to January, with Mondays being the least expensive days to stay. Utilize Expedia’s search tool to find the best hotel deals by filtering for budget options and eco-certified hotels. Consider booking a package that combines your hotel, flights, and activities for additional savings. For public transport, take advantage of the local bus system, and explore free activities in the area to enhance your experience without breaking the bank.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in Panacea are July and December to January, where the prices are slightly lower. This is in comparison to May and September to October, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in Panacea is Monday. The most expensive day to stay in Panacea is Friday.
  • Find cheap hotels on Expedia: Expedia's search tool lets you customize your travel preferences by setting your budget, choosing your ideal location, and more. You can easily arrange your search results from lowest to highest price, ensuring you find the most affordable hotels first. Additionally, you have the option to filter your choices by hotel type—if you select the Eco-certified filter, you'll be shown sustainable and eco-friendly hotels that you can book right away.
  • Consider bundling your trip: You can save money by combining your Panacea hotel reservation with your flights and activities through an Expedia package.

Find the best attractions in and around Panacea

Panacea, Florida, is perfect for beach and outdoor enthusiasts seeking beautiful scenery. The area boasts popular attractions such as stunning beaches, scenic state parks, and nearby islands, making it an ideal destination for those looking to explore nature. Whether you're lounging by the shore or hiking through lush landscapes, Panacea offers a variety of experiences that cater to adventure seekers and relaxation lovers alike.

  • Bald Point State Park: Experience the breathtaking scenery and diverse wildlife at Bald Point State Park. Enjoy outdoor activities like hiking, birdwatching, and fishing, while soaking in the serene coastal beauty and lush landscapes that make this park a true gem.
  • USS Mohawk CGC Veterans Memorial Reef: Discover history beneath the waves at the USS Mohawk CGC Veterans Memorial Reef. This unique underwater memorial offers a glimpse into maritime history and is a popular spot for divers, providing an enriching cultural experience amidst vibrant marine life.
  • Ochlockonee River State Park: Just a short drive from Panacea, Ochlockonee River State Park offers stunning natural scenery and outdoor adventure. Enjoy kayaking, hiking, and wildlife observation in this tranquil park, perfect for nature lovers and adventure seekers alike.

Best time to go to Panacea

The best time to visit Panacea can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in Panacea falls in July and August. August has average visitor numbers and mostly sunny weather. The coolest average temperature in Panacea falls in January, visitor numbers are average and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January53.6°F (12.0°C)Light RainMostly SunnyAverageSlightly Low
February57.6°F (14.2°C)Light RainMostly SunnyAverageAverage
March62.4°F (16.9°C)Light RainMostly SunnyAverageAverage
April68.2°F (20.1°C)Light RainMostly SunnyModerately HighAverage
May74.8°F (23.8°C)Light RainMostly SunnyAverageSlightly High
June80.4°F (26.9°C)Moderate RainMostly SunnyModerately HighAverage
July81.7°F (27.6°C)Moderate RainMostly SunnyModerately HighSlightly Low
August81.7°F (27.6°C)Moderate RainMostly SunnyAverageAverage
September78.4°F (25.8°C)Light RainMostly SunnyAverageSlightly High
October71.1°F (21.7°C)Light RainMostly SunnyModerately LowSlightly High
November61.9°F (16.6°C)Light RainMostly SunnyModerately LowAverage
December57.6°F (14.2°C)Light RainMostly SunnyModerately LowSlightly Low

The nearest major airports for your trip to Panacea

If you're planning a trip to Panacea, Florida, the nearest major airport is Tallahassee International Airport (TLH), situated 41.8km away. For accommodations nearby, consider the DoubleTree by Hilton Hotel Tallahassee and Hotel Duval, both 8.0km from the airport, offering convenient transportation services. Another option is Hotel Indigo Tallahassee - Collegetown, located 6.4km from TLH, providing easy access to airport shuttles. These hotels ensure a comfortable stay while making your travel to Panacea effortless.

Frequently asked questions

Where is the best place to stay in Panacea?
Expedia customers give high marks to The Panacea Motel. See all available top hotels, or vacation rentals in Panacea.
What's the top vacation rental in Panacea?
Oceanfront on a Private Beach-Hot Tub-Beautifully Remodeled-Dog Friendly Beach: Visitors give good reviews to this Panacea vacation home rental, which is located on the beach and has a fireplace, a balcony, and a barbecue grill to put you at ease in your new surroundings. It has 3 bedrooms as well as a kitchen with a dishwasher, a fridge, and a stovetop, so you can cook with friends or family. It offers a garden, a selection of games, and a hot tub so you can immerse yourself in your vacation. Other favorite homes for rent in Panacea are 7 Bedroom Beach House with POOL!! Gulf Front and Bay Front and NEW LISTING!!! Welcome to Ohana Shack! 4BR/4.5BA Private Beachfront Property!. See all vacation rentals in Panacea.
If I need to cancel my hotel reservation in Panacea, will I receive a refund?
Yes! Most hotel bookings are refundable provided that you cancel prior to the hotel's cancellation deadline, which is often 24 or 48 hours before your check-in date. If you booked a non-refundable reservation, you might be able to cancel it and be given a refund within a 24-hour period of booking. Filter your search by fully refundable to find flexible hotel deals in Panacea.
Where can I learn more about changing or cancelling my trip to Panacea?
For more details about changing or cancelling your trip to Panacea, click here.
What's the best pet-friendly place to stay in Panacea?
The Panacea Motel is a top pet-friendly option for your stay. See more pet-friendly hotel accommodations in Panacea.
What are some accommodations with pools in Panacea?
7 Bedroom Beach House with POOL!! Gulf Front and Bay Front: Offers complimentary wireless internet access, a pool, and kitchens. View all hotels with pools in Panacea.
What's the best hotel for staying near Tallahassee Regional Airport (TLH)?
Tallahassee Sun & Moon is one of the top choices for your stay and is a popular property, featuring free WiFi and free parking. It's located 3.5 mi (5.7 km) from Tallahassee Regional Airport. Other options close to the airport include Hampton Inn & Suites Tallahassee Capitol-University and Governors Inn.
What's it like to stay in Panacea?
Nature enthusiasts will enjoy exploring Panacea, and many visitors are sure to appreciate the beaches and seafood restaurants. The relaxing and tucked away setting also entices those visiting the city. In Panacea, there are 212 hotels and other accommodations to choose from. Find out more about Panacea.
What are the top places to visit in Panacea?
Natural beauty is on display at Mashes Sand Beach, Alligator Point Beach, and Bald Point State Park. Dolphin watching is a great activity, and Bayside Marina is one place to visit. A couple of additional sights to add to your agenda are Wilson Beach and Public Beach Access. Check out what more to see and do in Expedia's Panacea guide.
What's the seasonal weather like in Panacea?
The hottest months are usually July and August with an average temp of 81°F, while the coldest months are January and February with an average of 58°F. The rainiest months in Panacea are August, July, June, and September, with each month seeing an average of 8 inches of rainfall.

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