Panama Vacations
Book a Hotel + Flight together to unlock savings
- Plan, book, travel with confidence
- Better togetherSave up to AED 5,000 when you book a flight and hotel together*
- Find the right fitWith over 300,000 hotels worldwide, it's easy to create a perfect package
- Rest easyPlan, book, and manage your trip all in one place
Top destinations in Panama
Panama Hotel Deals
Hotel Riu Plaza Panama
Calle 50, Urb. Marbella Panama City Panama
Fully refundableReserve now, pay when you stay
AED 485
AED 533 total
1 Sep - 2 Sep
includes taxes & fees
9/10 Wonderful! (5,834 reviews)
"Beautiful hotel. Excelente service. Location is also great but the highlight of our stay was definitely the breakfast. It was delicious and had a great variety of foods. Will definitely stay here again"
Reviewed on 12 August 2026
Crowne Plaza Panama Airport by IHG
Ave. Domingo Diaz Tocumen Panama
Fully refundable
AED 477
AED 549 total
11 Sep - 12 Sep
includes taxes & fees
Central Hotel Panama Casco Viejo
Plaza de la Independencia Casco Viejo Panama City Panama
Fully refundableReserve now, pay when you stay
AED 674
AED 741 total
11 Sep - 12 Sep
includes taxes & fees
9.2/10 Wonderful! (1,001 reviews)
"Nice hotel. Great location. Good breakfast. Our only complaint is about noise. The hotel has live music in the atrium from early in the morning until about 10 pm. Our room, along with many others, had windows facing into the atrium, and the noise from the music, and sometimes large tour groups at ..."
Reviewed on 10 August 2026
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Stay near popular Panama attractions
Playa Blanca
8.2/10 (527 reviews)
Nothing says vacation like spending a lazy day at Playa Blanca, a popular beach in Rio Hato. Amble around this family-friendly area's seaside or experience its entertainment venues.
Photo by Fabiola Tile
Multiplaza Pacific Mall
9.0/10 (4,497 reviews)
During your trip to Panama City, you can enjoy retail therapy at Multiplaza Pacific Mall. You can enjoy the restaurants while in the area.
Photo by Rob Gosse
Cinta Costera
9.2/10 (3,823 reviews)
After visiting Cinta Costera, make a plan to see the other sights and activities in Panama City. While you're in the area, stroll along the seaside.
Albrook Shopping Mall
8.6/10 (4,561 reviews)
You can enjoy some retail therapy with a trip to Albrook Shopping Mall, a favorite shopping spot in Ancon. Amble around this culturally rich area's seaside and enjoy its top-notch restaurants.