Sikeston Vacations

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Find the Best Sikeston Vacation Packages

Sikeston Hotel Deals

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO

3 out of 5
2608 East Malone Ave, Miner Sikeston MO
Fully refundableReserve now, pay when you stay
The price is AEDĀ 375 per night from Jul 23 to Jul 24
AEDĀ 375
AEDĀ 431 total
23 Jul - 24 Jul
includes taxes & fees
9.6/10 Exceptional! (1,006 reviews)
"THE BEST PLACE TO STAY! PERIOD!"

Reviewed on 19 July 2026

Drury Inn & Suites Sikeston, MO
Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55

2.5 out of 5
120 S Interstate Drive Sikeston MO
Fully refundableReserve now, pay when you stay
The price is AEDĀ 331 per night from Jul 26 to Jul 27
AEDĀ 331
AEDĀ 377 total
26 Jul - 27 Jul
includes taxes & fees
8.4/10 Very Good! (1,001 reviews)
"Clean and comfortable room with good free breakfast"

Reviewed on 18 July 2026

Best Western Plus Sikeston I-55
Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston

2 out of 5
220 S Interstate Dr Sikeston MO
Fully refundableReserve now, pay when you stay
The price is AEDĀ 247 per night from Aug 9 to Aug 10
AEDĀ 247
AEDĀ 281 total
9 Aug - 10 Aug
includes taxes & fees
7.2/10 Good! (1,000 reviews)
"I had a stay at this hotel. The rooms were clean, comfortable, and well maintained. The staff was friendly, professional, and always willing to help. The location was in a convenient place for us to take a quick rest The breakfast was delicious with plenty of options, and the overall atmosphere was ..."

Reviewed on 4 July 2026

Days Inn and Suites by Wyndham Sikeston
See all 319 properties in Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Stay near popular Sikeston attractions

Sikeston Depot Museum

7.6/10 (57 reviews)
Housed in a restored 1916 train depot, this museum showcases Sikeston's cotton-growing heritage and local art. Explore regional history through rotating exhibits while admiring the building's National Register status.
See properties

Frequently asked questions

How much does a Sikeston vacation package cost?
You'll find cheap prices on Expedia for your Sikeston break. However, a range of factors like the season, choice of hotel and length of stay will influence how much your vacation to Sikeston costs.
What are the cheapest months to go to Sikeston?
If you'd like to score a cheap Sikeston vacation package, consider traveling in January, February and September. You'll typically find better prices on hotels and flights during these months ā€” ideal for a budget-friendly getaway.
How to find the best Sikeston package deals?
Finding a cheap Sikeston package deal is easy with Expedia. After you've entered your travel dates and destination under our "Packages" tab, set your maximum budget, add some filters and see what's available. You can customize your search by "Popular locations," "Property type," "Guest rating" and more. Sort the results by "Price: low to high" to discover the most affordable Sikeston package deals. Want a simple trick to get even more savings? Be flexible with your departure dates and consider going away on a weekday, when prices are usually lower.
Is it cheaper to book a Sikeston vacation as a package?
Expedia vacation packages are designed to help you keep more money in your pocket. Bundle your hotel, flight and car rental into one great-value price and enjoy significant savings. You'll usually score a better deal than booking each component separately. And you'll still get the freedom to create a tailored Sikeston vacation by choosing your favorite accommodation type, airline and car class.
When to book a vacation package to Sikeston?
If you've got your Sikeston travel dates finalized, book early to grab some terrific deals. With Expedia, you can typically reserve some flights up to one year in advance. Prefer spontaneous adventures? Our last-minute deals are ideal for setting off on a whim.
How to plan a trip to Sikeston?

  1. Pick your travel dates: What you want to do in Sikeston and your preferred season can help you decide when to go.
  2. Figure out your budget: Ensure you have enough money to pay for everything from transportation and meals to flights and activities. Your accommodations will probably be the largest expense during your trip to Sikeston.
  3. Decide your trip length: Think about how much time you'd like to spend exploring Sikeston. Plan your itinerary so you can get to all the activities and attractions you're interested in without rushing.
  4. Bundle your bookings: With your travel dates in place, you can combine your hotels, car rental, flights and more into a tailored Sikeston vacation package.