Find 4 Star Hotels in Santee, SC

    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Santee 4 Star Hotels

Tonight
6 Aug - 7 Aug
Tomorrow
7 Aug - 8 Aug
This weekend
8 Aug - 10 Aug
Next weekend
15 Aug - 17 Aug

Compare Santee 4 Star Hotels with updated room rates, reviews, and availability. Most hotels are fully refundable.

Wyndham Vacation Resorts Lake Marion
Exterior

Wyndham Vacation Resorts Lake Marion

4.0 star property
9.2 out of 10, Wonderful, (19)
"Friendly staff. Excellent accomodations. Peaceful and beautiful vacation."
Wyndham Vacation Resorts Lake Marion
Save an average of 15% on thousands of hotels when you're signed in
Sign in
Sign up, it's free

Learn more about Santee

Nestled along Lake Marion, this charming town offers prime fishing and boating opportunities for outdoor enthusiasts. Visitors can tee off at Santee National Golf Club or explore nearby Santee State Park's hiking trails and campgrounds.

See all hotels in Santee

Top Santee Hotel Reviews

Wyndham Vacation Resorts Lake Marion

Wyndham Vacation Resorts Lake Marion

10/10 Excellent
"Friendly staff. Excellent accomodations. Peaceful and beautiful vacation."
Frederick 2-night trip
Posted 9 months ago
Wyndham Vacation Resorts Lake Marion

Frequently asked questions

How much does it cost to stay in a 4-star hotel in Santee?
To book a 4-star hotel in Santee that's within your budget, use Expedia's handy filter tool. Browse what's available during your travel dates and use our pricing filter to set your maximum rate. You can also sort your results by the most wallet-friendly option first.

  • Search for the lowest price

What's the difference between 5-star and 4-star hotels in Santee?
Offering a friendly traveler experience and upmarket surroundings, 4-star hotels are a terrific option for your Santee trip. These types of accommodations generally feature loads of useful amenities that make it a breeze to unpack and relax — think large beds, bathrobes, pools and restaurants. Or live in the lap of luxury at a 5-star hotel designed to pamper with luxury perks and amenities. Concierge assistance, complimentary toiletries and world-class dining are typically included at these swanky retreats.
Does Santee have any 4-star all-inclusive resorts?
Enjoy a worry-free vacation experience where almost everything is included in one upfront price by using our "All inclusive" filter. Budgeting is easy when your room, food and many activities are already taken care of. Eager for more options? Check out the offers on Expedia's standard 4-star stays in and around Santee too.