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Vacation Homes in Alexander County

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Top cities in Alexander County

A steel bridge with a sunset in the background.
Hotels

Cairo

Cairo

Find vacation rentals that suit your style

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Apartments
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Condos
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Check prices for these dates

Next weekend
20 Nov - 22 Nov
In two weeks
27 Nov - 29 Nov
In one month
11 Dec - 13 Dec
In two months
8 Jan - 10 Jan

Our top choices for Alexander County vacation homes

A spacious living room with a brown leather sofa, a dining area with a wooden table and chairs, a kitchen with white cabinets and a central island, and large windows with blinds.

1. Pa’s House is an enjoyable, entirely remodeled, 2-bedroom farmhouse near Anna.

Pa’s House is an enjoyable, entirely remodeled, 2-bedroom farmhouse near Anna.
Anna
10.0 out of 10, Exceptional, (16 reviews)
"We enjoyed our stay here. The beds were very comfortable and it was close to all of the wineries along the wine trail."
United States
Kristi H.
The price is AED 450
AED 940 total
includes taxes & fees
16 Nov - 17 Nov
Pa’s House is an enjoyable, entirely remodeled, 2-bedroom farmhouse near Anna.
A dining area with a round wooden table, white chairs, a vase with flowers, and a view through large windows.

2. “Kozy on Kingsway” is a charming 4-bedroom house in Cape -The City of Roses

“Kozy on Kingsway” is a charming 4-bedroom house in Cape -The City of Roses
Cape Girardeau
9.4 out of 10, Exceptional, (15 reviews)
"Clean, homey, family friendly!"
United States
Merry J.
“Kozy on Kingsway” is a charming 4-bedroom house in Cape -The City of Roses
A wooden-paneled room with a dining table and chairs, a cabinet with glassware, and a window with curtains.

3. Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286

Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
Kevil
10.0 out of 10, Exceptional, (204 reviews)
"Clean place to stay and host was very responsive. Would definitely stay again."
United States
Jack B.
Quiet home on horse farm, halfway between Paducah & Wickliffe. Close to 60 & 286
A spacious living room with a brick wall, wooden beams, a black leather sofa, a wooden coffee table, and a dining area with a table and chairs.

4. * On the Wine Trail * Hot Tub * Wi-Fi *

* On the Wine Trail * Hot Tub * Wi-Fi *
Alto Pass
9.8 out of 10, Exceptional, (260 reviews)
"Had a great time!!! It was nice to relax in the hot tub each night after full days on the wine trail. Great host!!!"
United States
scott
* On the Wine Trail * Hot Tub * Wi-Fi *
Private kitchen

5. Kaoline Station House

Kaoline Station House
Cobden
9.6 out of 10, Exceptional, (8 reviews)
"I really only slept there as I was working near by, but very clean and comfortable beds! Road to it is treacherous although obviously not the owners fault. Beautiful decor!"
United States
Becky K.
Kaoline Station House
A wooden cabinet with a microwave, coffee maker, and plates.

6. Cozy and Updated Farmhouse with King Suite

Cozy and Updated Farmhouse with King Suite
Anna
10.0 out of 10, Exceptional, (30 reviews)
"Comfortable bed which is what we needed. We weren’t there long but is was everything we needed."
United States
Kathy H.
The price is AED 377
AED 602 total
includes taxes & fees
24 Nov - 25 Nov
Cozy and Updated Farmhouse with King Suite
A modern kitchen with white cabinets, a large island with stools, and pendant lighting.

7. 3 bedroom 2 bathroom home on 14 acres in a peaceful, relaxing setting.

3 bedroom 2 bathroom home on 14 acres in a peaceful, relaxing setting.
Vienna
10.0 out of 10, Exceptional, (66 reviews)
"Always the best!"
United States
Melissa A.
The price is AED 918
AED 1,269 total
includes taxes & fees
13 Dec - 14 Dec
3 bedroom 2 bathroom home on 14 acres in a peaceful, relaxing setting.
A compact living space with a sofa set, a dining table, and a kitchenette.

8. * Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *

* Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *
Alto Pass
10.0 out of 10, Exceptional, (124 reviews)
"Excellent location for the Shawnee Wine Trail, hiking and dining!"
United States
Myron F.
* Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *
A two-story house with a covered porch, a large window, and a chimney.

9. “Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau

“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau
Cape Girardeau
10.0 out of 10, Exceptional, (51 reviews)
"Spectacular place and great host! Highly recommend!"
United States
Eric P.
“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau
A hot tub with water, surrounded by a wooden fence and string lights.

10. Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen

Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen
Anna
9.8 out of 10, Exceptional, (188 reviews)
"Great location and comfortable home"
United States
Julie P.
Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top reviews in Alexander County

A hotel lobby with a reception desk, seating area, and a large window.
Quality Inn Cairo I-57

Quality Inn Cairo I-57

Quality Inn Cairo I-57
Cairo

10/10 Excellent

Amenities, microwave, refrigerator,iron and iron board,Shower soap options
United States
Maurice
Reviewed February 10, 2026
Quality Inn Cairo I-57

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