Defiance Vacations

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Defiance Hotel Deals

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Fully refundableReserve now, pay when you stay
The price is AED 328 per night from Feb 10 to Feb 11
AED 328
AED 379 total
10 Feb - 11 Feb
includes taxes & fees
7.8/10 Good! (1,091 reviews)
Great room, great people, great breakfast

Reviewed on 2 February 2026

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
Fully refundableReserve now, pay when you stay
The price is AED 477 per night from Feb 16 to Feb 17
AED 477
AED 611 total
16 Feb - 17 Feb
includes taxes & fees
8.4/10 Very Good! (2,225 reviews)
Everything was very, very nice. The casino smoke was unfortunate, but was not noticable in the room, of course.

Reviewed on 7 February 2026

Hollywood Casino & Hotel St. Louis
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
Fully refundableReserve now, pay when you stay
9.2/10 Wonderful! (1,626 reviews)
Clean room and easy parking.

Reviewed on 2 February 2026

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The Wildwood Hotel
See all 860 properties in Defiance
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Discover the most popular places to visit in Defiance

Union Station, St. Louis, MO

St. Louis Union Station

4/5(615 reviews)

You can learn about the local history of St. Louis when you make a stop at a well-known site like St. Louis Union Station. Experience the area's great live music or attend a baseball game.

St. Louis Union Station
Aerial view of vibrant downtown St. Louis with Enterprise Center and St. Louis Wheel, St. Louis, Missouri, United States.

Enterprise Center

4.5/5(491 reviews)

Catch an event at Enterprise Center during your trip to St. Louis. Experience the area's fascinating museums or attend a baseball game.

Enterprise Center
St. Louis, Missouri - 08.22.2021 - Brookings Hall on the Danforth Campus of Washington University in St. Louis.

Washington University in St. Louis

4.5/5(479 reviews)

Enjoy the collegiate vibe at Washington University in St. Louis during your stay in St. Louis. Amble around the area's lush forest or attend a sporting event.

Washington University in St. Louis

Frequently asked questions

How do I find cheap flights to Defiance that have flexible change policies?
We know that things can change in a flash, so reserving a flexible fare with Expedia is a sensible idea. Simply tick the "No change fee" box below the "Flexible change policies" filter. Your affordable, flexible flight to Defiance is just a few clicks away.
Which airlines fly to Defiance?
Heading to Defiance is as easy as choosing between two top airlines. Book yourself a seat with one of the following:

  • American Airlines - 927 flights to or near Defiance each month, including 927 flights to Lambert-St. Louis Intl. Airport (STL) per month.
  • United Airlines - 524 flights to or near Defiance each month, including 524 flights to Lambert-St. Louis Intl. Airport (STL) per month.

How can I find cheap tickets to Defiance?
In the last seven days, was the best price for a flight to Defiance. If you're eager to save even more, book in advance and be flexible with your dates. Search for your airfare to Defiance, then compare prices for similar time frames by clicking on the "flexible dates" link above.
How much is a flight to Defiance?
There were plenty of affordable fares up for grabs in the last seven days, with the cost of a return ticket to Defiance varying between and . Many lucky vacationers purchased one-way seats from () for only .
What are the most popular airports to fly into in Defiance?
Jet into Lambert-St. Louis Intl. Airport (STL) and sample the best that Defiance has to offer. As the region's primary entry point, around 5,604 flights touch down here every month.
When is the cheapest time to fly to Defiance?
Take off to Defiance early on in the week and you'll usually be rewarded with lower fares. Tuesday is known for being the cheapest day to hop on a plane, closely followed by Monday. If you're eager to avoid the most expensive flights, stay away from Saturdays.
How much is a plane ticket to Defiance?
In the last seven days, seats varied between and . Check out our sensational deals to Defiance, make a booking and get ready for your next fun vacation!
What months are the cheapest to book a flight to Defiance?
Grab your ticket in February to unlock amazing flight deals to Defiance. The festive month of December is usually the most expensive time to purchase a fare.
How long is a flight to Defiance?
It depends on a couple of things, including where you jet off from and whether it's a multi-stop or direct flight. Listed below are some of the busiest domestic routes to Defiance and their average flight durations:

  • Denver, CO (DEN-Denver Intl.) to Lambert-St. Louis Intl. Airport (STL) - 2 hours and 1 minute
  • Chicago, IL (ORD-O'Hare Intl.) to Lambert-St. Louis Intl. Airport (STL) - 1 hour and 24 minutes
  • New York, NY (LGA-LaGuardia) to Lambert-St. Louis Intl. Airport (STL) - 2 hours and 51 minutes