Find 2 Star Hotels in Defiance, MO from AED 269
Change your mindBook hotels with free cancellation
Be pickySearch almost a million properties worldwide
Check availability on Defiance 2 Star Hotels
Tonight
19 Sep - 20 SepTomorrow
20 Sep - 21 SepNext weekend
25 Sep - 27 SepIn two weeks
2 Oct - 4 OctOur top choices for Defiance 2-star hotels
1. Sleep Inn & Suites O'Fallon MO - Technology Drive
Sleep Inn & Suites O'Fallon MO - Technology DriveO'Fallon
Tim
AED 303
AED 357 total
includes taxes & fees
11 Oct - 12 Oct
2. Country Inn & Suites by Radisson, St. Charles Historic District
Country Inn & Suites by Radisson, St. Charles Historic DistrictSt. Charles Historic District
Eland
AED 450
AED 517 total
includes taxes & fees
11 Oct - 12 Oct
AED 348
AED 399 total
includes taxes & fees
4 Oct - 5 Oct
AED 306
AED 351 total
includes taxes & fees
11 Oct - 12 Oct
AED 314
AED 355 total
includes taxes & fees
27 Sep - 28 Sep
6. Americas Best Value Inn & Suites St. Louis, St. Charles Inn
Americas Best Value Inn & Suites St. Louis, St. Charles InnSt. Charles
Tom
AED 281
AED 326 total
includes taxes & fees
20 Sep - 21 Sep
AED 325
AED 377 total
includes taxes & fees
22 Sep - 23 Sep
8. Country Inn & Suites by Radisson, St. Peters, MO
Country Inn & Suites by Radisson, St. Peters, MOSt. Charles
Eugene
AED 294
AED 338 total
includes taxes & fees
11 Oct - 12 Oct
Save an average of 15% on thousands of hotels when you're signed in
Explore similar 3-star hotels
Many 3-star hotels have the same amenities as 2-star hotels. See all 3-star hotels in Defiance.
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
1088 South Highway Drive Fenton MO
AED 347
AED 400 total
20 Sep - 21 Sep
includes taxes & fees
Hollywood Casino & Hotel St. Louis
777 Casino Center Drive Maryland Heights MO
AED 306
AED 466 total
19 Oct - 20 Oct
includes taxes & fees
8.6/10 Excellent! (2,222 reviews)
Drury Inn & Suites St. Louis St. Peters
170 Mid Rivers Mall Circle St. Peters MO
AED 404
AED 464 total
4 Oct - 5 Oct
includes taxes & fees
Still don't see what you're looking for?
See all properties in Defiance.
You can also use these popular filters to refine your search.
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Learn more about Defiance
Nestled along the Missouri River, this historic village offers scenic hiking trails and access to nearby wine country. Visit the Daniel Boone Home in neighboring Defiance Township or enjoy tastings at the family-owned wineries dotting the surrounding countryside.
See all hotels in Defiance
Top Defiance Hotel Reviews
Studio 6 Extended Stay - St Louis, MO - Westport/Craig Road
10/10 Excellent
"The staff was cool and the area was nice and quiet!"
Explore a world of travel with Expedia
- Best Western Hotels in Weldon Spring Heights
- Red Carpet Inn Hotels in Labadie
- Cabin Rentals in Grover
- Hotels near Augusta Winery
- 3 Star Hotels in Marthasville
- 5 Star Hotels in Wentzville
- 2 Star Hotels in Innsbrook
- Extended Stay America Hotels in Weldon Spring Heights
- 3 Star Hotels in Foristell
- 5 Star Hotels in St. Peters
- Vacation Homes in New Melle
- 2 Star Hotels in Grover
- Extended Stay America Hotels in New Melle
- Cabin Rentals in Weldon Spring Heights
- 3 Star Hotels in Eureka
- Cabin Rentals in Defiance
- Aimbridge Hospitality Hotels in Defiance
- 4 Star Hotels in Eureka
- Drury Inn & Suites Hotels in Labadie
- Hotels with Hot Tubs in Grover
- Hilton Hotels in Lake St Louis
- Independent Hotels in New Melle
- Hotels with Hot Tubs in Augusta
- Red Carpet Inn Hotels in Saint Albans
- 5 Star Hotels in Grover
- 2 Star Hotels in Chesterfield
- Drury Inn & Suites Hotels in Defiance
- Hilton Hotels in Wildwood
- Cabin Rentals in Wildwood
- Marriott Hotels & Resorts in Defiance
- Hotels with Bars in Lake St Louis
- 4 Star Hotels in Pacific
- Drury Inn & Suites Hotels in Lake St Louis
- 3 Star Hotels in St. Peters
- Red Carpet Inn Hotels in Augusta
- Accor Hotels in Weldon Spring Heights
- Condo Rentals in Weldon Spring Heights
- Resorts & Hotels with Spas in Augusta
- 3 Star Hotels in Flinthill
- Adventure Hotels in Wildwood
- 2 Star Hotels in Union
- 3 Star Hotels in Washington
- Cottages in Gray Summit
- 4 Star Hotels in Ballwin
- Cabin Rentals in Gray Summit
- 5 Star Hotels in Labadie
- 5 Star Hotels in Ballwin
- 4 Star Hotels in O'Fallon
- Wyndham Hotels in Gray Summit
- Aimbridge Hospitality Hotels in Labadie
- 3 Star Hotels in New Melle
- Red Carpet Inn Hotels in Defiance
- 5 Star Hotels in Harvester
- 5 Star Hotels in St. Charles Historic District
- 5 Star Hotels in Eureka
- Marriott Hotels & Resorts in Wildwood
- La Quinta Inn & Suites Hotels in Weldon Spring Heights
- Drury Inn & Suites Hotels in Grover
- 2 Star Hotels in Villa Ridge
- Romantic Hotels in Wildwood
- 3 Star Hotels in Ellisville
- 2 Star Hotels in Harvester
- 4 Star Hotels in St. Charles Historic District
- Ski Hotels in Grover
- Marriott Hotels & Resorts in Saint Albans
- Hilton Hotels in New Melle
- Wyndham Hotels in Saint Albans
- 3 Star Hotels in Defiance
- Chalets in New Melle
- Hotels near Six Flags St. Louis
- 4 Star Hotels in St. Charles
- Cottages in Wildwood
- Red Carpet Inn Hotels in New Melle
- 2 Star Hotels in St. Peters
- Flights from Guangzhou (CAN) to St. Louis (SUS)
- Flights from Waco (ACT) to St. Louis (SUS)
- Flights from Ocala (OCF) to St. Louis (SUS)
- Flights from Wildwood
- Flights from Labadie
- Flights from Augusta
- Flights from New Melle
- Flights from Port of Spain (POS) to St. Louis (SUS)
- Flights from Spirit of St. Louis
- Flights from Hamilton (HAO) to St. Louis (SUS)
- Flights from Kos (KGS) to St. Louis (SUS)
- Flights from Houston (IAH) to St. Louis (SUS)
- Flights from Newark Liberty Intl. Airport (EWR) to St. Louis (SUS)
- Flights from Salina (SLN) to St. Louis (SUS)
- Flights from Moline (MLI) to St. Louis (SUS)
- Flights from Miami (MIA) to St. Louis (SUS)
- Flights from Grover
- Flights from Albany (ALB) to St. Louis (SUS)
- Flights from Gray Summit
- Flights from Riyadh (RUH) to St. Louis (SUS)
- Flights from Tupelo (TUP) to St. Louis (SUS)
- Flights from Liberal (LBL) to St. Louis (SUS)