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Find Resorts & Hotels with Spas in Southeast Missouri, MO

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Check availability on Southeast Missouri Resorts & Hotels with Spas

This weekend
30 Oct - 1 Nov
Next weekend
6 Nov - 8 Nov

Our top choices for Southeast Missouri hotels with a spa

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

1. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,006 reviews)
"Everything was great about the stay!"
United States
Denise
The price is AED 331
AED 371 total
includes taxes & fees
8 Nov - 9 Nov
Hampton Inn Poplar Bluff
A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

2. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,000 reviews)
"Clean room affordable and great breakfast I would definitely go back!"
United States
Lyn
The price is AED 294
AED 311 total
includes taxes & fees
8 Nov - 9 Nov
Drury Inn & Suites Jackson MO
A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

3. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (975 reviews)
"Everything was great- breakfast, cleanliness, price— will stay there again"
United States
ELAINE
The price is AED 356
AED 402 total
includes taxes & fees
8 Nov - 9 Nov
Fairfield Inn & Suites by Marriott Poplar Bluff
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

4. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,004 reviews)
"Great stay! Hot tub was enjoyable and the staff was super friendly!"
United States
Chris
The price is AED 367
AED 414 total
includes taxes & fees
1 Nov - 2 Nov
Drury Plaza Hotel Cape Girardeau Conference Center
A living room with a blue wall, a fireplace, a sofa, and a chair.

5. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.4 out of 10, Exceptional, (117 reviews)
"Awesome hotel and staff was first rate, everything was fantastic. If you are in the area, stay at this hotel and eat in!!"
United States
Jan
The price is AED 363
AED 395 total
includes taxes & fees
30 Nov - 1 Dec
EC Reed's Mercantile and Hotel
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

6. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.2 out of 10, Wonderful, (1,001 reviews)
"The stay was pleasant from start to finish. Extremely nice staff, good breakfast and convenient parking. The location was also great!"
United States
Celeste
The price is AED 264
AED 298 total
includes taxes & fees
8 Nov - 9 Nov
Pear Tree Inn Cape Girardeau West
A modern lounge area with seating arrangements, a kitchen area, and a bar.

7. Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
9.6 out of 10, Exceptional, (81 reviews)
"This place is Brand new and really great!"
United States
Bryan
The price is AED 358
AED 406 total
includes taxes & fees
15 Nov - 16 Nov
Hampton Inn By Hilton Dexter
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

8. The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (696 reviews)
"Clean, quiet, comfortable room. Very comfortable beds."
United States
Renee
The price is AED 395
AED 445 total
includes taxes & fees
1 Nov - 2 Nov
The Riverview
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

9. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
9.0 out of 10, Wonderful, (888 reviews)
"Breakfast was good."
United States
J
The price is AED 293
AED 318 total
includes taxes & fees
2 Nov - 3 Nov
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

10. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (198 reviews)
"Had a great stay friendly staff very clean facilities!"
United States
Shannon
The price is AED 328
AED 374 total
includes taxes & fees
8 Nov - 9 Nov
Tru By Hilton Cape Girardeau
An outdoor seating area with a circular fire pit surrounded by chairs, a covered patio, and a building with large windows in the background.

11. Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (118 reviews)
"Friendly staff, great breakfast, nice amenities"
United States
Roslyn
The price is AED 371
AED 422 total
includes taxes & fees
8 Nov - 9 Nov
Fairfield Inn & Suites by Marriott Sikeston
A spacious lobby with a reception desk, seating area, and large windows.

12. Drury Inn & Suites Poplar Bluff

Drury Inn & Suites Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,001 reviews)
"Clean, great food, excellent staff."
United States
Dean
The price is AED 345
AED 390 total
includes taxes & fees
12 Nov - 13 Nov
Drury Inn & Suites Poplar Bluff
A modern kitchen with a coffee machine, a sink, and a counter. There are four chairs and a table in the dining area.

13. Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very good, (1,002 reviews)
"Rooms were large and clean. Bathroom was large with a nice shower. Parking was convenient Would definitely stay again."
United States
Jim
The price is AED 261
AED 292 total
includes taxes & fees
12 Nov - 13 Nov
Motel 6 Poplar Bluff, MO
Two armchairs with a patterned upholstery, a small round table with a vase of flowers, and a large abstract painting on the wall.

14. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (856 reviews)
"Everything was lovely. Great room, breakfast, pool, and staff."
United States
Vonnie
The price is AED 358
AED 404 total
includes taxes & fees
8 Nov - 9 Nov
Hampton Inn Cape Girardeau I 55 East
A Holiday Inn hotel with a covered entrance, multiple floors, and a parking lot.

15. Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (799 reviews)
"Always an enjoyable stay"
United States
Nathan
The price is AED 290
AED 328 total
includes taxes & fees
29 Nov - 30 Nov
Holiday Inn Poplar Bluff by IHG
A spacious living room with a sofa set, a coffee table, and a dining area.

16. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (556 reviews)
"The staff was very friendly and rooms were great!"
United States
Jacqueline
The price is AED 426
AED 483 total
includes taxes & fees
15 Nov - 16 Nov
Courtyard by Marriott Cape Girardeau Downtown
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

17. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,002 reviews)
"Perfect location, beds were awesome & staff were friendly & accommodating!"
United States
Rebecca
The price is AED 349
AED 397 total
includes taxes & fees
29 Nov - 30 Nov
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

18. Shepherd Mountain Inn

Shepherd Mountain Inn
2.5 star property
Ironton
9.2 out of 10, Wonderful, (337 reviews)
"Clean room, wifi easy to connect to, parking right in front."
United States
Jonathan
The price is AED 453
AED 495 total
includes taxes & fees
2 Nov - 3 Nov
Shepherd Mountain Inn
A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

19. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very good, (1,003 reviews)
"Our room was spacious, clean and the bed was super comfortable!"
Canada
Kim
The price is AED 200
AED 228 total
includes taxes & fees
5 Nov - 6 Nov
Baymont Inn and Suites by Wyndham Farmington, MO
A hotel room with two beds, a TV, a desk, and a wardrobe.

20. The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.6 out of 10, Excellent, (623 reviews)
"Overall a nice room and good location. Only complaint: low water pressure in shower"
United States
Rufus
The price is AED 328
AED 373 total
includes taxes & fees
30 Nov - 1 Dec
The Farmstead Hotel
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Southeast Missouri

Pool
Breakfast included

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

10/10 Excellent
"Clean and tidy, friendly staff. Pet friendly. Easy access from the highway. In and out with a good night's sleep and no hassle"
eugene 1-night trip
Posted 3 days ago
Drury Inn & Suites Cape Girardeau
Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO

10/10 Excellent
"Clean and comfortable, friendly staff."
Stephanie 1-night trip
Posted 5 days ago
Drury Inn & Suites Jackson MO

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