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Find Resorts & Hotels with Spas in Southeast Missouri, MO

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Check availability on Southeast Missouri Resorts & Hotels with Spas

Our top choices for Southeast Missouri hotels with a spa

A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

1. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,001 reviews)
"Easy check in and room was very clean. The food for breakfast and dinner is the bomb."
United States
Melody
The price is AED 367
AED 414 total
includes taxes & fees
15 Nov - 16 Nov
Drury Plaza Hotel Cape Girardeau Conference Center
An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

2. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,001 reviews)
"Great place to stay!"
United States
Tiffany
The price is AED 345
AED 397 total
includes taxes & fees
22 Nov - 23 Nov
Drury Inn & Suites Sikeston, MO
A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

3. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,020 reviews)
"Everything was great about the stay!"
United States
Denise
The price is AED 328
AED 367 total
includes taxes & fees
6 Dec - 7 Dec
Hampton Inn Poplar Bluff
A modern retail area with a display of local items and snacks.

4. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (201 reviews)
"Had a great stay friendly staff very clean facilities!"
United States
Shannon
The price is AED 313
AED 357 total
includes taxes & fees
17 Nov - 18 Nov
Tru By Hilton Cape Girardeau
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

5. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.2 out of 10, Wonderful, (1,000 reviews)
"The lady's that works there are wonderful, and of course the breakfast was amazing!!"
United States
Livia
The price is AED 264
AED 298 total
includes taxes & fees
16 Nov - 17 Nov
Pear Tree Inn Cape Girardeau West
A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

6. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (978 reviews)
"Everything was great- breakfast, cleanliness, price— will stay there again"
United States
ELAINE
The price is AED 356
AED 402 total
includes taxes & fees
29 Nov - 30 Nov
Fairfield Inn & Suites by Marriott Poplar Bluff
A living room with a blue wall, a fireplace, a sofa, and a chair.

7. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.4 out of 10, Exceptional, (118 reviews)
"Awesome hotel and staff was first rate, everything was fantastic. If you are in the area, stay at this hotel and eat in!!"
United States
Jan
The price is AED 386
AED 420 total
includes taxes & fees
15 Nov - 16 Nov
EC Reed's Mercantile and Hotel
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

8. The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (703 reviews)
"Every time I stay here I truly enjoy my stay Clean rooms and staff is very attentive Will stay here again"
United States
Irvin
The price is AED 403
AED 455 total
includes taxes & fees
12 Nov - 13 Nov
The Riverview
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

9. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8 out of 10, Excellent, (896 reviews)
"Very clean and every one very nice and helpful"
United States
richard
The price is AED 293
AED 318 total
includes taxes & fees
12 Nov - 13 Nov
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
Two armchairs with a patterned upholstery, a small round table with a vase of flowers, and a large abstract painting on the wall.

10. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (860 reviews)
"Staff was friendly and helpful. Rooms and facilities were clean."
United States
Britney
The price is AED 358
AED 404 total
includes taxes & fees
22 Nov - 23 Nov
Hampton Inn Cape Girardeau I 55 East
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

11. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,000 reviews)
"Perfect location, beds were awesome & staff were friendly & accommodating!"
United States
Rebecca
The price is AED 349
AED 397 total
includes taxes & fees
11 Dec - 12 Dec
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A spacious lobby with a modern design, featuring a seating area with patterned armchairs and a round table, a large window, and a fireplace with decorative wall art.

12. Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville
3.0 star property
Hayti
9.2 out of 10, Wonderful, (1,001 reviews)
"The food & drinks were great & the staff was very friendly. Room was very nice."
United States
Cynthia
The price is AED 360
AED 410 total
includes taxes & fees
6 Dec - 7 Dec
Drury Inn & Suites Hayti Caruthersville
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

13. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (242 reviews)
"Everything is very clean. Excellent facility all around. Friendly staff"
United States
Dane
The price is AED 372
AED 419 total
includes taxes & fees
19 Nov - 20 Nov
Fairfield Inn & Suites by Marriott Cape Girardeau
A modern hotel lobby with a central dining area, a minibar, and a view of the outdoors.

14. Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
9.6 out of 10, Exceptional, (85 reviews)
"This place is Brand new and really great!"
United States
Bryan
The price is AED 358
AED 406 total
includes taxes & fees
4 Dec - 5 Dec
Hampton Inn By Hilton Dexter
A spacious living room with a sofa set, a coffee table, and a dining area.

15. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (559 reviews)
"Good stay"
United States
Kelly
The price is AED 426
AED 483 total
includes taxes & fees
29 Nov - 30 Nov
Courtyard by Marriott Cape Girardeau Downtown
A modern kitchen with a coffee machine, a sink, and a counter. There are four chairs and a table in the dining area.

16. Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very good, (1,000 reviews)
"Rooms were large and clean. Bathroom was large with a nice shower. Parking was convenient Would definitely stay again."
United States
Jim
The price is AED 228
AED 255 total
includes taxes & fees
25 Nov - 26 Nov
Motel 6 Poplar Bluff, MO
A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

17. Shepherd Mountain Inn

Shepherd Mountain Inn
2.5 star property
Ironton
9.2 out of 10, Wonderful, (338 reviews)
"Clean room, wifi easy to connect to, parking right in front."
United States
Jonathan
The price is AED 453
AED 495 total
includes taxes & fees
12 Nov - 13 Nov
Shepherd Mountain Inn
A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

18. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very good, (1,002 reviews)
"Our room was spacious, clean and the bed was super comfortable!"
Canada
Kim
The price is AED 200
AED 228 total
includes taxes & fees
18 Nov - 19 Nov
Baymont Inn and Suites by Wyndham Farmington, MO
A rustic interior with exposed brick walls, wooden railings, and a hanging floral chandelier.

19. The Atrium - A Boutique Hotel

The Atrium - A Boutique Hotel
2.0 star property
Perryville
9.6 out of 10, Exceptional, (14 reviews)
"Great place to stay"
United States
Matt
The price is AED 324
AED 371 total
includes taxes & fees
12 Nov - 13 Nov
The Atrium - A Boutique Hotel
A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

20. Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (657 reviews)
"Great hotel, clean spacious room, good breakfast choice"
United Kingdom
Deborah
The price is AED 372
AED 423 total
includes taxes & fees
19 Nov - 20 Nov
Hampton Inn Sikeston
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Southeast Missouri

Pool
Breakfast included

Top Southeast Missouri Hotel Reviews

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

10/10 Excellent
"Everything was great service, clean and very friendly staff only complaint is the bed was super uncomfortable but that’s not the hotel employees faults ):"
Madison 1-night trip
Posted 15 hours ago
Drury Plaza Hotel Cape Girardeau Conference Center

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