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Find Resorts & Hotels with Spas in Southeast Missouri, MO

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Check availability on Southeast Missouri Resorts & Hotels with Spas

Our top choices for Southeast Missouri hotels with a spa

A spacious lobby with a large sectional sofa, multiple armchairs, and a coffee table. There is a TV mounted on the wall and a large window providing a view of the outdoors.

1. Drury Inn & Suites Jackson MO

Drury Inn & Suites Jackson MO
3.0 star property
Jackson
9.6 out of 10, Exceptional, (1,002 reviews)
"The hotel was clean, comfortable and the breakfast was good."
United States
Leonardo
The price is AED 294
AED 311 total
includes taxes & fees
22 Nov - 23 Nov
Drury Inn & Suites Jackson MO
A spacious lobby with a circular seating area, a stone fireplace, and modern lighting fixtures.

2. Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (1,004 reviews)
"Easy check in and room was very clean. The food for breakfast and dinner is the bomb."
United States
Melody
The price is AED 367
AED 414 total
includes taxes & fees
13 Nov - 14 Nov
Drury Plaza Hotel Cape Girardeau Conference Center
A modern lounge area with a stone fireplace, blue seating, a round coffee table, and a large window offering a view.

3. Fairfield Inn & Suites by Marriott Poplar Bluff

Fairfield Inn & Suites by Marriott Poplar Bluff
3.0 star property
Poplar Bluff
9.4 out of 10, Exceptional, (977 reviews)
"Everything was great- breakfast, cleanliness, price— will stay there again"
United States
ELAINE
The price is AED 356
AED 402 total
includes taxes & fees
15 Nov - 16 Nov
Fairfield Inn & Suites by Marriott Poplar Bluff
A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

4. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,015 reviews)
"Everything was great about the stay!"
United States
Denise
The price is AED 328
AED 367 total
includes taxes & fees
6 Dec - 7 Dec
Hampton Inn Poplar Bluff
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

5. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.2 out of 10, Wonderful, (1,001 reviews)
"The stay was pleasant from start to finish. Extremely nice staff, good breakfast and convenient parking. The location was also great!"
United States
Celeste
The price is AED 264
AED 298 total
includes taxes & fees
15 Nov - 16 Nov
Pear Tree Inn Cape Girardeau West
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

6. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (200 reviews)
"Had a great stay friendly staff very clean facilities!"
United States
Shannon
The price is AED 313
AED 357 total
includes taxes & fees
15 Nov - 16 Nov
Tru By Hilton Cape Girardeau
A spacious lobby with a curved staircase, large windows, and a seating area with a rug.

7. The Riverview

The Riverview
4.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (702 reviews)
"Every time I stay here I truly enjoy my stay Clean rooms and staff is very attentive Will stay here again"
United States
Irvin
The price is AED 403
AED 455 total
includes taxes & fees
12 Nov - 13 Nov
The Riverview
A living room with a blue wall, a fireplace, a sofa, and a chair.

8. EC Reed's Mercantile and Hotel

EC Reed's Mercantile and Hotel
3.0 star property
Marble Hill
9.4 out of 10, Exceptional, (118 reviews)
"Awesome hotel and staff was first rate, everything was fantastic. If you are in the area, stay at this hotel and eat in!!"
United States
Jan
The price is AED 386
AED 420 total
includes taxes & fees
15 Nov - 16 Nov
EC Reed's Mercantile and Hotel
A hotel entrance with a large sign reading "LAQUINTA" and a sun graphic.

9. La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau

La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
3.0 star property
Jackson
8.8 out of 10, Excellent, (895 reviews)
"Very clean and every one very nice and helpful"
United States
richard
The price is AED 293
AED 318 total
includes taxes & fees
12 Nov - 13 Nov
La Quinta Inn & Suites by Wyndham Jackson/Cape Girardeau
A modern lounge area with seating arrangements, a kitchen area, and a bar.

10. Hampton Inn By Hilton Dexter

Hampton Inn By Hilton Dexter
2.5 star property
Dexter
9.6 out of 10, Exceptional, (83 reviews)
"This place is Brand new and really great!"
United States
Bryan
The price is AED 358
AED 406 total
includes taxes & fees
15 Nov - 16 Nov
Hampton Inn By Hilton Dexter
An indoor swimming pool with a 3 FT depth marker, a metal ladder, and a tiled floor.

11. Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.6 out of 10, Exceptional, (1,002 reviews)
"Great place to stay!"
United States
Tiffany
The price is AED 345
AED 397 total
includes taxes & fees
15 Nov - 16 Nov
Drury Inn & Suites Sikeston, MO
A spacious living room with a sofa set, a coffee table, and a dining area.

12. Courtyard by Marriott Cape Girardeau Downtown

Courtyard by Marriott Cape Girardeau Downtown
3.0 star property
Cape Girardeau
9.6 out of 10, Exceptional, (559 reviews)
"Good stay"
United States
Kelly
The price is AED 426
AED 483 total
includes taxes & fees
19 Nov - 20 Nov
Courtyard by Marriott Cape Girardeau Downtown
A modern living room with a sofa, armchairs, a coffee table, and a TV mounted on the wall.

13. Fairfield Inn & Suites by Marriott Cape Girardeau

Fairfield Inn & Suites by Marriott Cape Girardeau
3.0 star property
Cape Girardeau
9.4 out of 10, Exceptional, (242 reviews)
"Everything is very clean. Excellent facility all around. Friendly staff"
United States
Dane
The price is AED 372
AED 419 total
includes taxes & fees
15 Nov - 16 Nov
Fairfield Inn & Suites by Marriott Cape Girardeau
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

14. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,001 reviews)
"Perfect location, beds were awesome & staff were friendly & accommodating!"
United States
Rebecca
The price is AED 364
AED 414 total
includes taxes & fees
7 Dec - 8 Dec
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
Two armchairs with a patterned upholstery, a small round table with a vase of flowers, and a large abstract painting on the wall.

15. Hampton Inn Cape Girardeau I 55 East

Hampton Inn Cape Girardeau I 55 East
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (860 reviews)
"Everything was lovely. Great room, breakfast, pool, and staff."
United States
Vonnie
The price is AED 358
AED 404 total
includes taxes & fees
15 Nov - 16 Nov
Hampton Inn Cape Girardeau I 55 East
A cabin surrounded by a natural forest setting with a fire pit and outdoor seating.

16. Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
2.0 star property
French Village
10.0 out of 10, Exceptional, (119 reviews)
"Recomend this location"
United States
Jose
The price is AED 323
AED 534 total
includes taxes & fees
8 Dec - 9 Dec
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
A kitchen with wooden cabinets, a stainless steel refrigerator, a microwave, a stove, and a granite countertop.

17. Shepherd Mountain Inn

Shepherd Mountain Inn
2.5 star property
Ironton
9.2 out of 10, Wonderful, (338 reviews)
"Clean room, wifi easy to connect to, parking right in front."
United States
Jonathan
The price is AED 453
AED 495 total
includes taxes & fees
10 Nov - 11 Nov
Shepherd Mountain Inn
A modern kitchen with a coffee machine, a sink, and a counter. There are four chairs and a table in the dining area.

18. Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very good, (1,002 reviews)
"Rooms were large and clean. Bathroom was large with a nice shower. Parking was convenient Would definitely stay again."
United States
Jim
The price is AED 261
AED 292 total
includes taxes & fees
22 Nov - 23 Nov
Motel 6 Poplar Bluff, MO
A Holiday Inn hotel with a covered entrance, multiple floors, and a parking lot.

19. Holiday Inn Poplar Bluff by IHG

Holiday Inn Poplar Bluff by IHG
3.0 star property
Poplar Bluff
8.8 out of 10, Excellent, (806 reviews)
"Always an enjoyable stay"
United States
Nathan
The price is AED 294
AED 332 total
includes taxes & fees
15 Nov - 16 Nov
Holiday Inn Poplar Bluff by IHG
A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

20. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very good, (1,003 reviews)
"Our room was spacious, clean and the bed was super comfortable!"
Canada
Kim
The price is AED 200
AED 228 total
includes taxes & fees
16 Nov - 17 Nov
Baymont Inn and Suites by Wyndham Farmington, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Choose what matters most at spa hotels in Southeast Missouri

Pool
Breakfast included

Top Southeast Missouri Hotel Reviews

Drury Inn & Suites Hayti Caruthersville

Drury Inn & Suites Hayti Caruthersville

10/10 Excellent
"Clean and well maintained."
Randall 1-night trip
Posted 3 days ago
Drury Inn & Suites Hayti Caruthersville

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