Find Business Hotels in Southern Illinois, IL

Start date: Check-in selected.
End date: Check-out
    calendar shield illustration

    Change your mind

    Book hotels with free cancellation
    deals illustration

    Treat yourself

    Sign in to save 10% or more on thousands of hotels
    Sign in
    bed illustration

    Be picky

    Search almost a million properties worldwide

Check availability on Southern Illinois Business Hotels

Tonight
2 Sep - 3 Sep
Tomorrow
3 Sep - 4 Sep
This weekend
5 Sep - 7 Sep
Next weekend
12 Sep - 14 Sep

Top Southern Illinois Business Hotels

Our top choices for Southern Illinois business-friendly hotels

Drury Plaza Hotel Mt. Vernon
Lobby

Drury Plaza Hotel Mt. Vernon

3.0 star property
9.6 out of 10, Exceptional, (1445)
"Great place like a vacation every time I stay "
The price is AED 349
AED 395 total
includes taxes & fees
21 Sep - 22 Sep
Drury Plaza Hotel Mt. Vernon
Drury Inn & Suites Marion
Exterior

Drury Inn & Suites Marion

3.0 star property
9.4 out of 10, Exceptional, (1018)
"We had an excellent stay."
The price is AED 239
AED 286 total
includes taxes & fees
2 Oct - 3 Oct
Drury Inn & Suites Marion
SureStay Hotel by Best Western Whittington Rend Lake
Lobby

SureStay Hotel by Best Western Whittington Rend Lake

2.5 star property
8.8 out of 10, Excellent, (853)
"The staff was friendly and very helpful."
The price is AED 248
AED 275 total
includes taxes & fees
8 Sep - 9 Sep
SureStay Hotel by Best Western Whittington Rend Lake
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Free daily self-serve breakfast

Holiday Inn Express & Suites Murphysboro - Carbondale by IHG

2.5 star property
9.4 out of 10, Exceptional, (475)
"Rooms were clean and comfy, great breakfast "
The price is AED 382
AED 424 total
includes taxes & fees
7 Sep - 8 Sep
Holiday Inn Express & Suites Murphysboro - Carbondale by IHG
Country Inn & Suites by Radisson, Effingham, IL
Room, 2 Queen Beds, Non Smoking | Desk, soundproofing, iron/ironing board, rollaway beds

Country Inn & Suites by Radisson, Effingham, IL

2.5 star property
8.8 out of 10, Excellent, (1013)
"We had a very nice stay."
The price is AED 347
AED 385 total
includes taxes & fees
7 Sep - 8 Sep
Country Inn & Suites by Radisson, Effingham, IL
Holiday Inn Express & Suites Effingham by IHG
Exterior

Holiday Inn Express & Suites Effingham by IHG

2.5 star property
9.4 out of 10, Exceptional, (1000)
"Great hotel stay"
The price is AED 444
AED 498 total
includes taxes & fees
7 Sep - 8 Sep
Holiday Inn Express & Suites Effingham by IHG
Cobblestone Inn & Suites - Altamont
Lobby

Cobblestone Inn & Suites - Altamont

2.5 star property
9.6 out of 10, Exceptional, (755)
"Always a great place with comfortable rooms."
Cobblestone Inn & Suites - Altamont
Best Western Delta Inn
Free daily continental breakfast

Best Western Delta Inn

2.5 star property
9.2 out of 10, Wonderful, (1015)
"Courteous staff, feel safe, clean rooms Thank you"
The price is AED 343
AED 385 total
includes taxes & fees
9 Sep - 10 Sep
Best Western Delta Inn
Comfort Suites Mount Vernon
Terrace/patio

Comfort Suites Mount Vernon

2.5 star property
8.8 out of 10, Excellent, (1001)
"Nice hotel. Would stay here again."
The price is AED 400
AED 452 total
includes taxes & fees
3 Sep - 4 Sep
Comfort Suites Mount Vernon
Baymont by Wyndham Marion
Lobby sitting area

Baymont by Wyndham Marion

2.5 star property
8.4 out of 10, Very Good, (1024)
"We stayed overnight for work and were very impressed with the hotel."
The price is AED 298
AED 357 total
includes taxes & fees
7 Sep - 8 Sep
Baymont by Wyndham Marion
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Southern Illinois Hotel Reviews

Explore a world of travel with Expedia

Explore a world of travel with Expedia