Photo by Bill Dillard

Find 2 Star Hotels in Southeast Missouri, MO from AED 199

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Check prices for these dates

Tonight
10 Nov - 11 Nov
Tomorrow
11 Nov - 12 Nov
This weekend
13 Nov - 15 Nov
Next weekend
20 Nov - 22 Nov

Our top choices for Southeast Missouri 2-star hotels

A spacious dining area with multiple tables and chairs, a flat-screen TV mounted on the wall, and large windows providing natural light.

1. Hampton Inn Poplar Bluff

Hampton Inn Poplar Bluff
2.5 star property
Poplar Bluff
9.4 out of 10, Exceptional, (1,019 reviews)
"Everything was great about the stay!"
United States
Denise
The price is AED 328
AED 367 total
includes taxes & fees
6 Dec - 7 Dec
Hampton Inn Poplar Bluff
A hotel room with a blue sofa, an orange ottoman, a desk with a lamp, a television, and a window with curtains.

2. Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West
2.5 star property
Cape Girardeau
9.2 out of 10, Wonderful, (1,005 reviews)
"The lady's that works there are wonderful, and of course the breakfast was amazing!!"
United States
Livia
The price is AED 264
AED 298 total
includes taxes & fees
15 Nov - 16 Nov
Pear Tree Inn Cape Girardeau West
A dining area with tables and chairs, a kitchen area, and a TV mounted on the wall.

3. Baymont Inn and Suites by Wyndham Farmington, MO

Baymont Inn and Suites by Wyndham Farmington, MO
2.5 star property
Farmington
8.0 out of 10, Very good, (1,004 reviews)
"Our room was spacious, clean and the bed was super comfortable!"
Canada
Kim
The price is AED 200
AED 228 total
includes taxes & fees
16 Nov - 17 Nov
Baymont Inn and Suites by Wyndham Farmington, MO
A modern hotel room with a large bed, a smaller bed, a desk, and a chair. There is a window with curtains and a painting on the wall.

4. Days Inn and Suites by Wyndham Sikeston

Days Inn and Suites by Wyndham Sikeston
2.0 star property
Sikeston
7.4 out of 10, Good, (1,001 reviews)
"It was clean, the room was nice and roomy, bed was very comfortable. Some things were in need of minor repairs, but nothing major."
United States
Earl
The price is AED 244
AED 278 total
includes taxes & fees
15 Nov - 16 Nov
Days Inn and Suites by Wyndham Sikeston
A hotel lobby with a reception desk, two red armchairs, a floral centerpiece, a framed cityscape picture, and a dining area in the background.

5. Comfort Inn Festus - St Louis South

Comfort Inn Festus - St Louis South
2.5 star property
Festus
7.8 out of 10, Good, (1,004 reviews)
"Check in was easy, the room was clean, price was good, and the breakfast was good."
United States
Michelle
The price is AED 253
AED 295 total
includes taxes & fees
1 Dec - 2 Dec
Comfort Inn Festus - St Louis South
A Hampton Inn with a stone facade, outdoor seating area, and a fire pit.

6. Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (656 reviews)
"Great hotel, clean spacious room, good breakfast choice"
United Kingdom
Deborah
The price is AED 372
AED 423 total
includes taxes & fees
19 Nov - 20 Nov
Hampton Inn Sikeston
A hotel room with a bed, a desk with a chair, a TV, two bedside lamps, and a large window.

7. Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
7.0 out of 10, Good, (696 reviews)
"It is a clean place, and we enjoyed our stay"
United States
Laura
The price is AED 213
AED 243 total
includes taxes & fees
1 Dec - 2 Dec
Super 8 by Wyndham Sikeston/Miner Area
A modern kitchen with a coffee machine, a sink, and a counter. There are four chairs and a table in the dining area.

8. Motel 6 Poplar Bluff, MO

Motel 6 Poplar Bluff, MO
2.0 star property
Poplar Bluff
8.0 out of 10, Very good, (1,002 reviews)
"Rooms were large and clean. Bathroom was large with a nice shower. Parking was convenient Would definitely stay again."
United States
Jim
The price is AED 228
AED 255 total
includes taxes & fees
24 Nov - 25 Nov
Motel 6 Poplar Bluff, MO
A spacious lobby with a fireplace, comfortable seating, a staircase, and a large chandelier.

9. Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG

Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
2.5 star property
Cape Girardeau
9.4 out of 10, Exceptional, (1,002 reviews)
"Perfect location, beds were awesome & staff were friendly & accommodating!"
United States
Rebecca
The price is AED 349
AED 397 total
includes taxes & fees
11 Dec - 12 Dec
Holiday Inn Express Hotel & Suites Cape Girardeau I-55 by IHG
A hotel room with a large bed, a bathroom with a bathtub, and a mirror reflecting the room.

10. Days Inn by Wyndham Perryville

Days Inn by Wyndham Perryville
2.0 star property
Perryville
7.0 out of 10, Good, (464 reviews)
"Parking was good, smelled terribly"
United States
Jesse
The price is AED 262
AED 300 total
includes taxes & fees
11 Nov - 12 Nov
Days Inn by Wyndham Perryville
An indoor swimming pool with a brick border, wooden walls, and a view of the outdoors.

11. Crown Pointe Lodge, BW Signature Collection

Crown Pointe Lodge, BW Signature Collection
2.5 star property
Farmington
8.8 out of 10, Excellent, (702 reviews)
"Tucked away gem."
United States
christopher
The price is AED 372
AED 425 total
includes taxes & fees
19 Nov - 20 Nov
Crown Pointe Lodge, BW Signature Collection
A hotel lobby with a central bar area, multiple dining tables and chairs, large windows, and a patterned carpet.

12. Best Western Plus Sikeston I-55

Best Western Plus Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very good, (1,009 reviews)
"Clean rooms, great parking, very nice staff"
United States
Shelley
The price is AED 267
AED 304 total
includes taxes & fees
7 Dec - 8 Dec
Best Western Plus Sikeston I-55
A hotel lobby with a reception desk, seating area, and a patterned carpet.

13. Holiday Inn Express & Suites Perryville by IHG

Holiday Inn Express & Suites Perryville by IHG
2.5 star property
Perryville
9.2 out of 10, Wonderful, (645 reviews)
"Excellent stay , couldn't believe the property was 10 years old , it looks like it was just built , great place , highly recommend ."
United States
allan p.
The price is AED 371
AED 425 total
includes taxes & fees
15 Nov - 16 Nov
Holiday Inn Express & Suites Perryville by IHG
A hotel lobby with a reception desk, a blue armchair, a wall-mounted clock, and a framed welcome sign.

14. Super 8 by Wyndham Farmington

Super 8 by Wyndham Farmington
2.0 star property
Farmington
8.0 out of 10, Very good, (690 reviews)
"Clean nice staff are great"
United States
Marisa
The price is AED 219
AED 250 total
includes taxes & fees
16 Nov - 17 Nov
Super 8 by Wyndham Farmington
A hotel with a modern design, featuring a prominent sign for Candlewood Suites. There are multiple parking spaces visible in front of the building.

15. Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG
2.5 star property
Cape Girardeau
8.0 out of 10, Very good, (1,002 reviews)
"Nice clean room"
United States
James
The price is AED 261
AED 314 total
includes taxes & fees
22 Nov - 23 Nov
Candlewood Suites Cape Girardeau by IHG
A hotel room with two beds, a TV, a desk, and a wardrobe.

16. The Farmstead Hotel

The Farmstead Hotel
2.5 star property
Caruthersville
8.6 out of 10, Excellent, (628 reviews)
"The rooms were nice and clean and the hotel itself appears to have been redone fairly recently. The staff is across the road at the casino tower a lot so that can be inconvenient for disabled people. We have been here twice to go to the casino and it has been fun both times!"
United States
Lauren
The price is AED 338
AED 385 total
includes taxes & fees
11 Dec - 12 Dec
The Farmstead Hotel
A modern lounge area with seating options including sofas, chairs, and a hanging chair, with large windows providing a view of the outdoors.

17. Tru By Hilton Cape Girardeau

Tru By Hilton Cape Girardeau
2.5 star property
Cape Girardeau
9.6 out of 10, Exceptional, (201 reviews)
"Had a great stay friendly staff very clean facilities!"
United States
Shannon
The price is AED 313
AED 357 total
includes taxes & fees
16 Nov - 17 Nov
Tru By Hilton Cape Girardeau
A modern hotel with a stone facade, multiple windows, outdoor seating, and a visible sign for the Holiday Inn Express & Suites.

18. Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG

Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
2.5 star property
Festus
9.4 out of 10, Exceptional, (792 reviews)
"Hotel was very clean and comfortable to stay"
United States
Megnauth
The price is AED 367
AED 420 total
includes taxes & fees
22 Nov - 23 Nov
Holiday Inn Express Hotel & Suites FESTUS - SOUTH ST. LOUIS by IHG
A hotel room with two beds, a desk, a chair, a TV, and a window with curtains.

19. Super 8 by Wyndham Potosi

Super 8 by Wyndham Potosi
2.0 star property
Potosi
7.2 out of 10, Good, (433 reviews)
"Great hotel with amazing staff!"
United States
Clay
The price is AED 215
AED 234 total
includes taxes & fees
14 Nov - 15 Nov
Super 8 by Wyndham Potosi
A hotel room with a large bed, two bedside tables, a nightstand, and a framed picture on the wall.

20. Quality Inn Farmington

Quality Inn Farmington
2.5 star property
Farmington
7.6 out of 10, Good, (938 reviews)
"Nice hotel."
United States
Tracy
The price is AED 234
AED 280 total
includes taxes & fees
1 Dec - 2 Dec
Quality Inn Farmington

Top Southeast Missouri Hotel Reviews

A cabin surrounded by a natural forest setting with a fire pit and outdoor seating.
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy
French Village

10/10 Excellent

Limpio,muy fácil el check in cómodo y limpio.
United States
Dixon
Reviewed November 2, 2026
Postcard Cabins St Francois, Outdoor Collection by Marriott Bonvoy

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