A historic building with a large central archway and a pond in the foreground.

Search Vacation Homes in Central Iowa

  • Change your mind

    Book hotels with free cancellation
  • Treat yourself

    Sign in to save 10% or more on thousands of hotels
  • Be picky

    Search almost a million properties worldwide

Check prices for these dates

In two weeks
In two months
In three months
In four months

Our top choices for Central Iowa vacation homes

1. Campus & Downtown - Near Starbucks - Netflix - 2Br/1Ba

Campus & Downtown - Near Starbucks - Netflix - 2Br/1Ba
Ames
10.0 out of 10, Exceptional, (64 reviews)
"Great location!"
United States
Nancie F.
The price is AED 349
AED 605 total
includes taxes & fees
8 Nov - 9 Nov
Campus & Downtown - Near Starbucks - Netflix - 2Br/1Ba

2. Downtown & Campus Wifi with Netflix 2Br 1Ba

Downtown & Campus Wifi with Netflix 2Br 1Ba
Ames
10.0 out of 10, Exceptional, (24 reviews)
"This house was in the perfect location!! It was adorable and cozy!! We loved staying here."
United States
Kara V.
The price is AED 320
AED 572 total
includes taxes & fees
11 Nov - 12 Nov
Downtown & Campus Wifi with Netflix 2Br 1Ba

3. Cozy 2-bedroom house in peaceful Colo with AC

Cozy 2-bedroom house in peaceful Colo with AC
Colo
8.0 out of 10, Very good, (3 reviews)
"Stay was great"
United States
Cory S.
The price is AED 496
AED 987 total
includes taxes & fees
3 Nov - 4 Nov
Cozy 2-bedroom house in peaceful Colo with AC

4. 3BR Getaway, Sleeps 6 | 2-3 Miles to ISU

3BR Getaway, Sleeps 6 | 2-3 Miles to ISU
Ames
9.6 out of 10, Exceptional, (24 reviews)
"Great stay at an economic price!"
United States
Cory M.
The price is AED 437
AED 889 total
includes taxes & fees
8 Nov - 9 Nov
3BR Getaway, Sleeps 6 | 2-3 Miles to ISU

5. Sleeps 6, 3BR-2.5BA | Easy I-35 Access

Sleeps 6, 3BR-2.5BA | Easy I-35 Access
Huxley
10.0 out of 10, Exceptional, (2 reviews)
"We enjoyed our stay. Perfect for visiting our ISU student."
United States
Mary Jo T.
The price is AED 438
AED 885 total
includes taxes & fees
3 Nov - 4 Nov
Sleeps 6, 3BR-2.5BA | Easy I-35 Access

6. Natural Nesting Grounds - Boone, IA

Natural Nesting Grounds - Boone, IA
Boone
9.8 out of 10, Exceptional, (37 reviews)
"So cozy. Just wanted to stay in the house and not go anywhere."
United States
Brooke M.
The price is AED 422
AED 695 total
includes taxes & fees
8 Nov - 9 Nov
Natural Nesting Grounds - Boone, IA

7. Sleeps 10 - 5BR - Minutes to Campus - Next to Park, Golf, Shopping

Sleeps 10 - 5BR - Minutes to Campus - Next to Park, Golf, Shopping
Ames
9.8 out of 10, Exceptional, (6 reviews)
"Very family friendly- lots of room for all of us and the park across the street was great. Easy access and very quiet neighborhood. Neat clean home."
United States
Melanie K.
The price is AED 1,102
AED 2,012 total
includes taxes & fees
3 Nov - 4 Nov
Sleeps 10 - 5BR - Minutes to Campus - Next to Park, Golf, Shopping

8. Spacious 5-bedroom house with AC and WiFi in fantastic NE Ankeny

Spacious 5-bedroom house with AC and WiFi in fantastic NE Ankeny
Ankeny
10.0 out of 10, Exceptional, (17 reviews)
"Great location."
United States
Kevin L.
The price is AED 533
AED 1,230 total
includes taxes & fees
15 Nov - 16 Nov
Spacious 5-bedroom house with AC and WiFi in fantastic NE Ankeny

9. 1800s Home, Train-Themed Decor, Walk to Downtown & Attractions, Exclusive Perks

1800s Home, Train-Themed Decor, Walk to Downtown & Attractions, Exclusive Perks
Boone
10.0 out of 10, Exceptional, (79 reviews)
"Very peaceful and relaxing!"
United States
Matthew M.
The price is AED 823
AED 1,004 total
includes taxes & fees
3 Dec - 4 Dec
1800s Home, Train-Themed Decor, Walk to Downtown & Attractions, Exclusive Perks

10. Entire Home-Beautiful 4BR, 3.5BA Retreat in Ankeny, Iowa 2 King Beds, Fenced, AC

Entire Home-Beautiful 4BR, 3.5BA Retreat in Ankeny, Iowa 2 King Beds, Fenced, AC
Ankeny
9.6 out of 10, Exceptional, (31 reviews)
"Very nice home with all of the amenities."
United States
Catherine N.
The price is AED 512
AED 1,183 total
includes taxes & fees
3 Nov - 4 Nov
Entire Home-Beautiful 4BR, 3.5BA Retreat in Ankeny, Iowa 2 King Beds, Fenced, AC

11. Des Moines Entire home 3 Bdms King; Queen; Twins quiet near High Trestle Trail

Des Moines Entire home 3 Bdms King; Queen; Twins quiet near High Trestle Trail
Ankeny
9.4 out of 10, Exceptional, (32 reviews)
"Great property, clean and comfortable."
United States
Kelly H.
The price is AED 436
AED 1,134 total
includes taxes & fees
16 Nov - 17 Nov
Des Moines Entire home 3 Bdms King; Queen; Twins quiet near High Trestle Trail

12. 5 Min to Adventureland and Casino - Fenced in yard

5 Min to Adventureland and Casino - Fenced in yard
Altoona
9.4 out of 10, Exceptional, (10 reviews)
"We enjoyed this place and its location. The beds were awesome and felt safe in the neighborhood. "
United States
Danielle L.
The price is AED 382
AED 1,082 total
includes taxes & fees
5 Nov - 6 Nov
5 Min to Adventureland and Casino - Fenced in yard

13. Cute tiny home with everything you need!

Cute tiny home with everything you need!
Cedar Falls
9.8 out of 10, Exceptional, (18 reviews)
"So cozy and comfy!"
United States
Jenny C.
The price is AED 342
AED 753 total
includes taxes & fees
8 Nov - 9 Nov
Cute tiny home with everything you need!

14. Ankeny 3BR Duplex, King Bed, Workspace & Game Room

Ankeny 3BR Duplex, King Bed, Workspace & Game Room
Ankeny
7.0 out of 10, Good, (4 reviews)
"Our stay at this location was perfect for our plans. It was close to the trails in the downtown area with easy access to restaurants & bars. The house was easy to check into & clean. Communication with host was quick & responsive. We will definitely look into booking again."
United States
Amy S.
The price is AED 458
AED 1,385 total
includes taxes & fees
3 Nov - 4 Nov
Ankeny 3BR Duplex, King Bed, Workspace & Game Room

15. Four Winds - 1st Floor

Four Winds - 1st Floor
Saint Ansgar
10.0 out of 10, Exceptional, (4 reviews)
"This place was the perfect place to stay in St Ansgar."
United States
Roxanne C.
Four Winds - 1st Floor

16. 1-bedroom, 3 Gig-Fiber WiFi, timbered/view setting in WDM near RecPlex/DMU

1-bedroom, 3 Gig-Fiber WiFi, timbered/view setting in WDM near RecPlex/DMU
West Des Moines
9.2 out of 10, Wonderful, (15 reviews)
"Beautiful place to stay and very accommodating host."
United States
Amy K.
1-bedroom, 3 Gig-Fiber WiFi, timbered/view setting in WDM near RecPlex/DMU

17. Enjoy a stylish experience at this centrally-located newly built home.

Enjoy a stylish experience at this centrally-located newly built home.
Ankeny
10.0 out of 10, Exceptional, (12 reviews)
"Newly furnished, clean, close to activities. Would stay again!"
United States
Liz D.
The price is AED 479
AED 1,125 total
includes taxes & fees
9 Nov - 10 Nov
Enjoy a stylish experience at this centrally-located newly built home.

18. Ankeny’s Best/Hot tub/Theatre Room/Game Room

Ankeny’s Best/Hot tub/Theatre Room/Game Room
Ankeny
10.0 out of 10, Exceptional, (9 reviews)
"Fantastic place with a great vibe! Was perfect for our 4th of July Getaway!"
United States
Conor F.
The price is AED 687
AED 1,551 total
includes taxes & fees
3 Nov - 4 Nov
Ankeny’s Best/Hot tub/Theatre Room/Game Room

19. Farmhouse Oasis

Farmhouse Oasis
Dallas Center
10.0 out of 10, Exceptional, (32 reviews)
"The property was great and would stay again and recommend to family and friends if ciming into town."
United States
Michael D.
Farmhouse Oasis

20. New Spacious 4-bedroom house in charming Ankeny with WiFi, AC-Prime Location

New Spacious 4-bedroom house in charming Ankeny with WiFi, AC-Prime Location
Ankeny
9.8 out of 10, Exceptional, (40 reviews)
"Location worked out perfect for us. The house was clean and the hosts were very responsive."
United States
Steve D.
The price is AED 512
AED 1,162 total
includes taxes & fees
3 Nov - 4 Nov
New Spacious 4-bedroom house in charming Ankeny with WiFi, AC-Prime Location
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
Save an average of 15% on thousands of hotels when you're signed in

Top Central Iowa Hotel Reviews

Explore a world of travel with Expedia