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Candlewood Suites Cape Girardeau by IHG
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- Best Western Plus Sikeston I-55
- Fairfield Inn & Suites by Marriott Cape Girardeau
- Courtyard by Marriott Cape Girardeau Downtown
- Hampton Inn Cape Girardeau I 55 East
- Peaceful secluded cabin located near Horseshoe Lake
- Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
- Fairfield Inn & Suites by Marriott Sikeston
- Super 8 by Wyndham Sikeston/Miner Area
- Holiday Inn Express & Suites Sikeston Southwest by IHG
- Town House Inn Cape Giradreau
- Country Yard Inn and Suite
- TownePlace Suites by Marriott Sikeston
- Comfort Inn & Suites Sikeston I-55
- Cozy cabins on beautiful Horseshoe Lake
- Serenity South -- Gardens, River-Views, and Refreshing Space
- Quality Inn Cairo I-57
- Little Blue Cottage on Spanish
- “Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau