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Check prices for these dates

Next weekend
19 Dec - 21 Dec
In two weeks
26 Dec - 28 Dec
In one month
9 Jan - 11 Jan
In two months
6 Feb - 8 Feb

Our top choices for Defiance motels

Property amenity
Baymont by Wyndham Warrenton

Baymont by Wyndham Warrenton

2.5 star property
Warrenton
7.4 out of 10, Good, (1000)
"Room very clean, most of staff helpful"
United States
Ranata
The price is AED 307
AED 353 total
includes taxes & fees
21 Dec - 22 Dec
Baymont by Wyndham Warrenton
In-room safe, desk, laptop workspace, blackout drapes
Super 8 by Wyndham Warrenton

Super 8 by Wyndham Warrenton

2.0 star property
Warrenton
7.4 out of 10, Good, (619)
"Room was clean. Staff very helpful, accommodating. "
United States
Ranata
The price is AED 225
AED 258 total
includes taxes & fees
10 Jan - 11 January 2026
Super 8 by Wyndham Warrenton
Lobby
Relax Inn Saint Charles

Relax Inn Saint Charles

2.0 star property
St. Charles
6.6 out of 10, (1000)
"Great place to stay "
United States
Askar
The price is AED 224
AED 258 total
includes taxes & fees
18 Dec - 19 Dec
Relax Inn Saint Charles
Desk, laptop workspace, free WiFi, bed sheets
Motel 6 Maryland Heights, MO

Motel 6 Maryland Heights, MO

2.0 star property
Maryland Heights
6.0 out of 10, (1002)
"great value "
United States
gaspar
The price is AED 231
AED 268 total
includes taxes & fees
24 Dec - 25 Dec
Motel 6 Maryland Heights, MO
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Top Defiance Hotel Reviews

Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

10/10 Excellent
"Front staff was very friendly and very helpful. Check-in and check out was smooth and very easy. "
James 2-night trip
Posted 17 hours ago
Hollywood Casino & Hotel St. Louis

Frequently asked questions

What can I expect from a motel trip to Defiance?
If you're having difficulty finding a motel in Defiance, expand your search to find motels in the surrounding area or let Expedia help you find something similar from over 20 lodging options. Just use our search tools to filter by price per night or money-saving amenities such as free parking and free airport transportation.
What is a motel?
Motels often have free parking, and many also include an outdoor pool. Often one or two stories tall, motel properties usually have exterior corridors overlooking the parking lot or an outdoor pool. Introduced in the early 1950s, colorful neon signs were used as beacons for tired families on road trips, and you can see these today along the historic U.S. Route 66.
What are the best motels in Defiance?
Here are some of Expedia customers' favorite motels to book in the larger area. Relax Inn Saint Charles is located 16.2 mi (26 km) from the heart of Defiance. Enjoy access to the laundry facilities, and freebies including WiFi and parking. Motel 6 Maryland Heights, MO: Free WiFi, free parking, and a snack bar/deli are available during your stay. Central Defiance is 18.6 mi (29.9 km) away. Baymont by Wyndham Warrenton: Enjoy access to the 24-hour business center, and freebies including breakfast, WiFi, and parking. Located 23.8 mi (38.3 km) from the heart of Defiance. Super 8 by Wyndham Warrenton: Central Defiance is 22.8 mi (36.7 km) away. 24-hour room service along with freebies like breakfast, WiFi, and parking are available during your stay. BEST WAY INN: 21.3 mi (34.4 km) from the heart of Defiance. Enjoy access to the 24-hour front desk, and freebies including WiFi and parking.
What can I do in Defiance?
These are some of the parks and outdoorsy places: Matson Hill Park Trailhead, August A. Busch Memorial Conservation Area, and Missouri River. You'll find these family-friendly sights in the area: Chesterfield Sports Fusion, Sky Zone Indoor Trampoline Park - St. Louis, and Six Flags St. Louis. During your trip, here are some other places to visit: Yellow Farmhouse Winery, Chandler Hill Vineyards, and Sugar Creek Winery.
What's the weather like in Defiance?
Weather can make or break a roadtrip, so here's some data about year-round temperatures in Defiance to help you plan yours: The hottest months are usually July and August with an average temp of 76°F, while the coldest months are January and February with an average of 38°F. Average annual precipitation for Defiance is 48 inches.
What are my options for getting around Defiance when staying in a motel?
We've gathered some information about getting around Defiance to help you navigate your stay: Fly into St. Louis, MO (SUS-Spirit of St. Louis), which is located 7.5 mi (12 km) away from the heart of the city. You can also search for flights into St. Louis Lambert Intl. Airport (STL), which is 23.5 mi (37.8 km) away. If you'd like to explore around the area, you may want a rental car for your journey.