Find hotels in East Prairie, MO from AED 180

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Our top choices for East Prairie hotels

Drury Inn & Suites Sikeston, MO

Drury Inn & Suites Sikeston, MO
3.0 star property
Sikeston
9.4 out of 10, Exceptional, (1000)
Located just off the highway near Sikeston dining and shopping, this hotel offers both indoor and outdoor pools for year-round swimming. Guests praise the peaceful atmosphere, helpful staff, and complimentary breakfast, parking, and WiFi.

"This our favorite place to stop for a good night sleep. "
United States
Eileen
The price is AED 331
AED 380 total
includes taxes & fees
29 Dec - 30 Dec
Drury Inn & Suites Sikeston, MO

Best Western Plus Sikeston

Best Western Plus Sikeston
2.5 star property
Sikeston
8.4 out of 10, Very Good, (1009)
Located in Sikeston, this hotel offers an indoor pool for relaxing swims after a day of exploring. Near Central Park and the Sikeston Depot Museum, guests praise the delicious free breakfast and attentive service.

"Great stay, everything was clean and comfortable. "
United States
Charles
The price is AED 278
AED 317 total
includes taxes & fees
28 Dec - 29 Dec
Best Western Plus Sikeston

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)
2.5 star property
Sikeston
8.4 out of 10, Very Good, (722)
Enjoy tranquil accommodations at this welcoming Sikeston hotel where helpful staff receive consistent praise. Located near Central Park and Sikeston Depot Museum, guests appreciate the quiet atmosphere, clean rooms, and daily continental breakfast.

"Room was good as usual. This is 4th stay over past 5 years. Only issue I had on this stay was the orange juice from breakfast options. "
United States
Todd
The price is AED 204
AED 232 total
includes taxes & fees
25 Dec - 26 Dec
Travel Inn & Suites - Sikeston/Miner (i-55 Exit-67)

Holiday Inn Express & Suites Union City by IHG

Holiday Inn Express & Suites Union City by IHG
2.5 star property
Union City
9.4 out of 10, Exceptional, (310)
Experience comfort in the entertainment district of Union City at this welcoming hotel. Start your day with free breakfast before exploring nearby Discovery Park of America. After sightseeing, unwind in the indoor pool or maintain your routine at the 24-hour fitness center.

"Rooms were spotless and comfortable. The bathroom had all the amenities. Great view. Awesome buffet breakfast to wake up to. "
United States
Rickey Smith
The price is AED 345
AED 410 total
includes taxes & fees
2 Jan - 3 January 2026
Holiday Inn Express & Suites Union City by IHG

Sleep Inn at Discovery Park of America

Sleep Inn at Discovery Park of America
2.5 star property
Union City
9.2 out of 10, Wonderful, (320)
Located in Union City, this hotel offers convenient access to Discovery Park of America. Enjoy free breakfast, WiFi, and parking. Jump into the indoor pool or get active in the 24-hour fitness center, making your Tennessee adventure complete.

"Wonderful breakfast, awesome room"
United States
Kimberly
The price is AED 294
AED 349 total
includes taxes & fees
2 Jan - 3 January 2026
Sleep Inn at Discovery Park of America

Pear Tree Inn Sikeston

Pear Tree Inn Sikeston
2.5 star property
Sikeston
9.4 out of 10, Exceptional, (1001)
Escape to this serene retreat with both indoor and outdoor pools for year-round enjoyment. The fitness center keeps your routine intact while complimentary breakfast energizes your day exploring nearby Central Park and Sikeston Depot Museum.

"Everything was clean, staff was friendly "
United States
Matthew
The price is AED 275
AED 317 total
includes taxes & fees
28 Dec - 29 Dec
Pear Tree Inn Sikeston

Hampton Inn Sikeston

Hampton Inn Sikeston
2.5 star property
Sikeston
9.0 out of 10, Wonderful, (450)
Take a refreshing dip in the indoor pool or maintain your routine at the fitness center. Free breakfast, WiFi, and parking enhance your stay. Central Park and Sikeston Depot Museum are just moments away from this welcoming retreat.

"clean room, comfy bedding, nice staff, convenient location "
United States
Alexa
The price is AED 358
AED 406 total
includes taxes & fees
4 Jan - 5 January 2026
Hampton Inn Sikeston

Country Hearth Inn & Suites Union City

Country Hearth Inn & Suites Union City
2.5 star property
Union City
8.6 out of 10, Excellent, (548)
Discover convenience at this friendly Union City motel, where free breakfast and parking enhance every stay. Explore County Market Place and Reelfoot Shopping Center nearby. Guests consistently praise the clean rooms and helpful staff.

"Clean rooms, helpful and polite staff"
United States
Jennifer
The price is AED 264
AED 314 total
includes taxes & fees
25 Dec - 26 Dec
Country Hearth Inn & Suites Union City

Super 8 by Wyndham Charleston/Sikeston East MO

Super 8 by Wyndham Charleston/Sikeston East MO
2.0 star property
Charleston
6.6 out of 10, (613)
This Charleston motel offers complimentary on-the-go breakfast and WiFi for a hassle-free stay. Guests appreciate the helpful staff and free parking. Located within driving distance of Cape Girardeau Municipal Airport for easy regional access.

"Staff was great! Room was nice. "
United States
Lana
Super 8 by Wyndham Charleston/Sikeston East MO

Quality Inn Union City US 51

Quality Inn Union City US 51
2.5 star property
Union City
8.4 out of 10, Very Good, (488)
Unwind at this Union City hotel offering a seasonal outdoor pool and hot tub for relaxation. Just a short distance from County Market Place and Reelfoot Shopping Center, guests enjoy free breakfast, WiFi, and parking.

"The Staff for sure is what keeps me coming back! Plus the rooms are very clean!"
United States
Walter
The price is AED 247
AED 293 total
includes taxes & fees
11 Jan - 12 January 2026
Quality Inn Union City US 51

New Orleans Inn Portageville

New Orleans Inn Portageville
2.5 star property
Portageville
8.0 out of 10, Very Good, (732)
This welcoming motel offers clean rooms praised by guests, plus convenient amenities including free WiFi and parking. The 24-hour front desk ensures assistance anytime during your stay in charming Portageville.

"Friendly sta"
United States
Melissa
New Orleans Inn Portageville

Comfort Inn & Suites Sikeston I-55

Comfort Inn & Suites Sikeston I-55
2.5 star property
Sikeston
8.4 out of 10, Very Good, (282)
Experience refreshing comfort at this Sikeston hotel with an indoor swimming pool and fitness center. Near Central Park and Sikeston Depot Museum, travelers appreciate the helpful staff, complimentary WiFi, and free parking for a convenient, stress-free stay.

"Room was clean, breakfast was very good. "
United States
Connie
The price is AED 325
AED 370 total
includes taxes & fees
29 Dec - 30 Dec
Comfort Inn & Suites Sikeston I-55

Super 8 By Wyndham Marston

Super 8 By Wyndham Marston
2.0 star property
Marston
7.8 out of 10, Good, (39)
This hotel in Marston offers complimentary perks including daily full breakfast served between 6:00 AM and 9:00 AM, WiFi, and self parking. Conveniently located for travelers exploring the area.

"Great hotel, great staff"
United States
Dmitry
The price is AED 212
AED 242 total
includes taxes & fees
26 Dec - 27 Dec
Super 8 By Wyndham Marston

Holiday Inn Express & Suites Sikeston Southwest by IHG

Holiday Inn Express & Suites Sikeston Southwest by IHG
2.5 star property
Sikeston
8.6 out of 10, Excellent, (443)
Discover comfort at this Sikeston hotel with an indoor pool and fitness center. Enjoy complimentary breakfast, WiFi, and parking while exploring nearby Central Park and Sikeston Depot Museum. Guests consistently praise the helpful staff and immaculate rooms.

"Staff was great. Hotel was clean. Great sleep. "
United States
Jeffrey
The price is AED 386
AED 437 total
includes taxes & fees
4 Jan - 5 January 2026
Holiday Inn Express & Suites Sikeston Southwest by IHG

Fairfield Inn & Suites by Marriott Sikeston

Fairfield Inn & Suites by Marriott Sikeston
2.5 star property
Sikeston
9.2 out of 10, Wonderful, (41)
This business-friendly hotel offers an indoor pool, restaurant, and complimentary breakfast. Located near Sikeston Depot Museum, guests enjoy free WiFi and parking while exploring local attractions.

"THE ROOM WAS SPOTLESS, CLEAN LOBBY, WARM AND LOT OF VARITY BREAKFAST, STAFF IS SO NICE."
United States
AHMAD
The price is AED 371
AED 420 total
includes taxes & fees
1 Jan - 2 January 2026
Fairfield Inn & Suites by Marriott Sikeston

Reelfoot Lake Inn

Reelfoot Lake Inn
2.0 star property
Tiptonville
7.2 out of 10, Good, (461)
"Bed bugs in two separate rooms, wouldn’t refund my room"
United States
Jacquelynn
The price is AED 256
AED 294 total
includes taxes & fees
25 Dec - 26 Dec
Reelfoot Lake Inn

Hampton Inn Union City

Hampton Inn Union City
2.5 star property
Union City
9.6 out of 10, Exceptional, (165)
Located near County Market Place and Reelfoot Shopping Center, this welcoming hotel offers a free breakfast and convenient parking. Take a morning swim in the indoor pool after enjoying the complimentary meal. The helpful staff earns consistent praise from guests.

"Clean room, nice breakfast"
United States
STUART
The price is AED 376
AED 447 total
includes taxes & fees
4 Jan - 5 January 2026
Hampton Inn Union City

Quality Inn Cairo I-57

Quality Inn Cairo I-57
2.5 star property
Cairo
6.6 out of 10, (274)
Start your day with complimentary full breakfast before exploring nearby attractions. This hotel provides free WiFi and parking, making it an ideal base for visiting Fort Defiance State Park and Ballard Wildlife Management Area.

"Break fast was excellent "
United States
Uma
Quality Inn Cairo I-57

MainStay Suites Union City, TN

MainStay Suites Union City, TN
2.5 star property
Union City
8.6 out of 10, Excellent, (42)
Hiking trails surround this welcoming hotel with free breakfast and parking. The 24-hour fitness center and health club keep exercise routines on track, while in-room refrigerators and microwaves add convenience for extended stays.

"Perfect, staff was very helpful."
United States
Marcos
The price is AED 327
AED 388 total
includes taxes & fees
29 Dec - 30 Dec
MainStay Suites Union City, TN

Super 8 by Wyndham Sikeston/Miner Area

Super 8 by Wyndham Sikeston/Miner Area
2.0 star property
Sikeston
6.8 out of 10, (568)
Start your day with complimentary breakfast at this Sikeston hotel. Enjoy free WiFi and parking while staying minutes from Central Park and the Sikeston Depot Museum. Cape Girardeau Municipal Airport is just a 29-minute drive away.

"Awesomeness "
United States
Rick
The price is AED 218
AED 249 total
includes taxes & fees
25 Dec - 26 Dec
Super 8 by Wyndham Sikeston/Miner Area
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.
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Stay near popular East Prairie attractions

Learn more about East Prairie

Discover local heritage at the East Prairie Historical Museum, where artifacts tell the story of this Mississippi County town. Join the community for the annual Tour de Corn cycling event or explore nearby Big Oak Tree State Park for impressive ancient trees and wildlife viewing.

Bridge over Mississippi River, New Orleans in background

Top East Prairie Hotel Reviews

More cheap stays in East Prairie

Hotels in East Prairie with star-rating

Find out more about East Prairie

Top reasons to visit East Prairie

  • Scenic Trails: East Prairie features beautiful landscapes and trails perfect for hiking and outdoor adventures.
  • Romantic Getaways: Ideal for couples, the town offers charming settings for a cozy getaway.
  • Local History: Explore museums and historical sites that showcase the rich culture of the area.
  • Family-Friendly Parks: Enjoy lush parks that provide great spots for family excursions and picnics.
  • Comfortable Accommodations: A variety of hotels and motels cater to travelers' needs, ensuring a pleasant stay.

Find great hotels near East Prairie

Explore a variety of hotel accommodations in East Prairie, Missouri, ideal for travelers seeking comfort and convenience. Whether you're on a business trip, a family vacation, or traveling with pets, you'll find a range of options, including hotels and motels that cater to your needs. Discover the best hotels in East Prairie with positive reviews to ensure a pleasant stay in this charming town.

  • Days Inn and Suites by Wyndham Sikeston: Situated 17.7km from East Prairie, Days Inn and Suites by Wyndham Sikeston offers a welcoming atmosphere perfect for business travelers and pet owners alike. This hotel is designed with convenience in mind, featuring spacious rooms equipped with essential amenities. Guests can enjoy the comfort of a pet-friendly environment, with specific policies accommodating dogs and cats. The hotel also provides complimentary breakfast, making it easy to start your day off right. With its focus on practicality and comfort, this hotel is an excellent choice for those traveling with furry companions.
  • Drury Inn & Suites Sikeston, MO: Also located 17.7km from East Prairie, Drury Inn & Suites Sikeston, MO is a renowned 3-star hotel that embraces inclusivity, welcoming LGBTQIA travelers with open arms. The hotel boasts a variety of amenities designed for both business and leisure guests, including complimentary hot breakfast and evening snacks. Pet-friendly rooms are available with certain restrictions for dogs and cats, ensuring that your furry friends can join you on your journey. The inviting atmosphere and commitment to exceptional service make this hotel a favorite among travelers seeking comfort and community.
  • Pear Tree Inn Sikeston: Just 17.7km from East Prairie, Pear Tree Inn Sikeston caters to families, business travelers, and pet owners with its warm hospitality and thoughtful amenities. The hotel features family-friendly services, including complimentary cribs for younger guests, making it an ideal choice for those traveling with children. Pets are welcome too, with specific policies for dogs and cats. Guests can enjoy a cozy stay with comfortable accommodations and a complimentary breakfast that caters to all ages. Pear Tree Inn Sikeston strikes a balance between family-friendly warmth and professional service, ensuring a pleasant stay for everyone.

Where to stay near East Prairie

Discover the charm of East Prairie, Missouri, where outdoor enthusiasts and romantic getaways thrive. Just a short drive from Sikeston, explore lush parks and scenic open spaces perfect for family-friendly excursions. Enjoy the warm atmosphere filled with friendly people and delightful shopping experiences. Whether you're fishing, hiking, or simply relaxing, East Prairie offers a serene escape that will leave you refreshed and inspired.

  • Sikeston: Located 20.9km from East Prairie, Sikeston is a vibrant city known for its outdoor and family-friendly experiences. The city attracts visitors year-round, with peak seasons from June to August and December to February. Sikeston offers a variety of recreational areas, shopping centers, and educational venues. Notable attractions include a scenic lake and an event conference venue, making it an ideal spot for both relaxation and activities. Whether you're enjoying a day outdoors or exploring local shops, Sikeston provides a welcoming atmosphere for travelers.
  • Charleston: Just 16.1km away from East Prairie, Charleston is a charming city perfect for those seeking outdoor adventures and captivating scenery. Visitor numbers peak in April and from June to July, with a slight decline from October to December. Charleston boasts numerous recreational areas and shopping centers, alongside educational opportunities. The city is home to beautiful landmarks such as a national state park and various historic sites, offering a glimpse into the area's rich history. Nature enthusiasts and adventure seekers will find plenty to explore in Charleston.
  • Bertrand: Also located 16.1km from East Prairie, Bertrand is a picturesque city that attracts visitors for its outdoor adventures and scenic views. With peak travel periods in April, August, and from December to January, Bertrand offers a wealth of natural beauty. The nearby national park, lush forests, and serene lakes provide ample opportunities for hiking, fishing, and enjoying nature. Bertrand is perfect for those looking to escape the hustle and bustle of city life while immersing themselves in the great outdoors.

Things to do near East Prairie

East Prairie, Missouri, is an ideal destination for outdoor enthusiasts and couples seeking a romantic getaway. Visitors can enjoy scenic trails, a recreational area, and opportunities for skiing. Major attractions include the beautiful landscapes of the prairie and various local tourism experiences that showcase the area's natural beauty. Whether you're looking for adventure or relaxation, East Prairie offers a charming escape for all types of travelers.

Shopping

If you're up for a drive, County Market Place is a shopping center located 49.9km away from East Prairie. This venue offers a blend of city, family, and business vibes, making it a great spot for finding unique gifts and souvenirs during your visit.

Recreation

Experience tranquility at the East Prairie Wellness Center, offering yoga classes and holistic therapies in a calming environment. For outdoor fun, visit the nearby Lake County Park, where you can enjoy fishing, hiking trails, and picnicking amidst nature's beauty.

Adventure

In East Prairie, explore the beautiful landscapes at the nearby Mingo National Wildlife Refuge, ideal for hiking and birdwatching. Experience fishing at the local lakes, or try your hand at kayaking for an exciting adventure on the water, surrounded by nature's beauty.

Nightlife

In East Prairie, the Union City Masquerade Theatre, located 49.9km away, is a fantastic spot for a romantic night out, featuring captivating performances that blend entertainment and culture, perfect for immersing yourself in the local arts scene.

*Distances are measured in a straight line; actual driving distances may vary depending on the route.

Booking tips and Expedia advantages for East Prairie

To save money on your trip to East Prairie, plan your visit between December and February when accommodation prices are lowest. Sundays offer the cheapest stays, while Saturdays are the most expensive. Utilize Expedia’s search tool to compare hotel rates and consider booking a package that includes flights and activities for additional savings. For budget-friendly transportation, walking is a great option since the town is easy to navigate. Look for free activities and local attractions to make the most of your visit without overspending.

  • The most and least expensive months on average to stay in a hotel: The cheapest months to stay in East Prairie are December to February, where the prices are slightly lower. This is in comparison to April, June and August, where prices are slightly higher.
  • The most and least expensive days on average to stay in a hotel: The least expensive day to stay in East Prairie is Sunday. The most expensive day to stay in East Prairie is Saturday.
  • Find cheap hotels on Expedia: Utilize Expedia’s search tool to refine your options based on your budget, desired location, and preferred hotel type. To find the best prices and deals, simply arrange the price filter from lowest to highest.
  • Consider bundling your trip: You can save money by combining your East Prairie hotel reservation with your flights and activities through an Expedia package.

Find the best attractions in and around East Prairie

East Prairie, Missouri, offers a charming blend of outdoor adventures and cultural experiences perfect for a romantic getaway. Visitors can explore beautiful state parks, delve into local history at museums, or attend events at various venues. The area is ideal for those seeking scenic landscapes and engaging activities, with nearby attractions enhancing your exploration of this quaint town.

  • Big Oak Tree State Park: Experience the grandeur of one of the largest oak trees in the United States in this serene national park. With scenic trails and lush landscapes, it’s perfect for outdoor enthusiasts and those seeking adventure in nature.
  • Central Park: Located 20.9km from East Prairie, this vibrant urban park offers a family-friendly atmosphere with playgrounds, picnic areas, and walking paths. Enjoy a leisurely day surrounded by greenery while soaking up the lively city vibes.
  • Sikeston Depot Museum: Also 20.9km away, this art museum showcases the rich cultural history of the region. Explore fascinating exhibits and learn about local heritage while immersing yourself in the artistic ambiance.

Best time to go to East Prairie

The best time to visit East Prairie can depend on the weather and when visitor numbers rise and fall. The hottest average temperature in East Prairie falls in July, when visitor numbers are moderately high and weather is mostly sunny with light rain. The coolest average temperature in East Prairie falls in January, visitor numbers are moderately high and weather is mostly sunny with light rain.

calendarCalendar MonthtemperatureTemperaturerainPrecipitationmostlyCloudinessoccupationOccupancypricePricing
January36.3°F (2.4°C)Light RainMostly SunnyModerately HighSlightly Low
February39.4°F (4.1°C)Light RainMostly SunnyAverageSlightly Low
March49.5°F (9.7°C)Light RainMostly SunnyAverageAverage
April58.5°F (14.7°C)Light RainMostly SunnyAverageSlightly High
May68.2°F (20.1°C)Light RainMostly SunnyAverageAverage
June77.0°F (25.0°C)Light RainMostly SunnyModerately HighSlightly High
July79.5°F (26.4°C)Light RainMostly SunnyModerately HighAverage
August77.5°F (25.3°C)Light RainMostly SunnyAverageSlightly High
September72.1°F (22.3°C)Light RainMostly SunnyAverageAverage
October60.8°F (16.0°C)Light RainMostly SunnyModerately LowAverage
November48.6°F (9.2°C)Light RainMostly SunnyModerately LowAverage
December41.2°F (5.1°C)Light RainMostly SunnyModerately LowSlightly Low

The nearest major airports for your trip to East Prairie

Traveling to East Prairie, Missouri, is convenient with several nearby airports. Paducah, KY (PAH-Barkley Regional) is 62.8km away, with hotel options like The Respite Bed and Breakfast and Harrah's Metropolis Hotel & Casino located nearby. Cape Girardeau, MO (CGI-Cape Girardeau Municipal) is 51.5km from East Prairie, offering accommodations such as the Drury Plaza Hotel and Courtyard by Marriott. Cairo, IL (CIR-Cairo Regional) is the closest, just 33.8km away, with options including Quality Inn and Super 8 by Wyndham. Each airport provides easy access to local hotels, ensuring a comfortable stay for visitors.

Frequently asked questions

What's the best place for a stay in East Prairie?
Drury Inn & Suites Sikeston, MO, located 11.4 mi (18.4 km) from the heart of East Prairie, is a top choice for your stay based on our traveler data. Other good options for your visit to the area are Hampton Inn Sikeston and Sleep Inn at Discovery Park of America. See all available top hotels, or vacation rentals in East Prairie.
What are some of the best vacation rentals that East Prairie has to offer?
3 bedroom house on Reelfoot Lake, perfect for families, fisherman and hunters: Visitors like this East Prairie vacation home rental. It is located on a lake and has a fireplace, a patio, and a barbecue grill to put you at ease in your new surroundings. Kitchen amenities include a dishwasher, a fridge, and a stovetop. See all vacation rentals in East Prairie.
If I need to cancel my hotel reservation in East Prairie, will I receive a refund?
Yes! The majority of hotel room reservations are fully refundable if you cancel before the hotel's cancellation deadline, which is often 24 or 48 hours before the scheduled arrival. If your reservation is non-refundable, it may still be possible to cancel it and receive a refund within a 24-hour period of your booking. Filter your search by fully refundable to find flexible hotel deals in East Prairie.
Where can I learn more about changing or cancelling my trip to East Prairie?
To access more information about rescheduling or cancelling your trip to East Prairie, click here.
What's the best hotel for staying near Cape Girardeau Municipal Airport (CGI)?
Candlewood Suites Cape Girardeau is one of the top choices for your stay and is a popular hotel, featuring an indoor pool and free WiFi. It's located 4.4 mi (7 km) from Cape Girardeau Municipal Airport.
What's it like to stay in East Prairie?
Visitors are sure to enjoy all that East Prairie has to offer. There are 33 hotels and other accommodations in the surrounding area. Find out more about East Prairie.
What should I do while I'm visiting East Prairie?
The picturesque setting of Mississippi River and Big Oak Tree State Park exemplify the area's natural beauty. You'll also find Central Park and River Ridge Winery in the area. Check out what more to see and do in Expedia's East Prairie guide.
What's the weather like in East Prairie?
The hottest months are usually July and August with an average temp of 77°F, while the coldest months are January and February with an average of 41°F. Average annual precipitation for East Prairie is 60 inches.

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